| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishal Shinde, Nara Sobreira, Elizabeth S Wohler, George Maiti, Nan Hu, Giuliana Silvestri, Sonia George, Jonathan Jackson, Aravinda Chakravarti, Colin E Willoughby, Shukti Chakravart. Pathogenic alleles in microtubule, secretory granule and extracellular matrix-related genes in familial keratoconus. Human molecular genetics. vol 30. issue 8. 2021-05-17. PMID:33729517. |
we inhibited the expression of hspg2, eml6, nbeal2 and cenpf in stromal cell cultures and assayed for the expression of col1a1 as a readout of corneal matrix production. |
2021-05-17 |
2023-08-13 |
Not clear |
| Jose Alejandro Guerrero, Raquel Souto Silva, Izabella Lucas de Abreu Lima, Bianca Cristina Duffles Rodrigues, Breno Rocha Barrioni, Flávio Almeida Amaral, André Petenuci Tabanez, Gustavo Pompermaier Garlet, Diego Alexander Garzon Alvarado, Tarcília Aparecida Silva, Estevam Barbosa de Las Casas, Soraia Macar. Maxillary suture expansion: A mouse model to explore the molecular effects of mechanically-induced bone remodeling. Journal of biomechanics. vol 108. 2021-05-14. PMID:32635995. |
rme yielded increased expression of bone remodeling markers as osteocalcin (ocn), dentin matrix acidic phosphoprotein-1 (dmp1), runt-related transcription factor 2 (runx2), collagen type i alpha 1 (col1a1), alkaline phosphatase (alp), receptor activator of nuclear factor kappa b (rank), receptor activator of nuclear factor kappa b ligand (rankl), osteoprotegerin (opg), cathepsin k (ctsk), matrix metalloproteinases 9 and 13 (mmp9 and 13), transforming growth fator beta 1, 2 and 3 (tgfb 1, tgfb 2 and tgfb3), bone morphogenetic protein 2 (bmp-2), sclerostin (sost), beta-catenin-like protein 1 (ctnnbl) and wnt signaling pathways 3, 3a and 5a (wnt 3, wnt 3a and wnt 5a). |
2021-05-14 |
2023-08-13 |
mouse |
| Hui Li, Hsun-Ming Chang, Zhendan Shi, Peter C K Leun. The p38 signaling pathway mediates the TGF-β1-induced increase in type I collagen deposition in human granulosa cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 11. 2021-04-27. PMID:32996643. |
type i collagen, which is mainly composed of collagen type i alpha 1 chain (col1a1), is the most abundant extracellular matrix (ecm) protein in the mammalian ovary; and the cyclical remodeling of the ecm plays an essential role in the regulation of corpus luteum formation. |
2021-04-27 |
2023-08-13 |
human |
| Hao Chen, Peng Tan, Baolin Qian, Yichao Du, Ankang Wang, Hao Shi, Zhiwei Huang, Shiyao Huang, Tiancheng Liang, Wenguang F. Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-κB (p65)/IL-6 signalling pathway. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-04-23. PMID:31797546. |
we also found that the hic-5 up-regulation by cerulein activated the nf-κb (p65)/il-6 signalling pathway and regulated the downstream extracellular matrix (ecm) genes such as α-sma and col1a1. |
2021-04-23 |
2023-08-13 |
mouse |
| Hae-Young Kim, Gaurav Agrahari, Min Jung Lee, Lee-Jung Tak, Won-Kook Ham, Tae-Yoon Ki. Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33672928. |
furthermore, collagen type i alpha 1 and type iii alpha 1 (col1a1, col3a1) were increased after ltap exposure, but the expression level of matrix metalloproteinase-3 (mmp-3) was reduced. |
2021-04-19 |
2023-08-13 |
human |
| Nihal AlMuraikhi, Hanouf Alaskar, Sarah Binhamdan, Amal Alotaibi, Moustapha Kassem, Musaad Alfaye. JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells. Molecules (Basel, Switzerland). vol 26. issue 3. 2021-04-15. PMID:33503825. |
fedratinib exerted significant inhibitory effects on the osteoblastic differentiation of hmsc-tert cells, as demonstrated by reduced alp activity, in vitro mineralised matrix formation and downregulation of osteoblast-related gene expression, including alp, on, oc, runx2, opn, and col1a1. |
2021-04-15 |
2023-08-13 |
human |
