| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuguang Pan, Ying Hu, Lang Gan, Jiejuan Lai, Ping Zheng, YuJun Zhang, Ling Shuai, Yan Jiang, Mo Chen, Junping Wang, Yu H. Matrix metalloproteinase-2 inducing COL1A1 synthesis via integrin alpha Ⅴ promotes invasion and metastasis of cholangiocarcinoma cells. Annals of hepatology. 2023-12-20. PMID:38123132. |
matrix metalloproteinase-2 inducing col1a1 synthesis via integrin alpha Ⅴ promotes invasion and metastasis of cholangiocarcinoma cells. |
2023-12-20 |
2023-12-23 |
Not clear |
| Bin Ma, Fangfang Li, Binlin M. Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer. Open life sciences. vol 18. issue 1. 2023-12-04. PMID:38045487. |
down-regulation of col1a1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer. |
2023-12-04 |
2023-12-10 |
Not clear |
| Bin Ma, Fangfang Li, Binlin M. Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer. Open life sciences. vol 18. issue 1. 2023-12-04. PMID:38045487. |
we investigated the effects of collagen type i alpha 1 (col1a1) on tumor-associated fibroblast activation and matrix remodeling in the tumor microenvironment of breast cancer. |
2023-12-04 |
2023-12-10 |
Not clear |
| Bin Ma, Fangfang Li, Binlin M. Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer. Open life sciences. vol 18. issue 1. 2023-12-04. PMID:38045487. |
collectively, col1a1 down-regulation may inhibit exosome secretion possibly via inhibiting col Ⅰ and upregulating cav-1, thereby inhibiting tumor-associated fibroblast activation and matrix remodeling in the tumor microenvironment. |
2023-12-04 |
2023-12-10 |
Not clear |
| Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Re. The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis. Cell death & disease. vol 14. issue 11. 2023-11-30. PMID:38036508. |
surprisingly, the in vitro overexpression of colec10 in lx-2 cells promotes the mrna expression of extracellular matrix components including col1a1, col1a2 and col3a1 and the extracellular matrix degradation enzyme mmp2. |
2023-11-30 |
2023-12-10 |
mouse |
| Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Dua. Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion. Cytokine. vol 173. 2023-11-18. PMID:37979214. |
increased ctbp1/2 acts as transcriptional corepressors that, along with histone acetyltransferase p300 and runt-related transcription factor 2 (runx2), suppress the expression levels of six genes involved in bone healing: bglap (bone gamma-carboxyglutamate protein), alpl (alkaline phosphatase), spp1 (secreted phosphoprotein 1), col1a1 (collagen 1a1), ibsp (integrin binding sialoprotein), and mmp13 (matrix metallopeptidase 13). |
2023-11-18 |
2023-11-20 |
mouse |
| Yoshifumi Negishi, Arepati Adili, Susana de Vega, Masahiro Momoeda, Haruka Kaneko, Mehmet Zeynel Cilek, Chiho Yoshinaga, Kazuaki Takafuji, Yuta Otsuka, Masayuki Shimoda, Takako Negishi-Koga, Muneaki Ishijima, Yasunori Okad. Interleukin-6 reduces spheroid sizes of osteophytic cells derived from osteoarthritis knee joint via induction of apoptosis. The American journal of pathology. 2023-11-02. PMID:37918800. |
by examining the expression of the genes related to cartilage extracellular matrix (ecm), endochondral ossification and growth factor-signaling in articular cartilage and osteophyte obtained from oa knee joints, we demonstrated that several genes such as col1a1, vcan, bglap, bmp8b, runx2, and sost are overexpressed in osteophyte compared to articular cartilage. |
2023-11-02 |
2023-11-08 |
Not clear |
| Xinsheng Xie, Ye Yuan, Yulong Huang, Xiang Hong, Shichai Hong, Gang Chen, Yihui Chen, Yue Lin, Weifeng Lu, Weiguo Fu, Lixin Wan. Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm. Chinese medical journal. 2023-08-28. PMID:37640670. |
