| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veronica Di Fausto, Marco Fiore, Luigi Alo. Exposure in fetus of methylazoxymethanol in the rat alters brain neurotrophins' levels and brain cells' proliferation. Neurotoxicology and teratology. vol 29. issue 2. 2007-06-01. PMID:17142008. |
we found increased ngf and bdnf protein levels, associated with elevated trka and trkb expression, in the hippocampus, entorhinal cortex, olfactory lobes and subventricular zone (svz), brain areas playing a key role in the production and migration of new dividing cells. |
2007-06-01 |
2023-08-12 |
rat |
| D Paredes, A-Ch Granholm, P C Bickfor. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain research. vol 1141. 2007-06-01. PMID:17292337. |
it has been shown using in vitro techniques that bdnf and ngf evoke neurotransmitter release in the hippocampus but this phenomenon has not been demonstrated in vivo to date. |
2007-06-01 |
2023-08-12 |
rat |
| D Paredes, A-Ch Granholm, P C Bickfor. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain research. vol 1141. 2007-06-01. PMID:17292337. |
we found that bdnf and ngf, when administered into the hippocampus, evoked dopamine and glutamate release in a dose-dependent fashion. |
2007-06-01 |
2023-08-12 |
rat |
| D Paredes, A-Ch Granholm, P C Bickfor. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain research. vol 1141. 2007-06-01. PMID:17292337. |
these results demonstrate a close relationship between the growth factors bdnf and ngf and the neurotransmitters da and glu in the hippocampus of intact animals. |
2007-06-01 |
2023-08-12 |
rat |
| Thomas Frodl, Cornelius Schüle, Gisela Schmitt, Christine Born, Thomas Baghai, Peter Zill, Ronald Bottlender, Rainer Rupprecht, Brigitta Bondy, Maximilian Reiser, Hans-Jürgen Möller, Eva M Meisenzah. Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Archives of general psychiatry. vol 64. issue 4. 2007-06-01. PMID:17404118. |
brain-derived neurotrophic factor (bdnf) modulates hippocampal plasticity, which is believed to be altered in patients with major depression. |
2007-06-01 |
2023-08-12 |
Not clear |
| Yui Naoe, Takahiro Shinkai, Hiroko Hori, Yuko Fukunaka, Kensuke Utsunomiya, Shinichi Sakata, Chima Matsumoto, Kazuko Shimizu, Rudi Hwang, Osamu Ohmori, Jun Nakamur. No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis. Neuroscience letters. vol 415. issue 2. 2007-05-22. PMID:17267117. |
a single nucleotide polymorphism (snp) in the bdnf gene that causes a valine to methionine substitution at codon 66 (val66met) has been demonstrated to affect human memory and hippocampal function. |
2007-05-22 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
reduced levels of brain-derived neurotrophic factor (bdnf) in the hippocampus have been implicated in human affective disorders and behavioral stress responses. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
inescapable stress decreased bdnf mrna and protein in the hippocampus of sedentary rats. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
rats allowed voluntary access to running wheels for either 3 or 6 weeks prior to exposure to stress were protected against stress-induced reductions of hippocampal bdnf protein. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
despite reduced levels of hippocampal bdnf mrna following stress, physically active rats given the combination of fluoxetine and stress remained resistant against learned helplessness. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
finally, bilateral injections of bdnf (1 mug) into the dentate gyrus prior to stress prevented stress-induced reductions of hippocampal bdnf but did not prevent learned helplessness in sedentary rats. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
these data indicate that learned helplessness behaviors are independent of the presence or absence of hippocampal bdnf because blocking inescapable stress-induced bdnf suppression does not always prevent learned helplessness, and learned helplessness does not always occur in the presence of reduced bdnf. |
