| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Poirier, M C Delisle, R Quirion, I Aubert, M Farlow, D Lahiri, S Hui, P Bertrand, J Nalbantoglu, B M Gilfix, S Gauthie. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 26. 1996-06-07. PMID:8618881. |
these results strongly support the concept that apoe4 plays a crucial role in the cholinergic dysfunction associated with ad and may be a prognostic indicator of poor response to therapy with acetylcholinesterase inhibitors in ad patients. |
1996-06-07 |
2023-08-12 |
human |
| N C Inestrosa, A Alvarez, C A Pérez, R D Moreno, M Vicente, C Linker, O I Casanueva, C Soto, J Garrid. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron. vol 16. issue 4. 1996-05-28. PMID:8608006. |
acetylcholinesterase (ache), an important component of cholinergic synapses, colocalizes with amyloid-beta peptide (a beta) deposits of alzheimer's brain. |
1996-05-28 |
2023-08-12 |
mouse |
| W Yao, D A Godfre. Immunohistochemistry of muscarinic acetylcholine receptors in rat cochlear nucleus. Hearing research. vol 89. issue 1-2. 1996-04-30. PMID:8600134. |
to investigate the distribution of machrs and the correlation of pre- and post-synaptic cholinergic markers in cn, we used a monoclonal anti-machr antibody (m35) and a monoclonal antibody against choline acetyltransferase (chat) to perform immunohistochemistry on rat brain sections, and we also carried out histochemistry for acetylcholinesterase (ache) activity. |
1996-04-30 |
2023-08-12 |
rat |
| J T Laitinen, K S Laitinen, T Kokkol. Cholinergic signaling in the rat pineal gland. Cellular and molecular neurobiology. vol 15. issue 2. 1996-03-25. PMID:8590450. |
cholinergic signaling in the rat pineal gland is suggested based on the localization of choline acetyltransferase (chat) and acetylcholinesterase (ache), as well as muscarinic and nicotinic ach binding sites in the gland. |
1996-03-25 |
2023-08-12 |
rat |
| M E Pereira, J B Rocha, I Izquierd. Atropine reverses antinociception induced by 2,5-hexanedione in rats. Pharmacology & toxicology. vol 77. issue 2. 1996-03-21. PMID:8584510. |
in the present investigation, we examined the possible involvement of a cholinergic component in the 2,5-hexanedione-induced antinociception, since literature data indicate that this hexacarbon compound may act as a competitive inhibitor of acetylcholinesterase and that cholinesterase inhibitors are analgesic to rodents. |
1996-03-21 |
2023-08-12 |
rat |
| B S McEwen, E Gould, M Orchinik, N G Weiland, C S Woolle. Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing and neurodegenerative processes. Ciba Foundation symposium. vol 191. 1996-03-20. PMID:8582205. |
this paper describes three actions of oestrogens that are especially relevant to brain mechanisms involved in memory processes and their alterations during ageing and neurodegenerative diseases: (1) the regulation of cholinergic neurons by oestradiol in the rat basal forebrain, involving induction of choline acetyltransferase and acetylcholinesterase according to a sexually dimorphic pattern; (2) the regulation of synaptogenesis in the ca1 region of the hippocampus by oestrogens and progestins during the four- to five-day oestrus cycle of the female rat. |
1996-03-20 |
2023-08-12 |
rat |
| S Rossner, R Schliebs, V Big. 192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574666. |
to correlate the responses to cholinergic immunolesion in cholinoceptive cortical target regions with cholinergic hypoactivity, quantitative receptor autoradiography to measure nmda, ampa and kainate glutamate receptor subtypes, gabaa and benzodiazepine receptors as well as choline uptake sites, and histochemistry to estimate acetylcholinesterase activity were performed in adjacent brain sections. |
1996-03-14 |
2023-08-12 |
rat |
| S Rossner, R Schliebs, V Big. 192IgG-saporin-induced immunotoxic lesions of cholinergic basal forebrain system differentially affect glutamatergic and GABAergic markers in cortical rat brain regions. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574666. |
one week after a single intraventricular injection of 4 micrograms of 192igg-saporin, nmda receptor binding was markedly reduced in cortical regions displaying a reduced activity of acetylcholinesterase and high-affinity choline uptake sites as a consequence of cholinergic lesion, whereas ampa and kainate binding sites were significantly increased in these regions. |
1996-03-14 |
2023-08-12 |
rat |
| C T Lan, C Y Wen, C K Tan, E A Ling, J Y Shie. Ultrastructural identification of cholinergic neurons in the external cuneate nucleus of the gerbil: acetylcholinesterase histochemistry and choline acetyltransferase immunocytochemistry. Journal of neurocytology. vol 24. issue 11. 1996-03-14. PMID:8576713. |
