| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesús Pascual-Brazo, Elena Castro, Alvaro Díaz, Elsa M Valdizán, Fuencisla Pilar-Cuéllar, Rebeca Vidal, Begoña Treceño, Angel Pazo. Modulation of neuroplasticity pathways and antidepressant-like behavioural responses following the short-term (3 and 7 days) administration of the 5-HT₄ receptor agonist RS67333. The international journal of neuropsychopharmacology. vol 15. issue 5. 2012-09-06. PMID:21733238. |
administration of rs67333 for 7 d resulted in a higher increase in the rate of hippocampal cell proliferation, a significant desensitization of 5-ht₄ receptor-coupled adenylate cyclase activity and a more marked increase in the expression of neuroplasticity-related proteins (bdnf, creb, akt): these changes reached the same magnitude as those observed after 3 wk administration of classical antidepressants. |
2012-09-06 |
2023-08-12 |
rat |
| M Pan, H Han, C Zhong, Q Gen. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. The journal of nutrition, health & aging. vol 16. issue 4. 2012-09-06. PMID:22499464. |
effects of genistein and daidzein on hippocampus neuronal cell proliferation and bdnf expression in h19-7 neural cell line. |
2012-09-06 |
2023-08-12 |
Not clear |
| Lieve Desbonnet, Colm O'Tuathaigh, Gerard Clarke, Claire O'Leary, Emilie Petit, Niamh Clarke, Orna Tighe, Donna Lai, Richard Harvey, John F Cryan, Timothy G Dinan, John L Waddingto. Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction. Brain, behavior, and immunity. vol 26. issue 4. 2012-08-30. PMID:22426432. |
thereafter, in vitro cytokine responses to mitogen stimulation and corticosterone inhibition were assayed in spleen cells, with measurement of cytokine and brain-derived neurotrophic factor (bdnf) mrna in frontal cortex, hippocampus and striatum. |
2012-08-30 |
2023-08-12 |
mouse |
| N Kozlovsky, J Zohar, Z Kaplan, H Cohe. Microinfusion of a corticotrophin-releasing hormone receptor 1 antisense oligodeoxynucleotide into the dorsal hippocampus attenuates stress responses at specific times after stress exposure. Journal of neuroendocrinology. vol 24. issue 3. 2012-08-27. PMID:22151651. |
microinfusion of a crh-r1-asodn into the dorsal hippocampus 48 h after stress exposure, although not immediately after exposure (1 h), significantly reduced behavioural disruption and was associated with concomitant up-regulation of bdnf and perk1/2 protein levels compared to crh-r1-scrambled -odn controls. |
2012-08-27 |
2023-08-12 |
human |
| Fernando Gomez-Pinilla, Zhe Ying, Yumei Zhuan. Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injury. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384207. |
the injury reduced bdnf levels in the hippocampus in conjunction with the activated forms of p-synapsin i, p-creb and p-camk ii, while exercise prior to injury prevented these reductions. |
2012-08-27 |
2023-08-12 |
Not clear |
| Fernando Gomez-Pinilla, Zhe Ying, Yumei Zhuan. Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injury. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384207. |
furthermore, the response of the hippocampus to the spinal lesion appeared to be coordinated to that of the spinal cord, as evidenced by corresponding injury-related changes in bdnf levels in the brain and spinal cord. |
2012-08-27 |
2023-08-12 |
Not clear |
| Giorgia Quadrato, Marco Benevento, Stefanie Alber, Carolin Jacob, Elisa M Floriddia, Tuan Nguyen, Mohamed Y Elnaggar, Christine M Pedroarena, Jeffrey D Molkentin, Simone Di Giovann. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 23. 2012-08-27. PMID:22586092. |
indeed, cyclosporin a injection and stereotaxic delivery of the bdnf scavenger trkb-fc in the mouse dentate gyrus reduce the survival of hippocampal adult-born neurons in wild-type but not in nfatc4(-/-) mice and do not affect the net rate of neural precursor proliferation and their fate commitment. |
2012-08-27 |
2023-08-12 |
mouse |
| Norio Yasui-Furukor. Update on the development of lurasidone as a treatment for patients with acute schizophrenia. Drug design, development and therapy. vol 6. 2012-08-27. PMID:22675261. |
chronic treatment with lurasidone increases neurotrophin bdnf mrna levels in both the hippocampus (ventral and dorsal) and prefrontal cortex under basal conditions or in response to an acute swim stress. |
2012-08-27 |
2023-08-12 |
human |
| Venceslas Duveau, Amrita Madhusudan, Matteo Caleo, Irene Knuesel, Jean-Marc Fritsch. Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865728. |