| Chaoran Yu, Jie Chen, Junjun Ma, Lu Zang, Feng Dong, Jing Sun, Minhua Zhen. Identification of Key Genes and Signaling Pathways Associated with the Progression of Gastric Cancer. Pathology oncology research : POR. vol 26. issue 3. 2021-04-06. PMID:31848941. |
the ppi network-derived hub genes included collagen type i alpha 1 chain (col1a1), tissue inhibitor of the metalloproteinases (timp1), secreted phosphoprotein 1 (spp1), somatostatin (sst), neuropeptide y (npy), biglycan (bgn), matrix metallopeptidase 3 (mmp3), apolipoprotein e (apoe), atpase h+/k+ transporting alpha subunit (atp4a), lysyl oxidase (lox). |
2021-04-06 |
2023-08-13 |
Not clear |
| Yewen Shi, Dongmin Chang, Wenhan Li, FengYu Zhao, Xiaoyong Ren, Bin Ho. Identification of core genes and clinical outcomes in tumors originated from endoderm (gastric cancer and lung carcinoma) via bioinformatics analysis. Medicine. vol 100. issue 12. 2021-04-05. PMID:33761685. |
twelve candidate genes with positive statistical significance (p < .01), comp cthrc1 col1a1 spp1 col11a1 col10a1 cxcl13 cldn3 cldn1 matrix metalloproteinases 7 adam12 plau, were picked out to further analysis. |
2021-04-05 |
2023-08-13 |
Not clear |
| Min Wang, Zhi-Kuan Yang, Hong Liu, Rui-Qin Li, Yu Liu, Wen-Jun Zhon. Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 258. issue 5. 2021-03-05. PMID:32125507. |
this study investigated the effect of genipin on the scleral expression of the mir-29 cluster, matrix metalloproteinase 2 (mmp2), and collagen alpha1 chain of type i (col1a1) in a guinea pig model of myopia. |
2021-03-05 |
2023-08-13 |
Not clear |
| Matthias Gumpenberger, Barbara Wessner, Alexandra Graf, Marco V Narici, Christian Fink, Sepp Braun, Christian Hoser, Anthony J Blazevich, Robert Csap. Remodeling the Skeletal Muscle Extracellular Matrix in Older Age-Effects of Acute Exercise Stimuli on Gene Expression. International journal of molecular sciences. vol 21. issue 19. 2021-03-02. PMID:32992998. |
six hours post-exercise, vastus lateralis muscle biopsy samples were analyzed for the expression of genes associated with ecm collagen synthesis (col1a1), matrix metallopeptidases (collagen degradation; mmps) and peptidase inhibitors (timp1). |
2021-03-02 |
2023-08-13 |
Not clear |
| Heejei Yoon, Seung-Il Choi, Eung Kweon Ki. Uptake of cell debris and enhanced expression of inflammatory factors in response to dead cells in corneal fibroblast cells. Experimental eye research. vol 194. 2020-12-15. PMID:32217186. |
the corneal fibroblasts strongly expressed extracellular matrix molecules (fn and col1a1) and low or medium levels of macrophage markers (cd14, cd68, and cd36), inflammatory cytokines (il1a, il1b, and il6), and chemokines (il8 and ccl2), but not cd11b, suggesting that corneal fibroblasts are macrophage-like fibroblasts. |
2020-12-15 |
2023-08-13 |
Not clear |
| Jung-Seok Lee, Goran Mitulović, Layla Panahipour, Reinhard Grube. Proteomic Analysis of Porcine-Derived Collagen Membrane and Matrix. Materials (Basel, Switzerland). vol 13. issue 22. 2020-12-01. PMID:33212864. |
the common extracellular matrix proteins include fibrillar collagens (col1a1, col1a2, col2a1, col3a1, col5a1, col5a2, col5a3, col11a2), non-fibrillar collagens (col4a2, col6a1, col6a2, col6a3, col7a1, col16a1, col22a1), and leucine-rich repeat proteoglycans (dcn, lum, bgn, prelp, ogn). |
2020-12-01 |
2023-08-13 |
Not clear |
| Lianqun Wu, Shujie Zhang, Xiuyi Li, Jing Yao, Ling Ling, Xiao Huang, Chunchun Hu, Yihan Zhang, Xiantao Sun, Bing Qin, Guohua Liu, Chen Zha. Integrative transcriptomics and proteomic analysis of extraocular muscles from patients with thyroid-associated ophthalmopathy. Experimental eye research. vol 193. 2020-11-10. PMID:32057773. |
in addition, differentially expressed proteins related to the components and metabolism of extracellular matrix (ecm) (such as col1a1, col1a2, col2a1, vcan, ogn, and dcn) were identified. |
