| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Borhane Annabi, Carl Laflamme, Asmaa Sina, Marie-Paule Lachambre, Richard Bélivea. A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. Journal of neuroinflammation. vol 6. 2009-05-14. PMID:19272160. |
screening of a large panel of glioma samples increasing histological grade demonstrated frequencies of cd133(+) cells which correlated with high expression of cyclooxygenase (cox)-2 and of membrane type-1 matrix metalloproteinase (mt1-mmp). |
2009-05-14 |
2023-08-12 |
Not clear |
| C M Kyama, A Mihalyi, P Simsa, J M Mwenda, C Tomassetti, C Meuleman, T M D'Hoogh. Non-steroidal targets in the diagnosis and treatment of endometriosis. Current medicinal chemistry. vol 15. issue 10. 2008-06-05. PMID:18393858. |
the pathogenesis of endometriosis is still unclear and numerous immunological and inflammatory factors have been suggested to be involved in the development of the disease, including interleukin (il)-1, il-2, il-6, il-8, il-12, tumour necrosis factor -alpha (tnf-alpha), regulated on activation, normal t-cell expressed and secreted (rantes) and its receptor cognate chemokine receptor 1 (ccr1), peroxisome proliferator activated receptors (ppars), matrix metalloproteinases (mmps) and cyclooxygenase (cox). |
2008-06-05 |
2023-08-12 |
Not clear |
| S Cascinu, L Verdecchia, N Valeri, R Berardi, M Scartozz. New target therapies in advanced pancreatic cancer. Annals of oncology : official journal of the European Society for Medical Oncology. vol 17 Suppl 5. 2008-02-29. PMID:16807445. |
the recent elucidation both of the mechanisms involved in pancreatic cancer carcinogenesis and the related molecular events, has led to several distinct therapeutic advances, including many novel target agents, such as monoclonal antibodies against egfr, egfr-tyrosine kinase inhibitors, monoclonal antibody against vegf, farnesyl transferase inhibitors, matrix metalloproteinase inhibitors, cox 2 inhibitors, and the development of gene therapy to target pancreatic cancer. |
2008-02-29 |
2023-08-12 |
Not clear |
| Dana Skultetyova, Slavomira Filipova, Igor Riecansky, Jan Skultet. The role of angiotensin type 1 receptor in inflammation and endothelial dysfunction. Recent patents on cardiovascular drug discovery. vol 2. issue 1. 2008-02-21. PMID:18221099. |
activation of at(1) receptor via inducible cyclooxygenase (cox)-2 promotes biosynthesis of matrix metalloproteinases (mmps). |
2008-02-21 |
2023-08-12 |
Not clear |
| T Yamazaki, S Shimosaka, H Sasaki, T Matsumura, T Tukiyama, T Tokiw. (+)-Syringaresinol-di-O-beta-D-glucoside, a phenolic compound from Acanthopanax senticosus Harms, suppresses proinflammatory mediators in SW982 human synovial sarcoma cells by inhibiting activating protein-1 and/or nuclear factor-kappaB activities. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 8. 2008-02-15. PMID:17561367. |
sr was more potent than syringin and isofraxidin at inhibiting the expression of il-1beta, il-6, cyclooxygenase (cox)-2 and matrix metalloproteinases (mmp)-1 mrna, but was less potent than syringin at inhibiting the expression of mmp-2. |
2008-02-15 |
2023-08-12 |
human |
| Tao He, Yi-Qiao Xing, Xiao-Hui Zhao, Ming A. Interaction between iNOS and COX-2 in hypoxia-induced retinal neovascularization in mice. Archives of medical research. vol 38. issue 8. 2007-11-30. PMID:17923259. |
the aim of our study was to evaluate the possible interaction between the cox and nos pathways and the effect of this interaction on matrix metalloproteinases 2 (mmp-2) and vascular endothelial growth factor (vegf) expression and on retinal angiogenesis. |
2007-11-30 |
2023-08-12 |
mouse |
| Genevieve C Sparagna, Adam J Chicco, Robert C Murphy, Michael R Bristow, Christopher A Johnson, Meredith L Rees, Melissa L Maxey, Sylvia A McCune, Russell L Moor. Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. Journal of lipid research. vol 48. issue 7. 2007-10-15. PMID:17426348. |
l(4)cl decreases correlated with reduced cox activity (no decrease in protein levels) in shhf cardiac mitochondria, but with no change in citrate synthase (a matrix enzyme) activity. |
2007-10-15 |
2023-08-12 |
human |
| Aris Perperoglou, Saskia le Cessie, Hans C van Houwelinge. Reduced-rank hazard regression for modelling non-proportional hazards. Statistics in medicine. vol 25. issue 16. 2006-12-05. PMID:16158396. |
starting point is a cox model with p covariates and time-varying effects modelled by q time functions (constant included), leading to a pxq structure matrix that contains the regression coefficients for all covariate by time function interactions. |
2006-12-05 |
2023-08-12 |
Not clear |
| Aris Perperoglou, Saskia le Cessie, Hans C van Houwelinge. Reduced-rank hazard regression for modelling non-proportional hazards. Statistics in medicine. vol 25. issue 16. 2006-12-05. PMID:16158396. |
by reducing the rank of this structure matrix a whole range of models is introduced, from the very flexible full-rank model (identical to a cox model with time-varying effects) to the very rigid rank one model that mimics the structure of a gamma-frailty model, but is easier to interpret. |
2006-12-05 |
2023-08-12 |
Not clear |
