| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shih-Jen Tsa. TrkB partial agonists: potential treatment strategy for major depression. Medical hypotheses. vol 68. issue 3. 2007-04-05. PMID:16905274. |
since bdnf might be pro-depressive in the mesolimbic system and anti-depressive in the hippocampus region, it is proposed that these peptides or other partial trkb agonists may provide a novel strategy for the treatment of major depression, which may be associated with bdnf-trkb hypofunction in hippocampus and/or hyperfunction in the mesolimbic system. |
2007-04-05 |
2023-08-12 |
Not clear |
| Kamilla Miskowiak, Ursula O'Sullivan, Catherine J Harme. Erythropoietin enhances hippocampal response during memory retrieval in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360900. |
this is consistent with upregulation of hippocampal bdnf and neurotrophic actions found in animals and highlights epo as a promising candidate for treatment of psychiatric disorders. |
2007-04-05 |
2023-08-12 |
human |
| Christopher S Rex, Ching-Yi Lin, Eniko A Kramár, Lulu Y Chen, Christine M Gall, Gary Lync. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360925. |
brain-derived neurotrophic factor (bdnf) is an extremely potent, positive modulator of theta burst induced long-term potentiation (ltp) in the adult hippocampus. |
2007-04-05 |
2023-08-12 |
rat |
| Christopher S Rex, Ching-Yi Lin, Eniko A Kramár, Lulu Y Chen, Christine M Gall, Gary Lync. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360925. |
bdnf caused no changes in phalloidin labeling of filamentous actin (f-actin) when applied alone to rat hippocampal slices but markedly enhanced the number of densely labeled spines produced by a threshold level of theta burst stimulation. |
2007-04-05 |
2023-08-12 |
rat |
| Christopher S Rex, Ching-Yi Lin, Eniko A Kramár, Lulu Y Chen, Christine M Gall, Gary Lync. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 11. 2007-04-05. PMID:17360925. |
additional experiments confirmed that p21 activated kinase and cofilin, two actin-regulatory proteins implicated in spine morphogenesis, are concentrated in spines in mature hippocampus and further showed that both undergo rapid, dose-dependent phosphorylation after infusion of bdnf. |
2007-04-05 |
2023-08-12 |
rat |
| Marianne H Larsen, Holger Rosenbrock, Frank Sams-Dodd, Jens D Mikkelse. Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine. European journal of pharmacology. vol 555. issue 2-3. 2007-04-04. PMID:17112503. |
this study was undertaken to examine the effect of sub-chronic (5 days) and chronic (14 days) administration of tesofensine on the expression of brain derived neurotrophic factor (bdnf) and activity-regulated cytoskeleton protein (arc) in the rat hippocampus. |
2007-04-04 |
2023-08-12 |
rat |
| Marianne H Larsen, Holger Rosenbrock, Frank Sams-Dodd, Jens D Mikkelse. Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine. European journal of pharmacology. vol 555. issue 2-3. 2007-04-04. PMID:17112503. |
we find that chronic, but not sub-chronic treatment with tesofensine increases bdnf mrna in the ca3 region of the hippocampus (35%), and arc mrna in the ca1 of the hippocampus (65%). |
2007-04-04 |
2023-08-12 |
rat |
| B Bindu, P A Alladi, B M Mansooralikhan, B N Srikumar, T R Raju, B M Kutt. Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17097239. |
we have evaluated the efficacy of enriched environment on the dendritic morphology and brain-derived neurotrophic factor (bdnf) expression in the hippocampus of ventral subicular-lesioned rats. |
2007-03-28 |
2023-08-12 |
rat |
| B Bindu, P A Alladi, B M Mansooralikhan, B N Srikumar, T R Raju, B M Kutt. Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17097239. |
however, the bdnf expression in the hippocampus remained unchanged following subicular lesion and following environmental enrichment. |
2007-03-28 |
2023-08-12 |
rat |
| K Tsukinoki, J Saruta, N Muto, K Sasaguri, S Sato, N Tan-Ishii, Y Watanab. Submandibular glands contribute to increases in plasma BDNF levels. Journal of dental research. vol 86. issue 3. 2007-03-27. PMID:17314259. |
there were no significant differences between stressed (60 min) and non-stressed rats with respect to the bdnf mrna expression in the hippocampus, heart, lung, liver, pancreas, or spleen, as determined by real-time polymerase chain-reaction. |
