| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeong-Gon Choi, Jae-Hyun Park, Sabina Li. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19056464. |
acupuncture inhibited decreases in the immunoreactivities of tyrosine hydroxylase (th) and dopamine transporter (dat) that occurred as a result of mptp neurotoxicity. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
the dopamine transporter (dat) is a key mediator of dopaminergic neurotransmission and a major target for amphetamine. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
pkcbeta ko mice have less striatal surface dat, [3h]dopamine uptake, and amphetamine-stimulated dopamine efflux, yet higher novelty-induced locomotor activity than wt mice. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
although a short exposure (< or =90 s) to amphetamine rapidly increases striatal surface dat and [3h]dopamine uptake in wt mice, this treatment decreases surface dat and [3h]dopamine uptake in ko mice. |
2009-03-24 |
2023-08-12 |
mouse |
| Rong Chen, Cheryse A Furman, Minjia Zhang, Myung N Kim, Robert W Gereau, Michael Leitges, Margaret E Gneg. Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19098163. |
increases in surface dat and [3h]dopamine uptake are not evident in ko mice until a longer exposure (60 min) to amphetamine, by which time wt mice exhibit decreased surface dat and dopamine uptake. |
2009-03-24 |
2023-08-12 |
mouse |
| Yan-ming Xu, En-xiang Tao, Xiao-jun Din. [Responsive changes to MPTP in rats with DAT inhibited by antisense oligonucleotides]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 25. issue 2. 2009-03-19. PMID:18393256. |
to investigate the inhibitory effect of antisense oligonucleotides (odn) on dopamine transporter (dat) in rats and observe the response of the rats to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2009-03-19 |
2023-08-12 |
rat |
| Thomas Hillemacher, Helge Frieling, Thomas Hartl, Julia Wilhelm, Johannes Kornhuber, Stefan Bleic. Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. Journal of psychiatric research. vol 43. issue 4. 2009-03-18. PMID:18504048. |
epigenetic regulation via promoter specific dna methylation of the dopamine transporter gene (dat) may influence altered dopaminergic neurotransmission in alcoholism. |
2009-03-18 |
2023-08-12 |
Not clear |
| Lynette C Daw. Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacology & therapeutics. vol 121. issue 1. 2009-03-18. PMID:19022290. |
biogenic amine transporters for serotonin, norepinephrine and dopamine (sert, net and dat respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. |
2009-03-18 |
2023-08-12 |
Not clear |
| Vladimir Stepanov, Jaak Jär. Kinetic mechanism of dopamine transporter interaction with 1-(2-(bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909). Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18845198. |
it appears that the isomerization phenomenon previously described for pe2i is not limited to tropane-based dat inhibitors, but is, in fact, a general property of dopamine transporter protein, similar to "isomerization" process reported previously for g-protein coupled receptors. |
2009-03-09 |
2023-08-12 |
rat |
| Elisabeth M van de Giessen, Maartje M L de Win, Michael W T Tanck, Wim van den Brink, Frank Baas, Jan Booi. Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 1. 2009-03-06. PMID:19091889. |
polymorphisms in the dopamine transporter (dat) gene slc6a3 are associated with human striatal dat expression, but the exact effects on dat expression are not clear. |
2009-03-06 |
2023-08-12 |
human |
| Cindy Casteels, Erwin Lauwers, Guy Bormans, Veerle Baekelandt, Koen Van Laer. Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson's disease. European journal of nuclear medicine and molecular imaging. vol 35. issue 1. 2009-03-04. PMID:17906859. |
here, we have characterized this model in vivo by multitracer imaging [glucose metabolism and dopamine transporter (dat)] in relation to behavioral and histological parameters. |
2009-03-04 |
2023-08-12 |
rat |
| Trent J Volz, Sarah J Farnsworth, Shane D Rowley, Glen R Hanson, Annette E Fleckenstei. Age-dependent differences in dopamine transporter and vesicular monoamine transporter-2 function and their implications for methamphetamine neurotoxicity. Synapse (New York, N.Y.). vol 63. issue 2. 2009-03-03. PMID:19021208. |
