| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junqi Yao, Liming Zhang, Chunkui Zhang, Xing Chen, Ke Bao, Shaojun Hou, Yongyu Yin, Kun Liu, Qing Wen, Xin Huang, Lun Son. Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice. Brain, behavior, and immunity. 2024-07-23. PMID:39043349. |
rhythmic 40 hz lf exposure significantly decreased the number of iba1-positive microglia in the pfc and hippocampus, and the expression levels of the m1 markers of microglia inos and cd68 were reduced significantly in crs mice. |
2024-07-23 |
2024-07-26 |
mouse |
| Yanhui Cui, Zhaolan Hu, Laifa Wang, Bi Zhu, Ling Deng, Hui Zhang, Xueqin Wan. DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis. Neurochemical research. 2024-06-04. PMID:38834844. |
further experiments revealed that nbp inhibited the toll-like receptor 4/nuclear factor kappa b signaling pathway, decreased the level of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, and interleukin-6, and m1-type microglia markers (cd68, inducible nitric oxide synthase), and reduced the expression of panoptosis-related molecules including caspase-1, caspase-3, caspase-8, gasdermin d, and mixed lineage kinase domain-like protein in the hippocampus of the maco rats. |
2024-06-04 |
2024-06-07 |
rat |
| Koeul Choi, Joonhee Lee, Gukdo Kim, Younghyun Lim, Hyo Jung Kan. Recovery of synaptic loss and depressive-like behavior induced by GATA1 through blocking of the neuroinflammatory response. Frontiers in cellular neuroscience. vol 18. 2024-05-24. PMID:38784708. |
through flow cytometry and immunohistochemical analysis, we found that activated microglia showed pro-inflammatory phenotypes characterized by the expression of cd86 and cd68. |
2024-05-24 |
2024-05-27 |
Not clear |
| Mousumi Ghosh, Jinyoung Lee, Ashley N Burke, Thomas A Strong, Jacqueline Sagen, Damien D Pears. Sex Dependent Disparities in the Central Innate Immune Response after Moderate Spinal Cord Contusion in Rat. Cells. vol 13. issue 7. 2024-04-12. PMID:38607084. |
the altered expression of these markers is indicative of a disparate secretome between the microglia of males and females after sci and that the female microglia possesses higher phagocytic capabilities (increased cd68). |
2024-04-12 |
2024-04-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. |
2024-02-10 |
2024-02-12 |
rat |
| Sarah R Morris, Taylor Swift-LaPointe, Andrew Yung, Valentin H Prevost, Shana George, Andrew Bauman, Piotr Kozlowski, Zahra Samadi-Bahrami, Caron Fournier, Pushwant Mattu, Lisa Parker, Femke Streijger, Veronica Hirsch-Reinshagen, G R Wayne Moore, Brian K Kwon, Cornelia Laul. Advanced MRI biomarkers of the injured spinal cord - a comparative study of imaging and histology in human traumatic SCI. Journal of neurotrauma. 2024-02-06. PMID:38318802. |
the histologic features were analysed by staining with luxol fast blue (lfb) for myelin lipids, and class ii major histocompatibility complex (class ii mhc) and cd68 for microglia and macrophages. |
2024-02-06 |
2024-02-09 |
human |
| Mohit Kumar, Babita Bhatt, Chitralekha Gusain, Nayan Mahajan, Mahendra Bishno. Sex-Specific Effects of Ketogenic Diet on Anxiety-like Behavior and Neuroimmune Response in C57Bl/6J Mice. The Journal of nutritional biochemistry. 2024-02-04. PMID:38311044. |
kd suppressed the mrna expression of the putative microglial markers (cd68, p2ry12, nox2) and induced morphological changes in the male pfc microglia. |
2024-02-04 |
2024-02-07 |
mouse |
| Anja Steinmaurer, Christian Riedl, Theresa König, Giulia Testa, Ulrike Köck, Jan Bauer, Hans Lassmann, Romana Höftberger, Thomas Berger, Isabella Wimmer, Simon Hametne. The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis. Brain pathology (Zurich, Switzerland). 2024-01-23. PMID:38254312. |
here, we investigated the protein expression of btk and cd68 as well as iron accumulation in postmortem control (n = 10) and ms (n = 23) brain tissue, focusing on microglia and macrophages. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ke Chen, Xin Qi, Lin-Lin Zhu, Mei-Li Li, Bin Cong, Ying-Min L. Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats. Brain research bulletin. 2023-12-23. PMID:38141789. |
