| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Arak. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235988. |
our immunohistochemical study showed that th (tyrosine hydroxylase) and dat (dopamine transporter) immunoreactivity was decreased significantly in the striatum and substantia nigra 5 days after mptp treatment. |
2008-10-03 |
2023-08-12 |
mouse |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
it has been shown recently that the n-terminal domain of the dopamine transporter (dat) plays a role in several transporter functions. |
2008-09-30 |
2023-08-12 |
human |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
calpain truncation of the datn-terminus abolishes its interaction with the receptor of activated protein kinase c, rack1 and removes protein sequences previously implicated in amphetamine-induced dopamine release, pkc-dependent endocytosis and the interaction of dat with the dopamine d2 receptor. |
2008-09-30 |
2023-08-12 |
human |
| Veronika Franekova, Martina Baliova, Frantisek Jursk. Truncation of human dopamine transporter by protease calpain. Neurochemistry international. vol 52. issue 8. 2008-09-30. PMID:18468730. |
the above suggests that cleavage of dat by calpain may significantly modify dopamine homeostasis under pathological or physiological conditions. |
2008-09-30 |
2023-08-12 |
human |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
in the individuals with autism dopamine transporter (dat) binding did not differ from that of the comparison group. |
2008-09-26 |
2023-08-12 |
Not clear |
| Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether, Claus J Lolan. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. vol 11. issue 7. 2008-09-19. PMID:18568020. |
cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (dat). |
2008-09-19 |
2023-08-12 |
Not clear |
| Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether, Claus J Lolan. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. vol 11. issue 7. 2008-09-19. PMID:18568020. |
our models suggest that the binding site for cocaine and cocaine analogs is deeply buried between transmembrane segments 1, 3, 6 and 8, and overlaps with the binding sites for the substrates dopamine and amphetamine, as well as for benztropine-like dat inhibitors. |
2008-09-19 |
2023-08-12 |
Not clear |
| Chunyang Jin, Hernán A Navarro, Kevin Page, F Ivy Carrol. Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes. Bioorganic & medicinal chemistry. vol 16. issue 14. 2008-09-11. PMID:18556210. |
the 2beta-[3'-(substituted benzyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes (3a-h) showed high binding affinities for the dopamine transporter (dat). |
2008-09-11 |
2023-08-12 |
Not clear |
| S A McDougall, C M Reichel, C M Farley, M M Flesher, T Der-Ghazarian, A M Cortez, J J Wacan, C E Martinez, F A Varela, A E Butt, C A Crawfor. Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18485605. |
on pd 90, dopamine transporter (dat) immunoreactivity and [3h]dopamine uptake were assayed in the striatum and nucleus accumbens, while in vivo microdialysis was used to measure dopamine efflux in the same brain regions. |
2008-08-29 |
2023-08-12 |
rat |
| S A McDougall, C M Reichel, C M Farley, M M Flesher, T Der-Ghazarian, A M Cortez, J J Wacan, C E Martinez, F A Varela, A E Butt, C A Crawfor. Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18485605. |
results showed that postnatal mn exposure caused persistent declines in dat protein expression and [3h]dopamine uptake in the striatum and nucleus accumbens, as well as long-term reductions in striatal dopamine efflux. |
2008-08-29 |
2023-08-12 |
rat |
| Jan Booij, Paul Kem. Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. European journal of nuclear medicine and molecular imaging. vol 35. issue 2. 2008-08-26. PMID:17968545. |
[(123)i]n-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)i]fp-cit) single photon emission computed tomography (spect) is a frequently and routinely used technique to detect or exclude dopaminergic degeneration by imaging the dopamine transporter (dat) in parkinsonian and demented patients. |
2008-08-26 |
2023-08-12 |
Not clear |
| Heather L Kimmel, S Stevens Negus, Kristin M Wilcox, Sarah B Ewing, Jeffrey Stehouwer, Mark M Goodman, John R Votaw, Nancy K Mello, F Ivy Carroll, Leonard L Howel. Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18468667. |
although inhibition of dopamine transporters (dat) and the subsequent increase in dopamine clearly play a role in the effects of psychomotor stimulants, the reinforcing effectiveness of dat inhibitors varies. |
2008-08-25 |
2023-08-12 |
monkey |
| Gang Zhao, Zhi-Hua Jiang, Xiang-Wei Zheng, Shao-Yun Zang, Li-He Gu. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485464. |
the present study assessed whether fq is effective in dopamine transporter (dat) regulation and antiparkinsonism by utilizing in vitro and in vivo assays, respectively. |
2008-08-25 |
2023-08-12 |
mouse |
| Gang Zhao, Zhi-Hua Jiang, Xiang-Wei Zheng, Shao-Yun Zang, Li-He Gu. Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacology, biochemistry, and behavior. vol 90. issue 3. 2008-08-25. PMID:18485464. |
fq at concentrations of 1-1000 microg/ml concentration-dependently inhibited dopamine uptake by chinese hamster ovary (cho) cells stably expressing dat (d8 cells) and by synaptosomes. |
2008-08-25 |
2023-08-12 |
mouse |
| Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson, Jamin Boggs, Lisa K Dvorak, Michael A Letavic, Bruce E Maryanoff, Nicholas I Carruthers, Pascal Bonaventure, Timothy W Lovenber. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18499098. |
triple reuptake inhibitors, which block the serotonin transporter (sert), norepinephrine transporter (net) and dopamine transporter (dat) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. |
2008-08-25 |
2023-08-12 |
mouse |
| Michael R Tilley, Howard H G. Dopamine transporter inhibition is required for cocaine-induced stereotypy. Neuroreport. vol 19. issue 11. 2008-08-25. PMID:18596615. |
the primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (dat), norepinephrine, and serotonin. |
2008-08-25 |
2023-08-12 |
mouse |
| Christopher H van Dyck, Robert A Avery, Martha G MacAvoy, Kenneth L Marek, Donald M Quinlan, Ronald M Baldwin, John P Seibyl, Robert B Innis, Amy F T Arnste. Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology of aging. vol 29. issue 8. 2008-08-21. PMID:17363113. |
this research tested the hypothesis that striatal dopamine transporter (dat) availability in healthy elderly individuals was related to measures of motor performance. |
2008-08-21 |
2023-08-12 |
human |
| Teresa Marie du Bois, Ching-Wen Hsu, Yulin Li, Yean Yeow Tan, Chao Deng, Xu-Feng Huan. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18256931. |
this study examined how perinatal phencyclidine (pcp) treatment would affect dopamine d2 receptor and dopamine transporter (dat) binding at different stages after treatment cessation. |
2008-08-20 |
2023-08-12 |
rat |
| Frederic Boyer, Jean-Luc Dreye. The role of gamma-synuclein in cocaine-induced behaviour in rats. The European journal of neuroscience. vol 27. issue 11. 2008-08-20. PMID:18588534. |
the aim of this study was to investigate the role of gamma-synuclein in the rewarding effects of chronic cocaine administration and its putative interaction with the dopamine transporter (dat). |
2008-08-20 |
2023-08-12 |
rat |
| Christopher D Verrico, Laurie Lynch, Michele A Fahey, Ashley-Kay Fryer, Gregory M Miller, Bertha K Madra. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of psychopharmacology (Oxford, England). vol 22. issue 2. 2008-08-18. PMID:18308800. |
we postulated that mdma will compromise executive function in primates and that an inhibitor of the serotonin transporter (sert) and the norepinephrine transporter (net) but not the dopamine (dat) transporter, will prevent impairment. |
2008-08-18 |
2023-08-12 |
human |