furthermore, bont/e blocked upregulation of trkb in cajal-retzius cells, suggesting that production of truncated reelin in ka-treated hippocampus is activity-dependent and regulated by bdnf. |
2012-08-24 |
2023-08-12 |
mouse |
| Nancy A Dennis, Roberto Cabeza, Anna C Need, Sheena Waters-Metenier, David B Goldstein, Kevin S LaBa. Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865733. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin which has been shown to regulate cell survival and proliferation, as well as synaptic growth and hippocampal long-term potentiation. |
2012-08-24 |
2023-08-12 |
human |
| Nancy A Dennis, Roberto Cabeza, Anna C Need, Sheena Waters-Metenier, David B Goldstein, Kevin S LaBa. Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865733. |
additionally, previous studies have found a relationship between the bdnf val66met genotype and functional activity in the hippocampus during episodic and working memory tasks in healthy young adults. |
2012-08-24 |
2023-08-12 |
human |
| Francisco J Gil-Bea, Maite Solas, Laura Mateos, Bengt Winblad, María J Ramírez, Angel Cedazo-Míngue. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865740. |
cholinergic hypofunction impairs memory acquisition possibly through hippocampal arc and bdnf downregulation. |
2012-08-24 |
2023-08-12 |
rat |
| Francisco J Gil-Bea, Maite Solas, Laura Mateos, Bengt Winblad, María J Ramírez, Angel Cedazo-Míngue. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865740. |
the role of hippocampal cholinergic denervation on synaptic consolidation and further acquisition of spatial memory was hereby examined by analyzing arc and bdnf in standard environment and after behavioral training in morris water maze (mwm). |
2012-08-24 |
2023-08-12 |
rat |
| Francisco J Gil-Bea, Maite Solas, Laura Mateos, Bengt Winblad, María J Ramírez, Angel Cedazo-Míngue. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. vol 21. issue 9. 2012-08-24. PMID:20865740. |
recovery of memory acquisition was accompanied by normalization of arc and bdnf levels in hippocampus. |
2012-08-24 |
2023-08-12 |
rat |
| Bombi Lee, Bong-Jun Sur, Sunoh Kwon, Euntaek Jung, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22216057. |
consistently, the acupuncture significantly alleviated memory-associated decreases in cholinergic immunoreactivity and mrna expression of bdnf and creb in the hippocampus. |
2012-08-23 |
2023-08-12 |
rat |
| Kate L Weidner, Jeffrey H Goodman, Kathryn K Chadman, Daniel P McCloske. Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice. Aging and disease. vol 2. issue 4. 2012-08-23. PMID:22396883. |
aging-induced seizure-related changes to the hippocampal mossy fiber pathway in forebrain specific bdnf overexpressing mice. |
2012-08-23 |
2023-08-12 |
mouse |
| Kate L Weidner, Jeffrey H Goodman, Kathryn K Chadman, Daniel P McCloske. Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice. Aging and disease. vol 2. issue 4. 2012-08-23. PMID:22396883. |
bdnf is upregulated after pharmacological seizure induction and this upregulation contributes to enhanced excitability of the hippocampal mossy fiber-ca3 pathway, which is accompanied by neuropeptide y (npy) upregulation. |
2012-08-23 |
2023-08-12 |
mouse |
| Kate L Weidner, Jeffrey H Goodman, Kathryn K Chadman, Daniel P McCloske. Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice. Aging and disease. vol 2. issue 4. 2012-08-23. PMID:22396883. |
mice overexpressing a bdnf transgene in forebrain neurons provide an avenue for understanding the role of neurotrophic support in the aged hippocampus. |
2012-08-23 |
2023-08-12 |
mouse |
| Kate L Weidner, Jeffrey H Goodman, Kathryn K Chadman, Daniel P McCloske. Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice. Aging and disease. vol 2. issue 4. 2012-08-23. PMID:22396883. |
in this study bdnf transgenic (tg) mice were utilized to determine whether increased bdnf expression through genetic manipulation resulted in age-related changes in hippocampal excitability and npy expression. |
2012-08-23 |
2023-08-12 |
mouse |
| Kate L Weidner, Jeffrey H Goodman, Kathryn K Chadman, Daniel P McCloske. Aging-induced Seizure-related Changes to the Hippocampal Mossy Fiber Pathway in Forebrain Specific BDNF Overexpressing Mice. Aging and disease. vol 2. issue 4. 2012-08-23. PMID:22396883. |
together, these data suggest that the capability for bdnf to promote epileptogenesis is maintained, and may be enhanced, in the aging hippocampus. |
2012-08-23 |
2023-08-12 |
mouse |