| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulme. Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization. Systems biology in reproductive medicine. vol 65. issue 1. 2019-03-28. PMID:30571152. |
abbreviations: ivf: in vitro fertilization; mmp: matrix metalloproteinase; il: interleukins; ff: follicular fluid; vegf: vascular endothelial growth factor; nsaids: non-steroidal anti-inflammatories; por: poor ovarian response; amh: anti-mullerian hormone; tafc: total antral follicle count; hmg: human menopausal gonadotropin; hcg: human chorionic gonadotropin; cox: cyclooxygenase enzymes; pgh2: prostaglandin h2; rantes: regulated on activation, normal t expressed and secreted; nf-κb: nuclear factor kappa-light-chain-enhancer of activated b cells. |
2019-03-28 |
2023-08-13 |
human |
| Leticia Veloso R Franco, Chen-Hsien Su, Gavin P McStay, George J Yu, Alexander Tzagolof. Cox2p of yeast cytochrome oxidase assembles as a stand-alone subunit with the Cox1p and Cox3p modules. The Journal of biological chemistry. vol 293. issue 43. 2019-03-21. PMID:30224355. |
cytochrome oxidase (cox) is a hetero-oligomeric complex of the mitochondrial inner membrane that reduces molecular oxygen to water, a reaction coupled to proton transfer from the mitochondrial matrix to the intermembrane space. |
2019-03-21 |
2023-08-13 |
Not clear |
| Juan Ma, Ruibin Li, Guangbo Qu, Huiyu Liu, Bing Yan, Tian Xia, Yajun Liu, Sijin Li. Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines. Nanoscale. vol 8. issue 42. 2018-10-02. PMID:27714147. |
mechanistic studies showed that mwcnts-cooh stimulated pro-inflammatory effects by activating macrophages, and the secreted pro-inflammatory cytokines primed the synoviocytes and chondrocytes, resulting in enhanced production of a large array of enzymes involved in articular cartilage degeneration, including matrix metalloproteinase (mmp) members and cyclooxygenase (cox) members, and increased enzymatic activity of mmps was demonstrated. |
2018-10-02 |
2023-08-13 |
Not clear |
| Yuan Hu, Jin-Shu Tang, Shu-Xun Hou, Xiu-Xiu Shi, Jiang Qin, Tie-Song Zhang, Xiao-Jing Wan. Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF in a rat model. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901458. |
the aim of the present study was to investigate whether curcumin can alleviate lidd through regulating the expression of inducible nitric oxide synthase (inos), cyclooxygenase (cox)‑2, transforming growth factor (tgf)‑β1/2, matrix metalloproteinase (mmp)‑9 and brain‑derived neurotrophic factor (bdnf) in a rat model of lidd. |
2018-06-04 |
2023-08-13 |
rat |
| Min Jung Lee, Jang-Hee Oh, Chi-Hyun Park, Kyu Han Kim, Dong Hun Lee, Jin Ho Chun. Galanin contributes to ultraviolet irradiation-induced inflammation in human skin. Experimental dermatology. vol 26. issue 8. 2018-04-24. PMID:27943416. |
galanin knock-down by sirna transfection markedly inhibited uv irradiation-induced expression of matrix metalloproteinase (mmp)-1, interleukin (il)-1β, il-6 and cyclooxygenase (cox)-2. |
2018-04-24 |
2023-08-13 |
human |
| Nadja Adler, Axel Schoeniger, Herbert Fuhrman. Effects of transforming growth factor-β and interleukin-1β on inflammatory markers of osteoarthritis in cultured canine chondrocytes. American journal of veterinary research. vol 78. issue 11. 2018-02-28. PMID:29076366. |
gene expression of matrix metalloproteinase (mmp)-3, tissue inhibitor of metalloproteinase (timp)-2, inducible no synthase (inos), and cyclooxygenase (cox)-2 was quantified by use of real-time quantitative pcr assays. |
2018-02-28 |
2023-08-13 |
Not clear |
| Akira Sugiyama, Muneyoshi Okada, Hideyuki Yamawak. Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats. European journal of pharmacology. vol 807. 2017-12-05. PMID:28438649. |
canstatin stimulated proliferation, secretion of matrix metalloproteinases, expression of cyclooxygenase (cox)-2, and inhibited collagen gel contraction in myofibroblasts. |
