| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong Ho Lee, Jinu Lee, Kyu Yeong Choi, Regine Hepp, Jae-Youn Lee, Mi Kyung Lim, Mayumi Chatani-Hinze, Paul A Roche, Dong Goo Kim, Young Soo Ahn, Chul Hoon Kim, Katherine W Roch. Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 34. 2008-10-24. PMID:18715999. |
metabotropic glutamate receptors (mglurs) 1-8 are g protein-coupled receptors (gpcrs) that modulate excitatory neurotransmission, neurotransmitter release, and synaptic plasticity. |
2008-10-24 |
2023-08-12 |
Not clear |
| Berta Sunyer, Weifei Diao, Gert Lube. The role of post-translational modifications for learning and memory formation. Electrophoresis. vol 29. issue 12. 2008-09-15. PMID:18494028. |
ptms including phosphorylation of serine, threonine, and tyrosine are already well-documented to play a role for synaptic plasticity of the brain, neurotransmitter release, vesicle trafficking and synaptosomal or synaptosomal-associated proteins are substrates of a series of specific protein kinases and their counterparts, protein phosphatases. |
2008-09-15 |
2023-08-12 |
Not clear |
| Kristoffer Sahlholm, Daniel Marcellino, Johanna Nilsson, Kjell Fuxe, Peter Arhe. Differential voltage-sensitivity of D2-like dopamine receptors. Biochemical and biophysical research communications. vol 374. issue 3. 2008-09-05. PMID:18652803. |
agonist potency at some neurotransmitter receptors has been shown to be regulated by transmembrane voltage, a mechanism which has been suggested to play a crucial role in the regulation of neurotransmitter release by autoreceptors and in synaptic plasticity. |
2008-09-05 |
2023-08-12 |
human |
| D Häussinger, F Schlies. Pathogenetic mechanisms of hepatic encephalopathy. Gut. vol 57. issue 8. 2008-08-08. PMID:18628377. |
although the functional consequences of rna oxidation in this context remain to be established, these findings bear a potential biochemical explanation for the multiple alterations of neurotransmitter receptor systems and of synaptic plasticity. |
2008-08-08 |
2023-08-12 |
Not clear |
| Young Ho Suh, Kenneth A Pelkey, Gabriela Lavezzari, Paul A Roche, Richard L Huganir, Chris J McBain, Katherine W Roch. Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron. vol 58. issue 5. 2008-07-10. PMID:18549785. |
the presynaptic metabotropic glutamate receptor (mglur) mglur7 modulates excitatory neurotransmission by regulating neurotransmitter release and plays a critical role in certain forms of synaptic plasticity. |
2008-07-10 |
2023-08-12 |
mouse |
| Ayuko Sakane, Jun Miyoshi, Yoshimi Takai, Takuya Sasak. Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome. Methods in enzymology. vol 438. 2008-06-19. PMID:18413245. |
evidence is accumulating that rab3a plays a key role in neurotransmitter release and synaptic plasticity. |
2008-06-19 |
2023-08-12 |
mouse |
| Charles J Malemud, Andrew H Mille. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert opinion on therapeutic targets. vol 12. issue 2. 2008-03-13. PMID:18208366. |
peripheral inflammation in ra may influence neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, as well as growth factor production, which can modify neural circuitry and contribute to depression. |
2008-03-13 |
2023-08-12 |
Not clear |
| Masao Sugawar. Methodological aspects of in vitro sensing of L-glutamate in acute brain slices. Chemical record (New York, N.Y.). vol 7. issue 6. 2008-03-12. PMID:18050278. |
l-glutamate is a major amino acid neurotransmitter in the central neuronal system of the mammalian brain and plays a vital role in brain development, synaptic plasticity, neurotoxicity, and neuropathological disorders. |
2008-03-12 |
2023-08-12 |
Not clear |
| Souhayl Dahmani, Andrea Paris, Virginie Jannier, Lutz Hein, Danielle Rouelle, Jens Scholz, Pierre Gressens, Jean Mant. Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology. vol 108. issue 3. 2008-03-12. PMID:18292683. |
recent studies have emphasized the role of phosphorylated extracellular signal-regulated protein kinases (perk1 and 2) in coupling rapid events such as neurotransmitter release and receptor stimulation long-lasting changes in synaptic plasticity and cell survival. |
2008-03-12 |
2023-08-12 |
Not clear |
| Pietro Baldelli, Anna Fassio, Flavia Valtorta, Fabio Benfenat. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057210. |
synapsins (syns) are synaptic vesicle (sv) phosphoproteins that play a role in neurotransmitter release and synaptic plasticity by acting at multiple steps of exocytosis. |
2007-12-27 |
2023-08-12 |
mouse |
| Won Jin Cho, Aleksandar Jeremic, Huan Jin, Gang Ren, Bhanu P Jen. Neuronal fusion pore assembly requires membrane cholesterol. Cell biology international. vol 31. issue 11. 2007-12-18. PMID:17703958. |
