| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tayyaba Qureshi, Christina Sørensen, Paul Berghuis, Vidar Jensen, Marton B Dobszay, Tamás Farkas, Knut Tomas Dalen, Caiying Guo, Bjørnar Hassel, Tor Paaske Utheim, Øivind Hvalby, Torkel Hafting, Tibor Harkany, Marianne Fyhn, Farrukh Abbas Chaudhr. The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 12. 2020-11-04. PMID:31050701. |
despite these pivotal features, molecular determinants underscoring the rapid and cell-autonomous replenishment of the vesicular neurotransmitter gaba and its impact on synaptic plasticity remain elusive. |
2020-11-04 |
2023-08-13 |
mouse |
| Emilce Artur de la Villarmois, Laura A Gabach, Santiago Bianconi, Maria Belen Poretti, Victoria Occhieppo, Helgi B Schiöth, Valeria P Carlini, Mariela Fernanda Pére. Pharmacological NOS-1 Inhibition Within the Hippocampus Prevented Expression of Cocaine Sensitization: Correlation with Reduced Synaptic Transmission. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31378002. |
nitric oxide (no) is a neurotransmitter involved in both, hippocampal synaptic plasticity and cocaine sensitization. |
2020-10-07 |
2023-08-13 |
rat |
| Ludovic D Langlois, Matthieu Dacher, Fereshteh S Nugen. Dopamine Receptor Activation Is Required for GABAergic Spike Timing-Dependent Plasticity in Response to Complex Spike Pairing in the Ventral Tegmental Area. Frontiers in synaptic neuroscience. vol 10. 2020-10-01. PMID:30297996. |
stdp is subject to neuromodulation by dopamine (da), a potent neurotransmitter that significantly impacts synaptic plasticity and reward-related behavioral learning. |
2020-10-01 |
2023-08-13 |
human |
| Marco Tulio Núñez, Cecilia Hidalg. Noxious Iron-Calcium Connections in Neurodegeneration. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30809110. |
iron is required for mitochondrial function, synaptic plasticity, and the development of cognitive functions whereas cellular calcium signals mediate neurotransmitter exocytosis, axonal growth and synaptic plasticity, and control the expression of genes involved in learning and memory processes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Qing Cheng, Sang-Ho Song, George J Augustin. Molecular Mechanisms of Short-Term Plasticity: Role of Synapsin Phosphorylation in Augmentation and Potentiation of Spontaneous Glutamate Release. Frontiers in synaptic neuroscience. vol 10. 2020-09-30. PMID:30425632. |
we used genetic and pharmacological approaches to identify the signaling pathways involved in augmentation and potentiation, two forms of activity dependent, short-term synaptic plasticity that enhance neurotransmitter release. |
2020-09-30 |
2023-08-13 |
Not clear |
| Saeideh Momtaz, Zahra Memariani, Fardous F El-Senduny, Nima Sanadgol, Fereshteh Golab, Majid Katebi, Amir Hossein Abdolghaffari, Mohammad Hosein Farzaei, Mohammad Abdollah. Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411012. |
the ubiquitin-proteasome system (ups) is a non-lysosomal proteolytic pathway involved in numerous normal functions of the nervous system, modulation of neurotransmitter release, synaptic plasticity, and recycling of membrane receptors or degradation of damaged and regulatory intracellular proteins. |
2020-09-28 |
2023-08-13 |
Not clear |
| María Pilar Madrigal, Adrián Portalés, María Pérez SanJuan, Sandra Jurad. Postsynaptic SNARE Proteins: Role in Synaptic Transmission and Plasticity. Neuroscience. vol 420. 2020-09-22. PMID:30458218. |
traditionally recognized as major players in regulating presynaptic neurotransmitter release, accumulative evidence over recent years has identified several snare proteins implicated in important postsynaptic processes such as neurotransmitter receptor trafficking and synaptic plasticity. |
2020-09-22 |
2023-08-13 |
Not clear |
| Na-Ryum Bin, Mengjia Huang, Shuzo Sugit. Investigating the Role of SNARE Proteins in Trafficking of Postsynaptic Receptors using Conditional Knockouts. Neuroscience. vol 420. 2020-09-22. PMID:30481567. |
trafficking or delivery of neurotransmitter receptors on postsynaptic membranes is critical for basal neurotransmission and synaptic plasticity. |
2020-09-22 |
2023-08-13 |
Not clear |
| Alessandro Didonna, Puneet Opa. The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31097008. |
nfs belong to the family of cytoskeletal intermediate filament proteins (ifs) that give cells their shape; they determine axonal caliber, which controls signal conduction; and they regulate the transport of synaptic vesicles and modulate synaptic plasticity by binding to neurotransmitter receptors. |
2020-06-23 |
2023-08-13 |
Not clear |
| Samantha E Yohn, Jordan Galbraith, Erin S Calipari, P Jeffrey Con. Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway. ACS chemical neuroscience. vol 10. issue 5. 2020-05-21. PMID:30933466. |
group i metabotropic glutamate receptors (mglus) are highly expressed in the mesolimbic pathway and are poised in key positions to modulate disruptions in synaptic plasticity and neurotransmitter release observed in drug addiction, obesity, and bed. |
2020-05-21 |
2023-08-13 |
Not clear |
| C Andrew Frank, Thomas D James, Martin Mülle. Homeostatic control of Drosophila neuromuscular junction function. Synapse (New York, N.Y.). vol 74. issue 1. 2020-05-05. PMID:31556149. |
