| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshito Mizoguchi, Akihiko Kitamura, Hiroaki Wake, Hitoshi Ishibashi, Miho Watanabe, Takuya Nishimaki, Junichi Nabekur. BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074039. |
this demonstrates a novel aspect of the effects of bdnf on inhibitory transmissions in rat hippocampus, which may have some functional roles in the induction of developmental plasticity and/or pathophysiology of epilepsy. |
2006-12-21 |
2023-08-12 |
rat |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
after carrying out a behavioural evaluation, we determined the bdnf mrna levels, as well as mrna levels for subtypes (5-ht(1a), 5-ht(1b), 5-ht(2a) and 5-ht(2c)) of the 5-ht receptor and 5-ht transporter (5-htt), protein levels of bdnf and concentrations of 5-ht and 5-hiaa in the hypothalamus, hippocampus and frontal cortex. |
2006-12-21 |
2023-08-12 |
mouse |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
the concentrations of 5-ht and 5-hiaa in the frontal cortex, and 5-ht in the hippocampus, of bdnf(+/-) mice were significantly lower than those of wild-type mice. |
2006-12-21 |
2023-08-12 |
mouse |
| M J Webster, M M Herman, J E Kleinman, C Shannon Weicker. BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene expression patterns : GEP. vol 6. issue 8. 2006-12-20. PMID:16713371. |
bdnf and trkb mrna expression in the hippocampus and temporal cortex during the human lifespan. |
2006-12-20 |
2023-08-12 |
human |
| M J Webster, M M Herman, J E Kleinman, C Shannon Weicker. BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene expression patterns : GEP. vol 6. issue 8. 2006-12-20. PMID:16713371. |
within the hippocampus, levels of bdnf mrna did not change significantly with age. |
2006-12-20 |
2023-08-12 |
human |
| M J Webster, M M Herman, J E Kleinman, C Shannon Weicker. BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene expression patterns : GEP. vol 6. issue 8. 2006-12-20. PMID:16713371. |
in addition, since bdnf and both forms of its high affinity receptor are expressed throughout the development, maturation, and aging of the human hippocampus and surrounding neocortex they are likely to play roles not only in early growth but also in maintenance of neurons throughout life. |
2006-12-20 |
2023-08-12 |
human |
| Makoto Takahashi, Akiyoshi Kakita, Takashi Futamura, Yuichiro Watanabe, Makoto Mizuno, Kenji Sakimura, Eero Castren, Toshitaka Nabeshima, Toshiyuki Someya, Hiroyuki Naw. Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16903871. |
in contrast, subchronic postnatal administration increased bdnf protein and mrna levels in the hippocampus and entorhinal cortex, which were sustained until 8 weeks of age. |
2006-12-20 |
2023-08-12 |
rat |
| Makoto Takahashi, Akiyoshi Kakita, Takashi Futamura, Yuichiro Watanabe, Makoto Mizuno, Kenji Sakimura, Eero Castren, Toshitaka Nabeshima, Toshiyuki Someya, Hiroyuki Naw. Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16903871. |
the chronic bdnf increase appeared to contribute to the prepulse inhibition abnormality, as subchronic bdnf infusion into the hippocampus of normal rats mimicked the prepulse inhibition deficits. |
2006-12-20 |
2023-08-12 |
rat |
| Ursula Wyneken, Mauricio Sandoval, Soledad Sandoval, Franscisco Jorquera, Ignacio González, Francisco Vargas, Romina Falcon, Milena Monari, Fernando Orreg. Clinically relevant doses of fluoxetine and reboxetine induce changes in the TrkB content of central excitatory synapses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 11. 2006-12-12. PMID:16554746. |
the bdnf and trkb content in homogenates of cortex and hippocampus began to rise at 9 and 15 days, respectively, and remained high for up to 6 weeks. |
2006-12-12 |
2023-08-12 |
rat |
| Z Rogóz, G Skuza, B Legutk. Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 56. issue 4. 2006-12-07. PMID:16391422. |
in addition, repeated administration of ads induces an increase in rat hippocampal or cortical bdnf gene expression. |
2006-12-07 |
2023-08-12 |
rat |
| Z Rogóz, G Skuza, B Legutk. Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 56. issue 4. 2006-12-07. PMID:16391422. |
since the most potent effect of ads on bdnf gene expression was found after prolonged treatment, in the present study we investigated the influence of repeated treatment (twice daily for 14 days) of the new ad mirtazapine (5 or 10 mg/kg) on bdnf mrna level (the northern blot) in rat hippocampus and cerebral cortex. |
2006-12-07 |
2023-08-12 |
rat |
| Z Rogóz, G Skuza, B Legutk. Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 56. issue 4. 2006-12-07. PMID:16391422. |
the obtained results showed that, like imipramine (10 mg/kg), mirtazapine (10 mg/kg) increased bdnf gene expression in both the examined brain regions: in the hippocampus by 24.0 and 26.5%, in the cerebral cortex by 29.9 and 41.5%, respectively, compared with the vehicle-treated control. |
2006-12-07 |
2023-08-12 |
rat |
| Z Rogóz, G Skuza, B Legutk. Repeated treatment with mirtazepine induces brain-derived neurotrophic factor gene expression in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 56. issue 4. 2006-12-07. PMID:16391422. |
neither mirtazapine nor imipramine administered repeatedly at a lower dose (5 mg/kg) significantly changed bdnf mrna levels in the hippocampus and cerebral cortex. |
2006-12-07 |
2023-08-12 |
rat |
| Stefania Castellano, Francesca Macchi, Manuela Scali, Josh Z Huang, Yuri Bozz. Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828066. |
rt-pcr and in situ hybridization experiments showed that bcatc mrna is overexpressed in restricted regions of the cerebral cortex (parietal area) and hippocampus (hilus and ca3 pyramidal cell layer) of adult bdnf transgenic mice respect to wild-type animals. |
2006-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
chronic corticosterone decreases brain-derived neurotrophic factor (bdnf) mrna and protein in the hippocampus, but not in the frontal cortex, of the rat. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
this study examined the effects of chronic corticosterone (32 mg/kg/day, s.c., 21 days) on brain-derived neurotrophic factor (bdnf) mrna and protein in the frontal cortex and hippocampus of the rat. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
corticosterone modestly decreased bdnf protein (-16.6%) in whole hippocampus and bdnf mrna (-19%) in the ca3 area. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
however, our findings do suggest that chronic corticosterone impairs hippocampal bdnf function, a finding with potential relevance for the hippocampal atrophy reported in major depression. |
2006-12-06 |
2023-08-12 |
rat |
| Lucas Pozzo-Mille. BDNF enhances dendritic Ca2+ signals evoked by coincident EPSPs and back-propagating action potentials in CA1 pyramidal neurons. Brain research. vol 1104. issue 1. 2006-11-30. PMID:16797499. |
due to the critical role of postsynaptic ca(2+) signals in dendritic development and synaptic plasticity, we tested whether long-term exposure to bdnf affects ca(2+) elevations evoked by coincident excitatory postsynaptic potentials (epsps) and back-propagating action potentials (baps) in spiny dendrites of ca1 pyramidal neurons within hippocampal slice cultures. |
2006-11-30 |
2023-08-12 |
Not clear |
| Jun'ichi Semba, Maki Wakuta, Tetsuya Suhar. Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains. Addiction biology. vol 11. issue 2. 2006-11-30. PMID:16800825. |
bdnf levels in the hippocampus, striatum and frontal cortex were determined by elisa assay 24 hours after the last injection. |
2006-11-30 |
2023-08-12 |
rat |