| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Greenfield, S Nedergaard, C Webb, M Frenc. Pressure ejection of acetylcholinesterase within the guinea-pig substantia nigra has non-classical actions on the pars compacta cells independent of selective receptor and ion channel blockade. Neuroscience. vol 29. issue 1. 1989-06-08. PMID:2469038. |
in the substantia nigra, acetylcholinesterase may have a non-classical function unrelated to cholinergic transmission. |
1989-06-08 |
2023-08-11 |
Not clear |
| D A Krist. Acetylcholinesterase in immature thalamic neurons: relation to afferentation, development, regulation and cellular distribution. Neuroscience. vol 29. issue 1. 1989-06-08. PMID:2710346. |
second, that acetylcholinesterase expression is unlikely to result from a transient cholinergic input. |
1989-06-08 |
2023-08-11 |
rat |
| F J van der Staay, W G Raaijmakers, A J Lammers, J A Tonnae. Selective fimbria lesions impair acquisition of working and reference memory of rats in a complex spatial discrimination task. Behavioural brain research. vol 32. issue 2. 1989-05-04. PMID:2923658. |
transection of the fimbria caused pronounced cholinergic denervation, predominantly at the more ventral part of the hippocampus, as indicated by reduced acetylcholinesterase histochemistry. |
1989-05-04 |
2023-08-11 |
human |
| D Casper, P Davie. Stimulation of choline acetyltransferase activity by retinoic acid and sodium butyrate in a cultured human neuroblastoma. Brain research. vol 478. issue 1. 1989-04-27. PMID:2924123. |
choline acetyltransferase (acetyl-coa:choline o-acetyltransferase, ec 2.3.1.6, abbreviated chat), the biosynthetic enzyme for acetylcholine and acetylcholinesterase (ec 3.1.1.7, abbreviated ache) are expressed in a human cholinergic neuroblastoma cell line, mc-ixc. |
1989-04-27 |
2023-08-11 |
human |
| E C Hirsch, A M Graybiel, L B Hersh, C Duyckaerts, Y Agi. Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum. Neuroscience letters. vol 96. issue 2. 1989-04-24. PMID:2522606. |
the cholinergic neuropil was not uniformly distributed in the striatum, and especially in the caudate nucleus chat-poor zones corresponding to acetylcholinesterase (ache)-poor striosomes were identified. |
1989-04-24 |
2023-08-11 |
human |
| M Eriksdotter-Nilsson, S Skirboll, T Ebendal, L Hersh, J Grassi, J Massoulié, L Olso. NGF treatment promotes development of basal forebrain tissue grafts in the anterior chamber of the eye. Experimental brain research. vol 74. issue 1. 1989-04-24. PMID:2924843. |
following pretreatment with diisopropylfluorophosphate (dfp), the cholinergic neurons in the grafts were analyzed using three morphological markers: antibodies to cholineacetyltransferase (chat), antibodies to acetylcholinesterase (ache ab) and acetylcholinesterase histochemistry (ache). |
1989-04-24 |
2023-08-11 |
rat |
| S Kish, H Karlinsky, L Becker, J Gilbert, M Rebbetoy, L J Chang, L DiStefano, O Hornykiewic. Down's syndrome individuals begin life with normal levels of brain cholinergic markers. Journal of neurochemistry. vol 52. issue 4. 1989-04-21. PMID:2522539. |
we measured the activities of the cholinergic marker enzymes choline acetyltransferase (chat) and acetylcholinesterase (ache) in autopsied brains of seven infants (age range 3 months to 1 year) with down's syndrome (ds), a disorder in which virtually all individuals will develop by middle age the neuropathological changes of alzheimer's disease accompanied by a marked brain cholinergic reduction. |
1989-04-21 |
2023-08-11 |
Not clear |
| A Lysakowski, B H Wainer, G Bruce, L B Hers. An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex. Neuroscience. vol 28. issue 2. 1989-04-18. PMID:2646551. |
we have also compared, on an area-by-area basis, the pattern of acetylcholinesterase reactivity to that of choline acetyltransferase immunoreactivity, since acetylcholinesterase has been used for many years as a putative cholinergic marker. |
1989-04-18 |
2023-08-11 |
rat |
| J Schoene. [Amyotrophic lateral sclerosis. Physiopathology and experimental models. Chemical neuroanatomy of the human spinal cord: applications to pathologic cases including amyotrophic lateral sclerosis]. Revue neurologique. vol 144. issue 11. 1989-04-13. PMID:3068777. |
in this condition, certain modifications, such as the reductions of acetylcholinesterase, choline acetyltransferase, cholinergic muscarinic, glycine or trh receptors, are probably a consequence of motoneuron degeneration. |
1989-04-13 |
2023-08-11 |
human |
| D Casper, P Davie. Regulation of choline acetyltransferase activity by cell density in a cultured human neuroblastoma cell line. Developmental neuroscience. vol 10. issue 4. 1989-04-06. PMID:2465120. |
density did not increase acetylcholinesterase activity, another marker for the cholinergic phenotype, in mc-ixc cultures, demonstrating the independent regulation of these two cholinergic enzymes. |