2020-11-10 |
2023-08-13 |
Not clear |
| Adnan Naim, Mirza S Bai. Matrix metalloproteinase-8 (MMP-8) regulates the activation of hepatic stellate cells (HSCs) through the ERK-mediated pathway. Molecular and cellular biochemistry. vol 467. issue 1-2. 2020-10-19. PMID:32108279. |
our study suggests that, besides the degradation of the extracellular matrix, matrix metalloproteinase-8 (mmp-8) has a non-canonical role in activating the quiescent hscs to myofibroblasts by regulating the expression of col1a1 and αsma. |
2020-10-19 |
2023-08-13 |
Not clear |
| Jing Kuang, Mei Zhao, Huilian Li, Wei Dang, Wei L. Identification of potential therapeutic target genes and mechanisms in head and neck squamous cell carcinoma by bioinformatics analysis. Oncology letters. vol 11. issue 5. 2020-10-01. PMID:27123054. |
fibronectin 1 (fn1), epidermal growth factor receptor (egfr), collagen type i alpha 1 (col1a1) and matrix metallopeptidase-9 (mmp-9) were hub nodes in the ppi network. |
2020-10-01 |
2023-08-13 |
Not clear |
| Volker Weißmann, Philipp Drescher, Hermann Seitz, Harald Hansmann, Rainer Bader, Anika Seyfarth, Annett Klinder, Anika Jonitz-Heinck. Effects of Build Orientation on Surface Morphology and Bone Cell Activity of Additively Manufactured Ti6Al4V Specimens. Materials (Basel, Switzerland). vol 11. issue 6. 2020-10-01. PMID:29844256. |
hence, human osteoblasts were seeded on test specimens to determine cell viability (metabolic activity, live-dead staining) and gene expression of collagen type 1 (col1a1), matrix metalloprotease (mmp) 1 and its natural inhibitor, timp1, after 3 and 7 days. |
2020-10-01 |
2023-08-13 |
human |
| W H Nijhuis, D M Eastwood, J Allgrove, I Hvid, H H Weinans, R A Bank, R J Sakker. Current concepts in osteogenesis imperfecta: bone structure, biomechanics and medical management. Journal of children's orthopaedics. vol 13. issue 1. 2020-10-01. PMID:30838070. |
the majority of patients with osteogenesis imperfecta (oi) have mutations in the col1a1 or col1a2 gene, which has consequences for the composition of the bone matrix and bone architecture. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuming Huang, Kang Xu, Tingwen Zhou, Peng Zhu, Nianguo Dong, Jiawei Sh. Comparison of Rapidly Proliferating, Multipotent Aortic Valve-Derived Stromal Cells and Valve Interstitial Cells in the Human Aortic Valve. Stem cells international. vol 2019. 2020-10-01. PMID:31582988. |
valvular extracellular matrix genes of vdscs such as collagen type 1, alpha 1 (col1a1), col1a2, and fibronectin 1 were abundantly expressed. |
2020-10-01 |
2023-08-13 |
human |
| Bin Song, Juan Du, Neng Deng, Ji-Chen Ren, Zhen-Bo Sh. Comparative analysis of gene expression profiles of gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma. Oncology letters. vol 12. issue 5. 2020-09-30. PMID:27895742. |
genes [e.g., fibronectin 1, collagen type i α2 chain (col1a2) and col1a1] from the two subnetworks were implicated in extracellular matrix organization. |
2020-09-30 |
2023-08-13 |
Not clear |
| Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekar. Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant ( Data in brief. vol 16. 2020-09-30. PMID:29322079. |
for fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (has1), hyaluronan synthase 2 (has2), hyaluronidase-1 (hyal1), hyaluronidase-2 (hyal2), versican, aggrecan, cd44, collagen, type i, alpha 1 (col1a1), collagen, type iii, alpha 1 (col3a1), collagen, type vii, alpha 1 (col7a1), matrix metalloproteinase 1 (mmp1), acid ceramidase, basic fibroblast growth factor (bfgf), fibroblast growth factor-7 (fgf7), vascular endothelial growth factor (vegf), interleukin-1 alpha (il-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (tgf-β), and aquaporin 3 (aqp3). |
2020-09-30 |
2023-08-13 |
Not clear |