| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew Prideaux, Asiri R Wijenayaka, Duminda D Kumarasinghe, Renee T Ormsby, Andreas Evdokiou, David M Findlay, Gerald J Atkin. SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes. Calcified tissue international. vol 95. issue 2. 2015-03-30. PMID:24916279. |
during culture under the appropriate mineralising conditions, saos2 cells reproducibly synthesised a bone-like mineralised matrix and temporally expressed the mature osteocyte marker genes sost, dmp1, phex and mepe and down-regulated expression of runx2 and col1a1. |
2015-03-30 |
2023-08-13 |
human |
| Linlong Wang, Yunpeng Wu, Yang Tan, Xi Fei, Yu Deng, Hong Cao, Biao Chen, Hui Wang, Jacques Magdalou, Liaobin Che. Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells. Journal of applied toxicology : JAT. vol 34. issue 8. 2015-02-26. PMID:23813946. |
the mrna expression levels of matrix metalloproteinase (mmp)-1, mmp-3, mmp-13, tissue inhibitors of metalloproteinase (timp)-1, timp-3, col1a1, bcl-2, caspase-3 and inducible nitric oxide were analyzed by real-time polymerase chain reaction. |
2015-02-26 |
2023-08-12 |
rabbit |
| Andrea Lindenmair, Sylvia Nürnberger, Guido Stadler, Alexandra Meinl, Christa Hackl, Johann Eibl, Christian Gabriel, Simone Hennerbichler, Heinz Redl, Susanne Wolban. Intact human amniotic membrane differentiated towards the chondrogenic lineage. Cell and tissue banking. vol 15. issue 2. 2015-02-26. PMID:24828570. |
collagen i, ii and x was immunohistochemically determined and cartilage-specific mrna expression of (sex determining region y-) box 9, cartilage oligomeric matrix protein (comp), aggrecan (agc1), versican (cspg2), col1a1, col9a2, melanoma inhibitory activity (mia), and cartilage-linking protein 1 (crtl1) analyzed by quantitative real-time polymerase chain reaction. |
2015-02-26 |
2023-08-13 |
human |
| Arabella Elizabeth Gardiner Baird, Stuart D Carter, John F Innes, William E Ollier, Andrea D Shor. Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs. Connective tissue research. vol 55. issue 4. 2015-02-20. PMID:24684544. |
we identified snps in key genes involved in ligament strength, stability and extracellular matrix formation (col5a1, col5a2, col1a1, col3a1, col11a1, col24a1, fbn1, lox, ltbp2) which were significantly associated with cclr susceptibility across the dog breeds used in this study. |
2015-02-20 |
2023-08-12 |
dog |
| Thomas Fabre, Hassen Kared, Scott L Friedman, Naglaa H Shoukr. IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-β receptor on hepatic stellate cells in a JNK-dependent manner. Journal of immunology (Baltimore, Md. : 1950). vol 193. issue 8. 2015-01-07. PMID:25210118. |
however, il-17a sensitized hscs to the action of suboptimal doses of tgf-β as confirmed by strong induction of α-smooth muscle actin, collagen type i (col1a1), and tissue inhibitor of matrix metalloproteinase i gene expression and protein production. |
2015-01-07 |
2023-08-13 |
human |
| Elisabeth Aurstad Riksen, Maria A Landin, Sjur Reppe, Yukio Nakamura, Ståle Petter Lyngstadaas, Janne E Reselan. Enamel matrix derivative promote primary human pulp cell differentiation and mineralization. International journal of molecular sciences. vol 15. issue 5. 2015-01-06. PMID:24857913. |
both emd and dex enhanced the expression of amelogenin (amel), and the dentinogenic markers dentin sialophosphoprotein (dssp) and dentin matrix acidic phosphoprotein 1 (dmp1), as well as the osteogenic markers osteocalcin (oc, bglap) and collagen type 1 (col1a1). |
2015-01-06 |
2023-08-13 |
human |
| Diana G Morales-Hernandez, Damian C Genetos, David M Working, Kaitlin C Murphy, J Kent Leac. Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. Journal of functional biomaterials. vol 3. issue 2. 2014-06-24. PMID:24955539. |
