| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongbao Xu, Siying Chen, Weihu Chen, Xiaolong Zhou, Feifei Yan, Tao Huang, Yaqin Wang, Huangda Lu, Ayong Zha. Comparative analysis of the follicular transcriptome of Zhedong white geese (Anser Cygnoides) with different photoperiods. Poultry science. vol 101. issue 10. 2022-09-01. PMID:36049293. |
ten differentially expressed genes related to extracellular matrix and fatty acid metabolism (thbs2, col12a1, mrc2, tuba, col1a1, col11a1, hspg2, fabp, mgll, and olah) may be involved in the photoperiod regulation of follicle development in zhedong white geese. |
2022-09-01 |
2023-08-14 |
Not clear |
| Laura Otilia Damian, Diana Miclea, Romana Vulturar, Alexandra Crăciu. Osteogenesis imperfecta and rheumatoid arthritis: connective issues. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2022-08-19. PMID:35984463. |
the col1a1 mutations may affect collagen synthesis as well as post-translational modifications, extracellular matrix interactions, and receptor-mediated signaling. |
2022-08-19 |
2023-08-14 |
Not clear |
| Chen Li, Yi-Hong Qia. Inflammation-dependent activation of NCOA2 associates with p300 and c-MYC/Max heterodimer to transactivate RUNX2-AS1 and mediate RUNX2 downstream bone differentiation genes in the pathology of septic nonunion. Cytokine. vol 158. 2022-08-14. PMID:35964415. |
overexpression or knockdown of runx2-as1 in vitro could inhibit or induce, respectively, the expression of runx2 and runx2-downstream target genes, including alpl (alkaline phosphatase), col1a1 (collagen type i alpha 1 chain), ibsp (integrin binding sialoprotein), mmp13 (matrix metallopeptidases), and spp1 (secreted phosphoprotein 1), which are involved in bone differentiation. |
2022-08-14 |
2023-08-14 |
Not clear |
| Hamed Manoochehri, Akram Jalali, Hamid Tanzadehpanah, Amir Taherkhani, Rezvan Najaf. Aptamer-conjugated nanoliposomes containing COL1A1 siRNA sensitize CRC cells to conventional chemotherapeutic drugs. Colloids and surfaces. B, Biointerfaces. vol 218. 2022-07-29. PMID:35905589. |
col1a1 is an important extracellular matrix component that is associated with poor prognosis in cancers. |
2022-07-29 |
2023-08-14 |
Not clear |
| Shih-Yao Chen, I-Ming Jou, Po-Yen Ko, Kai-Lan Hsu, Wei-Ren Su, Li-Chieh Kuo, Pei-Yuan Lee, Chao-Liang Wu, Po-Ting W. Amelioration of experimental tendinopathy by lentiviral CD44 gene therapy targeting senescence-associated secretory phenotypes. Molecular therapy. Methods & clinical development. vol 26. 2022-07-18. PMID:35846572. |
cd44 overexpressed tenocyte transfectants exhibited reduced levels of il-6, matrix metalloproteinases (mmps), cyclooxygenase (cox)-2, p53, p21, p16, sa-β-gal, and phospho-nuclear factor (nf)-κb, whereas their collagen type i alpha 1 (col1a1) and tenomodulin (tnmd) levels were increased when compared with control transfectants under il-1β-stimulated conditions. |
2022-07-18 |
2023-08-14 |
human |
| Hang Yang, Zhen Xu, Sumei Tan, Chunyan Zhang, Xiaoqin Li, Xiangjun Len. In vitro effects of Eucommia ulmoides and its active components on the growth, lipid metabolism and collagen metabolism of grass carp (Ctenopharyngodon idellus) hepatocyte and intramuscular fibroblast. Journal of fish biology. 2022-06-06. PMID:35662011. |
in intramuscular fibroblasts, the ebe, ele, cga, qc and au supplementations significantly increased in vitro hydroxyproline concentrations, promoted the relative expressions of transforming growth factor-β1 (tgfβ1), connective tissue growth factor (ctgf), collagen type i alpha 1/2 chain (col1a1, col1a2), lysine oxidase (lox) and tissue inhibitor of matrix metalloproteinase-2 (timp2), and decreased matrix metalloproteinase-2 (mmp2) gene expression. |
2022-06-06 |
2023-08-14 |
