| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Liu, Qing Yang, Gui Fang, Bing-Shu Li, De-Bin Wu, Wen-Jun Guo, Sha-Sha Hong, Li Hon. Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament‑derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapse. Molecular medicine reports. vol 13. issue 4. 2016-12-30. PMID:26936098. |
the primary cultured huslfs were treated with exogenous h2o2 to establish an original os cell model, in which the expression levels of collagen, type 1, α1 (col1a1), matrix metalloproteinase (mmp)‑2, tissue inhibitor of metalloproteinase (timp)‑2 and transforming growth factor (tgf)‑β1 were evaluated by western blot and reverse transcription‑quantitative polymerase chain reaction analyses. |
2016-12-30 |
2023-08-13 |
human |
| Xiaohong Duan, Zhenxia Liu, Yunna Gan, Dan Xia, Qiang Li, Yanling Li, Jiaji Yang, Shan Gao, Mingdong Don. Mutations in COL1A1 Gene Change Dentin Nanostructure. Anatomical record (Hoboken, N.J. : 2007). vol 299. issue 4. 2016-12-13. PMID:26694865. |
although many studies have attempted to associate specific gene mutations with dentin phenotypic severity, it remains unknown how the mutations in col1a1 gene influence the mechanical behavior of dentin collagen and matrix. |
2016-12-13 |
2023-08-13 |
Not clear |
| Lina Zhou, Mei Shang, Mengchen Shi, Lu Zhao, Zhipeng Lin, Tingjin Chen, Yinjuan Wu, Zeli Tang, Hengchang Sun, Jinyun Yu, Yan Huang, Xinbing Y. Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2. Parasitology research. vol 115. issue 2. 2016-09-07. PMID:26486942. |
in the present study, lx-2 cells were stimulated with cslysopla in the presence of tgf-β1, and the expressions of collagen type i (col1a1), α-smooth muscle actin (α-sma), and matrix metalloproteinase 2 (mmp2) were decreased. |
2016-09-07 |
2023-08-13 |
Not clear |
| Roman Thaler, Antonio Maurizi, Paul Roschger, Ines Sturmlechner, Farzaneh Khani, Silvia Spitzer, Monika Rumpler, Jochen Zwerina, Heidrun Karlic, Amel Dudakovic, Klaus Klaushofer, Anna Teti, Nadia Rucci, Franz Varga, Andre J van Wijne. Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate. The Journal of biological chemistry. vol 291. issue 13. 2016-08-05. PMID:26757819. |
sfn enhances active dna demethylation viatet1andtet2and promotes preosteoblast differentiation by enhancing extracellular matrix mineralization and the expression of osteoblastic markers (runx2,col1a1,bglap2,sp7,atf4, andalpl). |
2016-08-05 |
2023-08-13 |
mouse |
| Kelli A Lytle, Christopher M Depner, Carmen P Wong, Donald B Jum. Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway. Journal of lipid research. vol 56. issue 10. 2016-08-04. PMID:26315048. |
dha was more effective than epa at preventing wd-induced effects on hepatic transcripts linked to fibrosis, including collagen 1a1 (col1a1), transforming growth factor-β (tgfβ) signaling and proteins involved in remodeling the extracellular matrix, including metalloproteases, tissue inhibitors of metalloproteases, and lysyl oxidase subtypes. |
2016-08-04 |
2023-08-13 |
mouse |
| Eric A Lewallen, Dakota L Jones, Amel Dudakovic, Roman Thaler, Christopher R Paradise, Hilal M Kremers, Matthew P Abdel, Sanjeev Kakar, Allan B Dietz, Robert C Cohen, David G Lewallen, Andre J van Wijne. Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene. vol 581. issue 2. 2016-08-02. PMID:26774799. |
compared to standard tissue culture plastic, amscs grown in the porous titanium microenvironment showed differences in temporal expression for genes involved in cell cycle progression (ccnb2, hist2h4), extracellular matrix production (col1a1, col3a1), mesenchymal lineage identity (acta2, cd248, cd44), osteoblastic transcription factors (dlx3, dlx5, id3), and epigenetic regulators (ezh1, ezh2). |
2016-08-02 |
2023-08-13 |
human |
| Shiva Shajari, Almudena Laliena, Janette Heegsma, María Jesús Tuñón, Han Moshage, Klaas Nico Fabe. Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase. Journal of pineal research. vol 59. issue 3. 2016-07-13. PMID:26308880. |