compared to cells on plg controls, runx2 expression in nhosts on composite scaffolds was lower at both 7 and 21 days, while expression of genes encoding for bone matrix proteins (col1a1 and sparc) was higher on bg-plg scaffolds at both time points. |
2014-06-24 |
2023-08-13 |
human |
| Ignacio Fernández, Daniel M Tiago, Vincent Laizé, M Leonor Cancela, Enric Gisber. Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins. The Journal of steroid biochemistry and molecular biology. vol 140. 2014-03-25. PMID:24291400. |
expression of hormone receptor genes (rars and rxrs), and extracellular matrix-related genes such as matrix and bone gla proteins (mgp and bglap), osteopontin (spp1) and type i collagen (col1a1) were differentially regulated upon exposure to ra in proliferating, differentiating and mineralizing cultures of vsa13 and vsa16 cells. |
2014-03-25 |
2023-08-12 |
Not clear |
| R Osborne, R S Carver, L A Mullins, D R Finla. Practical application of cellular bioenergetics to the care of aged skin. The British journal of dermatology. vol 169 Suppl 2. 2014-01-07. PMID:23786618. |
in one of the adult fibroblast strains evaluated, these changes in procollagen-1 and nad(+)/nadh in response to the complex of bioactives were in parallel with increased expression of mrna biomarkers related primarily to dermal matrix and basement membrane structure, including col1a1, col3a1, col5a1, col14a1, eln and loxl2, in addition to sod2, nampt and tgfbr3; mmp1 was decreased in expression. |
2014-01-07 |
2023-08-12 |
human |
| Matthieu Pérard, Justine Le Clerc, Tanguy Watrin, Fleur Meary, Fabienne Pérez, Sylvie Tricot-Doleux, Pascal Pellen-Muss. Spheroid model study comparing the biocompatibility of Biodentine and MTA. Journal of materials science. Materials in medicine. vol 24. issue 6. 2014-01-06. PMID:23515903. |
we investigated the expression of genes involved in odontogenic differentiation (runx2), matrix secretion (col1a1, spp1) and mineralisation (alp). |
2014-01-06 |
2023-08-12 |
Not clear |
| Alvin T Kho, Kaifeng Liu, Gary Visner, Thomas Martin, Francis Boudreaul. Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth. American journal of physiology. Lung cellular and molecular physiology. vol 305. issue 8. 2013-12-09. PMID:23997171. |
prominent expression at days 3 and 7 of genes related to cell proliferation (ccnb1, bub1, and cdk1), extracellular matrix (col1a1, eln, and tnc), and proteases (serpinb2 and mmp9) indicated regenerative processes that tapered off after 56 days. |
2013-12-09 |
2023-08-12 |
mouse |
| Jun-Wen Shi, Wei Liu, Ting-Ting Zhang, Sheng-Chun Wang, Xiao-Lin Lin, Jing Li, Jun-Shuang Jia, Hong-Fen Sheng, Zhi-Fang Yao, Wen-Tao Zhao, Zun-Lan Zhao, Rao-Ying Xie, Sheng Yang, Fei Gao, Quan-Rong Fan, Meng-Ya Zhang, Min Yue, Jin Yuan, Wei-Wang Gu, Kai-Tai Yao, Dong Xia. The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivation. Cell cycle (Georgetown, Tex.). vol 12. issue 7. 2013-10-21. PMID:23466707. |
qrt-pcr, immunofluorescence and western blot analysis illustrated that epithelial-like morphological changes were accompanied by the increased expression of epithelial markers [such as cell adhesion proteins (e-cadherin, α-catenin and bves), tight junction protein occludin and cytokeratins (krt8 and krt18)], the reduced expression of mesenchymal markers [vimentin, fibronectin 1 (fn1), snail1, collagen family of proteins (col1a1, col5a2) and matrix metalloproteinase (mmp) family (mmp12 and mmp14)] and the decreased cell motility and increased cell adhesion in c-myc-expressing pefs and pdfs. |
2013-10-21 |
2023-08-12 |
Not clear |
| Jérémie Silvent, Nadine Nassif, Christophe Helary, Thierry Azaïs, Jean-Yves Sire, Marie Madeleine Giraud Guill. Collagen osteoid-like model allows kinetic gene expression studies of non-collagenous proteins in relation with mineral development to understand bone biomineralization. PloS one. vol 8. issue 2. 2013-09-03. PMID:23460841. |
