| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
ketamine-induced antidepressant effects are associated with ampa receptors-mediated upregulation of mtor and bdnf in rat hippocampus and prefrontal cortex. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
therefore, we pretreated rats with nbqx, an ampa receptor antagonist, or cx546, an ampa receptor agonist, and subsequently observed the immobility time during the forced swimming test (fst) and the hippocampal and prefrontal cortical levels of mtor and bdnf. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
the results showed ketamine decreased the immobility time of rats during the fst and increased the hippocampal and prefrontal cortical mtor and bdnf. |
2015-05-15 |
2023-08-12 |
rat |
| W Zhou, N Wang, C Yang, X-M Li, Z-Q Zhou, J-J Yan. Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. European psychiatry : the journal of the Association of European Psychiatrists. vol 29. issue 7. 2015-05-15. PMID:24321772. |
our results suggest ketamine-induced antidepressant effects are associated with ampa receptors-mediated upregulation of mtor and bdnf in rat hippocampus and prefrontal cortex. |
2015-05-15 |
2023-08-12 |
rat |
| Sanaz Eftekhari, Soraya Mehrabi, Mansooreh Soleimani, Gholamreza Hassanzadeh, Amene Shahrokhi, Hossein Mostafavi, Parisa Hayat, Mahmood Barati, Hajar Mehdizadeh, Reza Rahmanzadeh, Mahmoud Reza Hadjighassem, Mohammad Taghi Joghatae. BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model. Acta neurobiologiae experimentalis. vol 74. issue 3. 2015-05-15. PMID:25231847. |
bdnf modifies hippocampal kcc2 and nkcc1 expression in a temporal lobe epilepsy model. |
2015-05-15 |
2023-08-13 |
rat |
| Meng Li, Qiang Fu, Ying Li, Shanshan Li, Jinsong Xue, Shiping M. Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia. vol 98. 2015-05-13. PMID:24932776. |
then plasma corticosterone concentration, hippocampal glucocorticoid receptor (gr) and brain-derived neurotrophic factor (bdnf) levels were tested to probe the mechanisms. |
2015-05-13 |
2023-08-13 |
mouse |
| Meng Li, Qiang Fu, Ying Li, Shanshan Li, Jinsong Xue, Shiping M. Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia. vol 98. 2015-05-13. PMID:24932776. |
our results indicated that 6 weeks of cums exposure induced significant depression-like behavior, with high, plasma corticosterone concentration and low hippocampal gr and bdnf expression levels. |
2015-05-13 |
2023-08-13 |
mouse |
| Meng Li, Qiang Fu, Ying Li, Shanshan Li, Jinsong Xue, Shiping M. Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia. vol 98. 2015-05-13. PMID:24932776. |
besides, hippocampal gr (mrna and protein) and bdnf (mrna) expressions were also up-regulated after emodin treatments. |
2015-05-13 |
2023-08-13 |
mouse |
| Meng Li, Qiang Fu, Ying Li, Shanshan Li, Jinsong Xue, Shiping M. Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia. vol 98. 2015-05-13. PMID:24932776. |
in conclusion, emodin remarkably improved depression-like behavior in cums mice and its antidepressant activity is mediated, at least in part, by the up-regulating gr and bdnf levels in hippocampus. |
2015-05-13 |
2023-08-13 |
mouse |
| Alejandro F De Nicola, Luciana Pietranera, Maria José Bellini, Rodolfo Goya, Maria Elvira Brocca, Luis Miguel Garcia-Segur. Protective effect of estrogens on the brain of rats with essential and endocrine hypertension. Hormone molecular biology and clinical investigation. vol 4. issue 2. 2015-05-13. PMID:25961231. |
two experimental models of hypertension, spontaneously hypertensive rats (shr) and deoxycorticosterone (doca)-salt hypertensive rats, develop hippocampal abnormalities, which include decreased neurogenesis in the dentate gyrus, astrogliosis, low expression of brain-derived neurotrophic factor (bdnf) and decreased number of neurons in the hilar region, with respect of their normotensive strains wistar kyoto (wky) and sprague-dawley rats. |
2015-05-13 |
2023-08-13 |
rat |
| Alejandro F De Nicola, Luciana Pietranera, Maria José Bellini, Rodolfo Goya, Maria Elvira Brocca, Luis Miguel Garcia-Segur. Protective effect of estrogens on the brain of rats with essential and endocrine hypertension. Hormone molecular biology and clinical investigation. vol 4. issue 2. 2015-05-13. PMID:25961231. |
thus, estradiol treatment positively modulated neurogenesis in the dentate gyrus of the hippocampus, according to bromodeoxyuridine incorporation and doublecortin immunocytochemistry, decreased reactive astrogliosis, increased bdnf mrna and protein expression in the dentate gyrus and increased neuronal number in the hilar region of the dentate gyrus. |
