| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pelin Saglam-Metiner, Sena Yanasik, Yusuf Caglar Odabasi, Jennifer Modamio, Moritz Negwer, Cigir Biray-Avci, Ayse Guler, Ali Erturk, Ender Yildirim, Ozlem Yesil-Celikta. ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation. Communications biology. vol 7. issue 1. 2024-12-05. PMID:39639082. |
subsequent to propofol administration, gene expressions of cd40 and tnf-α in mast cells, aif1 in microglia and gfap/s100b/olig2/mbp in macroglia were elevated, as well as nos2, cd80, cd40, cd68, il6 and tnf-α mediated proinflammation is noted in cerebral organoids, which resulted in higher expressions of gjb1, gaba-a and nmdar1 in the tissue construct of the platform. |
2024-12-05 |
2024-12-08 |
human |
| Maosha Dai, Shujun Sun, Yan Dai, Xiaoke Dou, Juexi Yang, Xiangdong Chen, Dong Yang, Yun Li. Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway. Neurochemical research. vol 50. issue 1. 2024-11-20. PMID:39565476. |
expression of microglial cell markers (iba1, cd11b, cd68, cd86 and cd206) and pro-inflammatory markers (inos and cox2) was assessed. |
2024-11-20 |
2024-11-23 |
mouse |
| Joanna Dunacka, Grzegorz Świątek, Danuta Wron. High Behavioral Reactivity to Novelty as a Susceptibility Factor for Memory and Anxiety Disorders in Streptozotocin-Induced Neuroinflammation as a Rat Model of Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519114. |
behavioral depression in hrs was associated with higher expression of β-amyloid deposits, particularly in the nacs, and activation of microglia (cd68 |
2024-11-09 |
2024-11-17 |
rat |
| Xindi Li, Jiayi Liu, Andrew J Boreland, Sneha Kapadia, Siwei Zhang, Alessandro C Stillitano, Yara Abbo, Lorraine Clark, Dongbing Lai, Yunlong Liu, Peter B Barr, Jacquelyn L Meyers, Chella Kamarajan, Weipeng Kuang, Arpana Agrawal, Paul A Slesinger, Danielle Dick, Jessica Salvatore, Jay Tischfield, Jubao Duan, Howard J Edenberg, Anat Kreimer, Ronald P Hart, Zhiping P Pan. Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. Science advances. vol 10. issue 45. 2024-11-08. PMID:39514655. |
ethanol exposure induced elevated cd68 expression and morphological changes in microglia, with differential responses between high-prs and low-prs microglial cells. |
2024-11-08 |
2024-11-16 |
human |
| Maria Gotkiewicz, Janne Capra, Pasi O Miettinen, Teemu Natunen, Heikki Tanil. Three-dimensional view of microglia-amyloid plaque interactions. Glia. 2024-10-22. PMID:39435610. |
these end-feet were filled with the lysosomal marker cd68, while both non-fibrillar and fibrillar amyloid was found in perinuclear vesicles of some "snowplower" microglia. |
2024-10-22 |
2024-10-24 |
mouse |
| Gabriela C De Paula, Rui F Simões, Alba M Garcia-Serrano, João M N Duart. High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice. Neurochemical research. 2024-09-20. PMID:39302596. |
we determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers iba1, cd68, gfap and emr1 in the hypothalamus, and analyzed morphology of microglia (iba-1 |
2024-09-20 |
2024-09-22 |
mouse |
| Zixuan Lin, Liping Wang, Yaozong Niu, Zhaopeng Xie, Xiaohan Zha. Interaction between microglial cells and CD1C+ B dendritic cells leads to CD8+ T cells depletion during the early stages of renal clear cell carcinoma. Medicine. vol 103. issue 31. 2024-08-02. PMID:39093774. |
the microglia marker cd68 and cd1c+ b dendritic cells marker cd11c were detected using multiplex immunofluorescence staining. |
2024-08-02 |
2024-08-06 |
Not clear |
| Junqi Yao, Liming Zhang, Chunkui Zhang, Xing Chen, Ke Bao, Shaojun Hou, Yongyu Yin, Kun Liu, Qing Wen, Xin Huang, Lun Son. Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice. Brain, behavior, and immunity. 2024-07-23. PMID:39043349. |
rhythmic 40 hz lf exposure significantly decreased the number of iba1-positive microglia in the pfc and hippocampus, and the expression levels of the m1 markers of microglia inos and cd68 were reduced significantly in crs mice. |
2024-07-23 |
2024-07-26 |
mouse |
| Yanhui Cui, Zhaolan Hu, Laifa Wang, Bi Zhu, Ling Deng, Hui Zhang, Xueqin Wan. DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis. Neurochemical research. 2024-06-04. PMID:38834844. |
