| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuang Qi, Yuan Yuan, Wen Yang, Jing-Yang Su, Li-Ying Ha. [Calcium Dyshomeostasis and Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 4. 2024-09-02. PMID:39223024. |
alzheimer's disease (ad) is a common neurodegenerative disease with the main manifestations of progressive cognitive dysfunction,behavioral disorders,and gradual decline of living ability.the etiology of ad is complex,and the pathogenesis of this disease remains controversial.calcium signaling plays an important role in regulating neuronal activities,including neurotransmitter release,synaptic plasticity,memory storage,and neuronal apoptosis.increasing studies have shown that neuronal calcium dyshomeostasis is a major pathological factor in the occurrence and development of ad.this article reviews the role and research progress in intracellular calcium dyshomeostasis in ad,including the relationship between calcium homeostasis and amyloid β,the role of calcium/calmodulin-dependent protein kinases in tau phosphorylation,calcium signaling pathways,the relationship between calcium homeostasis and mitochondrial function,autophagy,and neuroinflammation. |
2024-09-02 |
2024-09-05 |
Not clear |
| Giorgia Scarpellino, Valentina Brunetti, Roberto Berra-Romani, Giovambattista De Sarro, Germano Guerra, Teresa Soda, Francesco Mocci. The Unexpected Role of the Endothelial Nitric Oxide Synthase at the Neurovascular Unit: Beyond the Regulation of Cerebral Blood Flow. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201757. |
nitric oxide (no) is a highly versatile gasotransmitter that has first been shown to regulate cardiovascular function and then to exert tight control over a much broader range of processes, including neurotransmitter release, neuronal excitability, and synaptic plasticity. |
2024-08-29 |
2024-09-04 |
Not clear |
| Katalin Schlett, Carlos O Oueslati Morales, Norbert Bencsik, Angelika Hausse. Getting smart - Deciphering the neuronal functions of protein kinase D. Biochimica et biophysica acta. Molecular cell research. 2024-08-15. PMID:39147241. |
in the nervous system, pkd has been shown to be involved in learning and memory formation by regulating neurotransmitter release, neurite outgrowth and dendrite development, synapse formation and synaptic plasticity. |
2024-08-15 |
2024-08-18 |
Not clear |
| Qian Huang, Hiu Ham Lee, Bryan Volpe, Qingchen Zhang, Chang Xue, Brian C Liu, Yahia R Abuhasan, Lingyun Li, Jeremy S Yang, Julie Egholm, Cristina Gutierrez-Vazquez, Allen Li, Alyssa Lee, Sharon Tang, Chun Wa Wong, Tiemin Liu, Yuan Huang, Raddy L Ramos, Randy F Stout, Abdelfattah El Ouaamari, Francisco J Quintana, Bradford B Lowell, C Ronald Kahn, Emmanuel N Pothos, Weikang Ca. Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward. Molecular psychiatry. 2024-08-09. PMID:39122778. |
astrocytes are multi-functional glial cells in the central nervous system that play critical roles in modulation of metabolism, extracellular ion and neurotransmitter levels, and synaptic plasticity. |
2024-08-09 |
2024-08-13 |
mouse |
| Haley K Andersen, Duncan G Vardakas, Julie A Lamothe, Tannis E A Perault, Kenneth B Walsh, Robert B Laprairi. Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay. Scientific reports. vol 14. issue 1. 2024-08-07. PMID:39112591. |
the type 1 cannabinoid receptor (cb1r) mediates neurotransmitter release and synaptic plasticity in the central nervous system. |
2024-08-07 |
2024-08-10 |
Not clear |
| James Melros. CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity. Journal of neuroscience research. vol 102. issue 7. 2024-07-22. PMID:39034899. |
diverse cs, ks, and hspgs stabilize the blood-brain barrier and neurovascular unit, provide smart gel neurotransmitter neuron vesicle storage and delivery, organize the neuromuscular junction basement membrane, and provide motor neuron synaptic plasticity, and photoreceptor and neuron synaptic functions. |
2024-07-22 |
2024-07-24 |
Not clear |
| Ningning Guo, Xin Wang, Muran Xu, Jie Bai, Hao Yu, Le Zhan. PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression. Pharmacological research. 2024-07-11. PMID:38992850. |
numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. |
2024-07-11 |
2024-07-14 |
Not clear |
| Majid Zaki-Dizaji, Mohammad Foad Abazari, Hossein Razzaghi, Irene Shkolnikov, Brian R Christi. GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients. Brain, behavior, & immunity - health. vol 39. 2024-07-10. PMID:38983774. |
the metabotropic glutamate receptor 7 (mglur7) is a presynaptic g-protein-coupled glutamate receptor that modulates neurotransmitter release and synaptic plasticity at presynaptic terminals. |
2024-07-10 |
2024-07-12 |
Not clear |
| Mahdiyeh Hedayati-Moghadam, Fateme Razazpour, Mohammad Pourfridoni, Faezeh Mirzaee, Yousef Baghchegh. Ethanol's impact on the brain: a neurobiological perspective on the mechanisms of memory impairment. Molecular biology reports. vol 51. issue 1. 2024-06-25. PMID:38918289. |
key findings from the included studies shed light on the impact of ethanol on neurotransmitter systems, synaptic plasticity, and neuroinflammation in relation to memory impairment. |
2024-06-25 |
2024-06-29 |
Not clear |
| Sandilya Garemilla, Richa Kumari, Rahul Kuma. CDK5 as a therapeutic tool for the treatment of Alzheimer's Disease: A Review. European journal of pharmacology. 2024-06-20. PMID:38901526. |