meanwhile, microglia cd68 increased significantly, indicating that the microglia in the chronic stress group have greater phagocytosis activity. |
2023-12-23 |
2023-12-25 |
rat |
| Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. |
the immunophenotypes of microglia and astrocytes were assessed with phenotypic markers (iba1, cd68, hla-dr, cd64, cd32a, cd16 for microglia and gfap, eaat2, glutamine synthetase and aldh1l1 for astrocytes). |
2023-09-13 |
2023-10-07 |
mouse |
| Ruizhuo Chen, Brandy N Routh, Jillian E Straetker, Cecily R Gibson, Aidan S Weitzner, Kiersten S Bell, Andrew D Gaudet, Laura K Fonke. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice. Brain, behavior, and immunity. 2023-08-30. PMID:37648007. |
in both sexes, microglia depletion reduced microglial branching and decreased cd68 production without altering astrogliosis. |
2023-08-30 |
2023-09-07 |
mouse |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Mayur Choudhary, Goldis Male. CD68: Potential Contributor to Inflammation and RPE Cell Dystrophy. Advances in experimental medicine and biology. vol 1415. 2023-07-13. PMID:37440035. |
additionally, animal models of retinal degeneration have shown upregulation of cd68, in a protective population of retinal microglia. |
2023-07-13 |
2023-08-14 |
mouse |
| Madigan M Reid, Marie-Audrey I Kautzmann, Gethein Andrew, Andre Obenaus, Pranab K Mukherjee, Larissa Khoutorova, Jeff X Ji, Cassia R Roque, Reinaldo B Oria, Bola F Habeb, Ludmila Belayev, Nicolas G Baza. NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes. Cellular and molecular neurobiology. 2023-06-04. PMID:37270727. |
overall, we uncovered that protection after middle cerebral artery occlusion (mcao) by the lipid mediators elicits expression of microglia and astrocyte-specific genes (tmem119, fcrls, osmr, msr1, cd68, cd163, amigo2, thbs1, and tm4sf1) likely participating in enhancing homeostatic microglia, modulating neuroinflammation, promoting damp clearance, activating npc differentiation and maturation, synapse integrity and contributing to cell survival. |
2023-06-04 |
2023-08-14 |
Not clear |
| Gabrielle Angst, Xin Tang, Chenran Wan. Functional Analysis of a Novel Immortalized Murine Microglia Cell Line in 3D Spheroid Model. Neurochemical research. 2023-05-17. PMID:37195378. |
the img-1 cells kept their microglia morphology, and they expressed macrophage/microglia-specific proteins of cd11b, cd68, p2ry12, and iba1 in vitro. |
2023-05-17 |
2023-08-14 |
Not clear |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
higher synapse density in females was paralleled by higher activity of microglia, as indicated by morphological changes, cd68 expression, and proximity of microglia to synaptic sites. |
2023-05-12 |
2023-08-14 |
mouse |
| Dadi Li, Shuxian Zhao, Bin Zhu, Wanmin Zhao, Ya Ding, Xuejun Li, Donglin Fu, Haiyang Yu, Baogui Wang, Tan Pa. Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival. Drug development research. 2023-03-29. PMID:36988113. |
cd68 staining and western blot analysis were used to investigate the effect of cm on microglia activation. |
2023-03-29 |
2023-08-14 |
rat |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
males exhibited decreases in the phagocytic-lysosomal marker cd68 in microglia in these regions, whereas females showed an increase in cd68 in the hypothalamus suggesting sexually dimorphic and brain region specific change in microglia state in response to social isolation. |
2023-03-15 |
2023-08-14 |
mouse |
| María Vargas-Soria, Mónica García-Alloza, Miriam Corraliza-Góme. Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies. Journal of neuroinflammation. vol 20. issue 1. 2023-03-03. PMID:36869375. |
although a strict classification of microglia remains elusive given their capacity to adapt to the environment and their morphological, ultrastructural and molecular dynamism, diabetes modulates microglial phenotypic states, triggering specific responses that include upregulation of activity markers (such as iba1, cd11b, cd68, mhc-ii and f4/80), morphological shift to amoeboid shape, secretion of a wide variety of cytokines and chemokines, metabolic reprogramming and generalized increase of oxidative stress. |
2023-03-03 |
2023-08-14 |
Not clear |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |