| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Cao, Youping Fen. LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury. Biological research. vol 52. issue 1. 2019-09-25. PMID:31540582. |
this study aimed to investigate the role of lncrna x-inactive specific transcript (xist) in human skin fibroblasts (hsf) and extracellular matrix (ecm) as well as the regulatory network of xist/microrna-29b-3p (mir-29b-3p)/collagen 1 alpha 1 (col1a1). |
2019-09-25 |
2023-08-13 |
human |
| Mikako Harata, Siming Liu, Joseph A Promes, Anthony J Burand, James A Ankrum, Yumi Ima. Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets. Physiological reports. vol 6. issue 20. 2019-09-09. PMID:30370689. |
the expression of extracellular matrix markers (aspn, col1a1, col4a1) was also altered in pseudoislets compared with intact islets. |
2019-09-09 |
2023-08-13 |
human |
| Sarah A Marshall, Jonathan T McGuane, Yu May Soh, Helen M Gehring, Emma Simpson, Laura J Parr. Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity. Reproduction, fertility, and development. vol 30. issue 9. 2019-09-05. PMID:29533760. |
we hypothesised that abnormal collagen remodelling in the cervix of pregnant relaxin-deficient (rln1-/-) mice is due to excessive collagen (col1a1 and col3a1) and decreased matrix metalloproteinases (mmp2, mmp9, mmp13 and mmp7) and oestrogen receptors (esr1 and esr2). |
2019-09-05 |
2023-08-13 |
mouse |
| Lan Wang, Chi Liu, Xiru Chen, Peng L. Alamandine attenuates long‑term hypertension‑induced cardiac fibrosis independent of blood pressure. Molecular medicine reports. vol 19. issue 6. 2019-08-26. PMID:31059021. |
furthermore, ala deceased the density of cardiac fibrosis, as assessed by masson and sirius red staining; reduced expression of fibrotic proteins, including connective tissue growth factor, collagen i (col1a1) and matrix metalloproteinase 9, was also observed. |
2019-08-26 |
2023-08-13 |
rat |
| David Højland Ipsen, Josephine Skat-Rørdam, Maria Malvina Tsamouri, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nybor. Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model. Molecular genetics and genomics : MGG. vol 294. issue 3. 2019-06-03. PMID:30759275. |
mcp1, tnfα, β-pdgf and col1a1, > threefold, p < 0.05) and decreased matrix degradation. |
2019-06-03 |
2023-08-13 |
human |
| Matea Cedilak, Mihailo Banjanac, Daniela Belamarić, Andrea Paravić Radičević, Ivan Faraho, Krunoslav Ilić, Snježana Čužić, Ines Glojnarić, Vesna Eraković Haber, Martina Bosna. Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis. Pulmonary pharmacology & therapeutics. vol 55. 2019-04-16. PMID:30776489. |
we have shown that pcls during in vitro incubation retain characteristics of bleomycin model with increased expression of fibrosis related genes acta2 (α-smooth muscle actin), col1a1 (collagen 1), fn1 (fibronectin 1), mmp12 (matrix metalloproteinase 12) and timp1 (tissue inhibitor of metalloproteinases). |
2019-04-16 |
2023-08-13 |
mouse |
| Yuko Nakamichi, Nobuyuki Udagawa, Tatsuo Suda, Naoyuki Takahash. Mechanisms involved in bone resorption regulated by vitamin D. The Journal of steroid biochemistry and molecular biology. vol 177. 2019-03-12. PMID:29146302. |
one is a vdr cko mouse line using alpha 1, type i collagen (col1a1)-cre transgenic mice (here we call col1a1-vdr-cko mice) and the other is that using dentin matrix protein 1 (dmp1)-cre transgenic mice (dmp1-vdr-cko mice). |
2019-03-12 |
2023-08-13 |
mouse |
| Shen Sun, Yue Wang, Yue Wu, Yue Gao, Qi Li, Ayanlaja Abiola Abdulrahman, Xin-Feng Liu, Guang-Quan Ji, Jin Gao, Li Li, Fa-Ping Wan, Yun-Qing Li, Dian-Shuai Ga. Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma. International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30272346. |
