| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun'ichi Semba, Maki Wakuta, Tetsuya Suhar. Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains. Addiction biology. vol 11. issue 2. 2006-11-30. PMID:16800825. |
chronic pcp treatment of neonatal rats induced a dose-dependent decrease in bdnf in the hippocampus but not in the frontal cortex and striatum. |
2006-11-30 |
2023-08-12 |
rat |
| Jun'ichi Semba, Maki Wakuta, Tetsuya Suhar. Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains. Addiction biology. vol 11. issue 2. 2006-11-30. PMID:16800825. |
single injection of pcp to rat pups showed a slight reduction of bdnf in the hippocampus but only at higher doses. |
2006-11-30 |
2023-08-12 |
rat |
| Jun'ichi Semba, Maki Wakuta, Tetsuya Suhar. Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains. Addiction biology. vol 11. issue 2. 2006-11-30. PMID:16800825. |
these findings suggest that chronic blockade of nmda receptor in the early neonatal period has an inhibitory effect on bdnf synthesis in the hippocampus and may impair normal neurodevelopment in rat pups. |
2006-11-30 |
2023-08-12 |
rat |
| Daniel S Roberts, Yinghui Hu, Ingrid V Lund, Amy R Brooks-Kayal, Shelley J Russe. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. The Journal of biological chemistry. vol 281. issue 40. 2006-11-30. PMID:16901909. |
brain-derived neurotrophic factor (bdnf)-induced synthesis of early growth response factor 3 (egr3) controls the levels of type a gaba receptor alpha 4 subunits in hippocampal neurons. |
2006-11-30 |
2023-08-12 |
Not clear |
| In Koo Hwang, Ki-Yeon Yoo, Boo-Kyoung Jung, Jun Hwi Cho, Do-Hoon Kim, Tae-Cheon Kang, Young-Guen Kwon, Yong-Sun Kim, Moo Ho Wo. Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16678162. |
it is known that the hippocampus has vital functions in learning and memory, behavioral regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains high levels of brain-derived neurotrophic factor (bdnf). |
2006-11-14 |
2023-08-12 |
Not clear |
| In Koo Hwang, Ki-Yeon Yoo, Boo-Kyoung Jung, Jun Hwi Cho, Do-Hoon Kim, Tae-Cheon Kang, Young-Guen Kwon, Yong-Sun Kim, Moo Ho Wo. Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16678162. |
in the present study, we followed age-dependent changes of bdnf immunoreactivity and protein level in the gerbil hippocampus to identify the correlation between bdnf and aging. |
2006-11-14 |
2023-08-12 |
Not clear |
| In Koo Hwang, Ki-Yeon Yoo, Boo-Kyoung Jung, Jun Hwi Cho, Do-Hoon Kim, Tae-Cheon Kang, Young-Guen Kwon, Yong-Sun Kim, Moo Ho Wo. Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Experimental neurology. vol 201. issue 1. 2006-11-14. PMID:16678162. |
bdnf immunoreactivity and its protein level significantly increased at postnatal month (pm) 12 in the hippocampus and thereafter reduced. |
2006-11-14 |
2023-08-12 |
Not clear |
| Gye Sun Jeon, Sang-Ha Park, Kuem-Ju Lee, Min-Soo Lee, Boe-Gwun Chun, Kyung-Ho Shi. Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. European journal of pharmacology. vol 545. issue 2-3. 2006-11-13. PMID:16884712. |
however, mk801 significantly decreased bdnf expression in the granule cell layer of hippocampus, and valproate pretreatment before mk801 potentiated the mk801-induced decrease in bdnf expression in granule cell layer. |
2006-11-13 |
2023-08-12 |
rat |
| Christopher S Rex, Julie C Lauterborn, Ching-Yi Lin, Eniko A Kramár, Gary A Rogers, Christine M Gall, Gary Lync. Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor. Journal of neurophysiology. vol 96. issue 2. 2006-11-08. PMID:16707719. |
we report here that in middle-aged (8- to 10-mo-old) rats, in vivo treatments with a positive ampa-type glutamate receptor modulator both increase bdnf protein levels in the cortical telencephalon and restore stabilization of basal dendritic ltp as assessed in acute hippocampal slices 18 h after the last drug treatment. |
2006-11-08 |
2023-08-12 |
rat |
| Hanayo Okamoto, Takanori Miki, Kyoung-Youl Lee, Toshifumi Yokoyama, Hiromi Kuma, Zhi-Yu Wang, He Gu, Hong-Peng Li, Yoshiki Matsumoto, Satriotomo Irawan, Kuldip S Bedi, Yu Nakamura, Yoshiki Takeuch. Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption. Neuroscience letters. vol 406. issue 1-2. 2006-11-03. PMID:16905253. |
by using real-time reverse transcription-polymerase chain reaction (rt-pcr) techniques, this study aimed to determine whether chronic ethanol consumption could alter the mrna expression level of brain-derived neurotrophic factor (bdnf), glial-derived neurotrophic factor (gdnf), and oligodendrocyte myelin glycoprotein (omgp) in the hippocampus. |
