| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard C Shelton, Andrew H Mille. Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Progress in neurobiology. vol 91. issue 4. 2010-10-08. PMID:20417247. |
this includes the observations that: (1) people with inflammatory diseases such as multiple sclerosis, cardiovascular disease, and psoriasis have elevated rates of depression; (2) many people administered inflammatory cytokines such as interferon alpha develop depression that is indistinguishable from depression in non-medically ill populations; (3) a significant proportion of depressed persons show upregulation of inflammatory factors such as il-6, c-reactive protein, and tnfalpha; (4) inflammatory cytokines can interact with virtually every pathophysiologic domain relevant to depression, including neurotransmitter metabolism, neuroendocrine function, and synaptic plasticity. |
2010-10-08 |
2023-08-12 |
Not clear |
| Karin Berg, Pål Puntervoll, Stig Valdersnes, Anders Goksøy. Responses in the brain proteome of Atlantic cod (Gadus morhua) exposed to methylmercury. Aquatic toxicology (Amsterdam, Netherlands). vol 100. issue 1. 2010-10-06. PMID:20701987. |
these proteins include the strongest up-regulated protein, pyridoxal kinase (essential for synthesis of several neurotransmitters), g protein (coupled to neurotransmitter receptors), nicotinamide phosphoribosyl-transferase (protection against axonal degeneration), dihydropyrimidinase-like 5 (or collapsin response mediator protein 5, crmp-5) (axon guidance and regeneration), septin (dendrite development), phosphatidylethanolamine binding protein (precursor for hippocampal cholinergic neurostimulating peptide) and protein phosphatase 1 (control of brain recovery by synaptic plasticity). |
2010-10-06 |
2023-08-12 |
Not clear |
| Ashok N Hegd. The ubiquitin-proteasome pathway and synaptic plasticity. Learning & memory (Cold Spring Harbor, N.Y.). vol 17. issue 7. 2010-09-20. PMID:20566674. |
the upp regulates neurotransmitter receptors, protein kinases, synaptic proteins, transcription factors, and other molecules critical for synaptic plasticity. |
2010-09-20 |
2023-08-12 |
human |
| Tobias Mittelstaedt, Elena Alvaréz-Baron, Susanne Schoc. RIM proteins and their role in synapse function. Biological chemistry. vol 391. issue 6. 2010-09-17. PMID:20370319. |
active zones are specialized areas of the plasma membrane in the presynaptic nerve terminal that mediate neurotransmitter release and synaptic plasticity. |
2010-09-17 |
2023-08-12 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Andrew E Barry, William K Cullen, Michael J Rowa. Alzheimer's disease amyloid beta-protein and synaptic function. Neuromolecular medicine. vol 12. issue 1. 2010-05-24. PMID:19757208. |
this review addresses the involvement of neurotransmitter intercellular signaling in mediating or modulating the synaptic plasticity disrupting actions of soluble a beta, with particular emphasis on the different roles of glutamatergic and cholinergic mechanisms. |
2010-05-24 |
2023-08-12 |
Not clear |
| Rui Liu, Sridhar Hannenhalli, Maja Buca. Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons. Genome biology. vol 10. issue 7. 2010-01-13. PMID:19570198. |
hundreds of proteins modulate neurotransmitter release and synaptic plasticity during neuronal development and in response to synaptic activity. |
2010-01-13 |
2023-08-12 |
Not clear |
| Sameera Dasari, Yukun Yua. Low level postnatal methylmercury exposure in vivo alters developmental forms of short-term synaptic plasticity in the visual cortex of rat. Toxicology and applied pharmacology. vol 240. issue 3. 2009-10-26. PMID:19664649. |
short-term synaptic plasticity (stp) is primarily related to changes in the probability of neurotransmitter release. |
2009-10-26 |
2023-08-12 |
rat |
| Zdenek Fisa. Phytocannabinoids and endocannabinoids. Current drug abuse reviews. vol 2. issue 1. 2009-10-12. PMID:19630737. |
activation of cannabinoid receptors on synaptic terminals results in regulation of ion channels, neurotransmitter release and synaptic plasticity. |
2009-10-12 |
2023-08-12 |
Not clear |
| Giuseppe Astarita, Jennifer Geaga, Faizy Ahmed, Daniele Piomell. Targeted lipidomics as a tool to investigate endocannabinoid function. International review of neurobiology. vol 85. 2009-09-10. PMID:19607960. |
in the brain, they regulate ion-channel activity and neurotransmitter release critical to biological processes such as synaptic plasticity and learning and memory. |
2009-09-10 |
2023-08-12 |
Not clear |
| Okunola Jeyifous, Clarissa L Waites, Christian G Specht, Sho Fujisawa, Manja Schubert, Eric I Lin, John Marshall, Chiye Aoki, Tharani de Silva, Johanna M Montgomery, Craig C Garner, William N Gree. SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Nature neuroscience. vol 12. issue 8. 2009-09-09. PMID:19620977. |