liver damage generates an inflammatory reaction that activates hepatic stellate cells (hsc) that transdifferentiate from quiescent cells that control retinol metabolism to proliferative and migratory myofibroblasts that produce excessive amounts of extracellular matrix proteins, in particular collagen 1a1 (col1a1). |
2016-07-13 |
2023-08-13 |
rat |
| Jianwei Sun, Bingshan Yan, Wangping Yin, Xinchao Zhan. Identification of genes associated with osteoarthritis by microarray analysis. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26151199. |
the enriched pathways of downregulated and upregulated degs were predominantly associated with the cell cycle (bub1, bub1b, ccna2, ccnb1 and ccne1), and extracellular matrix (ecm)‑receptor interaction (cd36, col11a2, col1a1, col2a1 and col3a1). |
2016-06-27 |
2023-08-13 |
Not clear |
| Parameswari Govindarajan, Wolfgang Böcker, Thaqif El Khassawna, Marian Kampschulte, Gudrun Schlewitz, Britta Huerter, Ursula Sommer, Lutz Dürselen, Anita Ignatius, Natali Bauer, Gabor Szalay, Sabine Wenisch, Katrin S Lips, Reinhard Schnettler, Alexander Langheinrich, Christian Heis. Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet. The American journal of pathology. vol 184. issue 3. 2016-04-28. PMID:24384131. |
bone matrix markers (biglycan, col1a1, tenascin c, and fibronectin) and low-density lipoprotein-5 (bone mass marker) were down-regulated at m12 in ovx-diet rats. |
2016-04-28 |
2023-08-12 |
human |
| Bette K Kleinschmidt-DeMasters, Andrew M Donson, Hannes Vogel, Nicholas K Forema. Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. Brain pathology (Zurich, Switzerland). vol 25. issue 4. 2016-03-15. PMID:25521223. |
genes overexpressed in pma vs. pa, ranked according to fold-change, included developmental genes h19, dact2, extracellular matrix collagens (col2a1; col1a1) and igf2bp3 (imp3), the latter previously identified as an adverse prognostic factor in pma and pa. |
2016-03-15 |
2023-08-13 |
Not clear |
| G Tamagno, K Fedtke, M Eidenmüller, J Geks, A Hamann, K Langer, P H Kan. The polymorphism of type 1 collagen (COL1A1) gene does not correlate with an increased risk of foot ulcers in patients with diabetes mellitus. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 4. 2016-01-06. PMID:25502582. |
type i collagen α1 (col1a1) is the main component of type i collagen, the most abundant structural protein of the extracellular matrix of subcutaneous tissue. |
2016-01-06 |
2023-08-13 |
Not clear |
| Jetze Visser, Peter A Levett, Nikae C R te Moller, Jeremy Besems, Kristel W M Boere, Mattie H P van Rijen, Janny C de Grauw, Wouter J A Dhert, P René van Weeren, Jos Mald. Crosslinkable hydrogels derived from cartilage, meniscus, and tendon tissue. Tissue engineering. Part A. vol 21. issue 7-8. 2016-01-05. PMID:25557049. |
gene expression (col1a1, col2a1, acan, mmp-3, mmp-13, and mmp-14), cartilage-specific matrix formation, and hydrogel stiffness were analyzed after culture. |
2016-01-05 |
2023-08-13 |
Not clear |
| Seunghee Bae, Karam Kim, Hwa Jun Cha, Yeongmin Choi, Shang Hun Shin, In-Sook An, Jae Ho Lee, Su Jae Lee, Ji Young Kim, Seon Young Nam, Sungkwan A. Low-dose γ-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts. International journal of molecular medicine. vol 35. issue 1. 2015-11-09. PMID:25384363. |
reverse transcription quantitative pcr (rt-qpcr) revealed that ldr significantly upregulated the mrna expression of collagen type i alpha 1 (col1a1), but downregulated the mrna expression of matrix metalloproteinase 1 (mmp1) at 24 h post-irradiation. |
2015-11-09 |
2023-08-13 |
human |
| Lucas Almeida, Joyce Oliveira, Luiz Henrique Guimarães, Edgar M Carvalho, Jenefer M Blackwell, Léa Castellucc. Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil: role of COL1A1. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. vol 30. 2015-09-25. PMID:25562121. |
