| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Angelucci, Paola De Bartolo, Francesca Gelfo, Francesca Foti, Debora Cutuli, Paola Bossù, Carlo Caltagirone, Laura Petrosin. Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment. Cerebellum (London, England). vol 8. issue 4. 2010-02-19. PMID:19688409. |
the molecular mechanism of environmental enrichment (ee) on brain function and anatomy has been partially attributed to the up-regulation of proteins involved in neuronal survival and activity-dependent plasticity, such as the neurotrophins nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf), in the cerebral cortex and hippocampus of animal models. |
2010-02-19 |
2023-08-12 |
rat |
| C Montag, B Weber, K Fliessbach, C Elger, M Reute. The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19335934. |
mounting evidence comes from structural imaging, that the functional bdnf val66met polymorphism influences the hippocampal volume with carriers of the 66met allele (val/met and met/met group) having smaller hippocampi. |
2010-02-17 |
2023-08-12 |
Not clear |
| C Montag, B Weber, K Fliessbach, C Elger, M Reute. The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19335934. |
given that stress-induced atrophy of the hippocampus is associated with the pathogenesis of affective disorders, the functional bdnf val66met polymorphism could be an incremental risk factor. |
2010-02-17 |
2023-08-12 |
Not clear |
| A Dutt, C McDonald, E Dempster, D Prata, M Shaikh, I Williams, K Schulze, N Marshall, M Walshe, M Allin, D Collier, R Murray, E Bramo. The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19573260. |
the effect of comt, bdnf, 5-htt, nrg1 and dtnbp1 genes on hippocampal and lateral ventricular volume in psychosis. |
2010-02-17 |
2023-08-12 |
Not clear |
| Thomas Seifert, Patrice Brassard, Mads Wissenberg, Peter Rasmussen, Pernille Nordby, Bente Stallknecht, Helle Adser, Anne H Jakobsen, Henriette Pilegaard, Henning B Nielsen, Niels H Seche. Endurance training enhances BDNF release from the human brain. American journal of physiology. Regulatory, integrative and comparative physiology. vol 298. issue 2. 2010-02-17. PMID:19923361. |
because acute exercise increases bdnf production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of bdnf from the human brain as detected from arterial and internal jugular venous blood samples. |
2010-02-17 |
2023-08-12 |
mouse |
| Thomas Seifert, Patrice Brassard, Mads Wissenberg, Peter Rasmussen, Pernille Nordby, Bente Stallknecht, Helle Adser, Anne H Jakobsen, Henriette Pilegaard, Henning B Nielsen, Niels H Seche. Endurance training enhances BDNF release from the human brain. American journal of physiology. Regulatory, integrative and comparative physiology. vol 298. issue 2. 2010-02-17. PMID:19923361. |
additionally, eight mice completed a 5-wk treadmill running training protocol that increased the bdnf mrna expression in the hippocampus (4.5 + or - 1.6 vs. 1.4 + or - 1.1 mrna/ssdna; p < 0.05), but not in the cerebral cortex (4.0 + or - 1.4 vs. 4.6 + or - 1.4 mrna/ssdna) compared with untrained mice. |
2010-02-17 |
2023-08-12 |
mouse |
| Thomas Seifert, Patrice Brassard, Mads Wissenberg, Peter Rasmussen, Pernille Nordby, Bente Stallknecht, Helle Adser, Anne H Jakobsen, Henriette Pilegaard, Henning B Nielsen, Niels H Seche. Endurance training enhances BDNF release from the human brain. American journal of physiology. Regulatory, integrative and comparative physiology. vol 298. issue 2. 2010-02-17. PMID:19923361. |
the increased bdnf expression in the hippocampus and the enhanced release of bdnf from the human brain following training suggest that endurance training promotes brain health. |
2010-02-17 |
2023-08-12 |
mouse |
| Iu Iu Firstova, O V Dolotov, e A Kondrakhin, E V Dubynina, I A Grivennikov, G I Kovale. [Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy]. Eksperimental'naia i klinicheskaia farmakologiia. vol 72. issue 6. 2010-02-17. PMID:20095391. |
[effects of nootropic drugs on hippocampal and cortical bdnf levels in mice with different exploratory behavior efficacy]. |
2010-02-17 |
2023-08-12 |
mouse |
| Iu Iu Firstova, O V Dolotov, e A Kondrakhin, E V Dubynina, I A Grivennikov, G I Kovale. [Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy]. Eksperimental'naia i klinicheskaia farmakologiia. vol 72. issue 6. 2010-02-17. PMID:20095391. |
the influence of subchronic administration of nootropic drugs (piracetam, phenotropil, meclophenoxate, pantocalcine, semax, nooglutil) on the brain-derived neurotrophic factor (bdnf) content in hippocampal and cortical tissues in mice with different exploratory behavior--high efficacy (he) against low efficacy (le)--in cross-maze test has been studied. |
