| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zu-Yau Lin, Wan-Long Chuan. Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 6. 2013-01-30. PMID:22681909. |
for primary cultured invasive cells, differential expressions of several groups of common genes are known to have capacities to promote proliferation (cav1, il6, plat, rrad, srpx), remodeling of extracellular matrix (col1a1, col1a2, nid2, tnc, reln, sparc), migration (actg2, cav1, ccl2, ccl26, cdc42ep3, cnn1, phldb2, plat, rrad, srpx), implantation (il6), immune escape (cd70) and angiogenesis (ccl2, il6, il18, plat, slit3). |
2013-01-30 |
2023-08-12 |
human |
| Patricia K Russell, Michele V Clarke, Jarrod P Skinner, Tammy P S Pang, Jeffrey D Zajac, Rachel A Dave. Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice. Journal of molecular endocrinology. vol 49. issue 1. 2012-09-26. PMID:22525354. |
the osteoblast genes col1a1 and bglap and the osteoclast genes ctsk and rankl (tnfs11) were upregulated in the bones of mobl-arkos, consistent with the increased matrix synthesis, mineralization, and bone resorption observed previously in these mice. |
2012-09-26 |
2023-08-12 |
mouse |
| Elizabeth A Rondini, Maurice R Bennin. Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats. Journal of nutrition and metabolism. vol 2012. 2012-08-23. PMID:22496968. |
genes involved in the extracellular matrix (col1a1, fn1) and innate immunity (ratnp-3, pla2g2a) were induced by aom in all diets, but to a lower extent in bean-fed animals. |
2012-08-23 |
2023-08-12 |
rat |
| Philip H Zepli. Reduction of burn scar formation by halofuginone-eluting silicone gel sheets: a controlled study on nude mice. Annals of plastic surgery. vol 68. issue 3. 2012-06-18. PMID:22356780. |
subsequently, via real-time polymerase chain reaction, the cdna levels from key mediators of scar formation (transforming growth factor beta, col1a1, connective tissue growth factor, fibroblast growth factor 2, matrix metalloproteinase 2, matrix metalloproteinase 9) were established and statistically evaluated. |
2012-06-18 |
2023-08-12 |
mouse |
| Whitaik David Lee, Mark B Hurtig, Rita A Kandel, William L Stanfor. Membrane culture of bone marrow stromal cells yields better tissue than pellet culture for engineering cartilage-bone substitute biphasic constructs in a two-step process. Tissue engineering. Part C, Methods. vol 17. issue 9. 2012-04-09. PMID:21563981. |
chondrocytes predifferentiated on membrane culture accumulated similar matrix as those in conventional pellet culture, but expressed less col1a1 rna. |
2012-04-09 |
2023-08-12 |
Not clear |
| Yang Baohua, Li L. Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts. Cell biology international. vol 36. issue 1. 2012-04-06. PMID:21981042. |
to explore how sirt6 affects collagen metabolism and determine its role in skin aging, the levels of col1a1 (type i collagen), col3a1 (type iii collagen) and tgfβ1 (transforming growth factor β1) mrna expression were detected by rt-q-pcr (real-time quantitative pcr), and mmp1 (matrix metalloproteinase 1) concentration in hdf (human dermal fibroblast) supernatants was determined by elisa after blocking sirt6 using sirna (small interefering rna). |
2012-04-06 |
2023-08-12 |
mouse |
| Yu Deng, Biao Chen, Yongjian Qi, Jacques Magdalou, Hui Wang, Liaobin Che. The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro. Toxicology and applied pharmacology. vol 257. issue 1. 2012-01-13. PMID:21903125. |
moreover, levofloxacin significantly increased the mrna expression of matrix metalloproteinase 3 (mmp-3) and mmp-13 and decreased the expression of tissue inhibitors of metalloproteinase 1 (timp-1) in a concentration-dependent manner; timp-3 and collagen type i alpha 1 (col1a1) mrna expression was not affected. |