moreover, the results of in vitro transwell assay and western blot analysis revealed that the depleted levels of col1a1 also decreased the expression of several proteins associated with cell invasion, including phosphorylated‑signal transducer and activator of transcription 3, matrix metalloproteinase (mmp)‑2, mmp‑9 and nuclear factor‑κb. |
2019-03-04 |
2023-08-13 |
Not clear |
| A Palmieri, A Avantaggiato, F Cura, R Papalia, M Casale, F Bressi, L Scapol. Effect of biostimulation on oral fibroblast: a pilot study. Journal of biological regulators and homeostatic agents. vol 31. issue 4 Suppl 2. 2019-02-25. PMID:29202574. |
since the role of drugs used in biostimulation on human dermal fibroblasts is not completely understood, the aim of this study is to evaluate the effect of these substances in primary cell cultures by using rt-pcr and a panel of specific genes (eln, dsp, fn1, fbn1, itga1, itga2, itga5, itgb1, col1a1,col3a1) to detect their effect on cell metabolism and extracellular matrix components. |
2019-02-25 |
2023-08-13 |
human |
| Paolo Scollo, Martin Paul Snead, Allan James Richards, Rebecca Pollitt, Catherine DeVil. Bilateral giant retinal tears in Osteogenesis Imperfecta. BMC medical genetics. vol 19. issue 1. 2018-12-17. PMID:29329516. |
typically, mutations in col1a1 and col1a2 genes lead to the defective formation or quantity of type i collagen, the principle matrix in these tissues. |
2018-12-17 |
2023-08-13 |
Not clear |
| Mingyuan Wang, Liping Li, Jinglan Liu, Jinjin Wan. A gene interaction network‑based method to measure the common and heterogeneous mechanisms of gynecological cancer. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29749503. |
a protein‑protein interaction network was constructed to identify a hub of connective genes, including minichromosome maintenance complex component 2 (mcm2), matrix metalloproteinase 2 (mmp2), collagen type i α1 chain (col1a1) and jun proto‑oncogene ap‑1 transcription factor subunit (jun). |
2018-10-19 |
2023-08-13 |
Not clear |
| Dharmesh Patel, Sadhana Sharma, Hazel R C Screen, Stephanie J Bryan. Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Biochemical and biophysical research communications. vol 499. issue 3. 2018-10-09. PMID:29601813. |
genes associated with tendon (scx and tnmd), collagens (col1a1, col3a1, col11a1), and matrix remodelling (mmp1, mmp2, and timp3) were insensitive to cyclic strain. |
2018-10-09 |
2023-08-13 |
cattle |
| Xiaohui Gu, Xuejie Fu, Jihang Lu, Saijilafu, Bin Li, Zong-Ping Luo, Jianquan Che. Pharmacological inhibition of S6K1 impairs self-renewal and osteogenic differentiation of bone marrow stromal cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-05. PMID:28853173. |
under the basal osteogenic culture condition, s6ki significantly inhibited mrna expression of osteoblast marker genes (sp7, bglap, ibsp, and col1a1), alp activity and matrix mineralization. |
2018-07-05 |
2023-08-13 |
mouse |
| Jeffrey Yim, Hyokeun Cho, Simon W Rabki. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 40. issue 2. 2018-06-27. PMID:29140729. |
abbreviations inducible nitric oxide synthase (inos), neutrophil cytosolic factor 1 (p47phox), adrenomedullin (adm), atrial natriuretic peptide (anp), osteopontin (opn/spp1), angiotensin converting enzyme (ace), monocyte chemotactic protein 1 (mcp-1), cytochrome b-245 beta polypeptide (gp91phox), intercellular adhesion molecule 1 (icam-1), transforming growth factor beta 1 (tgf-β1), connective tissue growth factor (ctgf), endothelin-1 (et-1), cytochrome b-245, alpha polypeptide (p22phox), endothelin receptor type b (etb/ednrb), brain natriuretic peptide (bnp), endothelin receptor type a (eta/ednra), matrix metallopeptidase 13 (mmp13), type i collagen (col1a1), matrix metallopeptidase 2 (mmp2), timp metallopeptidase inhibitor 1 (timp1), type iii collagen (col3a1), interleukin 1 beta (il-1β), beta myocin heavy chain (β-mhc), endothelin converting enzyme 1 (ece1) matrix metallopeptidase 14 (mmp14), angiotensinogen (agt), angiotensin ii receptor type 1 (at1r), cytochrome c oxidase i (cox1), fms-like tyrosine kinase 1 (flt1), timp metallopeptidase inhibitor 2 (timp2), phospholamban (pln), vascular cell adhesion molecule 1 (vcam1), extracellular matrix (ecm). |
