| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Rafało-Ulińska, Agnieszka Pałucha-Poniewier. The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice. Behavioural brain research. vol 418. 2021-12-11. PMID:34673124. |
western blot analyses showed that (s)-ketamine action might be related to both mtor and erk pathway activation and to the increased expression of glua1 protein in the prefrontal cortex (pfc). |
2021-12-11 |
2023-08-13 |
mouse |
| Joko Poleksic, Milan Aksic, Slobodan Kapor, Dubravka Aleksic, Tihomir Stojkovic, Marina Radovic, Vuk Djulejic, Branka Markovic, Antonios Stamataki. Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes. Frontiers in behavioral neuroscience. vol 15. 2021-11-26. PMID:34819843. |
furthermore, md induced upregulation of brain-derived neurotrophic factor (bdnf), while it did not affect the overall expression of iba1 in neonatal or young adult pfc as measured by western blot, however, microglial activation in young adult md rats was detected immunohistochemically in deep layers of mo and infralimbic cortex (il). |
2021-11-26 |
2023-08-13 |
rat |
| Xiaoyan Li, Hongmei Wang, Chen Li, Jihong Wu, Jun Lu, Jian-You Guo, Ya T. Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 11. 2021-11-15. PMID:34636496. |
the protein levels of nlrp3, apoptotic speck-containing protein with a card (asc), and cysteinyl aspartate specific proteinase-1 (caspase-1) in the pfc were detected by western blot analysis. |
2021-11-15 |
2023-08-13 |
rat |
| A R Deane, N Potemkin, R D War. Mitogen-activated protein kinase (MAPK) signalling corresponds with distinct behavioural profiles in a rat model of maternal immune activation. Behavioural brain research. vol 396. 2021-11-09. PMID:32846206. |
using the maternal immune activation (mia) rat model of schizophrenia, the present study investigated the involvement of prefrontal cortex (pfc) mapk in sensorimotor gating and adaptive learning deficits via western blot, pre-pulse inhibition (ppi) testing, and a contingency degradation operant task, respectively. |
2021-11-09 |
2023-08-13 |
rat |
| Pablo San Segundo-Acosta, Ana Montero-Calle, August Jernbom-Falk, Miren Alonso-Navarro, Elisa Pin, Eni Andersson, Cecilia Hellström, MariCruz Sánchez-Martínez, Alberto Rábano, Guillermo Solís-Fernández, Alberto Peláez-García, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Anna Månberg, Peter Nilsson, Rodrigo Bardera. Multiomics Profiling of Alzheimer's Disease Serum for the Identification of Autoantibody Biomarkers. Journal of proteome research. vol 20. issue 11. 2021-11-05. PMID:34628858. |
moreover, ivd protein abundance in the prefrontal cortex was significantly two-fold higher in ad patients than in controls by western blot and immunohistochemistry, whereas cyfip1 and add2 were significantly down-regulated in ad patients. |
2021-11-05 |
2023-08-13 |
Not clear |
| Jiapeng Deng, Linyang Song, Zhiqin Yang, Sixie Zheng, Zhuolin Du, Li Luo, Jing Liu, Xiaobao Jin, Junhua Yan. Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level. Brain research bulletin. vol 171. 2021-10-07. PMID:33766557. |
lps-treated mice showed a transiently decreased pfc atp8a2 expression indicated by western blot results. |
2021-10-07 |
2023-08-13 |
mouse |
| Jiapeng Deng, Linyang Song, Zhiqin Yang, Sixie Zheng, Zhuolin Du, Li Luo, Jing Liu, Xiaobao Jin, Junhua Yan. Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level. Brain research bulletin. vol 171. 2021-10-07. PMID:33766557. |
using neutralizing mab, ifn-γ was identified as the key mediator of lps-induced pfc atp8a2 decrease indicated by western blot and immunofluorescence results. |
2021-10-07 |
2023-08-13 |
mouse |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |
| Carmen Rodríguez-Rivera, Rocío Girón, Eva Sánchez-Robles, Carmen González-Martín, Carlos Goicoechea, Luis F Alguaci. Sciatic Nerve Ligation Downregulates Mitochondrial Clusterin in the Rat Prefrontal Cortex. Neuroscience. vol 446. 2021-05-14. PMID:32798589. |
we studied the effects of sciatic nerve ligation on mechanical allodynia (von frey test), anxiety (elevated plus maze test), plasma clusterin (enzyme-linked immunosorbent assay) and clusterin expression in the nucleus accumbens (nac) and prefrontal cortex (pfc) of adult male wistar rats (western blot). |
2021-05-14 |
2023-08-13 |
human |
| Genmeng Yang, Liu Liu, Ruilin Zhang, Juan Li, Chi-Kwan Leung, Jian Huang, Yuanyuan Li, Baoyu Shen, Xiaofeng Zeng, Dongxian Zhan. Cannabidiol attenuates methamphetamine-induced conditioned place preference via the Sigma1R/AKT/GSK-3β/CREB signaling pathway in rats. Toxicology research. vol 9. issue 3. 2021-05-09. PMID:32670551. |
the protein expression levels of sigma1r, akt, p-akt, gsk-3β, p-gsk-3β, creb, and p-creb in the rats' prefrontal cortex, nucleus accumbens, and hippocampus and ventral tegmental were detected using western blot analysis. |