2007-03-27 |
2023-08-12 |
rat |
| Leszek Bidza. [Stressful events in childhood and psychiatric disorders in the elderly]. Psychiatria polska. vol 40. issue 1. 2007-03-20. PMID:16756035. |
adverse life events occurring early in development may alter the expression of brain-derived neurotrophic factor (bdnf) in the hippocampus and other brain areas and render the organism more vulnerable to psychiatric disorders. |
2007-03-20 |
2023-08-12 |
Not clear |
| Paola Tirassa, Nicola Cost. CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: Effects on kindling development. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16963163. |
cck-8 induces ngf and bdnf synthesis and modulates trka and trkb expression in the rat hippocampus and septum: effects on kindling development. |
2007-03-20 |
2023-08-12 |
rat |
| Paola Tirassa, Nicola Cost. CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: Effects on kindling development. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16963163. |
for this reason, this time point was chosen to compare the effects of cck-8 treatment on the expression of ngf, the brain derived neurotrophin factor (bdnf) and their receptors in the septum and hippocampus. |
2007-03-20 |
2023-08-12 |
rat |
| Paola Tirassa, Nicola Cost. CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: Effects on kindling development. Neurochemistry international. vol 50. issue 1. 2007-03-20. PMID:16963163. |
injections with cck-8 in adult rats result in: (1) an increase of ngf and bdnf protein and mrna levels in the septum and hippocampus; (2) a down-regulation of trka and p75ntr and an up-regulation of trkb; (3) reduced susceptibility to develop chemical kindling; (4) recovery of the ptz-induced changes in the expression of neurotrophin receptors in the septal and hippocampal tissues. |
2007-03-20 |
2023-08-12 |
rat |
| Olaf Schulte-Herbrüggen, Sabine Chourbaji, Stephanie Ridder, Christiane Brandwein, Peter Gass, Heide Hörtnagl, Rainer Hellwe. Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. Psychoneuroendocrinology. vol 31. issue 10. 2007-03-19. PMID:17098367. |
stress-resistant mice overexpressing glucocorticoid receptors display enhanced bdnf in the amygdala and hippocampus with unchanged ngf and serotonergic function. |
2007-03-19 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Sabine Chourbaji, Stephanie Ridder, Christiane Brandwein, Peter Gass, Heide Hörtnagl, Rainer Hellwe. Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. Psychoneuroendocrinology. vol 31. issue 10. 2007-03-19. PMID:17098367. |
bdnf concentrations in the hippocampus and amygdala/piriform cortex were significantly enhanced in gr overexpressing mice (by maximally +103%) compared to wildtype animals. |
2007-03-19 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Sabine Chourbaji, Stephanie Ridder, Christiane Brandwein, Peter Gass, Heide Hörtnagl, Rainer Hellwe. Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. Psychoneuroendocrinology. vol 31. issue 10. 2007-03-19. PMID:17098367. |
in conclusion, gr overexpression-dependent increases of hippocampal and amygdala bdnf content presumably represent a dynamic correlate of enhanced stress resistance. |
2007-03-19 |
2023-08-12 |
mouse |
| Susanne B Lang, Valentin Stein, Tobias Bonhoeffer, Christian Lohman. Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 5. 2007-03-16. PMID:17267564. |
here, we used calcium imaging to directly observe intrinsic bdnf signaling in developing hippocampal neurons. |
2007-03-16 |
2023-08-12 |
Not clear |
| Kerri A Massey, Wagner M Zago, Darwin K Ber. BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons. Molecular and cellular neurosciences. vol 33. issue 4. 2007-03-02. PMID:17029981. |
bdnf up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons. |
2007-03-02 |
2023-08-12 |
Not clear |
| Kerri A Massey, Wagner M Zago, Darwin K Ber. BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons. Molecular and cellular neurosciences. vol 33. issue 4. 2007-03-02. PMID:17029981. |
in the hippocampus, brain-derived neurotrophic factor (bdnf) regulates a number of synaptic components. |
2007-03-02 |
2023-08-12 |
Not clear |