| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhong, Yi Huang, Marcel B Santoso, Li-Dong W. Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. International journal of clinical and experimental pathology. vol 8. issue 3. 2016-03-08. PMID:26045743. |
cultured rabbit chondrocytes were pretreated with 1, 5 and 10 μg/ml sclareol for 1 h and followed by stimulation of il-1β (10 ng/ml) for 24 h. gene expression of matrix metalloproteinase-1 (mmp-1), mmp-3, mmp-13, tissue inhibitors of metalloproteinase-1 (timp-1), inducible nitric oxide synthase (inos) and cyclooxygenase (cox)-2 was determined by quantitative real-time polymerase chain reaction (qrt-pcr). |
2016-03-08 |
2023-08-13 |
rabbit |
| Xian-Ying Meng, Qiang Zhang, Qun Li, Shan Lin, Jie L. Immunohistochemical levels of cyclo-oxygenase-2, matrix metalloproteinase-9 and vascular endothelial growth factor in papillary thyroid carcinoma and their clinicopathological correlations. The Journal of international medical research. vol 42. issue 3. 2016-02-15. PMID:24670538. |
to measure the levels of cyclo-oxygenase (cox)-2, matrix metalloproteinase (mmp)-9 and vascular endothelial growth factor (vegf) immunostaining in papillary thyroid carcinoma (ptc) and benign thyroid tumours, and to investigate potential correlations between their levels and clinicopathological characteristics. |
2016-02-15 |
2023-08-12 |
Not clear |
| Praveen Prakhar, Sahana Holla, Devram Sampat Ghorpade, Martine Gilleron, Germain Puzo, Vibha Udupa, Kithiganahalli Narayanaswamy Balaj. Ac2PIM-responsive miR-150 and miR-143 target receptor-interacting protein kinase 2 and transforming growth factor beta-activated kinase 1 to suppress NOD2-induced immunomodulators. The Journal of biological chemistry. vol 290. issue 44. 2016-02-02. PMID:26391398. |
while ac2pim treatment of macrophages compromised their ability to induce nod2-dependent immunomodulators like cyclooxygenase (cox)-2, suppressor of cytokine signaling (socs)-3, and matrix metalloproteinase (mmp)-9, no change in the nod2-responsive no, tnf-α, vegf-a, and il-12 levels was observed. |
2016-02-02 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Bora. Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation. vol 11. issue 4. 2015-06-30. PMID:26124563. |
neuronal demise in ci has been linked to several pathways which include cyclooxygenases (cox) - mediated production of prostaglandins (pgs) and subsequently reactive oxygen species (ros), aquaporin-4 (aq-4) - mediated brain edema and acidsensing ion channel-1a (asic-1a) - mediated acidotoxicity, matrix remodeling, in addition to others. |
2015-06-30 |
2023-08-13 |
Not clear |
| Yun Jung Choi, Won-Seok Lee, Eun-Gyeong Lee, Myung-Soon Sung, Wan-Hee Yo. Sulforaphane inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2. Inflammation. vol 37. issue 5. 2015-06-22. PMID:24671668. |
this study was performed to define the effects of sulforaphane on interleukin-1β (il-1β)-induced proliferation of rheumatoid arthritis synovial fibroblasts (rasfs), the expression of matrix metalloproteinases (mmps) and cyclooxygenase (cox), and the production of prostaglandin e2 (pge2) by rasfs. |
2015-06-22 |
2023-08-12 |
Not clear |
| Ratana Lim, Gillian Barker, Martha Lappa. FOXM1 is lower in human fetal membranes after spontaneous preterm labour and delivery. Reproduction, fertility, and development. vol 26. issue 7. 2015-05-11. PMID:23953749. |