| A Haisch, U Marzahn, A Mobasheri, G Schulze-Tanzil, M Shakibae. Development and phenotypic characterization of a high density in vitro model of auricular chondrocytes with applications in reconstructive plastic surgery. Histology and histopathology. vol 21. issue 5. 2006-04-13. PMID:16493577. |
western blotting was used to analyse the expression of cartilage-specific markers, such as collagen type ii and cartilage specific proteoglycan, fibronectin, cell adhesion and signal transduction receptor beta1-integrin, matrix metalloproteinases (mmp-9, mmp-13), cyclo-oxygenase (cox)-2 and the apoptosis commitment marker, activated caspase-3. |
2006-04-13 |
2023-08-12 |
Not clear |
| Wei Hao Sun, Yun Liang Sun, Ren Nian Fang, Yun Shao, Hai Chen Xu, Qi Ping Xue, Guo Xian Ding, Yun Lin Chen. Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. Japanese journal of clinical oncology. vol 35. issue 12. 2006-03-03. PMID:16314343. |
to investigate the expression of cyclooxygenase (cox)-2 and matrix metalloproteinase (mmp)-9 in gastric carcinomas, and to correlate this expression with clinicopathological parameters and angiogenesis. |
2006-03-03 |
2023-08-12 |
Not clear |
| Seiji Iimoto, Shohei Watanabe, Toshiaki Takahashi, Akira Shimizu, Haruyasu Yamamot. The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitro. International journal of molecular medicine. vol 16. issue 6. 2006-02-21. PMID:16273290. |
to assess effects of celecoxib, selective cyclo-oxygenase (cox)-2 inhibitor, on matrix synthesis by chondrocytes under mechanical stress in vitro. |
2006-02-21 |
2023-08-12 |
rat |
| Takahiro Tsuruki, Kyoya Takahata, Masaaki Yoshikaw. Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin. Peptides. vol 26. issue 5. 2005-09-27. PMID:15808899. |
these results suggest that pge2, which is produced after activation of cox by soymetide-4, might suppress apoptosis of hair matrix cells and etoposide-induced alopecia by activating nf-kappab. |
2005-09-27 |
2023-08-12 |
rat |
| Hiroshi Miyamoto, Saleh Altuwaijri, Yi Cai, Edward M Messing, Chawnshang Chan. Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: potential therapeutic approaches for prostate cancer. Molecular carcinogenesis. vol 44. issue 1. 2005-09-23. PMID:16044418. |
in this article, among them, we focus on akt (also known as protein kinase b), cyclooxygenase (cox)-2, and matrix metalloproteinase (mmp)-9, whose activities or expressions have been found to be regulated by androgens/ar. |
2005-09-23 |
2023-08-12 |
Not clear |
| M Holzhausen, L C Spolidorio, N Vergnoll. Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats. Journal of dental research. vol 84. issue 2. 2005-04-04. PMID:15668333. |
inhibition of matrix metalloproteinase (mmp) and cyclo-oxygenase (cox) decreased par2 agonist-induced periodontitis. |
2005-04-04 |
2023-08-12 |
rat |
| Scot C Leary, Brett A Kaufman, Giovanna Pellecchia, Guy-Hellen Guercin, Andre Mattman, Michaela Jaksch, Eric A Shoubridg. Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. Human molecular genetics. vol 13. issue 17. 2005-03-18. PMID:15229189. |
chimeric proteins, constructed from the c-terminal copper-binding and n-terminal matrix domains of the two sco proteins failed to complement the cox deficiency in either patient background, but mapped the dominant-negative phenotype in the sco2 background to the n-terminal domain of sco1, the most divergent part of the two sco proteins. |
2005-03-18 |
2023-08-12 |
human |
| Andrea Mezzetti, Maria Fazia, Francesco Cipollon. [New insights on the molecular mechanisms of type-1 angiotensin II receptor blockers and their contribution to atherosclerotic plaque stabilization]. Recenti progressi in medicina. vol 95. issue 12. 2005-03-04. PMID:15666492. |
recently, we have demonstrated enhanced expression of inducible cox and pge synthase (cox-2/mpges-1) in human symptomatic plaques, and provided evidence that it is associated with plaque rupture induced by metalloproteinases (mmps), proteolytic enzymes of matrix structural components. |
2005-03-04 |
2023-08-12 |
human |
| David M Zucker, Donna Spiegelma. Inference for the proportional hazards model with misclassified discrete-valued covariates. Biometrics. vol 60. issue 2. 2005-01-14. PMID:15180657. |
when there is no misclassification, the regression coefficient vector is small in magnitude, and the censoring distribution does not depend on the covariates, our estimator has the same asymptotic covariance matrix as the cox partial likelihood estimator. |
2005-01-14 |
2023-08-12 |
human |
| Shishir Shishodia, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. Cancer research. vol 64. issue 14. 2004-09-09. PMID:15256475. |
cyclooxygenase (cox)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (nf)-kappab by suppressing activation of ikappabalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin d1, cox-2, and matrix metalloproteinase-9. |
2004-09-09 |
2023-08-12 |
human |
| Shishir Shishodia, Bharat B Aggarwa. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. Cancer research. vol 64. issue 14. 2004-09-09. PMID:15256475. |
cs-associated malignancies including cancers of the larynx, oral cavity, and pharynx, esophagus, pancreas, kidney, bladder, and lung; all are known to overexpress the nuclear factor-kappab (nf-kappab)-regulated gene products cyclin d1, cyclooxygenase (cox)-2, and matrix metalloprotease-9. |
2004-09-09 |
2023-08-12 |
human |