the neuromuscular junction (nmj) of drosophila melanogaster has provided a wealth of molecular information about how synapses implement homeostatic forms of synaptic plasticity, with a focus on the transsynaptic, homeostatic modulation of neurotransmitter release. |
2020-05-05 |
2023-08-13 |
drosophila_melanogaster |
| Steven J Girdler, Jamie E Confino, Mary E Woesne. Exercise as a Treatment for Schizophrenia: A Review. Psychopharmacology bulletin. vol 49. issue 1. 2020-03-30. PMID:30858639. |
although no clear etiology of schizophrenia has been discovered, many factors have been identified that contribute to the development of the disease, such as neurotransmitter alterations, decreased synaptic plasticity, and diminished hippocampal volume. |
2020-03-30 |
2023-08-13 |
Not clear |
| Gregg W Crabtree, Joseph A Gogo. Role of Endogenous Metabolite Alterations in Neuropsychiatric Disease. ACS chemical neuroscience. vol 9. issue 9. 2019-12-11. PMID:30044078. |
here we discuss this disease concept in the context of our recent findings demonstrating that neural dysfunction arising from accumulation of the schizophrenia-associated metabolite l-proline is due to its structural mimicry of the neurotransmitter gaba that leads to alterations in gaba-ergic short-term synaptic plasticity. |
2019-12-11 |
2023-08-13 |
human |
| Giovanna Cenini, Ana Lloret, Roberta Cascell. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative medicine and cellular longevity. vol 2019. 2019-12-11. PMID:31210837. |
neurons rely almost exclusively on the mitochondria, which produce the energy required for most of the cellular processes, including synaptic plasticity and neurotransmitter synthesis. |
2019-12-11 |
2023-08-13 |
human |
| Elena G Bochukova, Katherine Lawler, Sophie Croizier, Julia M Keogh, Nisha Patel, Garth Strohbehn, Kitty K Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G Bouret, Vincent Plagnol, I Sadaf Farooq. A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome. Cell reports. vol 22. issue 13. 2019-11-05. PMID:29590610. |
downregulated genes are expressed mainly in neuronal cells and contribute to neurogenesis, neurotransmitter release, and synaptic plasticity, while upregulated, predominantly microglial genes are involved in inflammatory responses. |
2019-11-05 |
2023-08-13 |
mouse |
| Na-Ryum Bin, Ke Ma, Hidekiyo Harada, Chi-Wei Tien, Fiona Bergin, Kyoko Sugita, Thomas T Luyben, Masahiro Narimatsu, Zhengping Jia, Jeffrey L Wrana, Philippe P Monnier, Liang Zhang, Kenichi Okamoto, Shuzo Sugit. Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons. Cell reports. vol 23. issue 10. 2019-10-31. PMID:29874582. |
trafficking of neurotransmitter receptors on postsynaptic membranes is critical for basal neurotransmission and synaptic plasticity, yet the underlying mechanisms remain elusive. |
2019-10-31 |
2023-08-13 |
mouse |
| Igor Delvendahl, Martin Mülle. Homeostatic plasticity-a presynaptic perspective. Current opinion in neurobiology. vol 54. 2019-08-22. PMID:30384022. |
we discuss php in the context of basic mechanisms controlling neurotransmitter release, highlight emerging similarities between different synapses in different species, and summarize new insights into the molecular mechanisms underlying this evolutionary conserved form of synaptic plasticity. |
2019-08-22 |
2023-08-13 |
Not clear |
| Lenka Schorova, Marie Pronot, Gwénola Poupon, Marta Prieto, Alessandra Folci, Anouar Khayachi, Frédéric Brau, Frédéric Cassé, Carole Gwizdek, Stéphane Marti. The synaptic balance between sumoylation and desumoylation is maintained by the activation of metabotropic mGlu5 receptors. Cellular and molecular life sciences : CMLS. vol 76. issue 15. 2019-07-30. PMID:30904951. |
sumoylation is a reversible post-translational modification essential to the modulation of neuronal function, including neurotransmitter release and synaptic plasticity. |
2019-07-30 |
2023-08-13 |
Not clear |
| T A Prokhorova, I S Boksha, O K Savushkina, E B Tereshkina, G Sh Burbaev. [α-Klotho protein in neurodegenerative and mental diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 119. issue 1. 2019-06-04. PMID:30778037. |
basing on the analysis of contemporary literature, the authors summarized the results of model experiments and a few clinical trials (in psychiatry and neurology) indicating the role of α-klotho protein in the brain processes of neurogenesis, dendrite growth, myelination (oligodendroglia differentiation and activity), regulation of antioxidant system, and synthesis of glutamate neurotransmitter system components, regulation of the activity and synthesis of ion channel protein components and membrane transporters, synaptic plasticity. |
2019-06-04 |
2023-08-13 |
Not clear |
| Xueyong Wang, J Michael McIntosh, Mark M Ric. Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 7. 2019-06-03. PMID:29326174. |
block of neurotransmitter receptors at the neuromuscular junction (nmj) has been shown to trigger upregulation of the number of synaptic vesicles released (quantal content, qc), a response termed homeostatic synaptic plasticity. |
2019-06-03 |
2023-08-13 |
mouse |