| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Hu, Hong-Bo Liao, Guo Dai-Hong, Ping Liu, Yu-Yu Wang, Khalid Rahma. Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Neurochemistry international. vol 56. issue 3. 2010-06-08. PMID:20018220. |
the present study was designed to examine the effects of 3,6'-disinapoyl sucrose (diss), a bioactive component of polygala tenuifolia willd, on the expressions of four plasticity-associated genes: cell adhesion molecule l1 (cam-l1), laminin, camp response element binding protein (creb) and brain-derived neurotrophic factor (bdnf) in hippocampus, all of which are involved in neuronal plasticity and neurite outgrowth. |
2010-06-08 |
2023-08-12 |
rat |
| Raffaella Molteni, Annamaria Cattaneo, Francesca Calabrese, Flavia Macchi, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Massimo Gennarelli, Marco A Riv. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20034565. |
we found that bdnf levels were significantly reduced in the hippocampus and prefrontal cortex of sert knockout rats, through transcriptional changes that affect different neurotrophin isoforms. |
2010-06-08 |
2023-08-12 |
human |
| Sophiya Benjamin, Douglas R McQuoid, Guy G Potter, Martha E Payne, James R MacFall, David C Steffens, Warren D Taylo. The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 18. issue 4. 2010-06-03. PMID:20220593. |
the authors examined the relationship between the bdnf gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus. |
2010-06-03 |
2023-08-12 |
Not clear |
| Gislaine Z Réus, Roberto B Stringari, Tamires R Kirsch, Gabriel R Fries, Flávio Kapczinski, Rafael Roesler, João Queved. Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression? Brain research bulletin. vol 81. issue 6. 2010-06-01. PMID:19954760. |
brain-derived neurotrophic factor (bdnf) hippocampal levels were assessed in imipramine- and memantine-treated rats by elisa sandwich assay. |
2010-06-01 |
2023-08-12 |
rat |
| Gislaine Z Réus, Roberto B Stringari, Tamires R Kirsch, Gabriel R Fries, Flávio Kapczinski, Rafael Roesler, João Queved. Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression? Brain research bulletin. vol 81. issue 6. 2010-06-01. PMID:19954760. |
interesting enough, acute administration, but not chronic administration of memantine at higher dose (20 mg/kg) increased bdnf protein levels in the rat hippocampus (p < 0.05). |
2010-06-01 |
2023-08-12 |
rat |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
we have demonstrated recently that sert knockout (ko) rats, generated by n-ethyl-n-nitrosourea-induced mutagenesis, show reduced expression of the neurotrophin brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex, suggesting that depression vulnerability can be associated with impaired neuronal plasticity. |
2010-05-28 |
2023-08-12 |
rat |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
in the present study, we demonstrate that chronic treatment with the antidepressant duloxetine (dlx) was able to normalize the expression of bdnf mrna-coding exon (ix) in the hippocampus and prefrontal cortex of sert ko rats through the modulation of selected neurotrophin transcripts, whose expression was up-regulated by dlx only in sert ko rats. |
2010-05-28 |
2023-08-12 |
rat |
| Stephen M Massa, Tao Yang, Youmei Xie, Jian Shi, Mehmet Bilgen, Jeffrey N Joyce, Dean Nehama, Jayakumar Rajadas, Frank M Long. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of clinical investigation. vol 120. issue 5. 2010-05-20. PMID:20407211. |
using in silico screening with a bdnf loop-domain pharmacophore, followed by low-throughput in vitro screening in mouse fetal hippocampal neurons, we have efficiently identified small molecules with nanomolar neurotrophic activity specific to trkb versus other trk family members. |
2010-05-20 |
2023-08-12 |
mouse |
| Stephen M Massa, Tao Yang, Youmei Xie, Jian Shi, Mehmet Bilgen, Jeffrey N Joyce, Dean Nehama, Jayakumar Rajadas, Frank M Long. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of clinical investigation. vol 120. issue 5. 2010-05-20. PMID:20407211. |
in in vitro models of neurodegenerative disease, it prevented neuronal degeneration with efficacy equal to that of bdnf, and when administered in vivo, it caused hippocampal and striatal trkb activation in mice and improved motor learning after traumatic brain injury in rats. |
2010-05-20 |
2023-08-12 |
mouse |
| Lulu Y Chen, Christopher S Rex, Yas Sanaiha, Gary Lynch, Christine M Gal. Learning induces neurotrophin signaling at hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 15. 2010-05-14. PMID:20356829. |