synaptic plasticity is dependent on the differential sorting, delivery and retention of neurotransmitter receptors, but the mechanisms underlying these processes are poorly understood. |
2009-09-09 |
2023-08-12 |
rat |
| Maaike Alaerts, Shana Ceulemans, Diego Forero, Lotte N Moens, Sonia De Zutter, Lien Heyrman, An-Sofie Lenaerts, Karl-Fredrik Norrback, Peter De Rijk, Lars-Göran Nilsson, Dirk Goossens, Rolf Adolfsson, Jurgen Del-Faver. Support for NRG1 as a susceptibility factor for schizophrenia in a northern Swedish isolated population. Archives of general psychiatry. vol 66. issue 8. 2009-08-11. PMID:19652122. |
neuregulin 1 (nrg1), a growth factor involved in neurodevelopment, myelination, neurotransmitter receptor expression, and synaptic plasticity, first joined the list of candidate genes for schizophrenia when a 7-marker haplotype at the 5' end of the gene (hap(ice)) was shown to be associated with the disorder in the icelandic population. |
2009-08-11 |
2023-08-12 |
Not clear |
| Guo-Rong Zhang, Meng Liu, Haiyan Cao, Lingxin Kong, Xiaodan Wang, Jennifer A O'Brien, Shuo-Chieh Wu, Robert G Cook, Alfred I Gelle. Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons. Hippocampus. vol 19. issue 5. 2009-06-08. PMID:18942114. |
pkc pathways are strong candidates for mediating the molecular changes that underlie spatial learning, as they play critical roles in neurotransmitter release and synaptic plasticity, including long-term potentiation (ltp) and long-term depression (ltd), and deletion of specific pkc genes results in deficits in learning. |
2009-06-08 |
2023-08-12 |
human |
| Julie A Kauer, Helen E Gibso. Hot flash: TRPV channels in the brain. Trends in neurosciences. vol 32. issue 4. 2009-06-04. PMID:19285736. |
here, we review evidence that trpv channels in the central nervous system might contribute to many basic neuronal functions including resting membrane potential, neurotransmitter release and synaptic plasticity. |
2009-06-04 |
2023-08-12 |
Not clear |
| Anna Francesconi, Ranju Kumari, R Suzanne Zuki. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295163. |
endocytic trafficking of neurotransmitter receptors is critical to neuronal signaling and activity-dependent synaptic plasticity. |
2009-04-13 |
2023-08-12 |
mouse |
| R I Westphalen, R S Gomez, H C Hemming. Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane. British journal of anaesthesia. vol 102. issue 3. 2009-03-20. PMID:19189985. |
activation of hippocampal nachrs stimulates the release of norepinephrine (ne), a neurotransmitter implicated in modulating hippocampal synaptic plasticity. |
2009-03-20 |
2023-08-12 |
Not clear |
| Adam J Rossano, Gregory T Macleo. Loading Drosophila nerve terminals with calcium indicators. Journal of visualized experiments : JoVE. issue 6. 2009-02-12. PMID:18997898. |
calcium plays many roles in the nervous system but none more impressive than as the trigger for neurotransmitter release, and none more profound than as the messenger essential for the synaptic plasticity that supports learning and memory. |
2009-02-12 |
2023-08-12 |
drosophila_melanogaster |
| Jillian Madine, Eleri Hughes, Andrew J Doig, David A Middleto. The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy. Molecular membrane biology. vol 25. issue 6-7. 2009-01-30. PMID:18949627. |
associations between the 140 amino acid protein alpha-synuclein (asyn) and presynaptic vesicles may play a role in maintaining synaptic plasticity and neurotransmitter release. |
2009-01-30 |
2023-08-12 |
Not clear |
| Karen F Neumann, Leonel Rojo, Leonardo P Navarrete, Gonzalo Farías, Paula Reyes, Ricardo B Maccion. Insulin resistance and Alzheimer's disease: molecular links & clinical implications. Current Alzheimer research. vol 5. issue 5. 2008-12-12. PMID:18855585. |
glucose homeostasis is critical for energy generation, neuronal maintenance, neurogenesis, neurotransmitter regulation, cell survival and synaptic plasticity. |
2008-12-12 |
2023-08-12 |
human |
| Zhao-Wen Wan. Regulation of synaptic transmission by presynaptic CaMKII and BK channels. Molecular neurobiology. vol 38. issue 2. 2008-11-24. PMID:18759010. |
in contrast, presynaptic camkii either enhances or inhibits neurotransmitter release and synaptic plasticity depending on experimental or physiological conditions and properties of specific synapses. |
2008-11-24 |
2023-08-12 |
Not clear |
| Tsutomu Iida, Hiroshi Egusa, Makio Saeki, Hirofumi Yatani, Yoshinori Kamisak. PICK1 binds to calcineurin B and modulates the NFAT activity in PC12 cells. Biochemical and biophysical research communications. vol 375. issue 4. 2008-10-27. PMID:18755154. |
in the central nervous system, calcineurin has been implicated in a number of ca2+-sensitive pathways, including the regulation of neurotransmitter release and modulation of synaptic plasticity. |
2008-10-27 |
2023-08-12 |
rat |