2017-12-05 |
2023-08-13 |
rat |
| Nils Ternès, Federico Rotolo, Georg Heinze, Stefan Michiel. Identification of biomarker-by-treatment interactions in randomized clinical trials with survival outcomes and high-dimensional spaces. Biometrical journal. Biometrische Zeitschrift. vol 59. issue 4. 2017-12-01. PMID:27862181. |
we evaluated 12 approaches in high-dimensional cox models in randomized clinical trials: penalization of the biomarker main effects and biomarker-by-treatment interactions (full-lasso, three kinds of adaptive lasso, ridge+lasso and group-lasso); dimensionality reduction of the main effect matrix via linear combinations (pca+lasso (where pca is principal components analysis) or pls+lasso (where pls is partial least squares)); penalization of modified covariates or of the arm-specific biomarker effects (two-i model); gradient boosting; and univariate approach with control of multiple testing. |
2017-12-01 |
2023-08-13 |
Not clear |
| Susana Barbosa Ribeiro, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo Júnior, Gerly Anne de Castro Brito, Renata Carvalho Leitão, Maisie Mitchele Barbosa, Vinicius Barreto Garcia, Aldo Cunha Medeiros, Caroline Addison Carvalho Xavier de Medeiro. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters. PloS one. vol 12. issue 10. 2017-11-13. PMID:29059216. |
dex (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (cox)-2, matrix metalloproteinase (mmp)-2, transforming growth factor (tgf)-β, mif, smad 2/3, smad 2/3 phosphorylated and nfκb p65 in the jugal mucosa. |
2017-11-13 |
2023-08-13 |
Not clear |
| Maryam Moeeni, Emran M Razaghi, Koen Ponnet, Fatemeh Torabi, Seyed Ali Shafiee, Tahereh Pashae. Predictors of time to relapse in amphetamine-type substance users in the matrix treatment program in Iran: a Cox proportional hazard model application. BMC psychiatry. vol 16. 2017-07-31. PMID:27455958. |
predictors of time to relapse in amphetamine-type substance users in the matrix treatment program in iran: a cox proportional hazard model application. |
2017-07-31 |
2023-08-13 |
Not clear |
| Zafar Rasheed, Naila Rasheed, Hani A Al-Shobail. Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes. Journal of cellular and molecular medicine. vol 20. issue 12. 2017-07-11. PMID:27515563. |
several mirnas have been identified which have shown to regulate expression of target genes relevant to oa pathogenesis such as matrix metalloproteinase (mmp)-13, cyclooxygenase (cox)-2, etc. |
2017-07-11 |
2023-08-13 |
human |
| Zhihua Yao, Tian Yuan, Haiying Wang, Shuna Yao, Yan Zhao, Ying Liu, Shuiling Jin, Junfeng Chu, Yuanlin Xu, Wenping Zhou, Shujun Yang, Yanyan Li. MMP-2 together with MMP-9 overexpression correlated with lymph node metastasis and poor prognosis in early gastric carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-05. PMID:28621235. |
multivariate cox regression analysis revealed that matrix metalloproteinase-2 and matrix metalloproteinase-9 expression were both independent factors of overall survival in patients with early gastric cancer. |
2017-07-05 |
2023-08-13 |
Not clear |
| Yi-Hsin Wang, Ke-Min Chen, Ping-Sung Chiu, Shih-Chan Lai, Hsing-Hui Su, Ming-Shiou Jan, Chia-Wei Lin, Dah-Yuu Lu, Yuan-Tsung Fu, Jiuan-Miaw Liao, Jinghua Tsai Chang, Shiang-Suo Huan. Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling. Journal of molecular and cellular cardiology. vol 99. 2017-05-31. PMID:27503317. |
lumbrokinase also inhibited the enhancement of i-r induced expressions of cyclooxygenase (cox)-2, inducible nitric oxide synthase (inos), and matrix metalloproteinase (mmp)-9 through toll-like receptor 4 (tlr4) signaling pathway. |
2017-05-31 |
2023-08-13 |
rat |
| Yue Shi, Duo Zuo, Xia Wang, Meng Han, Yan W. shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27599909. |