cholesterol has been proposed to play a critical role in regulating neurotransmitter release and synaptic plasticity. |
2007-12-18 |
2023-08-12 |
Not clear |
| Z-Q D Xu, X Zhang, L Scot. Regulation of G protein-coupled receptor trafficking. Acta physiologica (Oxford, England). vol 190. issue 1. 2007-12-07. PMID:17428231. |
in this mini review, we will discuss some of the recent findings on the mechanisms that regulate gpcr trafficking, which include (i) large dense-core vesicle (ldcv)-associated gpcr delivery which could be a general cell biological mechanism for rapid modulation of membrane receptors in response to certain stimuli; (ii) lateral diffusion of gpcrs in the plasma membrane for rapid change of the number of neurotransmitter receptors during synaptic plasticity and (iii) constitutive internalization of gpcrs, that contributes to receptor resensitization and distribution, including axonal polarization. |
2007-12-07 |
2023-08-12 |
Not clear |
| Maria B Moretto, Bruna Boff, Jeferson Franco, Thais Posser, Thisa Maite Roessler, Diogo Onofre Souza, Cristina W Nogueira, Susana Wofchuk, Joao B T Roch. (45)Ca(2+) influx in rat brain: effect of diorganylchalcogenides compounds. Toxicological sciences : an official journal of the Society of Toxicology. vol 99. issue 2. 2007-11-29. PMID:17656489. |
in nervous tissue, the calcium (ca(2+)) release induces neurotransmitter exocytosis and synaptic plasticity in neurons and is essential for ca(2+) waves and oscillations in astrocytes. |
2007-11-29 |
2023-08-12 |
rat |
| Gwyneth Zai, Emanuela Mundo, John Strauss, Gregory W H Wong, James L Kenned. Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania. Bipolar disorders. vol 9. issue 5. 2007-11-07. PMID:17680923. |
brain-derived neurotrophic factor (bdnf) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. |
2007-11-07 |
2023-08-12 |
Not clear |
| Balapal S Basavarajapp. The endocannabinoid signaling system: a potential target for next-generation therapeutics for alcoholism. Mini reviews in medicinal chemistry. vol 7. issue 8. 2007-10-18. PMID:17692039. |
following release, endocannabinoids diffuse back to the presynaptic neuron where they act as short-range modulators of synaptic activity by altering neurotransmitter release and synaptic plasticity. |
2007-10-18 |
2023-08-12 |
mouse |
| Takashi Yamauch. [Molecular mechanism of learning and memory based on the research for Ca2+/calmodulin-dependent protein kinase II]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 127. issue 8. 2007-09-25. PMID:17666869. |
neuronal cam kinase ii regulates important neuronal functions, including neurotransmitter synthesis, neurotransmitter release, modulation of ion channel activity, cellular transport, cell morphology and neurite extension, synaptic plasticity, learning and memory, and gene expression. |
2007-09-25 |
2023-08-12 |
Not clear |
| Leah R Reznikov, Claudia A Grillo, Gerardo G Piroli, Ravi K Pasumarthi, Lawrence P Reagan, Jim Fade. Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561824. |
stress affects amygdalar synaptic plasticity and several neurotransmitter systems have been implicated in stress-mediated changes in the brain, including the glutamatergic system. |
2007-08-17 |
2023-08-12 |
rat |
| Wayne S Sossi. Isoform specificity of protein kinase Cs in synaptic plasticity. Learning & memory (Cold Spring Harbor, N.Y.). vol 14. issue 4. 2007-07-03. PMID:17404386. |
in particular, we have shown that distinct isoforms mediate distinct types of synaptic plasticity induced by the same neurotransmitter: the novel calcium-independent pkc apl ii is required for actions mediated by serotonin (5-ht) alone, while the classical calcium-dependent pkc apl i is required for actions mediated when 5-ht is coupled to activity. |
2007-07-03 |
2023-08-12 |
aplysia |
| Tony D Gover, Thaís H V Moreira, Joseph P Y Kao, Daniel Weinreic. Calcium homeostasis in trigeminal ganglion cell bodies. Cell calcium. vol 41. issue 4. 2007-06-18. PMID:17046058. |
in primary sensory afferent neurons, ca2+ plays a vital role in the regulation of cellular processes including receptor and synaptic plasticity, neurotransmitter and trophic factor release and gene regulation. |
2007-06-18 |
2023-08-12 |
Not clear |
| Mark M Rich, Peter Wenne. Sensing and expressing homeostatic synaptic plasticity. Trends in neurosciences. vol 30. issue 3. 2007-04-10. PMID:17267052. |
furthermore, it is important to recognize that at least two different mechanisms underlie changes in quantal amplitude during homeostatic synaptic plasticity: changes in both the number of postsynaptic receptors and loading of synaptic vesicles with neurotransmitter. |
2007-04-10 |
2023-08-12 |
Not clear |