| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangqian Liu, Linda Chang, Michael Vigorito, Marley Kass, He Li, Sulie L Chan. Methamphetamine-induced behavioral sensitization is enhanced in the HIV-1 transgenic rat. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 4. issue 3. 2009-10-13. PMID:19444617. |
the involvement of the dopaminergic system was investigated by examining dopamine receptors 1 (d1r) and 2 (d2r) and dopamine transporter (dat) expression in the striatum and prefrontal cortex. |
2009-10-13 |
2023-08-12 |
rat |
| Magnus Schou, Carsten Steiger, Andrea Varrone, Denis Guilloteau, Christer Halldi. Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 19. issue 16. 2009-10-13. PMID:19577467. |
a new dopamine transporter (dat) ligand, (e)-n-(3-iodoprop-2-enyl)-2beta-carbofluoroethoxy-3beta-(4'-methyl-phenyl) nortropane (fe-pe2i, 6), derived from pe2i (1), was prepared and found to be a potent inhibitor of rodent dat in vitro. |
2009-10-13 |
2023-08-12 |
human |
| Morgane Thomsen, Dawn D Han, Howard H Gu, S Barak Cain. Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19602552. |
the dopamine transporter (dat) is suspected as the primary target mediating cocaine's abuse-related effects based on numerous pharmacological studies. |
2009-10-13 |
2023-08-12 |
mouse |
| Morgane Thomsen, Dawn D Han, Howard H Gu, S Barak Cain. Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19602552. |
here, we show that mice expressing a "knockin" of a cocaine-insensitive but functional dat did not self-administer cocaine intravenously despite normal food-maintained responding and normal intravenous self-administration of amphetamine and a direct dopamine agonist. |
2009-10-13 |
2023-08-12 |
mouse |
| David J Lapinsky, Shaili Aggarwal, Yurong Huang, Christopher K Surratt, John R Lever, James D Foster, Roxanne A Vaugha. A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorganic & medicinal chemistry. vol 17. issue 11. 2009-10-08. PMID:19442525. |
non-tropane-based photoaffinity ligands for the dopamine transporter (dat) are relatively unexplored in contrast to tropane-based compounds such as cocaine. |
2009-10-08 |
2023-08-12 |
Not clear |
| Prashant S Kharkar, Angela M Batman, Juan Zhen, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. ChemMedChem. vol 4. issue 7. 2009-10-08. PMID:19449323. |
in vitro uptake inhibition data of these molecules indicate high affinity for the dopamine transporter (dat) in addition to moderate to high affinity for the norepinephrine transporter (net). |
2009-10-08 |
2023-08-12 |
mouse |
| Li Chen, Dong-Mei He, Yuan Zhan. The differentiation of human placenta-derived mesenchymal stem cells into dopaminergic cells in vitro. Cellular & molecular biology letters. vol 14. issue 3. 2009-09-30. PMID:19412574. |
the expression of the nestin, dopamine transporter (dat), neuronal nuclear protein (neun) and th proteins was determined via immunofluorescence. |
2009-09-30 |
2023-08-12 |
human |
| Anna Paschali, Velissarios Lakiotis, Lambros Messinis, Elli Markaki, Constantine Constantoyannis, John Ellul, Pavlos Vassilako. Dopamine transporter SPECT/CT and perfusion brain SPECT imaging in idiopathic basal ganglia calcinosis. Clinical nuclear medicine. vol 34. issue 7. 2009-09-30. PMID:19542944. |
the nigrostriatal dopaminergic pathway and regional cerebral blood flow were evaluated using dopamine transporter (dat) brain single photon emission tomography combined with a low-dose x-ray computerized tomography transmission (hybrid spect/ct) and tc-99m hmpao brain perfusion spect study, respectively. |
2009-09-30 |
2023-08-12 |
Not clear |
| Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram, Robert Weiker. Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 37. issue 7. 2009-09-28. PMID:19389861. |
the objective of this study was to test this hypothesis by examining the relationship between in vitro binding affinity (k(i)) and in vivo activity quantified as the drug concentration occupying 50% of the transporters (oc(50)) for 18 serotonin (sert) and dopamine transporter (dat) inhibitors. |
2009-09-28 |
2023-08-12 |
rat |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
here, we confirm that the norepinephrine (net), the serotonin (sert), the dopamine (dat) uptake transporters and mao activity are inhibited by egb761 in vitro, although rather high concentrations are required for inhibition of mao-a and mao-b activity. |
2009-09-25 |
2023-08-12 |
mouse |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
as synaptic dopamine clearance in the frontal cortex is mediated by net, not dat, these findings may give an explanation for the enhancement of dopaminergic neurotransmission by egb761 seen in animal models, presumably linked to its positive effects on cognition and attention. |
