| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
dopamine transporter (dat) internalization is a mechanism underlying the decreased dopamine reuptake caused by addictive drugs like methamphetamine (meth). |
2008-04-17 |
2023-08-12 |
mouse |
| X Cen, A Nitta, D Ibi, Y Zhao, M Niwa, K Taguchi, M Hamada, Y Ito, Y Ito, L Wang, T Nabeshim. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Molecular psychiatry. vol 13. issue 4. 2008-04-17. PMID:18195717. |
expression of piccolo c2a domain attenuated meth-induced inhibition of dopamine uptake in pc12 cells expressing human dat. |
2008-04-17 |
2023-08-12 |
mouse |
| L Keith Henry, Jens Meiler, Randy D Blakel. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular interventions. vol 7. issue 6. 2008-04-17. PMID:18199851. |
the neurotransmitter transporters belonging to the solute carrier 6 (slc6) family, including the gamma-aminobutyric acid (gat), norepinephrine (net), serotonin (sert) and dopamine (dat) transporters are extremely important drug targets of great clinical relevance. |
2008-04-17 |
2023-08-12 |
human |
| Christoph Scherfler, Johannes Schwarz, Angelo Antonini, Donald Grosset, Francesc Valldeoriola, Kenneth Marek, Wolfgang Oertel, Eduardo Tolosa, Andrew J Lees, Werner Poew. Role of DAT-SPECT in the diagnostic work up of parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 9. 2008-04-16. PMID:17486648. |
loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative parkinsonism, is strongly related to decreases of dopamine transporter (dat) density, which can be measured by single photon emission computed tomography (spect). |
2008-04-16 |
2023-08-12 |
human |
| Jie Shi, Li-Yan Zhao, Marc L Copersino, Yu-Xia Fang, Yingmao Chen, Jiahe Tian, Yanping Deng, Yinliang Shuai, Jun Jin, Lin L. PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:17977528. |
to establish whether chronic opiate use might impair brain dopamine neurons in humans, we assessed dopamine transporter (dat) uptake function in the striatum (caudate and putamen), and analyzed the correlation between dat in the striatum and heroin craving and subjective anxiety in former heroin users with prolonged abstinence and in patients receiving methadone maintenance treatment. |
2008-04-15 |
2023-08-12 |
human |
| Ali Salahpour, Amy J Ramsey, Ivan O Medvedev, Brian Kile, Tatyana D Sotnikova, Ericka Holmstrand, Valentina Ghisi, Peter J Nicholls, Ling Wong, Karen Murphy, Susan R Sesack, R Mark Wightman, Raul R Gainetdinov, Marc G Caro. Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 11. 2008-04-15. PMID:18347339. |
the dopamine transporter (dat) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of dopamine. |
2008-04-15 |
2023-08-12 |
mouse |
| Yong Huang, Xue-mei Jiang, Dong-jiang L. [Effects on electro-scaip acupuncture on cerebral dopamine transporter in patients with Parkinson' s disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 26. issue 4. 2008-04-07. PMID:16688994. |
to investigate the effect of electro-scalp acupuncture (esa) on dopamine transporter (dat) in basal ganglia (bg) of patients with parkinson's disease (pd) by single photon emission computed tomography (spect). |
2008-04-07 |
2023-08-12 |
Not clear |
| Claus J Loland, Rajeev I Desai, Mu-Fa Zou, Jianjing Cao, Peter Grundt, Klaus Gerstbrein, Harald H Sitte, Amy Hauck Newman, Jonathan L Katz, Ulrik Gethe. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:17978168. |
cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (dat). |
2008-04-07 |
2023-08-12 |
rat |
| Claus J Loland, Rajeev I Desai, Mu-Fa Zou, Jianjing Cao, Peter Grundt, Klaus Gerstbrein, Harald H Sitte, Amy Hauck Newman, Jonathan L Katz, Ulrik Gethe. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:17978168. |
next, we investigated the changes in inhibition potency of [(3)h]dopamine uptake of the compounds at a mutant dat (y335a) characterized by a global change in the conformational equilibrium. |
2008-04-07 |
2023-08-12 |
rat |
| M Laura Parnas, Jon D Gaffaney, Mu Fa Zou, John R Lever, Amy Hauck Newman, Roxanne A Vaugha. Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18216182. |
the novel photoaffinity ligand n-[4-(4-azido-3-(125)i-iodophenyl)-butyl]-2-beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ([(125)i]mfz 2-24) was used to investigate the site for cocaine binding on the dopamine transporter (dat). |
2008-04-03 |
2023-08-12 |
human |