2012-01-13 |
2023-08-12 |
rabbit |
| Manoj Nair, Zachery R Belak, Nick Ovsene. Effects of fluoride on expression of bone-specific genes in developing Xenopus laevis larvae. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 89. issue 4. 2011-12-12. PMID:21790307. |
markers of bone formation, including col1a1, the transcription factors osterix, runx2-ii, and matrix metalloproteinases mmp1 and mmp13, decreased relative to age-matched controls, though the osteoblast marker bglap was not significantly altered. |
2011-12-12 |
2023-08-12 |
xenopus_laevis |
| Kevin L McFarland, Kathryn Glaser, Jennifer M Hahn, Steven T Boyce, Dorothy M Sup. Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 4. 2011-11-23. PMID:21747336. |
in general, higher expression of collagen type 1 alpha-1 (col1a1) and alpha-2 (col1a2) and matrix metalloproteinase 3 (mmp3) and lower levels of mmp1 were observed in all cell strains cultured in standard medium containing 10% fetal bovine serum compared with cells cultured in medium optimized for proliferation. |
2011-11-23 |
2023-08-12 |
human |
| Patricia Castillo-Briceño, Isabel Cabas, Marta Arizcun, Jose Meseguer, Victoriano Mulero, Alfonsa García-Ayal. Identification of a β1 integrin isoform with restricted tissue expression in a teleost fish. Reproduction, fertility, and development. vol 23. issue 5. 2011-09-30. PMID:21635814. |
expression profiles were analysed in the context of the reproductive cycle (rc) and in relation with other ecm-related molecules, including matrix metalloproteinase (mmp)-2, mmp-9, mmp-13, tissue-specific inhibitor of metalloproteinase (timp)-2a, timp-2b, collagen (col1a1) and itgb1a. |
2011-09-30 |
2023-08-12 |
Not clear |
| Kyle J Hewitt, Yulia Shamis, Ryan B Hayman, Mariam Margvelashvili, Shumin Dong, Mark W Carlson, Jonathan A Garlic. Epigenetic and phenotypic profile of fibroblasts derived from induced pluripotent stem cells. PloS one. vol 6. issue 2. 2011-09-01. PMID:21386890. |
dna methylation analysis of promoter regions associated with extracellular matrix (ecm)-production (col1a1) by ips- and hesc-derived fibroblasts and fibroblast lineage commitment (pdgfrβ), revealed promoter demethylation linked to their expression, and patterns of transcription and methylation of genes related to the functional properties of mature stromal cells were seen in both hips- and hes-derived fibroblasts. |
2011-09-01 |
2023-08-12 |
human |
| Esther Lau, W David Lee, Jason Li, Andrew Xiao, John E Davies, Qianhong Wu, Liyun Wang, Lidan Yo. Effect of low-magnitude, high-frequency vibration on osteogenic differentiation of rat mesenchymal stromal cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 29. issue 7. 2011-07-26. PMID:21344497. |
the os differentiation of rmscs under the loaded and non-loaded conditions was assessed by examining cell proliferation, alkaline phosphatase (alp) activity, mrna expression of various osteoblast-associated markers [alp, runx2, osterix (osx), collagen type i alpha 1 (col1a1), bone sialoprotein (bsp), osteopontin (opn), and osteocalcin (ocn)], and matrix mineralization. |
2011-07-26 |
2023-08-12 |
rat |
| Ignacio Fernández, Maria Darias, Karl B Andree, David Mazurais, Jose Luís Zambonino-Infante, Enric Gisber. Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A. BMC developmental biology. vol 11. 2011-07-22. PMID:21306609. |
therefore, in order to gain further knowledge of fish larval development and its disruption by nutritional va imbalance, the relative expression of some rars and rxrs, as well as several genes involved in morpho- and skeletogenesis such as peroxisome proliferator-activated receptors (ppara, pparb and pparg); retinol-binding protein (rbp); insulin-like growth factors i and ii (igf1 and igf2, respectively); bone morphogenetic protein 2 (bmp2); transforming growth factor β-1 (tgfb1); and genes encoding different extracellular matrix (ecm) proteins such as matrix gla protein (mgp), osteocalcin (bglap), osteopontin (spp1), secreted protein acidic and rich in cysteine (sparc) and type i collagen α1 chain (col1a1) have been studied in gilthead sea bream. |