2021-05-09 |
2023-08-13 |
rat |
| Ru-Yue Wang, Yue Wang, Song Han, Yue Liu, Jun-Fa Li, Li Zha. [Changes in microglia number and Iba1 expression level in the prefrontal cortex of type 1 diabetic mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665655. |
the number and activation of microglia in the prefrontal cortex of mice were detected by immunofluorescence staining and western blot. |
2021-03-08 |
2023-08-13 |
mouse |
| Andiara E Freitas, Isabella A Heinrich, Tainara M Moura, Daiane B Fraga, Ana P Costa, Dayane Azevedo, Patricia S Brocardo, Manuella P Kaster, Rodrigo B Leal, Ana Lúcia S Rodrigue. Agmatine potentiates antidepressant and synaptic actions of ketamine: Effects on dendritic arbors and spines architecture and Akt/S6 kinase signaling. Experimental neurology. vol 333. 2021-03-05. PMID:32659382. |
western blot analysis from prefrontal cortex tissue showed that the combined treatment, after 1 h, increased p70s6k and glua1, and reduced synapsin 1 phosphorylation. |
2021-03-05 |
2023-08-13 |
mouse |
| Dean-Chuan Wang, Hwai-Ting Lin, Yi-Ju Lee, Hsien-Fu Yu, Sin-Ru Wu, Muhammad Usama Qama. Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise. International journal of molecular sciences. vol 21. issue 11. 2021-02-16. PMID:32485872. |
the expressions of bdnf, dopamine d1 receptor (d1r), cannabinoid receptor 1 (cb1r), and fatty acid amide hydrolase (faah) in the prefrontal cortex were detected by western blot. |
2021-02-16 |
2023-08-13 |
rat |
| Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31866390. |
western blot analysis showed decreased levels of brain-derived neurotrophic factor (bdnf) and decreased ratio of phosphorylated-trkb (p-trkb) to trkb in the prefrontal cortex (pfc) and hippocampus of pcp-treated mice. |
2020-12-31 |
2023-08-13 |
mouse |
| Gen-Meng Yang, Lu Li, Feng-Lin Xue, Chen-Li Ma, Xiao-Feng Zeng, Yong-Na Zhao, Dong-Xian Zhang, Yang Yu, Qian-Wen Yan, Yi-Qing Zhou, Shi-Jun Hong, Li-Hua L. The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:31900897. |
the expression levels of pka, p-pka, creb, and p-creb proteins in the prefrontal cortex, nucleus accumbens, and ventral tegmental area of ma-induced cpp rats and in sh-sy5y cells were detected by western blot analysis. |
2020-12-21 |
2023-08-13 |
rat |
| Shouxing Duan, Ye Ma, Lei Xie, Lian Zheng, Jinzhuang Huang, Ruiwei Guo, Zongbo Sun, Yao Xie, Junyao Lv, Zhirong Lin, Shuhua M. Effects of Chronic Ephedrine Toxicity on Functional Connections, Cell Apoptosis, and CREB-Related Proteins in the Prefrontal Cortex of Rhesus Monkeys. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31858422. |
real-time pcr and western blot showed increased expression of creb mrna and creb/p-creb/c-fos/fosb protein in the prefrontal cortex after ephedrine toxicity. |
2020-12-04 |
2023-08-13 |
human |
| Ceren Sahin Ozkartal, Erdem Tuzun, Cem Ismail Kucukali, Canan Ulusoy, Murat Giris, Feyza Ariciogl. Antidepressant-like effects of agmatine and NOS inhibitors in chronic unpredictable mild stress model of depression in rats: The involvement of NLRP inflammasomes. Brain research. vol 1725. 2020-10-23. PMID:31518574. |
the levels of nlrp inflammasome components (nlrp1, nlrp3, asc, caspase-1 and il-1β) were investigated in the prefrontal cortex by real time pcr and western blot methods. |
2020-10-23 |
2023-08-13 |
rat |
| Ye Xiong, Dan-Qing Xin, Quan Hu, Ling-Xiao Wang, Jie Qiu, Hong-Tao Yuan, Xi-Li Chu, De-Xiang Liu, Gang Li, Zhen Wan. Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage. Neural regeneration research. vol 15. issue 10. 2020-10-09. PMID:32246641. |
rt-pcr and western blot analysis of the complement system showed that l-cysteine reduced expression of the complement factors, c1q, c3α and its receptor c3ar1, and the deposition of c1q in the prefrontal cortex. |
2020-10-09 |
2023-08-13 |
rat |
| Ye Xiong, Dan-Qing Xin, Quan Hu, Ling-Xiao Wang, Jie Qiu, Hong-Tao Yuan, Xi-Li Chu, De-Xiang Liu, Gang Li, Zhen Wan. Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage. Neural regeneration research. vol 15. issue 10. 2020-10-09. PMID:32246641. |
western blot assays and immunohistochemistry were used to detect the protein levels of chop and grp78 in the prefrontal cortex and the number of chop- and grp78-positive cells. |
2020-10-09 |
2023-08-13 |
rat |
| Xiao-Yang Dong, Zhen Fen. Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex. Neural regeneration research. vol 13. issue 2. 2020-10-01. PMID:29557373. |
enzyme-linked immunosorbent assay, western blot assay and immunohistochemistry were used to assess the levels of orexin-a and ox1r expression in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
rat |