| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian T Kipp, Polliana T Nunes, Lisa M Savag. Dysregulation of Neurotrophin Expression in Prefrontal Cortex and Nucleus Basalis Magnocellularis During and After Adolescent Intermittent Ethanol Exposure. Alcohol (Fayetteville, N.Y.). 2024-06-19. PMID:38897258. |
western blot analyses revealed that ethanol intoxication reduced the expression of bdnf and vesicular acetylcholine transporter (vacht) in the pfc, while ngf was lower in the nbm of aie treated animals. |
2024-06-19 |
2024-06-22 |
human |
| Qian-Yun Nie, Gen-Meng Yang, Peng Zhang, Wen-Juan Dong, Di Jing, Zhen-Ping Hou, Yan-Xia Peng, Yang Yu, Li-Hua Li, Shi-Jun Hon. Nrf2 expression, mitochondrial fission, and neuronal apoptosis in the prefrontal cortex of methamphetamine abusers and rats. Brain research. 2024-04-30. PMID:38685372. |
based on immunohistochemical staining and western blot analysis, the protein expression levels of nrf2 and mfn1 showed a decreasing trend, while levels of drp1, cyt-c, and caspase 3 showed an increasing trend in the cerebral prefrontal cortex of both ma abusers and ma-dependent rats. |
2024-04-30 |
2024-05-03 |
rat |
| Deniz Önal, Hilal Korkmaz, Gizem Önal, Bilge Pehlivanoğl. Body Weight Modulates the Impact of Oxytocin on Chronic Cold-Immobilization Stress Response. Peptides. 2024-03-31. PMID:38555975. |
prefrontal cortex and hypothalamic oxytocin receptor (oxtr) expression levels were identified using western blot analysis. |
2024-03-31 |
2024-04-03 |
rat |
| Sami Alzarea, Amna Khan, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. The α-7 Nicotinic Receptor Positive Allosteric Modulator Alleviates Lipopolysaccharide Induced Depressive-like Behavior by Regulating Microglial Function, Trophic Factor, and Chloride Transporters in Mice. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539677. |
therefore, we examined the effects of pnu120596, an α7 nachr positive allosteric modulator, on the expression of bdnf, kcc2, and nkcc1 in the hippocampus and prefrontal cortex using western blot analysis, immunofluorescence assay, and real-time polymerase chain reaction. |
2024-03-28 |
2024-03-30 |
mouse |
| Kaili Du, Qianwen Shi, Xiuya Zhou, Lifei Zhang, Hongliang Su, Chao Zhang, Zhiwen Wei, Ting Liu, Li Wang, Xiaohui Wang, Bin Cong, Keming Yu. Melatonin attenuates fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice. Physiology & behavior. 2024-03-16. PMID:38492912. |
the accompanying changes in the expression of brain and muscle arnt-like (bmal1), tyrosine hydroxylase (th), and monoamine oxidase a (mao-a) in relevant brain regions including the suprachiasmatic nucleus (scn), nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus (hip) were investigated by western blot assays to dissect the mechanism by which melatonin modulates fentanyl - induced behavioral sensitization and circadian rhythm disorders. |
2024-03-16 |
2024-03-19 |
mouse |
| b' David Olivares-Berjaga, Albert Mart\\xc3\\xadnez-Pinte\\xc3\\xb1o, Natalia Rodr\\xc3\\xadguez, Santiago Madero, Lluc\\xc3\\xada Prohens, Irene Mart\\xc3\\xadnez-Serrano, Sergi Mas, Constanza Mor\\xc3\\xa9n, Eduard Parellada, Patricia Gass\\xc3\\xb. Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 131. 2024-02-10. PMID:38296154.' |
we analysed the levels of proapoptotic (caspase-3 and bax) and antiapoptotic (bcl-2) proteins by western blot in the prefrontal cortex and hippocampus of jnj-treated mice. |
2024-02-10 |
2024-02-14 |
mouse |
| Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Szymon Rzeźniczek, Magdalena Sowa-Kućm. Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain. Neuropeptides. vol 104. 2024-01-20. PMID:38244260. |
the prefrontal cortex (pfc) and hippocampus (hc) were selected for pcr and western blot analyses. |
2024-01-20 |
2024-01-23 |
mouse |
| Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. |
the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. |
2024-01-11 |
2024-01-13 |
rat |
| Richard L Spinieli, Rafael Cazuza, Amanda J Sales, Ruither Carolino, Janete A Franci, Maral Tajerian, Christie R A Leite-Paniss. Acute restraint stress regulates brain DNMT3a and promotes defensive behaviors in male rats. Neuroscience letters. 2023-12-15. PMID:38101612. |
we employed biochemical (radioimmunoassay for corticosterone; global dna methylation by enzyme immunoassay and western blot for dnmt3a expression in the amygdala, ventral hippocampus, and prefrontal cortex) and behavioral (elevated plus maze and dark-light box for anxiety and hot plate test for nociception) tests in adult male wistar rats exposed to ars or handling (control). |
2023-12-15 |
2023-12-18 |
rat |
| Lucia Recinella, Maria Loreta Libero, Serena Veschi, Anna Piro, Guya Diletta Marconi, Francesca Diomede, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Rosalba Florio, Alessia Lamolinara, Renzhi Cai, Wei Sha, Andrew V Schally, Roberto Salvatori, Luigi Brunetti, Sheila Leon. Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice. Cells. vol 12. issue 22. 2023-11-25. PMID:37998350. |
moreover, immunohistochemical and western blot analyses suggested an evident activation of nrf2, ho1, and nqo1 in the prefrontal cortex of both +/+ mice treated with mia-602 (+/+ mia-602) and homozygous ghrhko (-/- control) animals. |
2023-11-25 |
2023-11-28 |
mouse |
