| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Graciano Leal, Pedro M Afonso, Ivan L Salazar, Carlos B Duart. Regulation of hippocampal synaptic plasticity by BDNF. Brain research. vol 1621. 2016-05-23. PMID:25451089. |
regulation of hippocampal synaptic plasticity by bdnf. |
2016-05-23 |
2023-08-13 |
Not clear |
| Graciano Leal, Pedro M Afonso, Ivan L Salazar, Carlos B Duart. Regulation of hippocampal synaptic plasticity by BDNF. Brain research. vol 1621. 2016-05-23. PMID:25451089. |
in this review we summarize the evidence pointing to a role for bdnf in generating functional and structural changes at synapses required for both early- and late phases of ltp in the hippocampus. |
2016-05-23 |
2023-08-13 |
Not clear |
| Richa S Rathod, Amrita A Khaire, Anvita A Kale, Sadhana R Josh. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. BioFactors (Oxford, England). vol 41. issue 4. 2016-05-20. PMID:26249019. |
bdo group showed higher (p < 0.05) levels of bdnf (brain derived neurotrophic factor) and dha (docosahexaenoic acid) in the cortex and hippocampus as compared with the bd group. |
2016-05-20 |
2023-08-13 |
rat |
| Richa S Rathod, Amrita A Khaire, Anvita A Kale, Sadhana R Josh. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. BioFactors (Oxford, England). vol 41. issue 4. 2016-05-20. PMID:26249019. |
the combined vitamin b12 and omega-3 fatty acid supplementation further enhanced the levels of dha (p < 0.05) and bdnf (p < 0.05) in the hippocampus and creb mrna (p < 0.01) in the cortex as compared with bs group. |
2016-05-20 |
2023-08-13 |
rat |
| Elena Franco-Robles, Alejandra Campos-Cervantes, Blanca O Murillo-Ortiz, José Segovia, Sergio López-Briones, Paula Vergara, Victoriano Pérez-Vázquez, Martha S Solís-Ortiz, Joel Ramírez-Emilian. Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 39. issue 2. 2016-05-17. PMID:24476477. |
we evaluated the effects of curcumin treatment on protein oxidation (po), lipid peroxidation (lp) and brain-derived neurotrophic factor (bdnf) levels in the hippocampus and frontal cortex (fc) of diabetic db/db mice (dm) and in sera of obese humans. |
2016-05-17 |
2023-08-12 |
mouse |
| Elena Franco-Robles, Alejandra Campos-Cervantes, Blanca O Murillo-Ortiz, José Segovia, Sergio López-Briones, Paula Vergara, Victoriano Pérez-Vázquez, Martha S Solís-Ortiz, Joel Ramírez-Emilian. Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 39. issue 2. 2016-05-17. PMID:24476477. |
bdnf levels decreased in hippocampus and fc of dm as compared with untreated wild-type mice. |
2016-05-17 |
2023-08-12 |
mouse |
| Tatiana Barichello, Jaqueline S Generoso, Lutiana R Simões, Cristiano Julio Faller, Renan A Ceretta, Fabricia Petronilho, Jéssica Lopes-Borges, Samira S Valvassori, João Queved. Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25284351. |
in the meningitis group that received saline, the animals presented memory impairment in both behavioural tasks, and hippocampal bdnf and gdnf expression was decreased. |
2016-05-17 |
2023-08-13 |
rat |
| Yi-huan Chen, Rui-guo Zhang, Fen Xue, Hua-ning Wang, Yun-chun Chen, Guang-tao Hu, Ye Peng, Zheng-wu Peng, Qing-rong Ta. Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26176197. |
the present study aimed to assess the effects of combined que and rtms treatment on depressive-like behaviors, hippocampal proliferation, and the in vivo and in vitro expressions of phosphorylated extracellular signal-regulated protein kinase (perk1/2) and brain-derived neurotrophic factor (bdnf) in male sprague-dawley rats. |
2016-05-17 |
2023-08-13 |
rat |
| Yi-huan Chen, Rui-guo Zhang, Fen Xue, Hua-ning Wang, Yun-chun Chen, Guang-tao Hu, Ye Peng, Zheng-wu Peng, Qing-rong Ta. Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26176197. |
the administration of que and rtms was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (cus) but also to restore the protein expressions of perk1/2 and bdnf and cell proliferation in the hippocampus. |
2016-05-17 |
2023-08-13 |
rat |
| Larissa Helena Torres, Raphael C T Garcia, Anne M M Blois, Lívia M M Dati, Ana Carolina Durão, Adilson Silva Alves, Maurílio Pacheco-Neto, Thais Mauad, Luiz R G Britto, Gilberto Fernando Xavier, Rosana Camarini, Tania Marcouraki. Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood. PloS one. vol 10. issue 8. 2016-05-16. PMID:26305213. |
ets also induced changes in synaptic components, including decreases in synapsin, synaptophysin, psd95 and bdnf levels in the hippocampus. |
2016-05-16 |
2023-08-13 |
mouse |