2007-05-21 |
2023-08-12 |
human |
| B N Greenwood, P V Strong, T E Foley, R S Thompson, M Fleshne. Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17161541. |
results also suggest that the prevention of stress-induced hippocampal bdnf suppression is not necessary for the protective effect of wheel running against learned helplessness. |
2007-05-21 |
2023-08-12 |
human |
| Olaf Schulte-Herbrüggen, Rainer Hellweg, Sabine Chourbaji, Stephanie Ridder, Christiane Brandwein, Peter Gass, Heide Hörtnag. Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17208231. |
the diurnal variation of hippocampal bdnf in wildtypes with higher levels in the morning was absent in gr(+/-) mice. |
2007-05-10 |
2023-08-12 |
mouse |
| Janne Grønli, Clive Bramham, Robert Murison, Tambudzai Kanhema, Eldbjørg Fiske, Bjørn Bjorvatn, Reidun Ursin, Chiara M Porta. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, biochemistry, and behavior. vol 85. issue 4. 2007-05-09. PMID:17204313. |
chronic mild stress inhibits bdnf protein expression and creb activation in the dentate gyrus but not in the hippocampus proper. |
2007-05-09 |
2023-08-12 |
rat |
| Janne Grønli, Clive Bramham, Robert Murison, Tambudzai Kanhema, Eldbjørg Fiske, Bjørn Bjorvatn, Reidun Ursin, Chiara M Porta. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, biochemistry, and behavior. vol 85. issue 4. 2007-05-09. PMID:17204313. |
here we investigated the effect of cms on bdnf protein expression and creb activation in the dentate gyrus and hippocampus proper. |
2007-05-09 |
2023-08-12 |
rat |
| Janne Grønli, Clive Bramham, Robert Murison, Tambudzai Kanhema, Eldbjørg Fiske, Bjørn Bjorvatn, Reidun Ursin, Chiara M Porta. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, biochemistry, and behavior. vol 85. issue 4. 2007-05-09. PMID:17204313. |
rats exposed for 5 weeks to repeated, unpredictable, mild stressors showed reduced bdnf expression and inhibited phosphorylation of creb (ser-133) in the dentate gyrus (-25.0%+/-3.5% and -29.7+/-7.3%, respectively), whereas no significant effects were observed in the hippocampus proper. |
2007-05-09 |
2023-08-12 |
rat |
| Qing-Shan Yan, Mei-Jinag Feng, Shu-E Ya. RNA interference-mediated inhibition of brain-derived neurotrophic factor expression increases cocaine's cytotoxicity in cultured cells. Neuroscience letters. vol 414. issue 2. 2007-05-08. PMID:17194538. |
transfection of neuroblastoma sk-n-as cells or primary rat hippocampal neurons with the small double-stranded interfering rna (sirna) targeting bdnf mrna, but not the scrambled sirna, resulted in reductions in levels of bdnf mrna and proteins by more than 70% in the transfected cells as compared with the control group, suggesting an rnai-mediated, sequence-specific gene silencing. |
2007-05-08 |
2023-08-12 |
rat |
| Kimiko Shimizu, Trongha Phan, Isabelle M Mansuy, Daniel R Stor. Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell. vol 128. issue 6. 2007-05-08. PMID:17382888. |
here we report that mapk and creb-mediated transcription are negatively regulated by scop (suprachiasmatic nucleus [scn] circadian oscillatory protein) and that scop is proteolyzed by calpain when hippocampal neurons are stimulated by brain-derived neurotrophic factor (bdnf), kcl depolarization, or nmda. |
2007-05-08 |
2023-08-12 |
mouse |
| Gary Lynch, Eniko A Kramar, Christopher S Rex, Yousheng Jia, Danielle Chappas, Christine M Gall, Danielle A Simmon. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 16. 2007-05-07. PMID:17442827. |
here we show that ltp is impaired in hippocampal slices from presymptomatic hdh(q92) and hdh(q111) knock-in mice, describe two factors contributing to this deficit, and establish that potentiation can be rescued with brain-derived neurotrophic factor (bdnf). |
2007-05-07 |
2023-08-12 |
mouse |