| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshinao Onoda, Takashi Ono, Dipok Kumar Dhar, Akira Yamanoi, Toshiyuki Fujii, Naofumi Nagasu. Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. The Journal of laboratory and clinical medicine. vol 143. issue 4. 2004-05-11. PMID:15085079. |
matrix metalloproteinases (mmps) and cyclooxygenase (cox) enzymes play pivotal roles in the metastatic process of colorectal cancers. |
2004-05-11 |
2023-08-12 |
human |
| João B Calixto, Maria M Campos, Michel F Otuki, Adair R Santo. Anti-inflammatory compounds of plant origin. Part II. modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta medica. vol 70. issue 2. 2004-04-06. PMID:14994184. |
ap-1:activator protein-1 ccr1:chemokine receptor 1 cinc-1:cytokine-induced neutrophil chemoattractant 1 cox:cyclooxygenase egcg:(-)-epigallocatechin gallate elam-1:endothelial-leukocyte adhesion molecule-1 erk:extracellular signal-regulated kinase gro:growth-related oncogene huvec:human umbilical vein endothelial cells icam-1:intercellular adhesion molecule-1 ifn:interferon il:interleukin inos:inducible nitric oxide synthase ira:the natural interleukin receptor activation jak:janus kinase jnk:c-jun nh2-terminal kinase lps:lipopolysaccharide mapk:mitogen-activated protein kinases mcp:monocyte chemotactic protein mhc:major histocompatibility complex mip:macrophage inflammatory protein mmp:matrix metalloproteinases mpo:myeloperoxidase nf-kappabnuclear factor kappa b no:nitric oxide paf:platelet aggregation factor pgee:prostaglandin pk:protein kinase pma/tpa:phorbol myristate acetate rantes:regulated upon activation normal t-cell expressed and secreted tgf-beta:transforming growth factor-beta tnfalpha:tumour necrosis factor vcam-1:vascular cell adhesion molecule-1 |
2004-04-06 |
2023-08-12 |
human |
| Nise H Yamaguchi, Ana J Lichtenfels, Lea M Demarchi, Alecsander P da Silva, Ana L Garippo, Venancio F Alves, Carolina Michelin, Pedro M Azevedo, Tatiana Moya, Tereza Takagaki, Paulo H Saldiva, Robin T Vollmer, Vera L Capelozz. COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil. American journal of clinical pathology. vol 121. issue 1. 2004-02-10. PMID:14750244. |
we report immunohistochemical staining results for cyclooxygenase (cox)-2 and matrix metalloproteinase (mmp)-9 in primary tumors of 117 patients with resected adenocarcinoma of the lung (median follow-up, 20 months). |
2004-02-10 |
2023-08-12 |
Not clear |
| Debabrata Saha, Konjeti R Sekhar, Carolyn Cao, Jason D Morrow, Hak Choy, Michael L Freema. The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity. Cancer research. vol 63. issue 20. 2003-12-22. PMID:14583492. |
increased expression of cyclooxygenase (cox) 2 and the production of pgs appear to provide a survival advantage to transformed cells through the inhibition of apoptosis, increased attachment to extracellular matrix, increased invasiveness and the stimulation of angiogenesis. |
2003-12-22 |
2023-08-12 |
Not clear |
| M Tsuzaki, D Bynum, L Almekinders, X Yang, J Faber, A J Bane. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. Journal of cellular biochemistry. vol 89. issue 3. 2003-11-12. PMID:12761889. |
load-induced endogenous il-1beta may trigger matrix remodeling or a more destructive pathway(s) involving il-1beta, cox 2, and mmp-3. |
2003-11-12 |
2023-08-12 |
human |
| J G Edwards, J McLaren, J L Jones, D A Waller, K J O'Byrn. Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. British journal of cancer. vol 88. issue 10. 2003-06-26. PMID:12771921. |
matrix metalloproteinases were correlated with clinicopathological factors and with survival using kaplan-meier and cox proportional hazard models. |
2003-06-26 |
2023-08-12 |
Not clear |
| S C Mastbergen, F P J G Lafeber, J W J Bijlsm. Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage. Rheumatology (Oxford, England). vol 41. issue 7. 2002-08-13. PMID:12096231. |
this study evaluated the in vitro effect of the selective cyclooxygenase-2 (cox) inhibitor celecoxib on cartilage matrix turnover under normal and inflammatory conditions. |
2002-08-13 |
2023-08-12 |
Not clear |
| J T Tung, J I Fenton, C Arnold, L Alexander, V Yuzbasiyan-Gurkan, P J Venta, T L Peters, M W Orth, D W Richardson, J P Caro. Recombinant equine interleukin-1beta induces putative mediators of articular cartilage degradation in equine chondrocytes. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. vol 66. issue 1. 2002-06-05. PMID:11858644. |