2015-05-13 |
2023-08-13 |
rat |
| Rachel A Hill, Maren Klug, Szerenke Kiss Von Soly, Michele D Binder, Anthony J Hannan, Maarten van den Buus. Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling. Hippocampus. vol 24. issue 10. 2015-05-12. PMID:24802968. |
post-mortem studies have demonstrated reduced expression of brain-derived neurotrophic factor (bdnf) in the hippocampus of schizophrenia and major depression patients. |
2015-05-12 |
2023-08-13 |
rat |
| Rachel A Hill, Maren Klug, Szerenke Kiss Von Soly, Michele D Binder, Anthony J Hannan, Maarten van den Buus. Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling. Hippocampus. vol 24. issue 10. 2015-05-12. PMID:24802968. |
the hippocampus was then dissected into dorsal (dhp) and ventral (vhp) regions and analyzed by qpcr for exon-specific bdnf gene expression or by western blot for bdnf protein expression and downstream signaling. |
2015-05-12 |
2023-08-13 |
rat |
| Ferenc Torma, Zoltan Bori, Erika Koltai, Klara Felszeghy, Gabriella Vacz, Lauren Koch, Steven Britton, Istvan Boldogh, Zsolt Rada. Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. Brain research bulletin. vol 107. 2015-05-12. PMID:25043449. |
bdnf content increased significantly in the hippocampus of hcr-dr groups compared to control groups (p<0.05). |
2015-05-12 |
2023-08-13 |
rat |
| Tianyun Zhao, Yuantao Li, Wei Wei, Sinead Savage, Libing Zhou, Daqing M. Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. Neurobiology of disease. vol 68. 2015-05-11. PMID:24780497. |
their neurobehavioral functions were tested at p25-30 after which the nr1 and nr2 subunits of n-methyl-d-aspartate (nmda) receptor, brain-derived neurotrophic factor (bdnf) and postsynaptic density protein 95 (psd-95) in the hippocampus were analyzed by western blot. |
2015-05-11 |
2023-08-13 |
rat |
| Clarissa M Comim, Napoleão C Silva, Francielle Mina, Diogo Dominguini, Giselli Scaini, Meline O S Morais, Daniela V Rosa, Luiz Alexandre V Magno, Emilio L Streck, Marco A Romano-Silva, João Quevedo, Felipe Dal-Pizzo. Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24978930. |
thus, the objective of this study is to evaluate the neuronal calcium sensor (ncs-1) and dopamine-camp regulated phosphoprotein of 32,000 kda (darpp-32) expression as well as brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) levels in prefrontal cortex and hippocampus of rats 12, 24, and 48 h after sepsis induction. |
2015-05-11 |
2023-08-13 |
rat |
| Clarissa M Comim, Napoleão C Silva, Francielle Mina, Diogo Dominguini, Giselli Scaini, Meline O S Morais, Daniela V Rosa, Luiz Alexandre V Magno, Emilio L Streck, Marco A Romano-Silva, João Quevedo, Felipe Dal-Pizzo. Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24978930. |
after 12 and 24 h, there was an increase of ngf levels in hippocampus; and up to 48 h, a decrease of ncs-1 expression in prefrontal cortex, a decrease of bdnf levels in hippocampus and an increase of ngf levels in hippocampus. |
2015-05-11 |
2023-08-13 |
rat |
| Clarissa M Comim, Napoleão C Silva, Francielle Mina, Diogo Dominguini, Giselli Scaini, Meline O S Morais, Daniela V Rosa, Luiz Alexandre V Magno, Emilio L Streck, Marco A Romano-Silva, João Quevedo, Felipe Dal-Pizzo. Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24978930. |
in conclusion, we believe that the low expression of ncs-1 in prefrontal cortex and low levels of bdnf in hippocampus may be associated with the pathophysiology of cognitive impairment during sepsis and a putative role of the dopaminergic system. |
2015-05-11 |
2023-08-13 |
rat |
| Qing Shu, Rongyin Qin, Yingzhu Chen, Gang Hu, Ming L. Asenapine sensitization from adolescence to adulthood and its potential molecular basis. Behavioural brain research. vol 273. 2015-05-11. PMID:25093543. |
rats were then sacrificed 1 day later and bdnf, d2 and Δfosb in the prefrontal cortex, striatum and hippocampus were examined using western blotting. |
2015-05-11 |
2023-08-13 |
rat |
| Young-Pyo Hong, Hyo-Chul Lee, Hyun-Tae Ki. Treadmill exercise after social isolation increases the levels of NGF, BDNF, and synapsin I to induce survival of neurons in the hippocampus, and improves depression-like behavior. Journal of exercise nutrition & biochemistry. vol 19. issue 1. 2015-05-11. PMID:25960950. |
treadmill exercise after social isolation increases the levels of ngf, bdnf, and synapsin i to induce survival of neurons in the hippocampus, and improves depression-like behavior. |
2015-05-11 |
2023-08-13 |
rat |