2010-02-17 |
2023-08-12 |
mouse |
| Iu Iu Firstova, O V Dolotov, e A Kondrakhin, E V Dubynina, I A Grivennikov, G I Kovale. [Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy]. Eksperimental'naia i klinicheskaia farmakologiia. vol 72. issue 6. 2010-02-17. PMID:20095391. |
thus, the obtained results demonstrate that clinically used drugs piracetam, phenotropil, meclophenoxate, and semax realize their nootrope effects, at least partially, via increase in hippocampal bdnf level, which is achieved only under conditions of cognitive deficiency. |
2010-02-17 |
2023-08-12 |
mouse |
| M Rapanelli, L R Frick, B S Zanutt. Differential gene expression in the rat hippocampus during learning of an operant conditioning task. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19632308. |
in this study, we measured mrna expression in the hippocampus by real time (rt)-pcr mrna levels of bdnf, creb, synapsin i, camkii, arc, c-jun and c-fos, during learning and operant conditioning task. |
2010-02-12 |
2023-08-12 |
rat |
| J Bakos, N Hlavacova, M Rajman, K Ondicova, C Koros, E Kitraki, H W M Steinbusch, D Jezov. Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19723563. |
in females the ee-induced rise in hippocampal bdnf, a neurotrophic factor associated with increased neural plasticity, was more pronounced than in males. |
2010-02-12 |
2023-08-12 |
rat |
| J Bakos, N Hlavacova, M Rajman, K Ondicova, C Koros, E Kitraki, H W M Steinbusch, D Jezov. Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19723563. |
plasma testosterone positively correlated with hippocampal bdnf in female but not male rats housed in ee. |
2010-02-12 |
2023-08-12 |
rat |
| Jannicke Hanne Andresen, Else Marit Løberg, Marianne Wright, Ingeborg Løstegaard Goverud, Babill Stray-Pedersen, Ola Didrik Saugsta. Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets. Journal of perinatal medicine. vol 37. issue 5. 2010-02-02. PMID:19492919. |
we examined the effects of nicotine on apoptosis-inducing factor (aif), caspase-3 and bdnf in the hippocampus of a neonatal piglet model of global hypoxia. |
2010-02-02 |
2023-08-12 |
Not clear |
| Jannicke Hanne Andresen, Else Marit Løberg, Marianne Wright, Ingeborg Løstegaard Goverud, Babill Stray-Pedersen, Ola Didrik Saugsta. Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets. Journal of perinatal medicine. vol 37. issue 5. 2010-02-02. PMID:19492919. |
we conclude that nicotine (130 microg/kg/h), infused over 1 h after global hypoxia in neonatal piglets, increases levels of both bdnf mrna and protein in the hippocampus. |
2010-02-02 |
2023-08-12 |
Not clear |
| Bruno Manadas, Ana Rita Santos, Krisztina Szabadfi, João R Gomes, Spiros D Garbis, Michael Fountoulakis, Carlos B Duart. BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. Journal of proteome research. vol 8. issue 10. 2010-02-01. PMID:19702335. |
we conducted a gel-based proteome profiling of the long-term (12 h) effects of bdnf in cultured hippocampal neurons. |
2010-02-01 |
2023-08-12 |
Not clear |
| Luigi Manni, Luigi Aloe, Marco Fior. Changes in cognition induced by social isolation in the mouse are restored by electro-acupuncture. Physiology & behavior. vol 98. issue 5. 2010-01-27. PMID:19733189. |
these findings were associated with decreased ngf and bdnf in the hippocampus and decreased ngf in the striatum of isolated mice exposed to ea. |
2010-01-27 |
2023-08-12 |
mouse |
| Georgia E Hodes, Tiffany E Hill-Smith, Raymond F Suckow, Thomas B Cooper, Irwin Luck. Sex-specific effects of chronic fluoxetine treatment on neuroplasticity and pharmacokinetics in mice. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19828877. |
fluoxetine increased bdnf levels in the hippocampus of both sexes. |
2010-01-26 |
2023-08-12 |
mouse |
| Haixia Dang, Ying Chen, Xinmin Liu, Qiong Wang, Liwei Wang, William Jia, Yuqing Wan. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 8. 2010-01-25. PMID:19632285. |
in addition, hplc-ecd and immunohistochemical staining analysis indicated that the cms-induced decrease in monoamine neurotransmitter concentration and brain-derived neurotrophic factor (bdnf) expression in the hippocampus were almost completely reversed by gts. |
2010-01-25 |
2023-08-12 |
mouse |
| Haixia Dang, Ying Chen, Xinmin Liu, Qiong Wang, Liwei Wang, William Jia, Yuqing Wan. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 8. 2010-01-25. PMID:19632285. |
the activity of gts in antidepression may be mediated partly through enhancing the monoamine neurotransmitter concentration and bdnf expression in the hippocampus. |
2010-01-25 |
2023-08-12 |
mouse |