the effects of the recombinant peptide on chondrocyte gene expression were determined by northern blotting using rna from equine chondrocyte cultures hybridized to probes for matrix metalloproteinases (mmp 1, mmp 3, mmp 13), tissue inhibitor of matrix metalloproteinases 1 (timp 1) and cyclooxygenase 2 (cox 2). |
2002-06-05 |
2023-08-12 |
Not clear |
| Newton Alexander Chiang Shuek Wong, Massimo Pignatell. Beta-catenin--a linchpin in colorectal carcinogenesis? The American journal of pathology. vol 160. issue 2. 2002-03-19. PMID:11839557. |
pro-oncogenic factors that also release beta-catenin from the adherens complex and/or encourage translocation to the nucleus include ras, epidermal growth factor (egf), c-erbb-2, pkc-betaii, muc1, and ppar-gamma, whereas anti-oncogenic factors that also inhibit nuclear beta-catenin signaling include transforming growth factor (tgf)-beta, retinoic acid, and vitamin d. association of nuclear beta-catenin with the t cell factor (tcf)/lymphoid enhancer factor (lef) family of transcription factors promotes the expression of several compounds that have important roles in the development and progression of colorectal carcinoma, namely: c-myc, cyclin d1, gastrin, cyclooxygenase (cox)-2, matrix metalloproteinase (mmp)-7, urokinase-type plasminogen activator receptor (apar), cd44 proteins, and p-glycoprotein. |
2002-03-19 |
2023-08-12 |
Not clear |
| C Lemaire, P Hamel, J Velours, G Dujardi. Absence of the mitochondrial AAA protease Yme1p restores F0-ATPase subunit accumulation in an oxa1 deletion mutant of Saccharomyces cerevisiae. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10816574. |
we have examined the role of oxa1p in light of its relationships with two mitochondrial proteases, the matrix protease afg3p-rca1p and the intermembrane space protease yme1p, by analyzing the assembly and activity of the cox and atpase complexes in deltaoxa1, deltaoxa1deltaafg3, and deltaoxa1deltayme1 mutants. |
2000-09-07 |
2023-08-12 |
Not clear |
| A J Williams, J Coakley, J Christodoulo. Automated analysis of mitochondrial enzymes in cultured skin fibroblasts. Analytical biochemistry. vol 259. issue 2. 1998-07-09. PMID:9618194. |
we report automated methods for assaying the activities of the mitochondrial respiratory chain enzyme cytochrome c oxidase (cox), the matrix enzyme citrate synthase (cs), and the cytoplasmic enzyme lactate dehydrogenase (ldh) on a random access analyzer, the roche mira s. cox activity was assayed by measuring the initial rate of oxidation of reduced cytochrome c. the cs assay was based on the reaction of this enzyme with oxaloacetate and acetyl-coa to produce coash, which further reacts with dithionitrobenzoic acid producing a free thionitrobenzoate ion. |
1998-07-09 |
2023-08-12 |
Not clear |
| W E Barlo. Global measures of local influence for proportional hazards regression models. Biometrics. vol 53. issue 3. 1997-10-14. PMID:9290233. |
cox proportional hazards regression models have been extended to multiple failure times and other situations by using a robust covariance matrix instead of the usual inverse of the information matrix. |
1997-10-14 |
2023-08-12 |
Not clear |
| T R Schmidt, S A Jaradat, M Goodman, M I Lomax, L I Grossma. Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. Molecular biology and evolution. vol 14. issue 6. 1997-08-07. PMID:9190060. |
maximum-parsimony analysis and sequence divergences from reconstructed ancestral sequences revealed that after the ancestral cox6a gene duplicated to yield the genes for the h and l isoforms, the sequences encoding the mitochondrial matrix region of the cox via protein experienced an elevated rate of nonsynonymous substitutions relative to synonymous substitutions. |
1997-08-07 |
2023-08-12 |
Not clear |
| F Rohdich, B Kadenbac. Tissue-specific regulation of cytochrome c oxidase efficiency by nucleotides. Biochemistry. vol 32. issue 33. 1993-09-27. PMID:8395207. |
the data suggest a regulatory effect of matrix nucleotides in heart and skeletal muscle mitochondria on the efficiency of energy transduction in cox. |
1993-09-27 |
2023-08-12 |
cattle |