effects of col1a1 and sytl2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm. |
2023-08-28 |
2023-09-07 |
Not clear |
| Qianming Jiang, Valentino Palombo, Danielle N Sherlock, Mario Vailati-Riboni, Mariasilvia D'Andrea, Ilkyu Yoon, Juan J Loo. Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes. Journal of animal science. 2023-08-24. PMID:37616596. |
an overall downregulation of cell and tissue structure genes (e.g., extracellular matrix proteins) associated with collagen (col6a1, col1a1, col4a1, col1a2, col6a2), laminin (lamb2), and integrins (itga8, itga2, itga5) also were detected with scfp. |
2023-08-24 |
2023-09-07 |
Not clear |
| Yue Liu, Yating Yang, Hanghang Wang, Han Li, Qi Lv, Xiachang Wang, Dalei Wu, Lihong Hu, Yinan Zhan. Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix. Chinese journal of natural medicines. vol 21. issue 8. 2023-08-23. PMID:37611978. |
through comprehensive evaluation involving col1a1 promoter assays and pp2cα activity assays, we established a definitive structure-activity relationship for these dammarane-type triterpenoids, affirming the indispensability of the c-3 saccharide chain and c-17 lactone ring in effectively impeding extracellular matrix (ecm) deposition within hepatic stellate cells. |
2023-08-23 |
2023-09-07 |
Not clear |
| Anamaria Balic, Dilara Perver, Pierfrancesco Pagella, Hubert Rehrauer, Bernd Stadlinger, Andreas E Moor, Viola Vogel, Thimios A Mitsiadi. Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing. International journal of oral science. vol 15. issue 1. 2023-08-02. PMID:37532703. |
these changes include the upregulation of genes encoding extracellular matrix (ecm) components, including col1a1 and fibronectin (fn1), and the enrichment of the fibroblast cluster with myofibroblasts. |
2023-08-02 |
2023-08-14 |
human |
| Jun Jiang, Jannat Altammar, Xiaobin Cong, Lukas Ramsauer, Vincent Steinbacher, Ulf Dornseifer, Arndt F Schilling, Hans-Günther Machens, Philipp Moo. Hypoxia Preconditioned Serum (HPS) Promotes Proliferation and Chondrogenic Phenotype of Chondrocytes In Vitro. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445617. |
the promotion of the chondrogenic phenotype was validated with quantitative real-time pcr for the expression of collagen type ii (col2a1), collagen type i (col1a1), sox9 and matrix metalloproteinase 13 (mmp13). |
2023-07-14 |
2023-08-14 |
human |
| Yunyang Bao, Tianyu Niu, Jingyang Zhu, Yuheng Mei, Yulong Shi, Runze Meng, Qionglu Duan, Na Zhang, Tianyun Fan, Yanxiang Wang, Yudong Pang, Yinghong Li, Hongwei He, Danqing Son. Evolution and Discovery of Matrine Derivatives as a New Class of Anti-Hepatic Fibrosis Agents Targeting Ewing Sarcoma Breakpoint Region 1 (EWSR1). Journal of medicinal chemistry. 2023-06-09. PMID:37294950. |
a series of new tricyclic matrinane derivatives were continuously synthesized and evaluated for their inhibitory effects on genes and proteins related to hepatic fibrosis at the cellular level, including collagen type i α1 chain (col1a1), α smooth muscle actin (α-sma), connective tissue growth factor (ctgf), and matrix metalloprotein 2 (mmp-2). |
2023-06-09 |
2023-08-14 |
Not clear |
| Yu Wang, Di Li, Dan Li, Honglei Wang, Yu W. Integrated bioinformatics analysis for exploring hub genes and related mechanisms affecting the progression of gastric cancer. Biotechnology & genetic engineering reviews. 2023-05-27. PMID:37243583. |
twelve hub genes were screened by cytoscape, including cholecystokinin b receptor (cckbr), collagen type i alpha 1 (col1a1), col1a2, col2a1, col6a3, col11a1, matrix metallopeptidase 1 (mmp1), mmp3, mmp7, mmp10, tissue inhibitor of matrix metalloprotease 1 (timp1) and secreted phosphoprotein 1 (spp1). |