2011-07-22 |
2023-08-12 |
Not clear |
| Tomohiko Murakami, Shin-Ichiro Hino, Riko Nishimura, Toshiyuki Yoneda, Akio Wanaka, Kazunori Imaizum. Distinct mechanisms are responsible for osteopenia and growth retardation in OASIS-deficient mice. Bone. vol 48. issue 3. 2011-05-23. PMID:21047569. |
we have previously demonstrated that oasis activates transcription of the type i collagen gene col1a1 and contributes to the secretion of bone matrix proteins in osteoblasts, and that oasis-/- mice exhibit osteopenia and growth retardation. |
2011-05-23 |
2023-08-12 |
mouse |
| Linda Harkness, Amer Mahmood, Nicholas Ditzel, Basem M Abdallah, Jens V Nygaard, Moustapha Kasse. Selective isolation and differentiation of a stromal population of human embryonic stem cells with osteogenic potential. Bone. vol 48. issue 2. 2011-05-02. PMID:20869473. |
when cultured in osteogenic differentiation media, up regulation of osteoblastic lineage markers (dlx5, msx2, runx2, sparc, alp, col1a1, bglap, ibsp, dcn, lox-l4) and production of in vitro mineralized matrix was detected. |
2011-05-02 |
2023-08-12 |
mouse |
| Hongwei He, Albert Mennone, James L Boyer, Shi-Ying Ca. Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology (Baltimore, Md.). vol 53. issue 2. 2011-03-18. PMID:21274875. |
furthermore, atra and udca significantly reduced liver messenger rna and/or protein expression of transforming growth factor β1 (tgf-β1), collagen 1a1 (col1a1), matrix metalloproteinase 2 (mmp2), cytokeratin 19, α-smooth muscle actin (α-sma), cytochrome p450 7a1 (cyp7a1), tumor necrosis factor α, and interleukin-β1. |
2011-03-18 |
2023-08-12 |
human |
| Zixue Jin, Rui Sun, Haiming Wei, Xiang Gao, Yongyan Chen, Zhigang Tia. Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology (Baltimore, Md.). vol 53. issue 1. 2011-03-02. PMID:21140473. |
we found liver fibrosis spontaneously developed in hbv-tg mice with the elevated transcription of col1a1, matrix metalloproteinase (mmp)2, and tissue inhibitor of metalloproteinase (timp)1. |
2011-03-02 |
2023-08-12 |
mouse |
| William H Catherino, Minnie Malik, Paul Driggers, Scott Chappel, James Segars, Joseph Davi. Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium. The Journal of steroid biochemistry and molecular biology. vol 122. issue 4. 2010-11-03. PMID:20493256. |
extracellular matrix components were decreased in leiomyoma cells, including col1a1 and col7a1 at nanomolar concentrations. |
2010-11-03 |
2023-08-12 |
human |
| Yang Liu, Eleanor B Carson-Walter, Anna Cooper, Bethany N Winans, Mahlon D Johnson, Kevin A Walte. Vascular gene expression patterns are conserved in primary and metastatic brain tumors. Journal of neuro-oncology. vol 99. issue 1. 2010-10-11. PMID:20063114. |
most of these genes localize to the cell surface (cxcr7, pv1) or extracellular matrix (col1a1, col3a1, col4a1, col6a2, mmp14, pxdn) and were selectively expressed by the microvasculature. |
2010-10-11 |
2023-08-12 |
Not clear |
| Hiroshi Sekiya, Tomohiko Murakami, Atsushi Saito, Shin-Ichiro Hino, Kenji Tsumagari, Kimiko Ochiai, Kazunori Imaizum. Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice. Journal of bone and mineral metabolism. vol 28. issue 4. 2010-09-23. PMID:20024590. |
recently, we demonstrated that oasis activates the transcription of the gene for type i collagen, col1a1, and contributes to the secretion of bone matrix proteins in osteoblasts. |
2010-09-23 |
2023-08-12 |
mouse |