| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rawan Bassal, Maria Rivkin-Natan, Alon Rabinovich, Daniel Moris Michaelson, Dan Frenkel, Ronit Pinkas-Kramarsk. APOE4 impairs autophagy and Aβ clearance by microglial cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 74. issue 1. 2025-04-01. PMID:40164781. |
here we studied, the effects of apoe isoforms expression in microglia cells. |
2025-04-01 |
2025-04-03 |
mouse |
| Rawan Bassal, Maria Rivkin-Natan, Alon Rabinovich, Daniel Moris Michaelson, Dan Frenkel, Ronit Pinkas-Kramarsk. APOE4 impairs autophagy and Aβ clearance by microglial cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 74. issue 1. 2025-04-01. PMID:40164781. |
by using an in-situ model, the clearance of aβ plaques from brain sections of transgenic 5xfad mice by the apoe expressing microglia was examined. |
2025-04-01 |
2025-04-03 |
mouse |
| Lynn van Olst, Brooke Simonton, Alex J Edwards, Anne V Forsyth, Jake Boles, Pouya Jamshidi, Thomas Watson, Nate Shepard, Talia Krainc, Benney Mr Argue, Ziyang Zhang, Joshua Kuruvilla, Lily Camp, Mengwei Li, Hang Xu, Jeanette L Norman, Joshua Cahan, Robert Vassar, Jinmiao Chen, Rudolph J Castellani, James Ar Nicoll, Delphine Boche, David Gat. Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease. Nature medicine. 2025-03-06. PMID:40050704. |
our analysis reveals upregulation of the triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) in microglia across immunization approaches, which correlate positively with antibody responses and aβ removal. |
2025-03-06 |
2025-03-09 |
Not clear |
| Sonja Meier, Anne Sofie Gry Larsen, Florian Wanke, Nicolas Mercado, Arianna Mei, Livia Takacs, Eva Suszanna Mracsko, Ludovic Collin, Martin Kampmann, Filip Roudnicky, Ravi Jagasi. An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models. Stem cell reports. 2025-02-21. PMID:39983727. |
we identify the mammalian target of rapamycin complex 1 (mtorc1) signaling pathway as a critical modulator of lipid storage in both apoe3 and apoe knockout microglia. |
2025-02-21 |
2025-02-24 |
human |
| Miguel A Jiménez-Acosta, Cristina A Luckie-Duque, Marco A Meraz-Río. APOE aggregation in microglia, seeds b-amyloidosis in Alzheimer's disease. Journal of leukocyte biology. 2025-01-23. PMID:39847540. |
apoe aggregation in microglia, seeds b-amyloidosis in alzheimer's disease. |
2025-01-23 |
2025-01-26 |
Not clear |
| Hanjie Liu, Maochun You, Hui Yang, Xiao Wu, Siyu Zhang, Sihan Huang, Huijuan Gao, Lushuang Xi. Exploring the molecular characterization of PANoptosis-related genes with features of immune dysregulation in Alzheimer's disease based on bulk and single-nuclei RNA sequencing. Metabolic brain disease. vol 40. issue 1. 2025-01-22. PMID:39841296. |
hdwgcna identified pvt1 and apoe as hub genes associated with microglia. |
2025-01-22 |
2025-01-24 |
Not clear |
| Kristine M Tran, Shimako Kawauchi, Nellie Kwang, Cassandra Mar, Donna Chao, Celia Da Cunha, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N Gree. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751248. |
given that the apoe protein is predominantly produced by astrocytes and activated microglia, and the apoe gene is among the disease-associated microglia (dam) genes, it is conceivable that the variance in pathological outcomes may be rooted in the glial response. |
2025-01-03 |
2025-01-05 |
Not clear |
| Georgia L Nolt, Steven M MacLean, Lesley R Golden, Isaiah O Stephens, Gabriela Hernandez, Dahlia Siano, Ellen Woodward, Joshua Moses, Josh M Morganti, Lance A Johnso. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751498. |
in the cns, apoe is predominantly synthesized by astrocytes and microglia, making these two cell types promising targets for apoe-directed therapeutic approaches. |
2025-01-03 |
2025-01-05 |
mouse |
| Li Gan, Sarah Nagui. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751696. |
trem2 is required for the induction of a disease-associated microglia (dam) signature and microglial neurodegenerative phenotype (mgnd) in response to disease pathology, signatures which both include apoe upregulation. |
2025-01-03 |
2025-01-05 |
Not clear |