2009-09-25 |
2023-08-12 |
mouse |
| Beate R Ritz, Angelika D Manthripragada, Sadie Costello, Sarah J Lincoln, Matthew J Farrer, Myles Cockburn, Jeff Bronstei. Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environmental health perspectives. vol 117. issue 6. 2009-09-23. PMID:19590691. |
research suggests that independent and joint effects of genetic variability in the dopamine transporter (dat) locus and pesticides may influence parkinson's disease (pd) risk. |
2009-09-23 |
2023-08-12 |
Not clear |
| Gianluigi Tanda, Amy Hauck Newman, Aaron L Ebbs, Valeria Tronci, Jennifer L Green, Ronald J Tallarida, Jonathan L Kat. Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. The Journal of pharmacology and experimental therapeutics. vol 330. issue 3. 2009-09-21. PMID:19483071. |
drugs that inhibit dopamine (da) reuptake through actions at the dopamine transporter (dat) have been proposed as candidates for development as pharmacotherapies for cocaine abuse. |
2009-09-21 |
2023-08-12 |
mouse |
| Diana P Prata, Andrea Mechelli, Cynthia H Y Fu, Marco Picchioni, Timothea Toulopoulou, Elvira Bramon, Muriel Walshe, Robin M Murray, David A Collier, Philip McGuir. Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 32. 2009-09-21. PMID:19666577. |
dopamine has a crucial role in the modulation of neurocognitive function, and synaptic dopamine activity is normally regulated by the dopamine transporter (dat) and catechol-o-methyltransferase (comt). |
2009-09-21 |
2023-08-12 |
human |
| Diana P Prata, Andrea Mechelli, Cynthia H Y Fu, Marco Picchioni, Timothea Toulopoulou, Elvira Bramon, Muriel Walshe, Robin M Murray, David A Collier, Philip McGuir. Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 32. 2009-09-21. PMID:19666577. |
these data demonstrate that comt and dat genes interact nonadditively to modulate cortical function during executive processing, and also, that this effect is significantly altered in schizophrenia, which may reflect abnormal dopamine function in the disorder. |
2009-09-21 |
2023-08-12 |
human |
| Susanne Nikolaus, Christina Antke, Konstantin Kley, Markus Beu, Andreas Wirrwar, Hans-Wilhelm Mülle. Pretreatment with haloperidol reduces (123)I-FP-CIT binding to the dopamine transporter in the rat striatum: an in vivo imaging study with a dedicated small-animal SPECT camera. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 7. 2009-09-15. PMID:19525450. |
synaptic dopamine is mainly regulated by presynaptic dopamine transporter (dat) activity. |
2009-09-15 |
2023-08-12 |
rat |
| Susanne Nikolaus, Christina Antke, Konstantin Kley, Markus Beu, Andreas Wirrwar, Hans-Wilhelm Mülle. Pretreatment with haloperidol reduces (123)I-FP-CIT binding to the dopamine transporter in the rat striatum: an in vivo imaging study with a dedicated small-animal SPECT camera. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 7. 2009-09-15. PMID:19525450. |
we hypothesized that variations in synaptic dopamine are reflected by variations of dat radioligand binding. |
2009-09-15 |
2023-08-12 |
rat |
| Susanne Nikolaus, Christina Antke, Konstantin Kley, Markus Beu, Andreas Wirrwar, Hans-Wilhelm Mülle. Pretreatment with haloperidol reduces (123)I-FP-CIT binding to the dopamine transporter in the rat striatum: an in vivo imaging study with a dedicated small-animal SPECT camera. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 7. 2009-09-15. PMID:19525450. |
the effect of haloperidol, which increases synaptic dopamine concentrations, was therefore assessed in the rat striatum using (123)i-n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)-nortropane ((123)i-fp-cit) as a dat radioligand. |
2009-09-15 |
2023-08-12 |
rat |
| Bryon Adinoff, Michael D Devous, Donald C Cooper, Susan E Best, Thomas S Harris, Mark J William. Neural response to lidocaine in healthy subjects. Psychiatry research. vol 173. issue 2. 2009-09-15. PMID:19560905. |
local anesthetics that lack cocaine's strong affinity for the dopamine transporter (dat) also produce sensory and mood effects, further suggesting a role for this neural pathway. |
2009-09-15 |
2023-08-12 |
human |
| E Lagrue, B Abert, L Nadal, L Tabone, S Bodard, F Medja, A Lombes, S Chalon, P Castelna. MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood. Metabolic brain disease. vol 24. issue 2. 2009-09-14. PMID:19319673. |
this model also reproduced the biochemical and pathological features of ls: mptp increased plasmatic lactate levels (p = 0.023) and triggered basal ganglia degeneration, as evaluated through dopamine transporter (dat) autoradiography, tyrosine hydroxylase (th) immunohistochemistry, and dopamine dosage. |
2009-09-14 |
2023-08-12 |
mouse |