2006-11-03 |
2023-08-12 |
human |
| Hiroyasu Akatsu, Hidehisa D Yamagata, Jun Kawamata, Kouzin Kamino, Masatoshi Takeda, Takayuki Yamamoto, Tetsuro Miki, Ikuo Tooyama, Shun Shimohama, Kenji Kosak. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dementia and geriatric cognitive disorders. vol 22. issue 3. 2006-10-30. PMID:16899999. |
brain-derived neurotrophic factor (bdnf) is associated with the hippocampus and the nigrostriatal dopaminergic function. |
2006-10-30 |
2023-08-12 |
Not clear |
| Hiroyasu Akatsu, Hidehisa D Yamagata, Jun Kawamata, Kouzin Kamino, Masatoshi Takeda, Takayuki Yamamoto, Tetsuro Miki, Ikuo Tooyama, Shun Shimohama, Kenji Kosak. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dementia and geriatric cognitive disorders. vol 22. issue 3. 2006-10-30. PMID:16899999. |
recently, a functional bdnf val66met polymorphism has been found to be associated with episodic memory and hippocampal function, with intracellular trafficking, and with activity-dependent secretion of bdnf. |
2006-10-30 |
2023-08-12 |
Not clear |
| Spartaco Santi, Silvia Cappello, Massimo Riccio, Matteo Bergami, Giorgio Aicardi, Ursula Schenk, Michela Matteoli, Marco Canoss. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. The EMBO journal. vol 25. issue 18. 2006-10-24. PMID:16957779. |
hippocampal neurons recycle bdnf for activity-dependent secretion and ltp maintenance. |
2006-10-24 |
2023-08-12 |
Not clear |
| Spartaco Santi, Silvia Cappello, Massimo Riccio, Matteo Bergami, Giorgio Aicardi, Ursula Schenk, Michela Matteoli, Marco Canoss. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. The EMBO journal. vol 25. issue 18. 2006-10-24. PMID:16957779. |
here we provide evidence that hippocampal neurons additionally recycle bdnf for activity-dependent secretion. |
2006-10-24 |
2023-08-12 |
Not clear |
| Spartaco Santi, Silvia Cappello, Massimo Riccio, Matteo Bergami, Giorgio Aicardi, Ursula Schenk, Michela Matteoli, Marco Canoss. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. The EMBO journal. vol 25. issue 18. 2006-10-24. PMID:16957779. |
moreover, bdnf recycling replaced the new synthesis pathway in mediating the maintenance of ltp in hippocampal slices: the late phase ltp, which is abolished by protein synthesis inhibition, was rescued in slices preincubated with bdnf. |
2006-10-24 |
2023-08-12 |
Not clear |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
the levels of il-6 and tnf-alpha mrnas increased both in pd and lbd, but those of bdnf mrna and protein drastically decreased specifically in lbd, in which neuronal loss was observed not only in the nigro-striatum but also in the hippocampus. |
2006-10-24 |
2023-08-12 |
mouse |
| Guang Qiu, Xiao-qiong Wu, Xue-gang Lu. [Effect of polygonum multiflorum thunb on BDNF expression in rat hippocampus induced by amyloid beta-protein (Abeta) 1-40]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 31. issue 2. 2006-10-13. PMID:16706113. |
[effect of polygonum multiflorum thunb on bdnf expression in rat hippocampus induced by amyloid beta-protein (abeta) 1-40]. |
2006-10-13 |
2023-08-12 |
rat |
| Vanja Duric, Kenneth E McCarso. Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression. The journal of pain. vol 7. issue 8. 2006-10-02. PMID:16885011. |
in situ hybridization assay results demonstrated that either pain or stress (acute or chronic treatments) reduced the levels of both nk-1 receptor and bdnf mrnas in the cornu ammonis 1-3 sublayers of the hippocampus, suggesting a possible role of these neuromediators in processing of pain in higher brain centers. |
2006-10-02 |
2023-08-12 |
rat |
| Arvind Govindarajan, B S Shankaranarayana Rao, Deepti Nair, Mimi Trinh, Nadya Mawjee, Susumu Tonegawa, Sumantra Chattarj. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16924103. |
bdnf overexpression also causes antidepressant effects, because transgenic mice exhibit improved performance on the porsolt forced-swim test and an absence of chronic stress-induced hippocampal atrophy. |
2006-09-29 |
2023-08-12 |
mouse |
| Arvind Govindarajan, B S Shankaranarayana Rao, Deepti Nair, Mimi Trinh, Nadya Mawjee, Susumu Tonegawa, Sumantra Chattarj. Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16924103. |
thus, structural changes in the amygdala and hippocampus, caused by genetic manipulation of the same molecule bdnf, give rise to contrasting effects on anxiety and depressive symptoms, both of which are major behavioral correlates of stress disorders. |
2006-09-29 |
2023-08-12 |
mouse |