on long term cultures human bone cells seeded on the osteoid-like matrix displayed a clear osteoblast phenotype as revealed by the osteoblast-like morphology, expression of specific protein such as alkaline phosphatase and expression of eight genes classically considered as osteoblast markers, including bglap, col1a1, and bmp2. |
2013-09-03 |
2023-08-12 |
human |
| Keitaro Kubo, Hideaki Yata, Naoya Tsunod. Effect of gene polymorphisms on the mechanical properties of human tendon structures. SpringerPlus. vol 2. 2013-08-20. PMID:23961408. |
recent studies showed that polymorphisms in alpha 1 chains of types i (col1a1) and v (col5a1) collagen, growth and differentiation factor 5 (gdf5), and matrix metalloproteinase 3 (mmp3) genes were associated with injuries in tendons and ligaments (e.g., september et al. |
2013-08-20 |
2023-08-12 |
human |
| Marieta Gencheva, Ian Hare, Susan Kurian, Jim Fortney, Debbie Piktel, Robert Wysolmerski, Laura F Gibso. Bone marrow osteoblast vulnerability to chemotherapy. European journal of haematology. vol 90. issue 6. 2013-07-12. PMID:23551534. |
sublethal concentrations of vp16 and melphalan also decreased the levels of several transcripts which contribute to the composition of the extracellular matrix (ecm) including osteopontin (opn), osteocalcin (ocn), and collagen 1a1 (col1a1). |
2013-07-12 |
2023-08-12 |
Not clear |
| Ravi N Vellanki, Liling Zhang, Allen Volchu. OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration. PloS one. vol 8. issue 1. 2013-06-27. PMID:23335989. |
knock-down of oasis in human glioma cell lines resulted in an attenuated unfolded protein response to er stress (reduced grp78/bip and grp94 induction) and decreased expression of chondroitin sulfate proteoglycan extracellular matrix proteins, but induction of the collagen gene col1a1 was unaffected. |
2013-06-27 |
2023-08-12 |
human |
| Kate Cameron, Paul Travers, Chaman Chander, Tom Buckland, Charlie Campion, Brendon Nobl. Directed osteogenic differentiation of human mesenchymal stem/precursor cells on silicate substituted calcium phosphate. Journal of biomedical materials research. Part A. vol 101. issue 1. 2013-05-07. PMID:22733430. |
osteogenic-associated proteins, alkaline phosphatase (1.4 fold), runx2, col1a1, and bglap, were also upregulated and there was an increased production of mineralized bone matrix (1.75 fold), as detected by the von kossa assay. |
2013-05-07 |
2023-08-12 |
human |
| Yumi Imai, Siobhan Boyle, Gladys M Varela, Emilie Caron, Xiaoyan Yin, Raina Dhir, Ravindra Dhir, Mark J Graham, Rexford S Ahim. Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression. Physiological genomics. vol 44. issue 22. 2013-05-03. PMID:23012396. |
plin2-aso also increased the expression of genes involved in regulation of hepatocyte proliferation (afp, h19), mitosis (ccna2, incenp, sgol1), and extracellular matrix (col1a1, col3a1, mmp8). |
2013-05-03 |
2023-08-12 |
mouse |
| Sun-Hong Chen, Ding Li, Chen X. Downregulation of Col1a1 induces differentiation in mouse spermatogonia. Asian journal of andrology. vol 14. issue 6. 2013-04-22. PMID:23064687. |
col1a1 (one of the subunit of collagen type i) is a collagen, which belongs to a family of extracellular matrix (ecm) proteins that play an important role in cellular proliferation and differentiation. |
2013-04-22 |
2023-08-12 |
mouse |
| Frank Thiele, Christian M Cohrs, Armando Flor, Thomas S Lisse, Gerhard K H Przemeck, Marion Horsch, Anja Schrewe, Valerie Gailus-Durner, Boris Ivandic, Hugo A Katus, Wolfgang Wurst, Catherine Reisenberg, Hollis Chaney, Helmut Fuchs, Wolfgang Hans, Johannes Beckers, Joan C Marini, Martin Hrabé de Angeli. Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Human molecular genetics. vol 21. issue 16. 2013-02-06. PMID:22589248. |
pulmonary and, especially, cardiac fibroblast of perinatal lethal aga2/+ animals display a strong down-regulation of col1a1 transcripts in vivo and in vitro, resulting in a loss of extracellular matrix integrity. |
2013-02-06 |
2023-08-12 |
mouse |