| Helia Aghamiri, Majid Jafari-Sabet, Mahmood Hoorman. Ameliorative Effect of Cannabidiol on Topiramate-Induced Memory Loss: The Role of Hippocampal and Prefrontal Cortical NMDA Receptors and CREB/BDNF Signaling Pathways in Rats. Neurochemical research. 2023-10-09. PMID:37814133. |
western blot analysis was used to evaluate variations in brain-derived neurotrophic factor (bdnf) and phosphorylated cyclic amp response element-binding protein (pcreb)/creb ratio in the prefrontal cortex (pfc) and hippocampus (hpc). |
2023-10-09 |
2023-10-15 |
rat |
| Tanthai Polvat, Tanya Prasertporn, Piyada Na Nakorn, Supitcha Pannengpetch, Wilasinee Suwanjang, Jiraporn Panmanee, Sukhonthar Ngampramuan, Jennifer L Cornish, Banthit Chetsawan. Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal. Journal of proteome research. 2023-09-07. PMID:37676068. |
cognitive performance of the mice was assessed using an attentional set shift task (asst), and possible underlying neurotoxic mechanisms were investigated by proteomic and western blot analysis of the prefrontal cortex (pfc). |
2023-09-07 |
2023-10-07 |
mouse |
| Nina Treder, Albert Martínez-Pinteño, Natalia Rodríguez, Néstor Arbelo, Santiago Madero, Marta Gómez, Clemente García-Rizo, Sergi Mas, Patricia Gassó, Eduard Parellada, Constanza Moré. The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674542. |
we analyzed the protein levels of nos isoforms in adult pfc and hpc of a postnatal ketamine induced murine model of sz receiving clz or jnj during adolescence by western blot. |
2023-01-21 |
2023-08-14 |
Not clear |
| Kornrawee Suwannakot, Nataya Sritawan, Salinee Naewla, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex. Oxidative medicine and cellular longevity. vol 2022. 2022-07-25. PMID:35873801. |
the hippocampus and pfc were harvested for western blot analysis and biochemical assessments of malondialdehyde (mda), catalase (cat), glutathione peroxidase (gpx), and superoxide dismutase (sod). |
2022-07-25 |
2023-08-14 |
rat |
| Qin Ru, Qi Xiong, Xiang Tian, Congyue Xu, Can Li, Lin Chen, Yuxiang W. Candidate Chinese Herbal Medicine Alleviates Methamphetamine Addiction Frontiers in molecular neuroscience. vol 15. 2022-04-15. PMID:35422687. |
western blot results showed that the protein expressions of drd2 in nucleus accumbens and prefrontal cortex were significantly decreased in meth group, while the protein expressions of htr3a were significantly increased. |
2022-04-15 |
2023-08-13 |
mouse |
| Ali Mooshekhian, Thaisa Sandini, Zelan Wei, Rebekah Van Bruggen, Haibo Li, Xin-Min Li, Yanbo Zhan. Low-field magnetic stimulation improved cuprizone-induced depression-like symptoms and demyelination in female mice. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-07. PMID:35126713. |
the prefrontal cortex and hippocampus were then collected to perform immunohistochemistry and western blot analysis to verify myelination status. |
2022-02-07 |
2023-08-13 |
mouse |
| Ali Mooshekhian, Thaisa Sandini, Zelan Wei, Rebekah Van Bruggen, Haibo Li, Xin-Min Li, Yanbo Zhan. Low-field magnetic stimulation improved cuprizone-induced depression-like symptoms and demyelination in female mice. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-07. PMID:35126713. |
lfms treatment demonstrated a significant antidepressant-like effect and markedly attenuated the cpz-induced demyelination in the prefrontal cortex after 3- and 6-weeks of treatment, as observed by changes in myelin basic protein immunostaining and western blot analysis. |
2022-02-07 |
2023-08-13 |
mouse |
| Paulina Misztak, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowa. Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase. Molecules (Basel, Switzerland). vol 27. issue 1. 2022-01-11. PMID:35011254. |
furthermore, the effects of crs, flu and zn given alone and combined treatment with flu + zn on the expression of proteins involved in the apoptotic, inflammatory, and epigenetic processes were evaluated in selected brain structures (prefrontal cortex, pfc; and hippocampus, hp) using western blot analysis or enzyme-linked immunosorbent assays (elisa). |
2022-01-11 |
2023-08-13 |
mouse |
| Chao Dong, Zheng Tian, Yuko Fujita, Atsuhiro Fujita, Noriko Hino, Michihiko Iijima, Kenji Hashimot. Antidepressant-like actions of the mGlu2/3 receptor antagonist TP0178894 in the chronic social defeat stress model: Comparison with escitalopram. Pharmacology, biochemistry, and behavior. 2021-12-30. PMID:34968554. |
in addition, western blot analyses showed that tp0178894 (3 mg/kg), but not low doses of tp0178894 and escitalopram, significantly attenuated the reduced expression of synaptic proteins [α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (glua1) and postsynaptic density protein 95 (psd-95)] in the prefrontal cortex from csds susceptible mice. |
2021-12-30 |
2023-08-13 |
mouse |
| Mawj Mandwie, Jocelyn Karunia, Aram Niaz, Kevin A Keay, Giuseppe Musumeci, Claire Rennie, Kristine McGrath, Ghaith Al-Badri, Alessandro Castorin. Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948457. |
after 16 weeks, the proinflammatory profile, glial activation markers, and changes within the pi3k/akt intracellular pathway and the pacap/vip system were evaluated by real-time qpcr and/or western blot in the hypothalamus, hippocampus, prefrontal cortex, and amygdala. |
2021-12-24 |
2023-08-13 |
mouse |