| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E A Reith, Aloke K Dutt. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249549. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin (5-ht) transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2008-06-13 |
2023-08-12 |
Not clear |
| Bin Liu, Jun Xia Xie, Lai Ling Tsang, Dewi Kenneth Rowlands, Lok Sze Ho, Yu Lin Gou, Yiu Wa Chung, Hsiao Chang Cha. Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity. Cell biology international. vol 32. issue 1. 2008-06-12. PMID:17920944. |
in the present study, we have investigated the possible neuroprotective action of bfp upon the nigrostriatal dopaminergic system by examining its effect on the expression patterns of tyrosine hydroxylase (th) and dopamine transporter (dat) in the 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (mptp)-induced parkinson's disease (pd) mouse model. |
2008-06-12 |
2023-08-12 |
mouse |
| Ekaterina Boudanova, Deanna M Navaroli, Haley E Melikia. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology. vol 54. issue 3. 2008-06-12. PMID:18164041. |
amphetamine (amph) is a potent dopamine (da) transporter (dat) inhibitor that markedly increases extracellular da levels. |
2008-06-12 |
2023-08-12 |
Not clear |
| James D Foster, Steven D Adkins, John R Lever, Roxanne A Vaugha. Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248623. |
we examined the mechanisms involved in protein kinase c (pkc)-dependent down-regulation of dopamine transporter (dat) activity and cell surface expression by treating heterologously expressing cells with the clathrin-mediated endocytosis inhibitor concanavalin a (con a) or the cholesterol depleter/membrane raft disrupter methyl-beta-cyclodextrin (mbetac) prior to treatment with the pkc activator phorbol 12-myristate, 13-acetate (pma). |
2008-06-12 |
2023-08-12 |
Not clear |
| Yen Kuang Yang, Tzung Lieh Yeh, Wei Jen Yao, I Hui Lee, Po See Chen, Nan Tsing Chiu, Ru Band L. Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. Psychiatry research. vol 162. issue 3. 2008-06-10. PMID:18295460. |
in order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal d(2)/d(3) receptor uptake and dopamine transporter (dat) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (spect) imaging technique. |
2008-06-10 |
2023-08-12 |
Not clear |
| Yen Kuang Yang, Tzung Lieh Yeh, Wei Jen Yao, I Hui Lee, Po See Chen, Nan Tsing Chiu, Ru Band L. Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. Psychiatry research. vol 162. issue 3. 2008-06-10. PMID:18295460. |
the striatal dopamine d(2)/d(3) receptor availability was measured using spect and [(123)i] ibzm, while dat was measured using spect and [(99m)tc] trodat-1. |
2008-06-10 |
2023-08-12 |
Not clear |
| Hiroaki Hozumi, Masato Asanuma, Ikuko Miyazaki, Saki Fukuoka, Yuri Kikkawa, Naotaka Kimoto, Yoshihisa Kitamura, Toshiaki Sendo, Taizo Kita, Yutaka Gomit. Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. Toxicology letters. vol 177. issue 2. 2008-06-06. PMID:18282668. |
intraperitoneal injection of ifn-gamma before meth injection significantly prevented meth-induced reduction of striatal dopamine transporter (dat)-positive signals and hyperthermia. |
2008-06-06 |
2023-08-12 |
mouse |
| R Cham, S A Studenski, S Perera, N I Bohne. Striatal dopaminergic denervation and gait in healthy adults. Experimental brain research. vol 185. issue 3. 2008-06-03. PMID:17973106. |
forty healthy subjects aged 21-85 years old underwent [(11)c]-beta-cft dopamine transporter (dat) positron emission tomography (pet). |
2008-06-03 |
2023-08-12 |
human |
| Panayotis K Thanos, Michael Michaelides, Helene Benveniste, Gene Jack Wang, Nora D Volko. The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18286542. |
cocaine's ability to block the dopamine transporter (dat) is crucial for its reinforcing effects. |
2008-06-03 |
2023-08-12 |
mouse |
| Panayotis K Thanos, Michael Michaelides, Helene Benveniste, Gene Jack Wang, Nora D Volko. The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18286542. |
to separate the dopaminergic from the non-dopaminergic effects of cocaine on brain function we compared the regional brain metabolic responses to cocaine between dopamine transporter deficient (dat(-/-)) mice with that of their dat(+/+) littermates. |
2008-06-03 |
2023-08-12 |
mouse |