| André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A Valente, David Blum, Ana Maria Sebastião, Maria José Diógene. Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24860020. |
in the present study, we found that (1) aβ selectively increases mrna levels for the truncated trkb isoforms without affecting trkb-fl mrna levels, (2) aβ induces a calpain-mediated cleavage on trkb-fl receptors, downstream of shc-binding site, originating a new truncated trkb receptor (trkb-t') and an intracellular fragment (trkb-icd), which is also detected in postmortem human brain samples, (3) aβ impairs bdnf function in a calpain-dependent way, as assessed by the inability of bdnf to modulate neurotransmitter (gaba and glutamate) release from hippocampal nerve terminals, and long-term potentiation in hippocampal slices. |
2016-05-10 |
2023-08-13 |
human |
| Jasmine J L Fuller, Ryan C Murray, Kristen A Horne. D-Amphetamine withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treatment with ketamine. Neuropharmacology. vol 97. 2016-05-10. PMID:25986696. |
diminished levels of brain-derived neurotrophic factor (bdnf), particularly in the hippocampus has been observed after exposure to stress, and recent data indicate that treatment with the n-methyl-d-aspartate (nmda) receptor antagonist, ketamine may reverse these changes. |
2016-05-10 |
2023-08-13 |
rat |
| Jasmine J L Fuller, Ryan C Murray, Kristen A Horne. D-Amphetamine withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treatment with ketamine. Neuropharmacology. vol 97. 2016-05-10. PMID:25986696. |
however, it is unclear whether bdnf levels in the hippocampus or other regions of the limbic system are altered following the stress of d-amph withdrawal and it is not currently known if treatment with ketamine has any effect on these changes. |
2016-05-10 |
2023-08-13 |
rat |
| Jasmine J L Fuller, Ryan C Murray, Kristen A Horne. D-Amphetamine withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treatment with ketamine. Neuropharmacology. vol 97. 2016-05-10. PMID:25986696. |
sprague-dawley rats were treated with d-amph and bdnf protein examined in the prefrontal cortex, nucleus accumbens, amygdala and hippocampus at 24 h and 4 days of withdrawal. |
2016-05-10 |
2023-08-13 |
rat |
| Jasmine J L Fuller, Ryan C Murray, Kristen A Horne. D-Amphetamine withdrawal-induced decreases in brain-derived neurotrophic factor in sprague-dawley rats are reversed by treatment with ketamine. Neuropharmacology. vol 97. 2016-05-10. PMID:25986696. |
our data show that at 24 h post-d-amph, bdnf levels were increased in the nucleus accumbens and decreased in the hippocampus. |
2016-05-10 |
2023-08-13 |
rat |
| Conghui Wang, Tingting Chen, Guoxi Li, Libin Zhou, Sha Sha, Ling Che. Simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology. vol 97. 2016-05-10. PMID:26051402. |
simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nachr-dependent cascading pi3k-akt and increasing bdnf via reduction of farnesyl pyrophosphate. |
2016-05-10 |
2023-08-13 |
mouse |
| Conghui Wang, Tingting Chen, Guoxi Li, Libin Zhou, Sha Sha, Ling Che. Simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology. vol 97. 2016-05-10. PMID:26051402. |
the sv-treatment could correct the decline of hippocampal bdnf concentration in aβ25-35-mice, which was blocked by mla and foh. |
2016-05-10 |
2023-08-13 |
mouse |
| Lu Zhang, Yu Fang, Yuming Xu, Yajun Lian, Nanchang Xie, Tianwen Wu, Haifeng Zhang, Limin Sun, Ruifang Zhang, Zhenhua Wan. Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. PloS one. vol 10. issue 6. 2016-05-10. PMID:26114940. |
in addition, the beneficial effect of curcumin is accompanied by increased bdnf levels and elevated levels of phosphorylated erk in the hippocampus. |
2016-05-10 |
2023-08-13 |
rat |
| Lu Zhang, Yu Fang, Yuming Xu, Yajun Lian, Nanchang Xie, Tianwen Wu, Haifeng Zhang, Limin Sun, Ruifang Zhang, Zhenhua Wan. Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway. PloS one. vol 10. issue 6. 2016-05-10. PMID:26114940. |
furthermore, the cognition enhancement effect of curcumin could be mimicked by the overexpression of bdnf in the hippocampus and blocked by either bilateral hippocampal injections with lentiviruses that express bdnf shrna or a microinjection of erk inhibitor. |
2016-05-10 |
2023-08-13 |
rat |
| A L Negrón, M Beymer, G Yu, K A Warren, M Acosta-Martíne. Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats. Neuroscience. vol 303. 2016-05-10. PMID:26166726. |
bdnf mrna expression did not differ as a function of treatment in the anterior vmh, paraventricular nucleus of the hypothalamus, the hippocampus, or the amygdala. |
2016-05-10 |
2023-08-13 |
rat |