2018-06-27 |
2023-08-13 |
rat |
| Julia Ettlin, Elena Clementi, Parisa Amini, Alexandra Malbon, Enni Markkane. Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas. International journal of molecular sciences. vol 18. issue 5. 2018-03-26. PMID:28531107. |
we found that col1a1 (collagen1α1), αsma (alpha smooth muscle actin), fap (fibroblast activation protein), pdgfrβ (platelet-derived growth factor receptor beta), and caveolin-1 were significantly upregulated in canine cas, and the expression of cxcl12 (stromal cell derived factor 1) significantly decreased, whereas mmp2 (matrix metalloproteinase 1) and il6 (interleukin 6) did not change. |
2018-03-26 |
2023-08-13 |
human |
| Christiana Polydorou, Fotios Mpekris, Panagiotis Papageorgis, Chrysovalantis Voutouri, Triantafyllos Stylianopoulo. Pirfenidone normalizes the tumor microenvironment to improve chemotherapy. Oncotarget. vol 8. issue 15. 2018-03-23. PMID:28445938. |
reduction of extracellular matrix components were mediated via tgfβ signaling pathway inhibition due to downregulation of tgfβ1, col1a1, col3a1, has2, has3 expression levels. |
2018-03-23 |
2023-08-13 |
Not clear |
| Jie Min, Bingshu Li, Cheng Liu, Wenjun Guo, Shasha Hong, Jianming Tang, Li Hon. Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts. Molecular medicine reports. vol 15. issue 5. 2018-01-22. PMID:28339064. |
mrna and protein expression levels of collagen type i α 1 chain (col1a1), collagen type iii α 1 chain (col3a1), elastin, matrix metalloproteinase (mmp) ‑2 and ‑9, and transforming growth factor (tgf)‑β1 were detected by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. |
2018-01-22 |
2023-08-13 |
human |
| Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitag. Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats. PloS one. vol 12. issue 12. 2018-01-16. PMID:29240779. |
female high fat diet offspring displayed altered expression of 86 genes (adjusted p-value<0.05), including genes coding for proteins of the extra cellular matrix, particularly collagen 1a1 (col1a1), col1a2, col3a1, and the imprinted insulin-like growth factor 2 (igf2) gene. |
2018-01-16 |
2023-08-13 |
rat |
| Ammar T Qureshi, Devaveena Dey, Erin M Sanders, Jonathan G Seavey, Allison M Tomasino, Kaitlyn Moss, Benjamin Wheatley, David Cholok, Shawn Loder, John Li, Benjamin Levi, Thomas A Davi. Inhibition of Mammalian Target of Rapamycin Signaling with Rapamycin Prevents Trauma-Induced Heterotopic Ossification. The American journal of pathology. vol 187. issue 11. 2017-11-28. PMID:29029772. |
there was significant attenuation of 1) total new bone and soft tissue ectopic bone with 0.5 mg/kg (38.5% and 14.7%) and 2.5 mg/kg rapamycin (90.3% and 82.9%), respectively, 2) connective tissue progenitor cells, 3) platelet-derived growth factor receptor-α-positive cells, 4) α-smooth muscle actin-positive blood vessels, and 5) of key extracellular matrix remodeling (cd44, col1a1, integrins), osteogenesis (sp7, runx2, bmp2), inflammation (cxcl5, 10, il6, ccl2), and angiogenesis (angpt2) genes. |
2017-11-28 |
2023-08-13 |
rat |
| Ronit Marom, Yi-Chien Lee, Ingo Grafe, Brendan Le. Pharmacological and biological therapeutic strategies for osteogenesis imperfecta. American journal of medical genetics. Part C, Seminars in medical genetics. vol 172. issue 4. 2017-11-20. PMID:27813341. |
the majority of cases are caused by autosomal dominant pathogenic variants in the col1a1 and col1a2 genes that encode type i collagen, the major component of the bone matrix. |
2017-11-20 |
2023-08-13 |
Not clear |