drosophila_melanogaster |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
in immature osteoblasts, runx2 regulates the expression of bone matrix protein genes, including col1a1, col1a2, spp1, ibsp, and bone gamma carboxyglutamate protein (bglap)/bglap2, and induces osteoblast maturation. |
2022-05-28 |
2023-08-13 |
mouse |
| Thira Faruangsaeng, Sermporn Thaweesapphitak, Chompak Khamwachirapitak, Thantrira Porntaveetus, Vorasuk Shotelersu. Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth. Scientific reports. vol 12. issue 1. 2022-05-25. PMID:35614192. |
the transcriptome profiles of two opposing premolar pairs and two molar pairs demonstrated that the upper premolars, lower premolars, upper molars, and lower molars expressed the same top-ranked genes, comprising fn1, col1a1, col1a2, actb, and eefia1, which are involved in extracellular matrix organization, immune system, signal transduction, hemostasis, and vesicle-mediated transport. |
2022-05-25 |
2023-08-13 |
mouse |
| Xing Wang, Huijing Ye, Shenglan Yang, Xiaotong Sha, Xiandai Wang, Te Zhang, Rongxin Chen, Wei Xiao, Huasheng Yan. Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves' Orbitopathy. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563653. |
additionally, dsf dose-dependently inhibited fibrosis and extracellular matrix production markers (fn1, col1a1, α-sma, ctgf) at the mrna and protein levels. |
2022-05-14 |
2023-08-13 |
human |
| Banu Bayram, Roman Thaler, Jacob W Bettencourt, Afton K Limberg, Kevin P Sheehan, Aaron R Owen, Daniel J Berry, Mark E Morrey, Joaquin Sanchez-Sotelo, Andre J van Wijnen, Amel Dudakovic, Matthew P Abde. Human outgrowth knee fibroblasts from patients undergoing total knee arthroplasty exhibit a unique gene expression profile and undergo myofibroblastogenesis upon TGFβ1 stimulation. Journal of cellular biochemistry. 2022-02-28. PMID:35224764. |
these knee outgrowth fibroblasts differentiated readily into myofibroblasts as reflected by enhanced α-smooth muscle actin (acta2) mrna and protein expression and increased mrna expression of collagen type 1 (col1a1) and type 3 (col3a1) with collagenous matrix deposition in the presence of tgfβ1. |
2022-02-28 |
2023-08-13 |
human |
| Sang Eun Ha, Preethi Vetrivel, Seong Min Kim, Pritam Bhagwan Bhosale, Hun Hwan Kim, Jung Eun Pak, Jeong Doo Heo, Young Sil Kim, Gon Sup Ki. Inhibitory effect of membrane‑free stem cell components derived from adipose tissues on skin inflammation in keratinocytes. Molecular medicine reports. vol 25. issue 4. 2022-02-16. PMID:35169867. |
treatment of detroit 551 cells with mfscc increased col1a1 and elastin but suppressed matrix metalloproteinase (mmp)‑1 and mmp‑8 protein expression levels. |
2022-02-16 |
2023-08-13 |
human |
| Julian C Lui, Adalbert Raimann, Hironori Hojo, Lijin Dong, Paul Roschger, Bijal Kikani, Uwe Wintergerst, Nadja Fratzl-Zelman, Youn Hee Jee, Gabriele Haeusler, Jeffrey Baro. A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder. Nature communications. vol 13. issue 1. 2022-02-05. PMID:35121733. |
the mutation alters the binding specificity of sp7 from at-rich motifs to a gc-consensus sequence (typical of other sp family members) and produces an aberrant gene expression profile, including increased expression of col1a1 and endogenous sp7, but decreased expression of genes involved in matrix mineralization. |
2022-02-05 |
2023-08-13 |
mouse |
| Paulraj Kanmani, Hojun Ki. Probiotics counteract the expression of hepatic profibrotic genes via the attenuation of TGF-β/SMAD signaling and autophagy in hepatic stellate cells. PloS one. vol 17. issue 1. 2022-01-20. PMID:35051234. |
tgf-β not only increased collagen deposition, but it also significantly upregulated the mrna levels of col1a1, alpha-smooth muscle actin (α-sma), matrix metalloproteinases-2 (mmp-2), il-6, cxcl-8, ccl2, and il-1β in lx-2 cells. |