2023-05-27 |
2023-08-14 |
Not clear |
| Shufang Wang, Tingting Liu, Nan Nan, Cong Lu, Min Liang, Siyu Wang, Hu Wang, Bin He, Xihua Chen, Xiangbo Xu, Yufeng Zhen. Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitates Injured Endometrial Restoring in Early Repair Period through miR-202-3p Mediating Formation of ECM. Stem cell reviews and reports. 2023-05-24. PMID:37226011. |
we observed that the mrna and protein of mmp11 were significantly decreased in exosome treatment group on day 3, and the components of extracellular matrix (ecm) col1a1, col3a1, colvi and fibronectin (fn) protein were increased. |
2023-05-24 |
2023-08-14 |
human |
| Shufang Wang, Tingting Liu, Nan Nan, Cong Lu, Min Liang, Siyu Wang, Hu Wang, Bin He, Xihua Chen, Xiangbo Xu, Yufeng Zhen. Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitates Injured Endometrial Restoring in Early Repair Period through miR-202-3p Mediating Formation of ECM. Stem cell reviews and reports. 2023-05-24. PMID:37226011. |
human umbilical cord mesenchymal stem cells exosomal mir-202-3p could regulate the expression of mmp11 and promote the accumulation of extracellular matrix, such as col1a1, col3a1, colvi, fn, in the early repair period of endometrial injury. |
2023-05-24 |
2023-08-14 |
human |
| Guangrui Chen, Jian Li, Huimeng Liu, Huiyu Zhou, Mingqiu Liu, Di Liang, Zhiyun Meng, Hui Gan, Zhuona Wu, Xiaoxia Zhu, Peng Han, Taoyun Liu, Ruolan Gu, Shuchen Liu, Guifang Do. Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677811. |
the expression levels of myofibroblast markers, including col1a1, vimentin, α-sma, and matrix metallopeptidase 2 (mmp2), were also suppressed by cep. |
2023-01-21 |
2023-08-14 |
rat |
| Hamid Taghvaei Javanshir, Mohammad Amin Malekraeisi, Seyedeh Sanaz Seyed Ebrahimi, Ahmad Bereimipour, Sara Fakharian Kashani, Amir Abbas Bostaki, Habibollah Mahmoodzadeh, Karim Nayerni. Investigation of key signaling pathways and appropriate diagnostic biomarkers selection between non-invasive to invasive stages in pancreatic cancer: a computational observation. Journal of medicine and life. vol 15. issue 9. 2022-11-23. PMID:36415513. |
for proper diagnostic biomarkers selection, the overexpressed genes that released protein into the extracellular matrix were examined in more detail, with 62 proteins selected and sparc, thbs2, col11a1, col1a1, col1a2, col3a1, serpinh1, plau proteins chosen. |
2022-11-23 |
2023-08-14 |
human |
| b' Berkay Erenay, Atiye Seda Yar Sa\\xc4\\x9flam, Bora Garipcan, Klaus D Jandt, Sedat Odaba\\xc5\\x9. Bone surface mimicked PDMS membranes stimulate osteoblasts and calcification of bone matrix. Biomaterials advances. vol 142. 2022-11-07. PMID:36341745.' |
osteoblast proliferation and calcification of bone matrix have significantly increased along with osteoblast-specific differentiation and maturation markers such as osteocalcin (osc), osterix (osx), collagen type i alpha 1 chain (col1a1), and alkaline phosphatase (alp) on bone surface mimicked (bsm) pdms membranes in addition to a unidirectional alignment of osteoblast cells compared to plain pdms surfaces. |
2022-11-07 |
2023-08-14 |
cattle |
| Jie Shen, Zeping Wang, Weimin Zhao, Yanfeng Fu, Bixia Li, Jinhua Cheng, Yanfei Deng, Saijiao Li, Hui L. TGF-β1 induces type I collagen deposition in granulosa cells via the AKT/GSK-3β signaling pathway-mediated MMP1 down-regulation. Reproductive biology. vol 22. issue 4. 2022-10-29. PMID:36308873. |
type i collagen is the most abundant extracellular matrix (ecm) protein in the mammalian ovary, and comprises two col1a1 subunits and one col1a2 subunit. |
2022-10-29 |
2023-08-14 |
Not clear |