unsupervised learning, but not exploratory activity alone, robustly increased the number of postsynaptic densities associated with activated (phosphorylated) forms of bdnf's trkb receptor in adult rat hippocampus; these increases were blocked by an nmda receptor antagonist. |
2010-05-14 |
2023-08-12 |
rat |
| Kirk I Erickson, Ruchika Shaurya Prakash, Michelle W Voss, Laura Chaddock, Susie Heo, Molly McLaren, Brandt D Pence, Stephen A Martin, Victoria J Vieira, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392958. |
in rodents, brain-derived neurotrophic factor (bdnf) promotes the growth and proliferation of cells in the hippocampus and is important in long-term potentiation and memory formation. |
2010-05-14 |
2023-08-12 |
Not clear |
| Kirk I Erickson, Ruchika Shaurya Prakash, Michelle W Voss, Laura Chaddock, Susie Heo, Molly McLaren, Brandt D Pence, Stephen A Martin, Victoria J Vieira, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392958. |
in this study, we tested whether age-related reductions in serum levels of bdnf would be related to shrinkage of the hippocampus and memory deficits in older adults. |
2010-05-14 |
2023-08-12 |
Not clear |
| Kirk I Erickson, Ruchika Shaurya Prakash, Michelle W Voss, Laura Chaddock, Susie Heo, Molly McLaren, Brandt D Pence, Stephen A Martin, Victoria J Vieira, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392958. |
we found that increasing age was associated with smaller hippocampal volumes, reduced levels of serum bdnf, and poorer memory performance. |
2010-05-14 |
2023-08-12 |
Not clear |
| Kirk I Erickson, Ruchika Shaurya Prakash, Michelle W Voss, Laura Chaddock, Susie Heo, Molly McLaren, Brandt D Pence, Stephen A Martin, Victoria J Vieira, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392958. |
in an exploratory mediation analysis, hippocampal volume mediated the age-related decline in spatial memory and bdnf mediated the age-related decline in hippocampal volume. |
2010-05-14 |
2023-08-12 |
Not clear |
| Kirk I Erickson, Ruchika Shaurya Prakash, Michelle W Voss, Laura Chaddock, Susie Heo, Molly McLaren, Brandt D Pence, Stephen A Martin, Victoria J Vieira, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392958. |
our results identify serum bdnf as a significant factor related to hippocampal shrinkage and memory decline in late adulthood. |
2010-05-14 |
2023-08-12 |
Not clear |
| Betina Elfving, Pia Høgh Plougmann, Gregers Wegene. Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions. Journal of neuroscience methods. vol 187. issue 1. 2010-05-13. PMID:20043947. |
the intra- and inter-assay variation and the accuracy and yield of the bdnf elisa kit in rat serum and brain tissue were conducted with the optimal dilutions of frontal cortex and hippocampus extract. |
2010-05-13 |
2023-08-12 |
rat |
| Betina Elfving, Pia Høgh Plougmann, Gregers Wegene. Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions. Journal of neuroscience methods. vol 187. issue 1. 2010-05-13. PMID:20043947. |
finally, we found that the accuracy and yield of the bdnf measurements were high in serum and low in hippocampus and frontal cortex. |
2010-05-13 |
2023-08-12 |
rat |
| Simone Macrì, Giovanni Laviola, Melanie P Leussis, Susan L Anderse. Abnormal behavioral and neurotrophic development in the younger sibling receiving less maternal care in a communal nursing paradigm in rats. Psychoneuroendocrinology. vol 35. issue 3. 2010-05-07. PMID:19762157. |
additionally, second-born rats show increased anxiety-related behavior in a plus-maze test in adolescence and adulthood and abnormal developmental trajectories in terms of social interaction and bdnf levels in the amygdala and hippocampus compared to both the first-born litter and to animal facility reared controls. |
2010-05-07 |
2023-08-12 |
rat |
| Jucélia J Fortunato, Gislaine Z Réus, Tamires R Kirsch, Roberto B Stringari, Gabriel R Fries, Flávio Kapczinski, Jaime E Hallak, Antônio W Zuardi, José A Crippa, João Queved. Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19772900. |
in this study, sweet food consumption, adrenal gland weight, adrenocorticotrophin hormone (acth) levels, and hippocampal brain-derived-neurotrophic factor (bdnf) protein levels were assessed. |
2010-05-06 |
2023-08-12 |
rat |
| Yan-Qing Shi, Tian-Wen Huang, Li-Min Chen, Xiao-Dong Pan, Jing Zhang, Yuan-Gui Zhu, Xiao-Chun Che. Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157253. |
in contrast, phospho-creb and brain derived neurotrophic factor (bdnf) levels were dramatically increased in the hippocampus of samp8 treated with rg1. |
2010-05-05 |
2023-08-12 |
mouse |