ultrastructural identification of cholinergic neurons in the external cuneate nucleus of the gerbil: acetylcholinesterase histochemistry and choline acetyltransferase immunocytochemistry. |
1996-03-14 |
2023-08-12 |
Not clear |
| C T Lan, C Y Wen, C K Tan, E A Ling, J Y Shie. Ultrastructural identification of cholinergic neurons in the external cuneate nucleus of the gerbil: acetylcholinesterase histochemistry and choline acetyltransferase immunocytochemistry. Journal of neurocytology. vol 24. issue 11. 1996-03-14. PMID:8576713. |
using acetylcholinesterase histochemical and choline acetyltransferase immunocytochemical localization methods, this study has provided conclusive evidence for the existence of cholinergic neurons in the external cuneate nucleus of gerbils. |
1996-03-14 |
2023-08-12 |
Not clear |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| H Schwegle. Transient postnatal thyroxine treatment leads to an increased number of cholinergic neurons in the medial septum and to a higher density of cholinergic fibers in hippocampal CA3 in rats. Neuroscience letters. vol 198. issue 3. 1996-02-21. PMID:8552320. |
at the age of 12 weeks, the number of immunocytochemically labeled cholinergic neuronal profiles in the medial septum/diagonal band (ms/vdb) was counted, and the density of acetylcholinesterase (ache)-positive fibers in four hippocampal subregions was measured. |
1996-02-21 |
2023-08-12 |
rat |
| S P Mahadik, S Mukherje. Monosialoganglioside cotreatment prevents haloperidol treatment-associated loss of cholinergic enzymes in rat brain. Biological psychiatry. vol 38. issue 4. 1996-02-20. PMID:8547447. |
effects of monosialoganglioside (gm1 ganglioside) cotreatment with haloperidol (hal) were studied in rat on the haloperidol treatment-associated changes in cholinergic enzymes, choline acetyltransferase (chat), and acetylcholinesterase (ache) in three brain regions of interest: striatum, hippocampus, and cerebral cortex. |
1996-02-20 |
2023-08-12 |
rat |
| K Ikeda, T Egashira, J Yamashita, S Okoyam. Effect of vagal autotransplantation and bifemelane hydrochloride on cholinergic markers and event-related potentials in rats with lesions of the nucleus basalis magnocellularis. Brain research. vol 688. issue 1-2. 1996-02-14. PMID:8542304. |
in addition, the effects on cholinergic markers were assessed by determining the specific binding of [3h]qnb (quinuclidinyl benzilate) to the muscarinic acetylcholine receptor (machr) as well as the activity of choline acetyltransferase (chat) and acetylcholinesterase (ache). |
1996-02-14 |
2023-08-12 |
rat |
| C Geula, M M Mesula. Cholinesterases and the pathology of Alzheimer disease. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534419. |
alzheimer disease (ad) is accompanied by a marked loss of acetylcholinesterase (ache) activity associated with cortical cholinergic axons and cholinoceptive neurons. |
1996-02-07 |
2023-08-12 |
Not clear |
| S Nochi, N Asakawa, T Sat. Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020). Biological & pharmaceutical bulletin. vol 18. issue 8. 1996-02-05. PMID:8535413. |
its mechanism of action is to increase central cholinergic activity by inhibiting acetylcholinesterase (ache) in the brain. |
1996-02-05 |
2023-08-12 |
Not clear |
| S Nakamura, T Ohn. Spatial learning impairment in aged rats: comparing between aged basal forebrain lesioned and normal aged rats. Behavioural brain research. vol 70. issue 1. 1996-01-24. PMID:8519430. |
histological examination showed that cholinergic fibers (acetylcholinesterase staining) in the frontal cortex reduced in aged bf-lesioned rats, but not in normal aged rats. |
1996-01-24 |
2023-08-12 |
rat |
| N Senanayake, P S Sanmuganatha. Extrapyramidal manifestations complicating organophosphorus insecticide poisoning. Human & experimental toxicology. vol 14. issue 7. 1995-12-28. PMID:7576821. |
the human extrapyramidal system is rich in cholinergic neurons and acetylcholinesterase (ache). |
1995-12-28 |
2023-08-12 |
human |
| A Fraichard, O Chassande, G Bilbaut, C Dehay, P Savatier, J Samaru. In vitro differentiation of embryonic stem cells into glial cells and functional neurons. Journal of cell science. vol 108 ( Pt 10). 1995-12-18. PMID:7593279. |
some neuronal-like cells were also positive for acetylcholinesterase activity or glutamic acid decarboxylase expression, indicating that es cells could differentiate into gabaergic and possibly cholinergic neurons. |
1995-12-18 |
2023-08-12 |
mouse |
| M Nag, P S Basu, N Nand. Parasympatholytic activity of psychoactive drugs in rat brain mitochondria. Indian journal of experimental biology. vol 33. issue 6. 1995-12-15. PMID:7590953. |
there is little cholinergic facilitation through acetylcholinesterase inhibition in the presence of psychoactive drugs. |
1995-12-15 |
2023-08-12 |
rat |