| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Luis Gómez-Olivares, Rosa María López-Durán, Sergio Enríquez-Flores, Gabriel López-Velázquez, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Rubí Viedma-Rodríguez, Rafael Valencia-Quintana, Mirta Milić, Luis Antonio Flores-Lópe. Preliminary exploration of the expression of acetylcholinesterase in normal human T lymphocytes and leukemic Jurkat T cells. Biomedical reports. vol 21. issue 5. 2024-09-14. PMID:39268406. |
the classic enzymatic function of acetylcholinesterase (ache) is the hydrolysis of acetylcholine (ach) in the neuronal synapse. |
2024-09-14 |
2024-09-16 |
human |
| Xueying Xu, Ximeng Ma, Jun Dou, Wenkai Chen, Jiying Chen, Mingsen Zhou, Anfu Shen, Xiangjiang Li. β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. Journal of hazardous materials. vol 479. 2024-09-10. PMID:39255669. |
transcriptomic analysis showed that β-ionone could significantly inhibit the expression of acetylcholinesterase (ache) mrna, while metabolomics further revealed that β-ionone could significantly increase the level of acetylcholine (ach) in d. sinensis. |
2024-09-10 |
2024-09-13 |
Not clear |
| Aditya Ganeshpurkar, Ankit Ganeshpurkar, Pushpendra Kumar Khangar, Likhit Akotkar, Swati Jain, Harshal Prajapati, Nazneen Dube. In Silico Investigation of Suillin Derived from Suillus luteus Mushroom (Agaricomycetes) Targeting Acetylcholinesterase: Docking and Virtual Screening Study. International journal of medicinal mushrooms. vol 26. issue 11. 2024-09-06. PMID:39241165. |
suillin, derived from suillus luteus mushrooms, shows promise as a mixed-type ache inhibitor, crucial for maintaining acetylcholine levels in neurodegenerative disorders like alzheimer's disease. |
2024-09-06 |
2024-09-09 |
Not clear |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats. Metabolic brain disease. 2024-08-13. PMID:39136806. |
hyperactivation of acetylcholine esterase (ache), oxidative stress, and inflammation are reported to cause memory and cognitive impairment in global cerebral ischemia. |
2024-08-13 |
2024-08-16 |
rat |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats. Metabolic brain disease. 2024-08-13. PMID:39136806. |
further, morin improved memory and cognition in bccao rats by decreasing the ache enzyme activity and enhancing the acetylcholine (ach) levels. |
2024-08-13 |
2024-08-16 |
rat |
| Leonardo V F Ferreira, Taináh M R Santos, Camila A Tavares, Hassan Rasouli, Teodorico C Ramalh. Atomistic Origins of Resurrection of Aged Acetylcholinesterase by Quinone Methide Precursors. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125089. |
nerve agents are organophosphates (ops) that act as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine. |
2024-08-10 |
2024-08-13 |
Not clear |
| Mahmoud K F El-Sayed, Manal M Elshahawi, Fatma S M Abu El-Azm, Eslam M Hosni, Mahmoud Kamal, Yasmeen M Al. Synthesis, molecular modelling and evaluation of larvicidal efficacy of annulated Benzo[h]chromenes against Culex pipiens L. Larvae. Scientific reports. vol 14. issue 1. 2024-08-08. PMID:39117743. |
the mode of action of these compounds was explored through molecular docking studies, indicating their potential as acetylcholine esterase (ache) inhibitors and nicotinic acetylcholine receptors (nachr) blockers. |
2024-08-08 |
2024-08-12 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
therefore, it is crucial to develop efficient ache inhibitors capable of increasing acetylcholine levels, ultimately leading to improved cholinergic neurotransmission. |
2024-07-22 |
2024-07-25 |
Not clear |
| Göksun Demirel, Sonia Sanajou, Anıl Yirün, Deniz Arca Çakır, Aylin Balcı Özyurt, Aysel Berkkan, Terken Baydar, Pınar Erkekoğl. Walnut oil: a promising nutraceutical in reducing oxidative stress and improving cholinergic activity in an Toxicology research. vol 13. issue 4. 2024-07-03. PMID:38957781. |
additionally, wo showed a significant reduction in tau protein levels (2-fold), increased acetylcholine (ach) levels (12%), and decreased acetylcholine esterase (ache) activity (~50%). |
2024-07-03 |
2024-07-06 |
human |
| Giovana R Oliveira, Matheus Gallas-Lopes, Rafael Chitolina, Leonardo M Bastos, Stefani M Portela, Thailana Stahlhofer-Buss, Darlan Gusso, Rosane Gomez, Angela T S Wyse, Ana P Herrmann, Angelo Piat. Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-26. PMID:38925284. |