further experiments revealed that nbp inhibited the toll-like receptor 4/nuclear factor kappa b signaling pathway, decreased the level of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, and interleukin-6, and m1-type microglia markers (cd68, inducible nitric oxide synthase), and reduced the expression of panoptosis-related molecules including caspase-1, caspase-3, caspase-8, gasdermin d, and mixed lineage kinase domain-like protein in the hippocampus of the maco rats. |
2024-06-04 |
2024-06-07 |
rat |
| Koeul Choi, Joonhee Lee, Gukdo Kim, Younghyun Lim, Hyo Jung Kan. Recovery of synaptic loss and depressive-like behavior induced by GATA1 through blocking of the neuroinflammatory response. Frontiers in cellular neuroscience. vol 18. 2024-05-24. PMID:38784708. |
through flow cytometry and immunohistochemical analysis, we found that activated microglia showed pro-inflammatory phenotypes characterized by the expression of cd86 and cd68. |
2024-05-24 |
2024-05-27 |
Not clear |
| Mousumi Ghosh, Jinyoung Lee, Ashley N Burke, Thomas A Strong, Jacqueline Sagen, Damien D Pears. Sex Dependent Disparities in the Central Innate Immune Response after Moderate Spinal Cord Contusion in Rat. Cells. vol 13. issue 7. 2024-04-12. PMID:38607084. |
the altered expression of these markers is indicative of a disparate secretome between the microglia of males and females after sci and that the female microglia possesses higher phagocytic capabilities (increased cd68). |
2024-04-12 |
2024-04-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. |
2024-02-10 |
2024-02-12 |
rat |
| Sarah R Morris, Taylor Swift-LaPointe, Andrew Yung, Valentin H Prevost, Shana George, Andrew Bauman, Piotr Kozlowski, Zahra Samadi-Bahrami, Caron Fournier, Pushwant Mattu, Lisa Parker, Femke Streijger, Veronica Hirsch-Reinshagen, G R Wayne Moore, Brian K Kwon, Cornelia Laul. Advanced MRI biomarkers of the injured spinal cord - a comparative study of imaging and histology in human traumatic SCI. Journal of neurotrauma. 2024-02-06. PMID:38318802. |
the histologic features were analysed by staining with luxol fast blue (lfb) for myelin lipids, and class ii major histocompatibility complex (class ii mhc) and cd68 for microglia and macrophages. |
2024-02-06 |
2024-02-09 |
human |
| Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishno. Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice. The Journal of nutritional biochemistry. 2024-02-04. PMID:38311044. |
kd suppressed the mrna expression of the putative microglial markers (cd68, p2ry12, nox2) and induced morphological changes in the male pfc microglia. |
2024-02-04 |
2024-02-07 |
mouse |
| Anja Steinmaurer, Christian Riedl, Theresa König, Giulia Testa, Ulrike Köck, Jan Bauer, Hans Lassmann, Romana Höftberger, Thomas Berger, Isabella Wimmer, Simon Hametne. The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis. Brain pathology (Zurich, Switzerland). 2024-01-23. PMID:38254312. |
here, we investigated the protein expression of btk and cd68 as well as iron accumulation in postmortem control (n = 10) and ms (n = 23) brain tissue, focusing on microglia and macrophages. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
meanwhile, microglia cd68 increased significantly, indicating that the microglia in the chronic stress group have greater phagocytosis activity. |
2023-12-23 |
2023-12-25 |
rat |
| Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. |
the immunophenotypes of microglia and astrocytes were assessed with phenotypic markers (iba1, cd68, hla-dr, cd64, cd32a, cd16 for microglia and gfap, eaat2, glutamine synthetase and aldh1l1 for astrocytes). |
2023-09-13 |
2023-10-07 |
mouse |
| Ruizhuo Chen, Brandy N Routh, Jillian E Straetker, Cecily R Gibson, Aidan S Weitzner, Kiersten S Bell, Andrew D Gaudet, Laura K Fonke. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice. Brain, behavior, and immunity. 2023-08-30. PMID:37648007. |
in both sexes, microglia depletion reduced microglial branching and decreased cd68 production without altering astrogliosis. |
2023-08-30 |
2023-09-07 |
mouse |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Mayur Choudhary, Goldis Male. CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy. Advances in experimental medicine and biology. vol 1415. 2023-07-13. PMID:37440035. |
additionally, animal models of retinal degeneration have shown upregulation of cd68, in a protective population of retinal microglia. |
2023-07-13 |
2023-08-14 |
mouse |