All Relations between apoe and microglial cell

Publication Sentence Publish Date Extraction Date Species
Neta Rosenzweig, Kilian L Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K Krishnan, Kisha N Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael J Properzi, Roni Nowarski, Hayk Davtyan, Howard L Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J L Eggen, Reisa A Sperling, Oleg Butovsk. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nature medicine. 2024-07-03. PMID:38961225. leveraging single-cell transcriptomics across apoe variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of apoe4 female carriers with ad, we identify a new subset of neutrophils interacting with microglia associated with cognitive impairment. 2024-07-03 2024-07-10 Not clear
Neta Rosenzweig, Kilian L Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K Krishnan, Kisha N Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael J Properzi, Roni Nowarski, Hayk Davtyan, Howard L Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J L Eggen, Reisa A Sperling, Oleg Butovsk. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nature medicine. 2024-07-03. PMID:38961225. this phenotype is defined by increased interleukin (il)-17 and il-1 coexpressed gene modules in blood neutrophils and in microglia of cognitively impaired female apoe ε4 carriers, showing increased infiltration to the ad brain. 2024-07-03 2024-07-10 Not clear
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. microglia exhibit a substantial upregulation of apoe in ad-associated circumstances, despite astrocytes being the primary source of apoe expression and secretion in the brain. 2024-06-13 2024-06-15 human
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. although the role of astrocytic apoe in the brain has been extensively investigated, it remains unclear that whether and how apoe particles generated from astrocytes and microglia differ in biological characteristic and function. 2024-06-13 2024-06-15 human
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. here, we demonstrate the differences in size between apoe particles generated from microglia and astrocytes. 2024-06-13 2024-06-15 human
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. for the first time, these results offer concrete evidence that apoe particles produced by microglia are involved in neuronal senescence and toxicity. 2024-06-13 2024-06-15 human
Hanjie Liu, Hui Yang, Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xi. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829108. protein-protein interaction network (ppi) identified mt3, calm2, dlg2, kcnd2, pakacb, camk2d, and nlgn4y in astrocytes, trem2, fos, apoe, app, and nlgn4y in microglia, and grin2a, itpr2, gnas, and nlgn4y in oligodendrocytes as key genes. 2024-06-03 2024-06-05 Not clear
Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V Pearse, Atlas Khan, Badri N Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A Bennett, Vilas Menon, Philip L De Jage. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain. Nature genetics. 2024-03-22. PMID:38514782. a new variant influences apoe expression only in microglia and is associated with greater cerebral amyloid angiopathy but not alzheimer's disease pathology, after adjusting for apoeε4, providing mechanistic insights into both pathologies. 2024-03-22 2024-03-24 Not clear
Nicholas R W Cleland, Garrett J Potter, Courtney Buck, Daphne Quang, Dean Oldham, Mikaela Neal, Anthony Saviola, Christy S Niemeyer, Evgenia Dobrinskikh, Kimberley D Bruc. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain research. 2024-01-20. PMID:38244754. transcriptomic analysis revealed increased expression of disease-associated microglia (dam) genes (e.g., apoe, trem2, lpl), and genes involved in glycolysis and oxidative metabolism in microglia from aged females compared to males. 2024-01-20 2024-01-23 mouse
Qingyun L. TIMely connections: APOE4, aging, and Alzheimer's. Immunity. vol 57. issue 1. 2024-01-10. PMID:38198855. examine microglia in ad mice bearing different apoe alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and apoe4 ad brains. 2024-01-10 2024-01-13 mouse
Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jone. Microglial APOE4: more is less and less is more. Molecular neurodegeneration. vol 18. issue 1. 2023-12-20. PMID:38115077. yet, the cell-specific effects of apoe on microglia function have remained unclear. 2023-12-20 2023-12-23 Not clear
Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014339. these findings highlight the concerted roles of neuronal apoe, especially apoe4, and microglia in ad pathogenesis. 2023-11-28 2023-11-29 mouse
Jazmin Rivera, Bhupender Sharma, Melissa M Torres, Subodh Kuma. Factors affecting the GABAergic synapse function in Alzheimer's Disease: Focus on microRNAs. Ageing research reviews. 2023-11-15. PMID:37967653. this study explored the types of gaba receptors associated with neurological dysfunction and various biological and environmental factors that cause gabaergic neuron dysfunction in ad, such as aβ, p-tau, aging, sex, astrocytes, microglia, apoe, mental disorder, diet, physical activity, and sleep. 2023-11-15 2023-11-20 human
Emile Wogram, Marco Prin. APOE set the microglia free. Nature immunology. 2023-10-23. PMID:37872317. apoe set the microglia free. 2023-10-23 2023-11-08 Not clear
Chia-Chen Liu, Na Wang, Yuanxin Chen, Yasuteru Inoue, Francis Shue, Yingxue Ren, Minghui Wang, Wenhui Qiao, Tadafumi C Ikezu, Zonghua Li, Jing Zhao, Yuka Martens, Sydney V Doss, Cassandra L Rosenberg, Suren Jeevaratnam, Lin Jia, Ana-Caroline Raulin, Fangfang Qi, Yiyang Zhu, Alla Alnobani, Joshua Knight, Yixing Chen, Cynthia Linares, Aishe Kurti, John D Fryer, Bin Zhang, Long-Jun Wu, Betty Y S Kim, Guojun B. Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease. Nature immunology. 2023-10-19. PMID:37857825. here, using conditional mouse models expressing apoe isoforms in microglia and central nervous system-associated macrophages (cams), we demonstrate a cell-autonomous effect of apoe3-mediated microglial activation and function, which are negated by apoe4. 2023-10-19 2023-11-08 mouse
Lisa Kian. ApoE attracts microglia to amyloid-β plaques. Nature reviews. Neurology. 2023-10-09. PMID:37813951. apoe attracts microglia to amyloid-β plaques. 2023-10-09 2023-10-15 Not clear
Zhuoran Yin, Neta Rosenzweig, Kilian L Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A Margeta, Caitlin Schroeder, Kisha N Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Deik, Daniel G Tenen, Tsuneya Ikezu, Nicolas G Santander, Gabriel L McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J L Eggen, Clary Clish, Rudolph E Tanzi, Charlotte Madore, Thomas D Arnold, David M Holtzman, Oleg Butovsk. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature immunology. 2023-09-25. PMID:37749326. the contribution of microglial apoe4 to ad pathogenesis is unknown, although apoe has the most enriched gene expression in neurodegenerative microglia (mgnd). 2023-09-25 2023-10-07 mouse
Shun-Fat Lau, Wei Wu, Hiu Yi Wong, Li Ouyang, Yi Qiao, Jiahui Xu, Jessica Hiu-Yan Lau, Carlton Wong, Yuanbing Jiang, David M Holtzman, Amy K Y Fu, Nancy Y I. The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology. Nature aging. 2023-09-21. PMID:37735240. here, we show that il-33 induces vcam1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (aβ) plaque-associated apoe, and leads to aβ clearance. 2023-09-21 2023-10-07 Not clear
Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. finally, a series of molecular biological experiments including knock-down of triggering receptor expressed on myeloid cells 2 (trem2) and analysis of the level of apolipoprotein e (apoe) expression were performed to investigate the underlying mechanism of involvement of ccm-activated oecs in modulating microglia polarization, leading to neural regeneration and function recovery. 2023-09-02 2023-09-07 rat
Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. 2023-08-17 2023-09-07 Not clear