1989-04-06 |
2023-08-11 |
human |
| B V Sastr. Cholinergic systems and multiple cholinergic receptors in ocular tissues. Journal of ocular pharmacology. vol 1. issue 2. 1989-03-17. PMID:3916849. |
cholinergic markers, choline acetyltransferase and acetylcholinesterase, differ quantitatively and qualitatively in retinas of different species. |
1989-03-17 |
2023-08-11 |
Not clear |
| M M Mesulam, C Geul. Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase. The Journal of comparative neurology. vol 275. issue 2. 1989-03-16. PMID:3220975. |
nucleus basalis (ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase. |
1989-03-16 |
2023-08-11 |
human |
| J Hartikka, F Heft. Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro. Journal of neuroscience research. vol 21. issue 2-4. 1989-03-08. PMID:3216428. |
we now report that, first, cholinergic neurons of striatum and nucleus basalis develop a more extensive fiber network and contain more acetylcholinesterase (ache) per neuron than do cholinergic neurons of septum. |
1989-03-08 |
2023-08-11 |
rat |
| K Hisanaga, H Tsukui, N Takei, H Hatanak. Transplantation of fetal and early postnatal rat septal cholinergic neurons cultured in serum-free and serum-containing medium with nerve growth factor. Brain research. vol 475. issue 2. 1989-02-28. PMID:3214739. |
the cholinergic septal neurons, which were visualized by acetylcholinesterase (ache) histochemistry, always survived in transplantation to the adult brains from nearly pure neuronal cultures. |
1989-02-28 |
2023-08-11 |
rat |
| B E Lams, O Isacson, M V Sofronie. Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons. Brain research. vol 475. issue 2. 1989-02-28. PMID:3214743. |
to assess the validity of using loss of transmitter-associated enzyme staining to document the death of injured cholinergic neurons, vagal and hypoglossal cholinergic neurons were quantitatively identified at 7 and 28 days following unilateral axotomy using staining procedures for choline acetyltransferase (chat) or acetylcholinesterase (ache), using nissl stains, and using the retrogradely transported dye, true blue, as an intracellular marker. |
1989-02-28 |
2023-08-11 |
Not clear |
| R J Polinsky, K V Holmes, R T Brown, V Weis. CSF acetylcholinesterase levels are reduced in multiple system atrophy with autonomic failure. Neurology. vol 39. issue 1. 1989-02-09. PMID:2909912. |
diminished csf levels of acetylcholinesterase in patients with multiple system atrophy attended by autonomic failure suggest that cns cholinergic involvement may occur in this disorder. |
1989-02-09 |
2023-08-11 |
Not clear |
| R J Polinsky, K V Holmes, R T Brown, V Weis. CSF acetylcholinesterase levels are reduced in multiple system atrophy with autonomic failure. Neurology. vol 39. issue 1. 1989-02-09. PMID:2909912. |
normal csf acetylcholinesterase levels in those patients with pure autonomic failure are consistent with functional integrity of central cholinergic pathways and support a pathophysiologic involvement limited to the peripheral nervous system. |
1989-02-09 |
2023-08-11 |
Not clear |
| S A Welner, S B Dunnett, J D Salamone, B MacLean, S D Iverse. Transplantation of embryonic ventral forebrain grafts to the neocortex of rats with bilateral lesions of nucleus basalis magnocellularis ameliorates a lesion-induced deficit in spatial memory. Brain research. vol 463. issue 1. 1989-01-25. PMID:3058269. |
when the same animals were treated with the acetylcholinesterase inhibitor physostigmine (0.05 mg/kg), however, performance on the behavioral task was not further promoted, and therefore, under these conditions, the cholinergic cortical transplants appear not to be subject to modulation by anticholinesterase drugs. |
1989-01-25 |
2023-08-11 |
human |
| E A Grov. Efferent connections of the substantia innominata in the rat. The Journal of comparative neurology. vol 277. issue 3. 1989-01-24. PMID:2461973. |
the cells of origin for many projections arising from the si were identified as cholinergic or noncholinergic by combining the retrograde transport of wga-hrp with histochemical and immunohistochemical procedures to demonstrate acetylcholinesterase activity or choline acetyltransferase immunoreactivity. |
1989-01-24 |
2023-08-11 |
rat |
| K K Hreib, D L Rosene, M B Mos. Basal forebrain efferents to the medial dorsal thalamic nucleus in the rhesus monkey. The Journal of comparative neurology. vol 277. issue 3. 1989-01-24. PMID:2461974. |
in order to determine the extent of the cholinergic input to mdmc from the bf, one of the hrp cases was processed for the simultaneous visualization of hrp, and acetylcholinesterase (ache), the hydrolytic enzyme for acetylcholine, and a second case was processed for simultaneous visualization of hrp, and choline acetyltransferase (chat), the synthetic enzyme for acetylcholine. |
1989-01-24 |
2023-08-11 |
monkey |