research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (ache), inducing an accumulation of acetylcholine in the brain. |
2024-06-26 |
2024-06-29 |
zebrafish |
| Behjat Pouramiri, Maryam Abbasi, Elahe Hadadianpou. Design, Green Synthesis and in silico Studies of New Substituted Naphtho[1,2-e][1,3]Oxazines as Potential Acetylcholinesterase Inhibitors. Chemistry & biodiversity. 2024-06-26. PMID:38923807. |
acetylcholinesterase (ache) inhibitors as the primary pharmacotherapy for numerous neurodegenerative conditions, leveraging their capacity to modulate acetylcholine levels crucial for cognitive function. |
2024-06-26 |
2024-06-29 |
Not clear |
| Sundaram Mohanthi, Jesudass Sutha, Murugesh Gayathri, Mathan Rames. Evaluation of the citalopram toxicity on early development of zebrafish: Morphological, physiological and biochemical responses. Environmental pollution (Barking, Essex : 1987). 2024-06-21. PMID:38906410. |
a significant decrease in acetylcholine esterase (ache) activity was also observed in citalopram exposed groups. |
2024-06-21 |
2024-06-24 |
cat |
| Huma Ikram, Rumaisa Zakir, Darakhshan Jabeen Halee. Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia. Metabolic brain disease. 2024-06-19. PMID:38896206. |
to monitor memory enhancing and neuroprotective effects of apomorphine, we determined the antioxidant enzymes activities, lipid peroxidation, acetylcholine esterase (ache) activity in brain and plasma, following repetitive administration of apomorphine in rat model of dementia. |
2024-06-19 |
2024-06-21 |
rat |
| Liyuan Guo, Zelei Chang, Jianbo Tong, Peng Gao, Yakun Zhang, Yuan Liu, Yulu Yang, Chunying Wan. Design of vilazodone-donepezil chimeric derivatives as acetylcholinesterase inhibitors by QSAR, molecular docking and molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2024-06-19. PMID:38896464. |
acetylcholinesterase (ache) can increase acetylcholine concentrations and improve cognitive function in patients, and is a potential target to develop small molecule inhibitors for the treatment of alzheimer's disease (ad). |
2024-06-19 |
2024-06-21 |
Not clear |
| Yashika Sarangle, Kiran Bamel, Ram Singh Purt. Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. Communicative & integrative biology. vol 17. issue 1. 2024-06-03. PMID:38827581. |
acetylcholine hydrolyzing enzyme acetylcholinesterase (ache) belongs to the gdsl lipase/acylhydrolase protein family and has been found in several plant species. |
2024-06-03 |
2024-06-05 |
Not clear |
| Haiyan Hao, Ailong Sh. Study on Anti-fatigue Effects and Mechanisms of Polysaccharide from Paris polyphylla. Doklady. Biochemistry and biophysics. vol 516. issue 1. 2024-05-25. PMID:38722403. |
the effects of pppm-1 on the contents of blood lactate, serum urea nitrogen, hepatic glycogen, muscle glycogen in the exercise fatigue model of mice, and acetylcholine (ach) content and acetylcholinesterase (ache) activity at the junction of the frog sciatic nerve-gastrocnemius under normal physiological, and na |
2024-05-25 |
2024-05-27 |
mouse |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
moreover, cerebellar neurotransmission was disturbed by pb with increasing acetylcholine (ach) and decreasing acetylcholinesterase (ache), dopamine (da), γ-aminobutyric acid (gaba) and na |
2024-05-10 |
2024-05-27 |
Not clear |
| Dayan Liu, Tao Song, Kang Na, Shudong Wan. PED: a novel predictor-encoder-decoder model for Alzheimer drug molecular generation. Frontiers in artificial intelligence. vol 7. 2024-05-01. PMID:38690194. |
acetylcholinesterase (ache) is an efficient hydrolase that catalyzes the hydrolysis of acetylcholine (ach), which regulates the concentration of ach at synapses and then terminates ach-mediated neurotransmission. |
2024-05-01 |
2024-05-03 |
Not clear |
| Qiyun Wu, Yingjie Xia, Maggie Suisui Guo, Tsz Yu Au, Gary K W Yuen, Ivan Kong, Zhengqi Wang, Yingyi Lin, Tina T X Dong, Karl W K Tsi. Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-01. PMID:38690717. |
this skin problem is hypothesized to be attributed to a reduced expression of acetylcholinesterase (ache), an enzyme responsible for hydrolyzing acetylcholine (ach). |
2024-05-01 |
2024-05-03 |
Not clear |