the initial velocities of dopamine (da) transport into, meth-induced da efflux from, and da transporter (dat) immunoreactivity in striatal suspensions are greater in pnd38-42 rats than in pnd88-92 rats. |
2009-03-03 |
2023-08-12 |
rat |
| Leonard L Howel. Nonhuman primate neuroimaging and cocaine medication development. Experimental and clinical psychopharmacology. vol 16. issue 6. 2009-03-03. PMID:19086766. |
given the important role of the dopamine transporter (dat) in the addictive properties of cocaine, the development and use of compounds that target the dat represents a reasonable approach for the pharmacological treatment of cocaine abuse. |
2009-03-03 |
2023-08-12 |
Not clear |
| Leonard L Howel. Nonhuman primate neuroimaging and cocaine medication development. Experimental and clinical psychopharmacology. vol 16. issue 6. 2009-03-03. PMID:19086766. |
a profile of slow rate of drug uptake in brain accompanied by a gradual increase in extracellular dopamine may account for the more limited reinforcing effectiveness of the dat inhibitors. |
2009-03-03 |
2023-08-12 |
Not clear |
| Balachandra K Gorentla, Amy E Moritz, James D Foster, Roxanne A Vaugha. Proline-directed phosphorylation of the dopamine transporter N-terminal domain. Biochemistry. vol 48. issue 5. 2009-03-03. PMID:19146407. |
phosphorylation of the dopamine transporter (dat) on n-terminal serines and unidentified threonines occurs concomitantly with protein kinase c (pkc)- and substrate-induced alterations in transporter activity, subcellular distribution, and dopamine efflux, but the residues phosphorylated and identities of protein kinases and phosphatases involved are not known. |
2009-03-03 |
2023-08-12 |
rat |
| J E de Leeuw van Weenen, L Hu, K Jansen-Van Zelm, M G de Vries, J T Tamsma, J A Romijn, H Pij. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain research. vol 1250. 2009-02-27. PMID:19028458. |
we monitored in vivo dopamine release in the dorsomedial region of the hypothalamus, and determined hypothalamic gene expression patterns of dopamine receptors 1 and 2 (drd1 and 2), tyrosine hydroxylase (th) and the dopamine transporter (dat) in c57bl6 mice maintained on a high fat diet for 4 weeks. |
2009-02-27 |
2023-08-12 |
mouse |
| Ole Valente Mortensen, Mads Breum Larsen, Balakrishna M Prasad, Susan G Amar. Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking. Molecular biology of the cell. vol 19. issue 7. 2009-02-25. PMID:18434601. |
to identify molecules in pathways that regulate dopamine transporter (dat) internalization, we used a genetic complementation screen in xenopus oocytes to identify a mitogen-activated protein (map) kinase phosphatase, mkp3/pyst1/dusp6, as a molecule that inhibits protein kinase c-induced (pkc) internalization of transporters, resulting in enhanced dat activity. |
2009-02-25 |
2023-08-12 |
xenopus_laevis |
| Eriko Aoki, Ryohei Yano, Hironori Yokoyama, Hiroyuki Kato, Tsutomu Arak. Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice. Experimental and molecular pathology. vol 86. issue 1. 2009-02-25. PMID:19027004. |
densities of dat (dopamine transporter) immunoreactivity were also significantly decreased in nigral neurons of mice from 1 up to 21 days after mptp treatment. |
2009-02-25 |
2023-08-12 |
mouse |
| Tatiana Sorkina, Toni L Richards, Anjali Rao, Nancy R Zahniser, Alexander Sorki. Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 5. 2009-02-24. PMID:19193883. |
the plasma membrane dopamine transporter (dat) takes extracellular dopamine back up into dopaminergic neurons. |
2009-02-24 |
2023-08-12 |
human |
| Joanna S Fowler, Nora D Volkow, Jean Logan, David Alexoff, Frank Telang, Gene-Jack Wang, Christopher Wong, Yeming Ma, Aarti Kriplani, Kith Pradhan, David Schlyer, Millard Jayne, Barbara Hubbard, Pauline Carter, Donald Warner, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Karen Apelsko. Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine. NeuroImage. vol 43. issue 4. 2009-02-10. PMID:18708148. |
among individuals, those with the highest striatal (but not cerebellar) methamphetamine accumulation also had the highest dopamine transporter availability suggesting a relationship between meth exposure and dat availability. |
2009-02-10 |
2023-08-12 |
human |