| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alice H M Beare, Sharon O'Kane, Stephen M Krane, Mark W J Ferguso. Severely impaired wound healing in the collagenase-resistant mouse. The Journal of investigative dermatology. vol 120. issue 1. 2003-02-06. PMID:12535212. |
immunostaining for matrix metalloproteinases revealed significant upregulation of matrix metalloproteinase 13 in col1a1(r/r) wounds, but minimal changes in other matrix metalloproteinases. |
2003-02-06 |
2023-08-12 |
mouse |
| Kitti Torrungruang, Marta Alvarez, Rita Shah, Jude E Onyia, Simon J Rhodes, Joseph P Bidwel. DNA binding and gene activation properties of the Nmp4 nuclear matrix transcription factors. The Journal of biological chemistry. vol 277. issue 18. 2002-07-02. PMID:11867614. |
splice variants of the nmp4 gene include nuclear matrix transcription factors that regulate the type i collagen alpha1(i) polypeptide chain (col1a1) promoter and several matrix metalloproteinase (mmp) genes. |
2002-07-02 |
2023-08-12 |
Not clear |
| F Verrecchia, J Rossert, A Mauvie. Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis. The Journal of investigative dermatology. vol 116. issue 5. 2001-07-05. PMID:11348466. |
transfection of human dermal fibroblasts with several extracellular matrix gene (col1a1, col1a2, col3a1, col5a2, col7a1, timp-1, and decorin) promoter/reporter constructs demonstrated that anti-sense sp1-induced reduction of extracellular matrix gene mrna steady-state levels results from transcriptional repression, consistent with the role of sp1 as a transcription factor. |
2001-07-05 |
2023-08-12 |
mouse |
| P Thunyakitpisal, M Alvarez, K Tokunaga, J E Onyia, J Hock, N Ohashi, H Feister, S J Rhodes, J P Bidwel. Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 1. 2001-03-01. PMID:11149472. |
we previously indicated that nuclear matrix proteins (np/nmp4) interact with the rat type i collagen alpha1(i) polypeptide chain (col1a1) promoter at two poly(dt) sequences (sites a and b) and bend the dna. |
2001-03-01 |
2023-08-12 |
rat |
| J E Onyia, L V Hale, R R Miles, R L Cain, Y Tu, J F Hulman, J M Hock, R F Santerr. Molecular characterization of gene expression changes in ROS 17/2.8 cells cultured in diffusion chambers in vivo. Calcified tissue international. vol 65. issue 2. 1999-08-19. PMID:10430646. |
to investigate the molecular basis of osteogenesis in dc, we examined the temporal pattern of gene expression of the proliferation marker histone h4, immediate early response genes (iegs), c-fos, c-jun, c-myc, osteoblast phenotype-associated genes, osteocalcin (oc), osteopontin (op), type i collagen (col1a1), alkaline phosphatase (alp), parathyroid hormone receptor (pthr) and matrix modifying enzyme, matrix metalloproteinase-9 (mmp-9). |
1999-08-19 |
2023-08-12 |
rat |
| K P O'Brien, E Seroussi, P Dal Cin, R Sciot, N Mandahl, J A Fletcher, C Turc-Carel, J P Dumansk. Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes, chromosomes & cancer. vol 23. issue 2. 1999-04-13. PMID:9739023. |
we have recently shown that these aberrations are cytogenetic manifestations of gene fusions between the platelet-derived growth factor b-chain gene (pdgfb), the cellular equivalent of the v-sis oncogene, and the collagen type 1 alpha 1 gene (col1a1), the major protein constituent of the extracellular matrix in connective tissue of skin. |
1999-04-13 |
2023-08-12 |
Not clear |
| P McClelland, J E Onyia, R R Miles, Y Tu, J Liang, A K Harvey, S Chandrasekhar, J M Hock, J P Bidwel. Intermittent administration of parathyroid hormone (1-34) stimulates matrix metalloproteinase-9 (MMP-9) expression in rat long bone. Journal of cellular biochemistry. vol 70. issue 3. 1998-10-20. PMID:9706876. |
we identified three pth-responsive transcripts as matrix metalloproteinase-9 (mmp-9), creatine kinase, and the alpha1 (i) polypeptide chain (col1a1) of type i collagen. |
1998-10-20 |
2023-08-12 |
human |
| G M Wildey, C A McDevit. Matrix protein mRNA levels in canine meniscus cells in vitro. Archives of biochemistry and biophysics. vol 353. issue 1. 1998-06-08. PMID:9578595. |
the mrna levels of five matrix protein genes (col1a1, col2a1, aggrecan, col6a1, and fibronectin) were measured in meniscus cells by northern blotting and compared with those of patellar tendon fibroblasts and femoral articular cartilage chondrocytes. |
1998-06-08 |
2023-08-12 |
Not clear |
| M P Simon, F Pedeutour, N Sirvent, J Grosgeorge, F Minoletti, J M Coindre, M J Terrier-Lacombe, N Mandahl, R D Craver, N Blin, G Sozzi, C Turc-Carel, K P O'Brien, D Kedra, I Fransson, C Guilbaud, J P Dumansk. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nature genetics. vol 15. issue 1. 1997-01-28. PMID:8988177. |
col1a1 is a major constituent of the connective tissue matrix. |
1997-01-28 |
2023-08-12 |
Not clear |
| M Alvarez, H Long, J Onyia, J Hock, W Xu, J Bidwel. Rat osteoblast and osteosarcoma nuclear matrix proteins bind with sequence specificity to the rat type I collagen promoter. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977438. |
we hypothesize that the osteoblast nuclear matrix contributes to the transcriptional control of type i collagen (col1a1) expression. |
1997-01-23 |
2023-08-12 |
rat |
| M Alvarez, H Long, J Onyia, J Hock, W Xu, J Bidwel. Rat osteoblast and osteosarcoma nuclear matrix proteins bind with sequence specificity to the rat type I collagen promoter. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977438. |
our aim was to identify osteoblast nuclear matrix proteins (nmps) that associated with sequence-specificity to the col1a1 promoter. |
1997-01-23 |
2023-08-12 |
rat |
| S R Lamandé, J F Batema. A type I collagen reporter gene construct for protein engineering studies. Functional equivalence of transfected reporter COL1A1 and endogenous gene products during biosynthesis and in vitro extracellular matrix accumulation. The Biochemical journal. vol 293 ( Pt 2). 1993-09-01. PMID:8343119. |
functional equivalence of transfected reporter col1a1 and endogenous gene products during biosynthesis and in vitro extracellular matrix accumulation. |
1993-09-01 |
2023-08-12 |
mouse |
| S R Lamandé, J F Batema. A type I collagen reporter gene construct for protein engineering studies. Functional equivalence of transfected reporter COL1A1 and endogenous gene products during biosynthesis and in vitro extracellular matrix accumulation. The Biochemical journal. vol 293 ( Pt 2). 1993-09-01. PMID:8343119. |
a type i collagen reporter gene construct, designed to facilitate detailed analysis of the consequences of introduced structural and regulatory mutations on collagen biosynthesis and participation in the extracellular matrix, was produced by site-directed mutagenesis of the mouse col1a1 gene. |
1993-09-01 |
2023-08-12 |
mouse |