we begin by elucidating the physiological functions of cdk5 in normal brain development and neuronal maintenance, highlighting its involvement in synaptic plasticity, neurotransmitter release, and cytoskeletal dynamics. |
2024-06-20 |
2024-06-23 |
Not clear |
| Sijing Li, Zijian Xia. Recent Research Progress on the Use of Transcranial Magnetic Stimulation in the Treatment of Vascular Cognitive Impairment. Neuropsychiatric disease and treatment. vol 20. 2024-06-17. PMID:38883416. |
next, the article explained the potential physiological mechanisms of tms in treating vci, particularly its role in promoting synaptic plasticity, regulating neurotransmitter balance, and improving the function of the default mode network. |
2024-06-17 |
2024-06-19 |
Not clear |
| Liangye Ji, ZiJun Meng, Xiangjun Dong, Qunxian Wang, Yanshuang Jiang, Jie Zhang, Dongjie Hu, Shipeng Guo, Weihui Zhou, Weihong Son. ICA1 affects APP processing through the PICK1-PKCα signaling pathway. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-17. PMID:38884369. |
islet cell autoantigen 1 (ica1) is involved in autoimmune diseases and may affect synaptic plasticity as a neurotransmitter. |
2024-06-17 |
2024-06-19 |
mouse |
| Felipe Araujo Gouhie, Karina Oliveira Barbosa, Amanda Borges Rufino Cruz, Milena Mariana Wellichan, Tainá Montini Zampoll. Cognitive effects of piracetam in adults with memory impairment: A systematic review and meta-analysis. Clinical neurology and neurosurgery. vol 243. 2024-06-15. PMID:38878641. |
piracetam, a widely recognized nootropic drug, is hypothesized to enhance memory function through its influence on synaptic plasticity and neurotransmitter levels. |
2024-06-15 |
2024-06-18 |
Not clear |
| Marzieh Abdollahi, Jesus D Castaño, Jennifer Ben Salem, Francis Beaudr. Anandamide Modulates Thermal Avoidance in Caenorhabditis elegans Through Vanilloid and Cannabinoid Receptor Interplay. Neurochemical research. 2024-06-07. PMID:38847909. |
enrichment analysis unveiled significant involvement of ion homeostasis pathways, which are crucial for maintaining neuronal function and synaptic transmission, suggesting aea's impact on neurotransmitter release and synaptic plasticity. |
2024-06-07 |
2024-06-10 |
human |
| Pawan Faris, Doris Pischedda, Fulvia Palesi, Egidio D'Angel. New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment. Frontiers in cellular neuroscience. vol 18. 2024-05-27. PMID:38799988. |
we initially consider the major forebrain alterations in cias, addressing impairments in neurotransmitter systems, synaptic plasticity, and connectivity. |
2024-05-27 |
2024-05-31 |
Not clear |
| Fu-Li Zhang, Xiao-Ke Yang, Yu-Ting Qi, Si-Yu Tian, Wei-Hua Huan. Nanoelectrochemistry reveals how presynaptic neurons regulate vesicle release to sustain synaptic plasticity under repetitive stimuli. Chemical science. vol 15. issue 20. 2024-05-24. PMID:38784745. |
although there is a considerable body of knowledge on protein expression and receptor migration in different categories of synaptic plasticity, the contribution and impact of presynaptic vesicle release and neurotransmitter levels towards plasticity remain largely unclear. |
2024-05-24 |
2024-05-27 |
Not clear |
| Nengyin Xia, Lingyun Xu, Mengyuan Huang, Dengrui Xu, Yang Li, Haoming Wu, Zhinan Mei, Zejun Y. Neuroprotection of macamide in a mouse model of Alzheimer's disease involves Nrf2 signaling pathway and gut microbiota. European journal of pharmacology. vol 975. 2024-05-12. PMID:38734297. |
the animal experiments showed that m 18:2 prevented the scopolamine (scp)-induced cognitive impairment and neurotransmitter disorders, increased the positive rates of nrf2 and ho-1 in hippocampal ca1, improved the synaptic plasticity by maintaining synaptic morphology and increasing the synapse density. |
2024-05-12 |
2024-05-27 |
mouse |
| Lei Wang, Xiaoming Liu, Chenlu Zhu, Shouyi Wu, Zhilei Li, Lipeng Jing, Zhenchang Zhang, Yuhong Jing, Yonggang Wan. Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice. The journal of headache and pain. vol 25. issue 1. 2024-05-10. PMID:38724948. |
central sensitization refers to the enhanced response to sensory stimulation, which involves changes in neuronal excitability, synaptic plasticity, and neurotransmitter release. |
2024-05-10 |
2024-05-27 |
mouse |
| Arpna Srivastava, Priya Rajput, Manjari Tripathi, Poodipedi Sarat Chandra, Ramesh Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Jyotirmoy Banerjee, Aparna Banerjee Dixi. Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy. Molecular neurobiology. 2024-04-30. PMID:38687446. |
our findings reveal a molecular blueprint of altered protein networks in mtle brain and highlight dysregulated pathways and processes including altered cargo transport, neurotransmitter release from synaptic vesicles, synaptic plasticity, proteostasis, rna homeostasis, ion transport and transmembrane transport, cytoskeleton disorganization, metabolic and mitochondrial dysfunction, blood micro-particle function, extracellular matrix organization, immune response, neuroinflammation, and cell signaling. |
2024-04-30 |
2024-05-03 |
human |
| Junyu Wu, Xue Xu, Shifeng Zhang, Minping Li, Yuemin Qiu, Gengxin Lu, Zhihui Zheng, Haiwei Huan. Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation. Molecular neurobiology. 2024-04-30. PMID:38689145. |
notable molecular candidates implicated in this process include variations in ion channels and neurotransmitter profiles, as well as neuronal and synaptic plasticity, metabolic processes, and electrophysiological modifications. |
2024-04-30 |
2024-05-03 |
Not clear |