| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Ghisi, Amy J Ramsey, Bernard Masri, Raul R Gainetdinov, Marc G Caron, Ali Salahpou. Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18929645. |
the dopamine transporter (dat) regulates the temporal and spatial actions of dopamine by reuptaking this neurotransmitter into the presynaptic neurons. |
2009-02-06 |
2023-08-12 |
mouse |
| Timothy M Fountaine, Lara Lourenco Venda, Nicholas Warrick, Helen C Christian, Patrik Brundin, Keith M Channon, Richard Wade-Martin. The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons. The European journal of neuroscience. vol 28. issue 12. 2009-02-03. PMID:19032594. |
in attempting to understand how this occurred we found that lowering alpha-synuclein levels caused changes to intracellular vesicles, dopamine transporter (dat) and vesicular monoamine transporter (vmat2), each of which is known to be an important component of the early events leading to mpp+ toxicity. |
2009-02-03 |
2023-08-12 |
mouse |
| Paul Crits-Christoph, Andrew Newberg, Nancy Wintering, Karl Ploessl, Mary Beth Connolly Gibbons, Sarah Ring-Kurtz, Robert Gallop, Julie Presen. Dopamine transporter levels in cocaine dependent subjects. Drug and alcohol dependence. vol 98. issue 1-2. 2009-01-23. PMID:18565692. |
cocaine use is a significant problem in the us and it is well established that cocaine binds to the dopamine transporter (dat) in the brain. |
2009-01-23 |
2023-08-12 |
human |
| Jason R Richardson, W Michael Caudle, Min Zheng Wang, E Danielle Dean, Kurt D Pennell, Gary W Mille. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18577399. |
exposure of pregnant mice to heptachlor led to increased levels of the dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) levels at both the protein and mrna level in their offspring. |
2009-01-23 |
2023-08-12 |
mouse |
| Jason R Richardson, W Michael Caudle, Min Zheng Wang, E Danielle Dean, Kurt D Pennell, Gary W Mille. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)in a gender-specific manner. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18577399. |
increased dat and vmat2 levels were accompanied by alterations of mrna levels of nuclear transcription factors that control dopamine neuron development and regulate dat and vmat2 levels in adulthood. |
2009-01-23 |
2023-08-12 |
mouse |
| Chunyang Jin, Hernán A Navarro, F Ivy Carrol. Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053748. |
previous studies showed that the mixed monoamine transporter inhibitor (6, rti-112) reduced cocaine self-administration at a high level of serotonin transporter (5-htt) occupancy with no detectable dopamine transporter (dat) occupancy. |
2009-01-22 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Vernon M Camp, Eugene J Malveaux, John R Votaw, Leonard Howell, Michael J Owens, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053782. |
in vitro competition binding assays demonstrated that 1-4 have a high affinity for the sert (k(i) values = 0.3-0.4 nm) and are selective for the sert over the dopamine and norepinephrine transporters (dat and net). |
2009-01-22 |
2023-08-12 |
monkey |
| Miguel Miguéns, José Antonio Crespo, Nuria Del Olmo, Alejandro Higuera-Matas, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosi. Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18634806. |
the brains in each triad were removed and processed for quantitative autoradiography immediately after the last session of cocaine self-administration (day 0), or after 1, 5, or 10 days of extinction, and excitatory amino acid transporters (eaats) and dopamine transporter (dat) binding was examined. |
2009-01-15 |
2023-08-12 |
rat |
| Jack W Lipton, Emeline G Tolod, Valerie B Thompson, Lin Pei, Katrina L Paumier, Brian T Terpstra, Kaari A Lynch, Timothy J Collier, Caryl E Sortwel. 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18655796. |
mdma significantly increased the expression of the slc6a3 gene (dopamine transporter; dat) in culture. |
2009-01-15 |
2023-08-12 |
Not clear |
| Kyle C Schmitt, Juan Zhen, Prashant Kharkar, Manoj Mishra, Nianhang Chen, Aloke K Dutta, Maarten E A Reit. Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18786172. |
the widely abused psychostimulant cocaine is thought to elicit its reinforcing effects primarily via inhibition of the neuronal dopamine transporter (dat). |
2009-01-15 |
2023-08-12 |
human |
| Claude Wicker-Thomas, Mickael Haman. Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster. Journal of insect physiology. vol 54. issue 10-11. 2009-01-07. PMID:18762189. |
