| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myung-Soon Sung, Eun-Gyeong Lee, Hyun-Soon Jeon, Han-Jung Chae, Seoung Ju Park, Yong Chul Lee, Wan-Hee Yo. Quercetin inhibits IL-1β-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. vol 35. issue 4. 2013-01-30. PMID:22592909. |
this study was aimed to determine the effects of quercetin on the interleukin-1β (il-1β)-induced proliferation of rheumatoid synovial fibroblasts (rasfs) and production of matrix metalloproteinases (mmps), cyclooxygenase (cox), and prostaglandin e2 (pge2) by rasfs. |
2013-01-30 |
2023-08-12 |
Not clear |
| Agostino Virdis, Rocchina Colucci, Mario Fritsch Neves, Ilaria Rugani, Fatma Aydinoglu, Matteo Fornai, Chiara Ippolito, Luca Antonioli, Emiliano Duranti, Anna Solini, Nunzia Bernardini, Corrado Blandizzi, Stefano Tadde. Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition. European heart journal. vol 33. issue 17. 2012-12-31. PMID:21606076. |
the aim of this study was to investigate the role of cyclooxygenase (cox)-1 on vascular alterations in structure, mechanics, and extracellular matrix (ecm) components induced by angiotensin (ang) ii in mesenteric arteries from wild-type (wt) and cox-1 knockout (cox-1(-/-)) mice. |
2012-12-31 |
2023-08-12 |
mouse |
| Egeria Scoditti, Nadia Calabriso, Marika Massaro, Mariangela Pellegrino, Carlo Storelli, Giuseppe Martines, Raffaele De Caterina, Maria Annunziata Carlucci. Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Archives of biochemistry and biophysics. vol 527. issue 2. 2012-12-13. PMID:22595400. |
inflammatory angiogenesis is a key pathogenic process both in cancer and atherosclerosis, and is tightly regulated by the proinflammatory enzyme cyclooxygenase (cox)-2 and the matrix degrading enzymes matrix metalloproteinases (mmps). |
2012-12-13 |
2023-08-12 |
human |
| Jin Lee, Kye-Taek Li. Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice. Drug and chemical toxicology. vol 35. issue 3. 2012-10-22. PMID:21939363. |
subsequently, we evaluated nitric oxide (no), alpha-fetoprotein (afp), activator protein (ap)-1, cyclooxygenase (cox)-2, inducible nitric oxide synthase (inos), matrix metalloproteinase (mmp)-9, and interleukin (il)-6 using biochemical reaction, immunoblot analysis, and reverse-transcription polymerase chain reaction. |
2012-10-22 |
2023-08-12 |
mouse |
| Khaled Khoufache, Sylvie Bazin, Karine Girard, Julie Guillemette, Marie-Christine Roy, Jean-Pierre Verreault, Yousef Al-Abed, Warren Foster, Ali Akou. Macrophage migration inhibitory factor antagonist blocks the development of endometriosis in vivo. PloS one. vol 7. issue 5. 2012-10-09. PMID:22649515. |
actually, mice treatment with iso-1 significantly reduced the expression of cell adhesion receptors αv and ß3 integrins (p<0.05), matrix metalloproteinases (mmp) 2 and 9 (p<0.05), vascular endothelial cell growth factor (vegf) (p<0.01), interleukin 8 (il8) (p<0.05), cyclooxygenease (cox)2 (p<0.001) and the anti-apoptotic protein bcl2 (p<0.01), but significantly induced the expression of bax (p<0.05), a potent pro-apoptotic protein. |
2012-10-09 |
2023-08-12 |
mouse |
| Susanne Arnol. Cytochrome c oxidase and its role in neurodegeneration and neuroprotection. Advances in experimental medicine and biology. vol 748. 2012-09-06. PMID:22729864. |
at high atp/adp ratios, adp is exchanged for atp at the matrix side of cox iv-1 leading to an inhibition of cox activity, thus enabling cox to sense the energy level and to adjust atp synthesis to energy demand. |
2012-09-06 |
2023-08-12 |
human |
| Salvatore DiMauro, Kurenai Tanji, Eric A Scho. The many clinical faces of cytochrome c oxidase deficiency. Advances in experimental medicine and biology. vol 748. 2012-09-06. PMID:22729865. |
cytochrome c oxidase (cox) catalyzes the last step in respiration, transferring electrons from cytochrome c to molecular oxygen and coupling electron transfer with proton translocation from the mitochondrial matrix to the intermembrane space. |
2012-09-06 |
2023-08-12 |
human |