| Una D McCann, Hiroto Kuwabara, Anil Kumar, Michael Palermo, Rubyna Abbey, James Brasic, Weiguo Ye, Mohab Alexander, Robert F Dannals, Dean F Wong, George A Ricaurt. Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users. Synapse (New York, N.Y.). vol 62. issue 2. 2008-03-21. PMID:17992686. |
studies in abstinent methamphetamine (meth) users have demonstrated reductions in brain dopamine transporter (dat) binding potential (bp), as well as cognitive and motor deficits, but it is not yet clear whether cognitive deficits and brain dat reductions fully reverse with sustained abstinence, or whether behavioral deficits in meth users are related to dopamine (da) deficits. |
2008-03-21 |
2023-08-12 |
Not clear |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
for example, serotonin is transported by the dopamine transporter (dat) under conditions in which serotonin transporter (sert) activity is eliminated (e.g., pharmacological inhibition). |
2008-03-21 |
2023-08-12 |
rat |
| William E Fantegross. In vivo pharmacology of MDMA and its enantiomers in rhesus monkeys. Experimental and clinical psychopharmacology. vol 16. issue 1. 2008-03-06. PMID:18266547. |
using pet neuroimaging, negligible occupancy at the dopamine transporter (dat) was observed following administration of r(-)-mdma, but reasonable dat interaction was quantified following injection of s(+)-mdma. |
2008-03-06 |
2023-08-12 |
monkey |
| Yi-Hsin Weng, Yah-Huei Wu Chou, Wen-Shiang Wu, Kun-Ju Lin, Hsiu-Chen Chang, Tzu-Chen Yen, Rou-Shayn Chen, Shiaw-Pyng Wey, Chin-Song L. PINK1 mutation in Taiwanese early-onset parkinsonism : clinical, genetic, and dopamine transporter studies. Journal of neurology. vol 254. issue 10. 2008-02-29. PMID:17960343. |
using the (99m)tc-trodat-1 (trodat) scan, we investigated the differences in the dopamine transporter (dat) activities between the pink1 patients, late-onset parkinson's disease (lopd) patients and healthy controls. |
2008-02-29 |
2023-08-12 |
Not clear |
| Yi-Hsin Weng, Yah-Huei Wu Chou, Wen-Shiang Wu, Kun-Ju Lin, Hsiu-Chen Chang, Tzu-Chen Yen, Rou-Shayn Chen, Shiaw-Pyng Wey, Chin-Song L. PINK1 mutation in Taiwanese early-onset parkinsonism : clinical, genetic, and dopamine transporter studies. Journal of neurology. vol 254. issue 10. 2008-02-29. PMID:17960343. |
the slower annual reduction of dat activity might indicate the insidious degeneration of dopamine neurons and a benign prognosis. |
2008-02-29 |
2023-08-12 |
Not clear |
| Krisztina Hejjas, Judit Vas, Eniko Kubinyi, Maria Sasvari-Szekely, Adam Miklosi, Zsolt Rona. Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mammalian genome : official journal of the International Mammalian Genome Society. vol 18. issue 12. 2008-02-25. PMID:18049838. |
highly variable repetitive sequence regions were found in the tyrosine hydroxylase (th), dopamine transporter (dat), and dopamine beta-hydroxylase (dbh) genes. |
2008-02-25 |
2023-08-12 |
human |
| Eduardo Tolosa, Thierry Vander Borght, Emilio Moren. Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 16. 2008-02-20. PMID:17914722. |
we previously reported on the role of dopamine transporter (dat) spect in the workup of patients with clinically uncertain parkinsonian syndromes (cups). |
2008-02-20 |
2023-08-12 |
Not clear |
| Fanxing Zeng, Nachwa Jarkas, Jeffrey S Stehouwer, Ronald J Voll, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorganic & medicinal chemistry. vol 16. issue 2. 2008-02-20. PMID:17983754. |
six new (s,s)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (net), serotonin transporter (sert) or dopamine transporter (dat). |
2008-02-20 |
2023-08-12 |
human |
| Stéphanie Weiss, Marika Nosten-Bertrand, J Michael McIntosh, Bruno Giros, Marie-Pascale Martre. Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17375139. |
mice deficient in the dopamine transporter (dat ko) exhibit a phenotype reminiscent of schizophrenia and adhd, including hyperdopaminergia, hyperactivity, paradoxical calming by methylphenidate and cognitive deficits, some of which being improved by antipsychotic agents. |
2008-02-14 |
2023-08-12 |
mouse |
| Regina Hünnerkopf, Alexander Strobel, Lise Gutknecht, Burkhard Brocke, Klaus Peter Lesc. Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17392738. |
in the present study, we evaluated the impact of the bdnf val66met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-httlpr) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (dat vntr). |
2008-02-14 |
2023-08-12 |
human |