the dat mutation, which resulted in more dopamine being produced in the brain, showed no pheromone modification. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Yoshihiro Takeuch. [Neurotransmission in developmental disorders]. No to hattatsu = Brain and development. vol 40. issue 6. 2009-01-07. PMID:19039985. |
the neurotransmission of dopamine in subcortical regions such as the basal ganglia and limbic areas is synaptic; on the other hand, dopamine neurotransmission in the frontal cortex is quite different, because there are very few dopamine transporters (dat) in the frontal cortex that allow dopamine to diffuse away from the dopamine synapse ("volume transmission"). |
2009-01-07 |
2023-08-12 |
Not clear |
| S Johansson, H Halleland, A Halmøy, K K Jacobsen, E T Landaas, M Dramsdahl, O B Fasmer, P Bergsholm, A J Lundervold, C Gillberg, K Hugdahl, P M Knappskog, J Haavi. Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 8. 2009-01-06. PMID:18081165. |
in this study of adults with adhd, we evaluated the three most commonly studied adhd candidate genetic polymorphisms; the dopamine receptor d4 (drd4) exon 3 vntr repeat, a microsatellite repeat 18.5 kb upstream of the drd5 locus and the 3'utr dopamine transporter slc6a3 (dat 1) vntr. |
2009-01-06 |
2023-08-12 |
Not clear |
| Júlia P Genro, Guilherme V Polanczyk, Cristian Zeni, Angélica S Oliveira, Tatiana Roman, Luis A Rohde, Mara H Hut. A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 8. 2009-01-06. PMID:18802919. |
the dopamine transporter (dat) is the major site of methylphenidate action, which is one of the main drugs used to treat attention-deficit/hyperactivity disorder (adhd). |
2009-01-06 |
2023-08-12 |
Not clear |
| D A Abaimov, T A Zenina-Antipova, G I Kovalev, S B Seredeni. Effect of antiparkinsonian drug himantane on the content of dopamine transporter DAT protein in rat striatum and cultured pheochromocytoma PC-12 cells. Bulletin of experimental biology and medicine. vol 145. issue 3. 2009-01-05. PMID:19039936. |
effect of antiparkinsonian drug himantane on the content of dopamine transporter dat protein in rat striatum and cultured pheochromocytoma pc-12 cells. |
2009-01-05 |
2023-08-12 |
rat |
| D A Abaimov, T A Zenina-Antipova, G I Kovalev, S B Seredeni. Effect of antiparkinsonian drug himantane on the content of dopamine transporter DAT protein in rat striatum and cultured pheochromocytoma PC-12 cells. Bulletin of experimental biology and medicine. vol 145. issue 3. 2009-01-05. PMID:19039936. |
we studied the effects of antiparkinsonian drug himantane (acute and subchronic administration) on the content of dopamine transporter protein dat in rat striatum ex vivo and on the content of dta in cultured pc-12 cells (10(-5) - 10(-7) m, the preparation was added to the incubation medium once or 7 times). |
2009-01-05 |
2023-08-12 |
rat |
| Susan B Powell, Jared W Young, Jacob C Ong, Marc G Caron, Mark A Geye. Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. Behavioural pharmacology. vol 19. issue 5-6. 2008-12-31. PMID:18690110. |
interestingly, mice lacking the dopamine (da) transporter (dat) gene display markedly increased levels of da, deficits in sensorimotor gating, and hyperactivity relative to wild-type mice. |
2008-12-31 |
2023-08-12 |
mouse |
| Matthew T Whittaker, Terrell T Gibbs, David H Far. Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18710414. |
ps does not affect dopamine transporter (dat) mediated uptake of [3h]da, demonstrating that it specifically affects the transmitter release mechanism. |
2008-12-24 |
2023-08-12 |
human |
| Robert L Arias, Mei-Li A Sung, Dmytro Vasylyev, Mei-Yi Zhang, Kristin Albinson, Katie Kubek, Natasha Kagan, Chad Beyer, Qian Lin, Jason M Dwyer, Margaret M Zaleska, Mark R Bowlby, John Dunlop, Michael Monagha. Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18606547. |
amiloride was found to protect substantia nigra (snc) neurons from mptp-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (th) and dopamine transporter (dat) immunohistochemistry, as well as smaller declines in striatal dat radioligand binding and dopamine levels. |
2008-12-15 |
2023-08-12 |
mouse |
| Robert L Arias, Mei-Li A Sung, Dmytro Vasylyev, Mei-Yi Zhang, Kristin Albinson, Katie Kubek, Natasha Kagan, Chad Beyer, Qian Lin, Jason M Dwyer, Margaret M Zaleska, Mark R Bowlby, John Dunlop, Michael Monagha. Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18606547. |
administration of psalmotoxin venom (pctx), an asic1a blocker, resulted in a much more modest effect, attenuating only the deficits in striatal dat binding and dopamine. |
2008-12-15 |
2023-08-12 |
mouse |