| Min Zhang, Shuzheng Lu, Xiaofan Wu, Yundai Chen, Xiantao Song, Zening Jin, Hong Li, Yujie Zhou, Fang Chen, Yong Hu. Multimarker approach for the prediction of cardiovascular events in patients with mild to moderate coronary artery lesions. A 3-year follow-up study. International heart journal. vol 53. issue 2. 2012-08-23. PMID:22688311. |
few studies have assessed the incremental usefulness of multimarkers as predictors of cardiovascular events in patients with mild to moderate coronary artery lesions.we examined 9 plasma inflammatory cytokines (cathepsin s, cxcl16, sopluble cd40 ligand, interleukin-10, placental growth factor, gdf15, matrix metalloproteinase 9, monocyte chemoattractant protein-1, and high-sensitivity c-reactive protein) in 964 patients showing mild to moderate lesions and assessed their association with risk of cardiovascular events during 3 years of follow-up (median 17 months).in a backward cox regression procedure, cystatin s (hazard ratio [hr]: 1.788, 95% ci: 1.233 to 2.593, p = 0.02), soluble cd40 ligand (hr: 1.255, 95% ci: 1.054 to 1.494, p = 0.011), placental growth factor (hr: 1.194, 95% ci: 0.976 to 1.461, p = 0.035), and gdf15 (hr: 0.725, 95% ci: 0.550 to 0.956, p = 0.023) were significantly related to cardiovascular events. |
2012-08-23 |
2023-08-12 |
Not clear |
| Jin Lee, Kye-Taek Li. Inhibitory effect of plant-originated glycoprotein (27 kDa) on expression of matrix metalloproteinase-9 in cadmium chloride-induced BNL CL.2 cells. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 25. issue 4. 2012-05-21. PMID:21924884. |
intracellular ros and intracellular ca(2+) using fluorescence, activities of activator protein (ap)-1, cyclooxygenase (cox)-2, matrix metalloproteinase (mmp)-9, and arachidonic acid (aa) using immunoblot analysis or radioactivity were evaluated. |
2012-05-21 |
2023-08-12 |
human |
| Won Ho Kim, Young-Guk Ko, Ki Woon Kang, Jung-Sun Kim, Byung-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jan. Effects of combination therapy with celecoxib and doxycycline on neointimal hyperplasia and inflammatory biomarkers in coronary artery disease patients treated with bare metal stents. Yonsei medical journal. vol 53. issue 1. 2012-04-24. PMID:22187234. |
cyclooxygenase (cox)-2 and matrix metalloproteinase (mmp)-9 play a key role in the pathogenesis of in-stent restenosis. |
2012-04-24 |
2023-08-12 |
Not clear |
| Young Mee Lee, So Min Kang, Se Rah Lee, Kyung Hwan Kong, Jeong Yoon Lee, Eun Ju Kim, Jin Ho Chun. Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice. Archives of dermatological research. vol 303. issue 10. 2012-03-30. PMID:21656169. |
in the present study, we investigated whether or not trpv1-specific blocker, 5'-iodoresiniferatoxin (i-rtx), can reduce uv-induced matrix metalloproteinases (mmps), pro-inflammatory cytokines, cyclooxygenase (cox)-2, and p53 expression in the skin of hairless mice. |
2012-03-30 |
2023-08-12 |
mouse |
| Eun-Gyeong Lee, Sang-Il Lee, Han-Jung Chae, Seoung Ju Park, Yong Chul Lee, Wan-Hee Yo. Adrenomedullin inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production. Inflammation. vol 34. issue 5. 2012-01-16. PMID:20697789. |
to determine the effects of adrenomedullin (am) on interleukin (il)-1β-induced proliferation of rheumatoid synovial fibroblasts (rasfs) and production of matrix metalloproteinases (mmps), cyclooxygenase (cox) and prostaglandin e2 (pge2) by rasfs. |
2012-01-16 |
2023-08-12 |
Not clear |
| Che-Feng Chang, Shu-Fen Chen, Tzong-Shyuan Lee, Hung-Fu Lee, Szu-Fu Chen, Song-Kun Shyu. Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage. The American journal of pathology. vol 178. issue 4. 2011-07-15. PMID:21435456. |
the protective mechanism in cav-1 knockout mice was associated with marked reduction in leukocyte infiltration, decreased expression of inflammatory mediators, including macrophage inflammatory protein (mip)-2 and cyclooxygenase (cox)-2, and reduced matrix metalloproteinase-9 activity. |
2011-07-15 |
2023-08-12 |
mouse |
| Eun-Gyeong Lee, Sang-ll Lee, Han-Jung Chae, Seoung Ju Park, Yong Chul Lee, Wan-Hee Yo. Ethyl acetate fraction from Cudrania tricuspidata inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production. Biological research. vol 43. issue 2. 2011-05-05. PMID:21031267. |