foxm1 silencing in primary amnion cells increased interleukin (il)-1β-induced pro-inflammatory cytokines (il-6 and il-8 mrna expression and secretion), cyclooxygenase (cox)-2 expression and subsequent prostaglandin (pg)e2 and pgf2α release as well as gene expression and secretion of the matrix-degrading enzyme matrix metalloproteinase 9 (mmp-9). |
2015-05-11 |
2023-08-12 |
human |
| Iuliana Nenu, Tiberiu Popescu, Mihaela D Aldea, Lucian Craciun, Diana Olteanu, Corina Tatomir, Pompei Bolfa, Rodica M Ion, Adriana Muresan, Adriana G Fili. Metformin associated with photodynamic therapy--a novel oncological direction. Journal of photochemistry and photobiology. B, Biology. vol 138. 2015-03-31. PMID:24911275. |
the apoptotic rate, inducible nitric oxide synthase (inos) and cyclooxygenase (cox)-2 expressions and matrix metalloproteinases activities were also quantified. |
2015-03-31 |
2023-08-13 |
rat |
| K J A Cox, P R Adam. Hebbian learning from higher-order correlations requires crosstalk minimization. Biological cybernetics. vol 108. issue 4. 2015-03-02. PMID:24862556. |
we previously reported that even if the matrix is only approximately orthogonal, a nonlinear-specific hebbian rule can usually learn almost correct unmixing weights (cox and adams in front comput neurosci 3: doi: 10.3389/neuro.10.011.2009 2009). |
2015-03-02 |
2023-08-13 |
Not clear |
| Yasuyoshi Miyata, Shigeru Kanda, Kensuke Mitsunari, Akihiro Asai, Hideki Saka. Heme oxygenase-1 expression is associated with tumor aggressiveness and outcomes in patients with bladder cancer: a correlation with smoking intensity. Translational research : the journal of laboratory and clinical medicine. vol 164. issue 6. 2015-02-04. PMID:25063314. |
microvessel density, lymph vessel density (lvd), proliferation index (pi), and expression of the vascular endothelial growth factor (vegf)-a, -c, and -d, cyclooxygenase (cox)-2, matrix metalloproteinase (mmp)-2, and mmp-9 were investigated by similar methods. |
2015-02-04 |
2023-08-13 |
Not clear |
| S C Su, K Tanimoto, Y Tanne, R Kunimatsu, N Hirose, T Mitsuyoshi, Y Okamoto, K Tann. Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress. Osteoarthritis and cartilage. vol 22. issue 6. 2015-01-26. PMID:24721459. |
high magnitude cyclic tensile strain (cts) up-regulates pro-inflammatory cytokines and matrix metalloproteinases (mmps) in chondrocytes, while selective cyclooxygenase (cox)-2 inhibition has been shown to be beneficial to cytokine-induced cartilage damage. |
2015-01-26 |
2023-08-13 |
Not clear |
| M Mouradian, K D Kikawa, E D Johnson, K L Beck, R S Pardin. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. Prostaglandins, leukotrienes, and essential fatty acids. vol 90. issue 4. 2014-11-25. PMID:24374147. |
enrichment of la increased cyclooxygenase (cox) activity and led to increases in prostaglandin e2 (pge2), followed by increases in matrix metalloproteinase (mmp) and transforming growth factor alpha (tgf-α) levels, which are all key elements involved in the enhancement of cancer cell growth. |
2014-11-25 |
2023-08-12 |
mouse |
| Egeria Scoditti, Alessia Nestola, Marika Massaro, Nadia Calabriso, Carlo Storelli, Raffaele De Caterina, Maria Annunziata Carlucci. Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition. Atherosclerosis. vol 232. issue 1. 2014-09-16. PMID:24401212. |
the production of cyclooxygenase (cox)-2-dependent inflammatory eicosanoids and the functionally linked release of matrix metalloproteinase (mmp)-9 by macrophages likely contribute to plaque instability leading to acute coronary events. |
2014-09-16 |
2023-08-12 |
human |
