All Relations between cd68 and microglial cell

Publication Sentence Publish Date Extraction Date Species
Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. 2024-02-10 2024-02-12 rat
Sarah R Morris, Taylor Swift-LaPointe, Andrew Yung, Valentin H Prevost, Shana George, Andrew Bauman, Piotr Kozlowski, Zahra Samadi-Bahrami, Caron Fournier, Pushwant Mattu, Lisa Parker, Femke Streijger, Veronica Hirsch-Reinshagen, G R Wayne Moore, Brian K Kwon, Cornelia Laul. Advanced MRI biomarkers of the injured spinal cord - a comparative study of imaging and histology in human traumatic SCI. Journal of neurotrauma. 2024-02-06. PMID:38318802. the histologic features were analysed by staining with luxol fast blue (lfb) for myelin lipids, and class ii major histocompatibility complex (class ii mhc) and cd68 for microglia and macrophages. 2024-02-06 2024-02-09 human
Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishno. Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice. The Journal of nutritional biochemistry. 2024-02-04. PMID:38311044. kd suppressed the mrna expression of the putative microglial markers (cd68, p2ry12, nox2) and induced morphological changes in the male pfc microglia. 2024-02-04 2024-02-07 mouse
Anja Steinmaurer, Christian Riedl, Theresa König, Giulia Testa, Ulrike Köck, Jan Bauer, Hans Lassmann, Romana Höftberger, Thomas Berger, Isabella Wimmer, Simon Hametne. The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis. Brain pathology (Zurich, Switzerland). 2024-01-23. PMID:38254312. here, we investigated the protein expression of btk and cd68 as well as iron accumulation in postmortem control (n = 10) and ms (n = 23) brain tissue, focusing on microglia and macrophages. 2024-01-23 2024-01-25 Not clear
Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. meanwhile, microglia cd68 increased significantly, indicating that the microglia in the chronic stress group have greater phagocytosis activity. 2023-12-23 2023-12-25 rat
Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. the immunophenotypes of microglia and astrocytes were assessed with phenotypic markers (iba1, cd68, hla-dr, cd64, cd32a, cd16 for microglia and gfap, eaat2, glutamine synthetase and aldh1l1 for astrocytes). 2023-09-13 2023-10-07 mouse
Ruizhuo Chen, Brandy N Routh, Jillian E Straetker, Cecily R Gibson, Aidan S Weitzner, Kiersten S Bell, Andrew D Gaudet, Laura K Fonke. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice. Brain, behavior, and immunity. 2023-08-30. PMID:37648007. in both sexes, microglia depletion reduced microglial branching and decreased cd68 production without altering astrogliosis. 2023-08-30 2023-09-07 mouse
Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. 2023-08-04 2023-08-14 mouse
Mayur Choudhary, Goldis Male. CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy. Advances in experimental medicine and biology. vol 1415. 2023-07-13. PMID:37440035. additionally, animal models of retinal degeneration have shown upregulation of cd68, in a protective population of retinal microglia. 2023-07-13 2023-08-14 mouse
Madigan M Reid, Marie-Audrey I Kautzmann, Gethein Andrew, Andre Obenaus, Pranab K Mukherjee, Larissa Khoutorova, Jeff X Ji, Cassia R Roque, Reinaldo B Oria, Bola F Habeb, Ludmila Belayev, Nicolas G Baza. NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes. Cellular and molecular neurobiology. 2023-06-04. PMID:37270727. overall, we uncovered that protection after middle cerebral artery occlusion (mcao) by the lipid mediators elicits expression of microglia and astrocyte-specific genes (tmem119, fcrls, osmr, msr1, cd68, cd163, amigo2, thbs1, and tm4sf1) likely participating in enhancing homeostatic microglia, modulating neuroinflammation, promoting damp clearance, activating npc differentiation and maturation, synapse integrity and contributing to cell survival. 2023-06-04 2023-08-14 Not clear
Gabrielle Angst, Xin Tang, Chenran Wan. Functional Analysis of a Novel Immortalized Murine Microglia Cell Line in 3D Spheroid Model. Neurochemical research. 2023-05-17. PMID:37195378. the img-1 cells kept their microglia morphology, and they expressed macrophage/microglia-specific proteins of cd11b, cd68, p2ry12, and iba1 in vitro. 2023-05-17 2023-08-14 Not clear
Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. higher synapse density in females was paralleled by higher activity of microglia, as indicated by morphological changes, cd68 expression, and proximity of microglia to synaptic sites. 2023-05-12 2023-08-14 mouse
Dadi Li, Shuxian Zhao, Bin Zhu, Wanmin Zhao, Ya Ding, Xuejun Li, Donglin Fu, Haiyang Yu, Baogui Wang, Tan Pa. Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival. Drug development research. 2023-03-29. PMID:36988113. cd68 staining and western blot analysis were used to investigate the effect of cm on microglia activation. 2023-03-29 2023-08-14 rat
Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. males exhibited decreases in the phagocytic-lysosomal marker cd68 in microglia in these regions, whereas females showed an increase in cd68 in the hypothalamus suggesting sexually dimorphic and brain region specific change in microglia state in response to social isolation. 2023-03-15 2023-08-14 mouse
María Vargas-Soria, Mónica García-Alloza, Miriam Corraliza-Góme. Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies. Journal of neuroinflammation. vol 20. issue 1. 2023-03-03. PMID:36869375. although a strict classification of microglia remains elusive given their capacity to adapt to the environment and their morphological, ultrastructural and molecular dynamism, diabetes modulates microglial phenotypic states, triggering specific responses that include upregulation of activity markers (such as iba1, cd11b, cd68, mhc-ii and f4/80), morphological shift to amoeboid shape, secretion of a wide variety of cytokines and chemokines, metabolic reprogramming and generalized increase of oxidative stress. 2023-03-03 2023-08-14 Not clear
Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). 2023-02-25 2023-08-14 rat
Kjell Johansson, Camilla Mohli. Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614320. biomarkers for reactive microglia included p2ry12, cd63 and cd68 and the general microglial markers were cd11b, iba1 and isolectin b 2023-01-08 2023-08-14 Not clear
Rachel Gilfarb, Zoe Tapp, Elise Lemanski, John Velasquez, Sydney Cornelius, Olga N Kokiko-Cochran, Benedetta Leune. Multiparity differentially affects specific aspects of the acute neuroinflammatory response to traumatic brain injury in female mice. Neuroscience. 2022-12-19. PMID:36535576. increased cortical iba1, gfap, and cd68 immunolabeling was observed following tbi independent of parity and microglia morphology did not differ between tbi groups. 2022-12-19 2023-08-14 mouse
E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. furthermore, microglia in the ca1 sr region showed an increase in soma and a more extensive arborization, an increased prevalence of immature lysosomes accompanied by an elevation in mrna expression of phagocytic markers mertk and cd68 and a surge in the expression of microglial outward k 2022-12-09 2023-08-14 mouse
Hala M F Mohammad, Amani A El-Baz, Omayma M Mahmoud, Sahar Khalil, Rasha Atta, Samar Imbab. Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism. Journal of chemical neuroanatomy. 2022-12-04. PMID:36464068. the mid-brain tissues were processed for light and electron microscopy examinations, and immunohistochemical staining for tyrosine hydroxylase [th], and microglia cells' markers: [cd68 and iba1]. 2022-12-04 2023-08-14 rat