the objective of this study is to determine the effects of ethyl acetate fraction from cudrania tricuspidata (eact) on the interleukin-1b (il-1b)-induced proliferation of rheumatoid synovial fibroblasts (rasfs) and production of matrix metalloproteinases (mmps), cyclooxygenase (cox) and prostaglandin e2 (pge2) by rasfs. |
2011-05-05 |
2023-08-12 |
Not clear |
| Sandra L Silva, Ana R Vaz, Andreia Barateiro, Ana S Falcão, Adelaide Fernandes, Maria A Brito, Rui F M Silva, Dora Brite. Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20727973. |
in the present study we report that microglia primary cultures stimulated by ucb react by the acquisition of a phagocytic phenotype that shifted into an inflammatory response characterized by the secretion of the pro-inflammatory cytokines tumour necrosis factor (tnf)-α, interleukin (il)-1β, and il-6, upregulation of cyclooxygenase (cox)-2 and increased matrix metalloproteinase (mmp)-2 and -9 activities. |
2011-01-25 |
2023-08-12 |
Not clear |
| Markus Lamla, Hartmut Seliger, Dieter Kaufman. Differences in uptake, localization, and processing of PNAs modified by COX VIII pre-sequence peptide and by triphenylphoshonium cation into mitochondria of tumor cells. Drug delivery. vol 17. issue 4. 2010-11-29. PMID:20307248. |
in the second approach the cox viii pre-sequence peptide was added to the pna resulting in slow uptake of the peptide-pna into the mitochondrial matrix. |
2010-11-29 |
2023-08-12 |
Not clear |
| Jongmin Kim, Seok Joo Hong, Jin Young Park, Jun Ho Park, Yun-Suk Yu, Sun Young Park, Eun Kyung Lim, Kwan Yong Choi, Eun Kyu Lee, Seung Sam Paik, Kyeong Geun Lee, Hee Jung Wang, In-Gu Do, Jae-Won Joh, Dae Shick Ki. Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma. Cancer science. vol 101. issue 6. 2010-09-14. PMID:20331628. |
from a univariate cox analysis for a training cohort of 128 hepatocellular carcinoma patients, four candidate genes (e-cadherin [cdh1], inhibitor of dna binding 2 [id2], matrix metalloproteinase 9 [mmp9], and transcription factor 3 [tcf3]) with significant prognostic values were selected to develop a risk score of patient survival. |
2010-09-14 |
2023-08-12 |
human |
| Longhuo Wu, Xiao Wang, William Xu, Farzin Farzaneh, Ruian X. The structure and pharmacological functions of coumarins and their derivatives. Current medicinal chemistry. vol 16. issue 32. 2010-01-22. PMID:19754420. |
these include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease matrix metalloproteinase (mmp) activity, block the cell cycle in the s or g2/m phases to interfere with processes of cell division, suppress o2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione s-transferases (gsts) and/or nad(p)h quinine oxidoreductase (nqo1), suppress the phosphorylation of akt/pkb as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (nos) and cyclooxygenase (cox), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (huvec). |
2010-01-22 |
2023-08-12 |
human |
| Cigdem Tokyol, Fatma Aktepe, Fatma Hüsniye Dilek, Onder Sahin, Dagstan Tolga Ario. Expression of cyclooxygenase-2 and matrix metalloproteinase-2 in adenomyosis and endometrial polyps and its correlation with angiogenesis. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 28. issue 2. 2009-10-01. PMID:19188819. |
this study investigates the expression of cyclooxgenase (cox)-2 and matrix metalloproteinase (mmp)-2 in patients with adenomyosis or endometrial polyps and their possible relation to microvascular density in these lesions. |
2009-10-01 |
2023-08-12 |
human |
| V Sivaramakrishnan, S Niranjali Devara. Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chemico-biological interactions. vol 180. issue 3. 2009-07-16. PMID:19539802. |
the present study was conducted to decipher, in vivo, the role of morin on the expression of matrix metalloproteinases, cyclooxygenase (cox)-2 and nuclear factor kappa b (nf-kappab)-p65 during diethylnitrosamine (den)-induced hepatocarcinogenesis in wistar albino rats. |
2009-07-16 |
2023-08-12 |
rat |