| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhihua Xie, Gregory M Mille. A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19364908. |
here, we show that methamphetamine interaction with taar1 inhibits [(3)h]dopamine uptake, enhances or induces [(3)h]dopamine efflux, and triggers dat internalization. |
2009-07-27 |
2023-08-12 |
mouse |
| Manju A Kurian, Juan Zhen, Shu-Yuan Cheng, Yan Li, Santosh R Mordekar, Philip Jardine, Neil V Morgan, Esther Meyer, Louise Tee, Shanaz Pasha, Evangeline Wassmer, Simon J R Heales, Paul Gissen, Maarten E A Reith, Eamonn R Mahe. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19478460. |
genetic variants of the slc6a3 gene that encodes the human dopamine transporter (dat) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder. |
2009-07-24 |
2023-08-12 |
mouse |
| Manju A Kurian, Juan Zhen, Shu-Yuan Cheng, Yan Li, Santosh R Mordekar, Philip Jardine, Neil V Morgan, Esther Meyer, Louise Tee, Shanaz Pasha, Evangeline Wassmer, Simon J R Heales, Paul Gissen, Maarten E A Reith, Eamonn R Mahe. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19478460. |
functional studies demonstrated that both mutations were loss-of-function mutations that severely reduced levels of mature (85-kda) dat while having a differential effect on the apparent binding affinity of dopamine. |
2009-07-24 |
2023-08-12 |
mouse |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
the dopamine transporter (dat) retrieves the neurotransmitter dopamine from the synaptic cleft at dopaminergic synapses. |
2009-07-24 |
2023-08-12 |
human |
| Craig Blackston. Infantile parkinsonism-dystonia: a dopamine "transportopathy". The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19504720. |
report that an autosomal recessive infantile parkinsonism-dystonia is caused by loss-of-function mutations in dat that impair dopamine reuptake (see the related article beginning on page 1595). |
2009-07-24 |
2023-08-12 |
human |
| Franklin R Schneier, Anissa Abi-Dargham, Diana Martinez, Mark Slifstein, Dah-Ren Hwang, Michael R Liebowitz, Marc Laruell. Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder. Depression and anxiety. vol 26. issue 5. 2009-07-22. PMID:19180583. |
dopamine d2 receptor and dopamine transporter (dat) availability in the striatum (str) have each been reported abnormal in generalized social anxiety disorder (gsad) in studies using single photon emission computerized tomography (spect). |
2009-07-22 |
2023-08-12 |
human |
| Franklin R Schneier, Anissa Abi-Dargham, Diana Martinez, Mark Slifstein, Dah-Ren Hwang, Michael R Liebowitz, Marc Laruell. Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder. Depression and anxiety. vol 26. issue 5. 2009-07-22. PMID:19180583. |
d2 receptors and dat have not previously been studied within the same gsad subjects, however, and prior gsad studies have not assessed dopamine release or subdivided the str into functional subregions. |
2009-07-22 |
2023-08-12 |
human |
| Hernán A Navarro, James L Howard, Gerald T Pollard, F Ivy Carrol. Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. British journal of pharmacology. vol 156. issue 7. 2009-07-21. PMID:19226282. |
in our search for an indirect dopamine agonist as therapy for cocaine addiction, several selective inhibitors of the dopamine transporter (dat), which are 3-phenyltropane analogues, were assayed for their effect on locomotor activity in mice. |
2009-07-21 |
2023-08-12 |
mouse |
| Alfredo R Ramírez, Maite A Castro, Constanza Angulo, Laura Ramió, M Montserrat Rivera, Mauricio Torres, Teresa Rigau, Joan E Rodríguez-Gil, Ilona I Conch. The presence and function of dopamine type 2 receptors in boar sperm: a possible role for dopamine in viability, capacitation, and modulation of sperm motility. Biology of reproduction. vol 80. issue 4. 2009-07-16. PMID:19074002. |
this can be explained by the presence of the dopamine transporters (dat, official symbol slc6a3) in sperm, as demonstrated by western blot analysis and immunocytochemistry. |
2009-07-16 |
2023-08-12 |
Not clear |
| Ying-Jian Liang, Juan Zhen, Nianhang Chen, Maarten E A Reit. Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19519772. |
our previous work suggested that collapsing the na(+) gradient and membrane potential converts the dopamine (da) transporter (dat) to an inward-facing conformation with a different substrate binding profile. |
2009-07-16 |
2023-08-12 |
human |