| Panayotis K Thanos, Michael Michaelides, Helene Benveniste, Gene Jack Wang, Nora D Volko. The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 62. issue 5. 2008-06-03. PMID:18286542. |
the greater baseline metabolism in dat(-/-) than dat(+/+) mice in cerebellum (brain region mostly devoid of dat) suggests that dopamine indirectly regulates activity of these brain regions. |
2008-06-03 |
2023-08-12 |
mouse |
| H Förstl, S Gratz, U Hahn, J Schwarz, M Jarni. [Dementia with Lewy bodies and reduced dopamine transporter binding indicates significant acetylcholine deficiency]. Deutsche medizinische Wochenschrift (1946). vol 133 Suppl 1. 2008-05-30. PMID:18437636. |
if the clinical presentation of dlb is uncharacteristic, the demonstration of reduced presynaptic striatal dopamine transporter (dat) sites supports a suspicion of dlb and may lead to important therapeutic consequences. |
2008-05-30 |
2023-08-12 |
Not clear |
| Johanna Kraus. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert review of neurotherapeutics. vol 8. issue 4. 2008-05-28. PMID:18416663. |
with special radiolabeled ligands selective imaging of the dopamine transporter (dat), which has a key function in dopamine metabolism, can be performed by spect and pet. |
2008-05-28 |
2023-08-12 |
Not clear |
| Teija Koivula, Päivi Marjamäki, Merja Haaparanta, Veronica Fagerholm, Tove Grönroos, Tiina Lipponen, Outi Perhola, Jouko Vepsäläinen, Olof Soli. Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-fluorophenyl)nortropane in rats. Nuclear medicine and biology. vol 35. issue 2. 2008-05-27. PMID:18312827. |
the dopamine transporter (dat) ligand n-(3-fluoropropyl)-2 beta-carbomethoxy-3beta-(4-fluorophenyl)nortropane (beta-cft-fp) was labeled with fluorine-18, and its biodistribution was evaluated in rats ex vivo. |
2008-05-27 |
2023-08-12 |
rat |
| Gang Zhao, Shao-Yun Zang, Xiang-Wei Zheng, Xiao-Hua Zhang, Li-He Gu. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18329002. |
monoamine transporter inhibition by delta3,2-hydroxybakuchiol was more selective for the dopamine transporter (dat) (ic50=0.58+/-0.1 microm) and norepinephrine transporter (net) (ic50=0.69+/-0.12 microm) than for the serotonin transporter (sert) (ic50=312.02+/-56.69 microm). |
2008-05-27 |
2023-08-12 |
mouse |
| Nianhang Chen, Maarten E A Reit. Substrates dissociate dopamine transporter oligomers. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18088380. |
substrate-induced endocytic trafficking of dopamine transporter (dat) has been observed, but little is known about the regulation of dat oligomerization by substrate. |
2008-05-22 |
2023-08-12 |
human |
| Nianhang Chen, Maarten E A Reit. Substrates dissociate dopamine transporter oligomers. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18088380. |
dopamine (100 microm) or amphetamine (2-10 microm) reduced myc-dat coimmunoprecipitated along with flag-dat (oligomeric dat) in tandem with a reduction in surface dat determined by biotinylation. |
2008-05-22 |
2023-08-12 |
human |
| Nianhang Chen, Maarten E A Reit. Substrates dissociate dopamine transporter oligomers. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18088380. |
dopamine (10-1000 microm) and amphetamine (0.2-200 microm) reduced dat oligomerization as assessed by cross-linking with copper sulfate phenanthroline or cu2+. |
2008-05-22 |
2023-08-12 |
human |
| Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Journal of pharmacological sciences. vol 106. issue 2. 2008-05-22. PMID:18277051. |
to investigate the role of tissue plasminogen activator (tpa) in methamphetamine (meth)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (th) and dopamine transporter (dat) levels in the striatum after repetitive treatment of meth at 4 mg/kg among wild-type, tpa-deficient (tpa-/-), and protease activated receptor-1-deficient (par-1-/-) mice. |
2008-05-22 |
2023-08-12 |
mouse |
| Wen-Juh Hwang, Wei-Jen Yao, Ying-Kai Fu, An-Shoei Yan. [99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. Psychiatry research. vol 162. issue 2. 2008-05-16. PMID:18248965. |
in this case-control study of 10 ts patients and 15 age-matched healthy controls, we evaluated (i) presynaptic and postsynaptic striatal dopaminergic function using [(99m)tc]trodat-1/[(123)i]ibzm single photon emission computed tomography (spect) and (ii) correlations between dopamine transporter (dat)/d2 receptor binding sites and tic severity scores. |
2008-05-16 |
2023-08-12 |
Not clear |