reduction of fli1 expression in mice has been shown to result in up-regulation of collagen type i alpha 1 (col1a1) and alpha 2 (col1a2) genes and, conversely, in down-regulation of the matrix metalloproteinase 1 (mmp1) gene, suggesting that fli1 suppression is involved in activation of the profibrotic gene program. |
2015-09-25 |
2023-08-13 |
mouse |
| Marina Y Zemskova, Jin H Song, Bo Cen, Javier Cerda-Infante, Viviana P Montecinos, Andrew S Kraf. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cellular signalling. vol 27. issue 1. 2015-08-10. PMID:25451079. |
the ability of pim1 to regulate the biologic activity of stromal cells is demonstrated by the observation that expression of pim1 kinase in human prostate fibroblasts increases the level and secretion of the extracellular matrix molecule, collagen 1a1 (col1a1), the pro-inflammatory chemokine ccl5, and the platelet-derived growth factor receptors (pdgfr). |
2015-08-10 |
2023-08-13 |
human |
| Helen Pullisaar, Anders Verket, Krisztina Szoke, Hanna Tiainen, Håvard J Haugen, Jan E Brinchmann, Janne E Reseland, Esben Østru. Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds. Journal of tissue engineering. vol 6. 2015-06-19. PMID:26090086. |
enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers col1a1, tnfrsf11b, and bglap and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative. |
2015-06-19 |
2023-08-13 |
human |
| Muhammad Fawwaz Abdullah, Siti Fadilah Abdullah, Nor Shamsuria Omar, Zuliani Mahmood, Siti Noor Fazliah Mohd Noor, Thirumulu Ponnuraj Kannan, Khairani Idah Mokhta. Proliferation rate of stem cells derived from human dental pulp and identification of differentially expressed genes. Cell biology international. vol 38. issue 5. 2015-06-15. PMID:24375868. |
timp1 is involved in degradation of the extracellular matrix, cell proliferation and anti-apoptotic function and rps8 is involved as a rate-limiting factor in translational regulation; col1a1 is involved in the resistance and elasticity of the tissues; fstl1 is an autoantigen associated with rheumatoid arthritis; lgals1 is involved in cell growth, differentiation, adhesion, rna processing, apoptosis and malignant transformation. |
2015-06-15 |
2023-08-12 |
human |
| Yoann Bricard, Cécile Rallière, Veronique Lebret, Florence Lefevre, Pierre-Yves Resca. Early fish myoseptal cells: insights from the trout and relationships with amniote axial tenocytes. PloS one. vol 9. issue 3. 2015-05-29. PMID:24622730. |
the myoseptal cells do not express myogenic markers such as pax3, pax7 and myogenin but express several tendon-associated collagens including col1a1, col5a2 and col12a1 and angiopoietin-like 7, which is a secreted molecule involved in matrix remodelling. |
2015-05-29 |
2023-08-12 |
Not clear |
| Nadeen O Chahine, Nicole M Collette, Cynthia B Thomas, Damian C Genetos, Gabriela G Loot. Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization. Tissue engineering. Part A. vol 20. issue 17-18. 2015-05-19. PMID:24593020. |
outcome measures included cell viability, histological and sem evaluation, gag biochemical content, compressive and tensile biomechanical properties, and gene expression quantification, including extracellular matrix (ecm) markers aggrecan (agc), collagen-1 (col1a1), collagen-2 (col2a1), collagen-10 (col10a1), surface adhesion proteins fibronectin (fn), cd44 antigen (cd44), and tumor marker (tp53). |
2015-05-19 |
2023-08-12 |
Not clear |
| Catherine M Willis, Michael Klüppe. Chondroitin sulfate-E is a negative regulator of a pro-tumorigenic Wnt/beta-catenin-Collagen 1 axis in breast cancer cells. PloS one. vol 9. issue 8. 2015-04-14. PMID:25090092. |
importantly, negative regulation of the pro-metastatic extracellular matrix gene col1a1 was required for the anti-migratory effects of exogenous cs-e. knock-down of col1a1 gene expression mimics the effects of cs-e treatment, while exposing cells to a preformed collagen i matrix interfered with the anti-migratory effects of cs-e. |
2015-04-14 |
2023-08-13 |
human |