| G Zhao, X-W Zheng, G-W Qin, Y Gai, Z-H Jiang, L-H Gu. In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.). Cellular and molecular life sciences : CMLS. vol 66. issue 9. 2009-07-15. PMID:19322517. |
a pcs isolate delta(3),2-hydroxybakuchiol (bu) can inhibit dopamine uptake in dopamine transporter (dat) transfected chinese hamster ovary (cho) cells, and dopamine reuptake blockade may provide an alternative approach for ameliorating parkinsonism. |
2009-07-15 |
2023-08-12 |
mouse |
| Laura Filonzi, Cinzia Magnani, Anna Maria Lavezzi, Guido Rindi, Stefano Parmigiani, Giulio Bevilacqua, Luigi Matturri, Francesco Nonnis Marzan. Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. Neurogenetics. vol 10. issue 1. 2009-07-13. PMID:18810510. |
considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (slc6a3, dat) and monoamine oxidase a (maoa) genes in sids and stillbirth (sudden intrauterine unexplained death, siud) was investigated. |
2009-07-13 |
2023-08-12 |
Not clear |
| Christian Pifl, Alexandra Wolf, Patrick Rebernik, Harald Reither, Michael L Berge. Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:19000913. |
the dopamine transporter (dat), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by zn(2+) which directly interacts with the protein. |
2009-07-01 |
2023-08-12 |
Not clear |
| Christian Pifl, Alexandra Wolf, Patrick Rebernik, Harald Reither, Michael L Berge. Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:19000913. |
whereas low mumolar zn(2+) decreased dopamine uptake by dat expressing hek293 cells, it stimulated uptake by dat expressing sk-n-mc cells. |
2009-07-01 |
2023-08-12 |
Not clear |
| W Adriani, F Boyer, L Gioiosa, S Macrì, J-L Dreyer, G Laviol. Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19135135. |
we used lentivirus tools for over-expressing or silencing the dopamine transporter (dat) and we evaluated the resulting behavioral profiles in terms of motivation and self-control. |
2009-06-25 |
2023-08-12 |
rat |
| B Meyers, M F Kritze. In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex. Neuroscience. vol 159. issue 1. 2009-06-25. PMID:19138725. |
specifically, (3)h win 35,428 and (3)h nisoxetine, ligands selective for the dopamine (dat)- and norepinephrine transporter (net) respectively, were used in in vitro binding assays to ask whether gonadectomy altered transporter affinity (kd) and/or binding site number (bmax) in prefrontal cortex, sensorimotor cortex and/or caudate. |
2009-06-25 |
2023-08-12 |
rat |
| Xiaomian Sun, Jing Yue, Chongxun Zhen. [Study of dopamine transporter imaging on the brain of children with autism]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 25. issue 2. 2009-06-23. PMID:18610616. |
this study was conducted to evaluate the applicability of 99mtc-2beta-[ n, n'-bis (2-mercaptoethyl) ethylenediamino]methyl,3beta(4-chlorophenyl)tropane(trodat-1) dopamine transporter(dat) spect imaging in children with autism, and thus to provide an academic basis for the etiology, mechanism and clinical therapy of autism. |
2009-06-23 |
2023-08-12 |
Not clear |
| Jun Zhu, Charles F Mactutus, David R Wallace, Rosemarie M Booz. HIV-1 Tat protein-induced rapid and reversible decrease in [3H]dopamine uptake: dissociation of [3H]dopamine uptake and [3H]2beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (WIN 35,428) binding in rat striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19325033. |
dopamine (da) transporter (dat) function is strikingly altered in patients with hiv-1-associated dementia and a history of chronic drug abuse. |
2009-06-23 |
2023-08-12 |
human |
| Jacob Eriksen, Søren G F Rasmussen, Trine Nygaard Rasmussen, Christian Bjerggaard Vaegter, Joo Hwan Cha, Mu-Fa Zou, Amy Hauck Newman, Ulrik Gethe. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474307. |
the dopamine transporter (dat) mediates reuptake of dopamine from the synaptic cleft and is a target for widely abused psychostimulants such as cocaine and amphetamine. |
2009-06-23 |
2023-08-12 |
human |
| Yu-Ting Lai, Yen-Ping N Tsai, Chianfang G Cherng, Jing-Jer Ke, Ming-Che Ho, Chia-Wen Tsai, Lung Y. Lipopolysaccharide mitagates methamphetamine-induced striatal dopamine depletion via modulating local TNF-alpha and dopamine transporter expression. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 4. 2009-06-09. PMID:19271121. |
finally, single lps treatment caused a rapid down-regulation of dopamine transporter (dat) in striatum. |
2009-06-09 |
2023-08-12 |
mouse |