2022-01-20 |
2023-08-13 |
Not clear |
| Chee Chin Chu, Zafarizal Aldrin Bin Azizul Hasan, Chin Ping Tan, Kar Lin Nya. In Vitro Antiaging Evaluation of Sunscreen Formulated from Nanostructured Lipid Carrier and Tocotrienol-Rich Fraction. Journal of pharmaceutical sciences. vol 110. issue 12. 2021-12-06. PMID:34425132. |
quantitative real-time polymerase chain reaction (qpcr) was used to evaluate the mrna expression of fibroblast growth factor (fgf), vascular endothelial growth factor (vegf), transforming growth factor-β1 (tgf-β1), type i collagen (col1a1), elastin (eln), mmp-1, mmp-2, and tissue inhibitor matrix metalloproteinase-1 (timp-1). |
2021-12-06 |
2023-08-13 |
Not clear |
| Yankang Cui, Chenkui Miao, Shouyong Liu, Jingyuan Tang, Jing Zhang, Hengtao Bu, Yuhao Wang, Chao Liang, Meiling Bao, Chao Hou, Jiajin Wu, Xiaochao Chen, Xiang Zhang, Zengjun Wang, Bianjiang Li. Clusterin suppresses invasion and metastasis of testicular seminoma by upregulating COL15a1. Molecular therapy. Nucleic acids. vol 26. 2021-12-03. PMID:34853731. |
besides, extracellular matrix protein col15a1 was demonstrated as the downstream of clu to affect the epithelial-mesenchymal transition (emt) process via competitively binding to ddr1 with col1a1 and inhibiting the phosphorylation of pyk2. |
2021-12-03 |
2023-08-13 |
Not clear |
| J Schiavi, D M Fodera, M A Brennan, L M McNamar. Estrogen depletion alters osteogenic differentiation and matrix production by osteoblasts in vitro. Experimental cell research. vol 408. issue 1. 2021-11-29. PMID:34492267. |
under estrogen depletion and daily mechanical stimulation, changes in expression of runx2 occurred earlier (4 days) and by 14 days, changes in matrix production (col1a1) were reported. |
2021-11-29 |
2023-08-13 |
Not clear |
| Haneen A Abusharkh, Olivia M Reynolds, Juana Mendenhall, Bulent A Gozen, Edwin Tingstad, Vincent Idone, Nehal I Abu-Lail, Bernard J Van Wi. Combining stretching and gallic acid to decrease inflammation indices and promote extracellular matrix production in osteoarthritic human articular chondrocytes. Experimental cell research. vol 408. issue 2. 2021-11-23. PMID:34563516. |
a 5% cyclic tensile strain (cts) was applied to the silicone chambers and the deposition of collagen and glycosaminoglycan, and gene expressions of collagen types ii (col2a1), xi (col11a2), i (col1a1), and x (col10a1), and matrix metalloproteinases (mmp-1 and mmp-13) as inflammation markers, were quantified. |
2021-11-23 |
2023-08-13 |
human |
| Justin F Bejar, Zachary DiSanza, Suzanne M Quartucci. The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells. Experimental cell research. vol 407. issue 2. 2021-11-22. PMID:34461108. |
go analysis revealed alterations in proteinaceous extracellular matrix genes including col1a1. |
2021-11-22 |
2023-08-13 |
human |
| Seongki Min, Young-Kyoung Lee, Jiwon Hong, Tae Jun Park, Hyun Goo Woo, So Mee Kwon, Gyesoon Yoo. MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness. Cell death & disease. vol 12. issue 11. 2021-11-18. PMID:34772924. |
unlike the action of mmp7 on extracellular matrix destruction, col1a1 modulated invasiveness via the zeb1-mediated epithelial-to-mesenchymal transition. |
2021-11-18 |
2023-08-13 |
Not clear |
| Y Sun, D M Wang, H Yu, C Liu, T Y Ji, S Wang, Y Wu, X Y Liu, Y W Jiang, L X Cai, Q Z Li. [The screening of potential biological markers of seizure onset zone in focal cortical dysplasia based on bioinformatics analysis]. Zhonghua yi xue za zhi. vol 101. issue 41. 2021-11-12. PMID:34758547. |
"extracellular matrix"was significantly enriched, which included collagen synthesis genes (e.g., col1a1). |
2021-11-12 |
2023-08-13 |
Not clear |