| Qian-Qian Liang, Dao-Fang Ding, Zhi-Jie Xi, Yan Chen, Chen-Guang Li, Shu-Fen Liu, Sheng Lu, Yong-Jian Zhao, Qi Shi, Yong-Jun Wan. Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-05-29. PMID:24872832. |
we found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type x collagen, matrix metalloproteinase (mmp)-13, and mmp3; upregulated type ii collagen; and decreased il-1 β , cyclooxygenase (cox)-2, and inducible nitric oxide synthase (inos) expression. |
2014-05-29 |
2023-08-13 |
rat |
| Ha-Yong Yoon, Eun-Gyeong Lee, Hyun Lee, In Jin Cho, Yun Jung Choi, Myung-Soon Sung, Han-Gyul Yoo, Wan-Hee Yo. Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23934131. |
inflammatory cytokines, matrix metalloproteinases (mmps) and cyclooxygenase (cox)-2 released from rheumatoid arthritis synovial fibroblasts (rasfs) are involved in the destruction of both articular bone and cartilage. |
2014-03-27 |
2023-08-12 |
Not clear |
| Lin Wang, Yixiang Wang, Huan Bian, Yinfei Pu, Chuanbin Gu. Molecular characteristics of homologous salivary adenoid cystic carcinoma cell lines with different lung metastasis ability. Oncology reports. vol 30. issue 1. 2014-01-17. PMID:23673996. |
29 of the 136 differentially expressed genes including ereg, s100p, cyclooxygenase (cox)-2, phospho-akt (p-akt), matrix metalloproteinase (mmp)-1, mmp-2, mmp-3, mmp-9, mmp-13 and mmp-14 were found following gene screening in sacc-83 and sacc-lm cells. |
2014-01-17 |
2023-08-12 |
Not clear |
| Ji-Yun Ko, You-Jeong Choi, Geun-Jae Jeong, Gun-Il I. Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis. Biomaterials. vol 34. issue 21. 2013-12-03. PMID:23601658. |
the in vitro anti-inflammatory effect on markers such as cyclooxygenase (cox)-2, a disintegrin and metalloproteinase with thrombospondin motifs (adamts)-5, and matrix metalloproteinase (mmp)-2 was assessed by real-time pcr and western blotting. |
2013-12-03 |
2023-08-12 |
rat |
| Ratana Lim, Gillian Barker, Martha Lappa. A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells. Biology of reproduction. vol 88. issue 6. 2013-10-21. PMID:23636809. |
we found that the loss of foxo3 in myometrial cells was associated with a significant decrease in il1b-induced il6 and il8 expression and production, cyclooxygenase ([cox]-2, official symbol ptgs2) expression and subsequent prostaglandin (pge2 and pgf2alpha) release, and matrix metalloproteinase 9 (mmp9) and mrna expression and activity. |
2013-10-21 |
2023-08-12 |
human |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Amélie Vézina, Rima Chokor, Borhane Annab. EGCG targeting efficacy of NF-κB downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells. Cancer immunology, immunotherapy : CII. vol 61. issue 12. 2013-05-07. PMID:22707304. |
nf-κb-mediated signaling during hl-60 macrophage differentiation was reversed by egcg, in part through reduced iκb phosphorylation and led to the inhibition of moderately to highly expressed nf-κb gene targets among which the matrix metalloproteinase (mmp)-9 and the cyclooxygenase (cox)-2. |
2013-05-07 |
2023-08-12 |
Not clear |
| Guangyue Li, Yuan Yue, Ye Tian, Jin-le Li, Min Wang, Hao Liang, Peixi Liao, Wings T Y Loo, Mary N B Cheung, Louis W C Cho. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. Cytokine. vol 60. issue 2. 2013-02-19. PMID:22819245. |
association of matrix metalloproteinase (mmp)-1, 3, 9, interleukin (il)-2, 8 and cyclooxygenase (cox)-2 gene polymorphisms with chronic periodontitis in a chinese population. |
2013-02-19 |
2023-08-12 |
human |