| Printha Wijesinghe, Hao Ran Li, Zhengyuan Ai, Matthew Campbell, Si Xuan Chen, Jeanne Xi, Wellington Pham, Joanne A Matsubar. Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation, glial markers, and amyloid pathology. Frontiers in aging neuroscience. vol 16. 2025-01-02. PMID:39744521. |
apolipoprotein e (apoe) plays a crucial role in lipid homeostasis, predominantly expressed in astrocytes and to a lesser extent in microglia within the central nervous system (cns). |
2025-01-02 |
2025-01-04 |
Not clear |
| Guoqiang George Sun, Cheng Wang, Randall C Mazzarino, Paula Andrea Perez-Corredor, Hayk Davtyan, Mathew Blurton-Jones, Francisco Lopera, Joseph F Arboleda-Velasquez, Yanhong Sh. Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. Cell reports. vol 43. issue 12. 2024-11-29. PMID:39612244. |
moreover, we show that an apoe mimetic peptide can mimic the protective effects of apoech microglia. |
2024-11-29 |
2024-12-02 |
human |
| Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Mark Fiers, Bart De Stroope. APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. EMBO molecular medicine. 2024-11-13. PMID:39528861. |
apoe from astrocytes restores alzheimer's aβ-pathology and dam-like responses in apoe deficient microglia. |
2024-11-13 |
2024-11-17 |
mouse |
| Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Mark Fiers, Bart De Stroope. APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. EMBO molecular medicine. 2024-11-13. PMID:39528861. |
the major genetic risk factor for alzheimer's disease (ad), apoe4, accelerates beta-amyloid (aβ) plaque formation, but whether this is caused by apoe expressed in microglia or astrocytes is debated. |
2024-11-13 |
2024-11-17 |
mouse |
| Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Mark Fiers, Bart De Stroope. APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. EMBO molecular medicine. 2024-11-13. PMID:39528861. |
microglia and astrocytes show specific alterations in function of apoe genotype expressed in astrocytes. |
2024-11-13 |
2024-11-17 |
mouse |
| Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M Arranz, Mark Fiers, Bart De Stroope. APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. EMBO molecular medicine. 2024-11-13. PMID:39528861. |
our experiments indicate a central role of the astrocytes in apoe mediated amyloid plaque pathology and in the induction of associated microglia responses. |
2024-11-13 |
2024-11-17 |
mouse |
| Haven Tillmon, Breeanne M Soteros, Liang Shen, Qifei Cong, Mackenna Wollet, Julianne General, Hanna Chin, John Beichen Lee, Flavia R Carreno, David A Morilak, Jun Hee Kim, Gek Ming Si. Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice. Nature communications. vol 15. issue 1. 2024-11-12. PMID:39532876. |
single cell rna sequencing also reveals a stress-associated microglia state marked by high expression of the apolipoprotein e gene (apoe |
2024-11-12 |
2024-11-17 |
mouse |
| Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Zherui Liang, David Shostak, Yanxia Hao, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Misha Zilberter, Yadong Huan. Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model. Cell stem cell. 2024-11-05. PMID:39500314. |
these findings highlight the concerted roles of neuronal apoe, especially apoe4, and microglia in ad pathogenesis. |
2024-11-05 |
2024-11-08 |
mouse |
| Maria Gotkiewicz, Janne Capra, Pasi O Miettinen, Teemu Natunen, Heikki Tanil. Three-dimensional view of microglia-amyloid plaque interactions. Glia. 2024-10-22. PMID:39435610. |
further, they support a chemotactic role of apoe for microglia contacts with amyloid plaques. |
2024-10-22 |
2024-10-24 |
mouse |
| Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simon. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024-10-18. PMID:39419029. |
sporadic ad is linked genetically to apolipoprotein e (apoe) and other genes expressed in microglia related to immune, lipid, and endocytic functions. |
2024-10-18 |
2024-10-20 |
mouse |
| Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simon. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024-10-18. PMID:39419029. |
these apoe aggregates that stained positive for β sheet-binding dyes triggered aβ amyloidosis within the endo-lysosomal system of microglia, in a process influenced by microglial lipid metabolism and the jak/stat signaling pathway. |
2024-10-18 |
2024-10-20 |
mouse |