western blotting and reverse transcription‑quantitative polymerase chain reaction indicated that the protein expression levels of amyloid β (a4) precursor protein (app) and zinc finger protein 395 (znf395) were upregulated, while expression levels of pro‑metastatic proteins including interleukin (il)‑1β, il‑8, cyclooxygenase (cox)‑2, matrix metalloproteinase 2 (mmp2) and mmp9 were downregulated. |
2017-04-17 |
2023-08-13 |
human |
| Yan-Feng Liu, Yun-Qing Bai, Ming Q. Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27222119. |
in addition, daidzein strongly suppressed the gene expression of cyclooxygenase (cox)‑2, matrix metalloproteinase 2 (mmp‑2), tissue inhibitor of metalloproteinase 1 (timp-1), transforming growth factor β1 (tgf‑β1), and inhibited inducible nitric oxide synthase (inos) protein expression in angiotensin ii‑induced aaa mice. |
2017-04-06 |
2023-08-13 |
mouse |
| Melania Collu-Marchese, Michael Shuen, Marion Pauly, Ayesha Saleem, David A Hoo. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation. Bioscience reports. vol 35. issue 3. 2016-12-13. PMID:26182383. |
during differentiation, the accumulating tfam protein was progressively distributed to the mitochondrial matrix where it augmented the expression of mtdna and cox (cytochrome c oxidase) subunit i, an mtdna gene product. |
2016-12-13 |
2023-08-13 |
Not clear |
| Malarvizhi Gurusamy, Saeed Nasseri, Hana Lee, Birgit Jung, Dongwon Lee, Gilson Khang, William M Abraham, Henri Doods, Dongmei W. Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice. Pharmacological research. vol 104. 2016-12-13. PMID:26747401. |
treatment with bi113823 and dexamethasone also significantly reduced total protein content, ige, tnf-α and il-1β in lavage fluid, reduced myeloperoxidase activity, mucus secretion in lung tissues, and reduced the expression of b1 receptors, matrix metalloproteinase (mmp)-2 and cyclooxygenase (cox)-2 compared to vehicle-treated mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Yi Wang, Quan Li, Xianzhao Wei, Jie Xu, Qi Chen, Shuang Song, Zhe Lu, Zimin Wan. Targeted knockout of TNF-α by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26130073. |
morphological observations revealed that the number of inflammatory cells were reduced and damage to tendon fibers was attenuated in this group, suggesting that the downregulation of the protein expression levels of tnf‑α‑associated nuclear factor‑κb, matrix metalloproteinase (mmp)1, mmp9, cyclooxygenase (cox)‑1 and cox‑2 may exert a therapeutic effect on inflammation of the sab caused by rheumatoid arthritis. |
2016-05-17 |
2023-08-13 |
rat |
| Won-Seok Lee, Jin-Han Lim, Myung-Soon Sung, Eun-Gyeong Lee, Yoo-Jeong Oh, Wan-Hee Yo. Ethyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production. Biological research. vol 47. 2016-04-11. PMID:25299270. |
this study aimed to determine the effects of ethyl acetate fraction from angelica sinensis (eaas) on the interleukin-1β (il-1β)-induced proliferation of rheumatoid arthritis synovial fibroblasts (rasfs), and production of matrix metalloproteinases (mmps), cyclooxygenase (cox) 2, and prostaglandin e2 (pge2), involved in articular bone and cartilage destruction, by rasfs. |
2016-04-11 |
2023-08-13 |
Not clear |
| Yange Ma, Airong Shen, Canyu Li, Shengnan Xu, Huanhuan Guo, Shunhong Zo. [Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF, MMP-9, the activity of COX-2 and stimulates the apoptosis in eutopic, ectopic endometrial stromal cells of women with endometriosis]. Zhonghua fu chan ke za zhi. vol 50. issue 10. 2016-03-16. PMID:26675577. |
to investigate the effect of targeted interruption of cyclooxygenase-2 (cox-2) gene by small interference rna (sirna) on the expression of cox-2, vascular endothelial growth factor (vegf) and matrix metalloproteinase-9 (mmp-9) in eutopic and ectopic endometrial stromal cells (esc) with endometriosis, and the effect on the content of 6-keto-prostaglandin-f1α (6-keto-pgf1α, metabolites of cox) and the apoptosis of eutopic and ectopic esc with endometriosis. |
2016-03-16 |
2023-08-13 |
Not clear |