| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Rose Branch, John R Heple. Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. PloS one. vol 12. issue 9. 2017-10-18. PMID:28934222. |
regulator of g protein signaling 14 (rgs14) is a multifunctional scaffolding protein that integrates g protein and h-ras/mapkinase signaling pathways to regulate synaptic plasticity important for hippocampal learning and memory. |
2017-10-18 |
2023-08-13 |
rat |
| M Jiang, J Polepalli, L Y Chen, B Zhang, T C Südhof, R C Malenk. Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism. Molecular psychiatry. vol 22. issue 3. 2017-10-02. PMID:27217145. |
we inactivated neuroligins by stereotactic viral expression of cre-recombinase in hippocampal ca1 region pyramidal neurons at postnatal day 0 (p0) or day 21 (p21) and measured synaptic function, synaptic plasticity and spine numbers in acute hippocampal slices 2-3 weeks later. |
2017-10-02 |
2023-08-13 |
mouse |
| Hong-Tao Wang, Fu-Lian Huang, Zhao-Lan Hu, Wen-Juan Zhang, Xiao-Qing Qiao, Yan-Qing Huang, Ru-Ping Dai, Fang Li, Chang-Qi L. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092020. |
esi also decreased expression of hippocampal nmda receptor subunits, nr1, and ampa receptor subunits, glur1 and glur2, which are involved in synaptic plasticity, but it did not affect expression of psd95 and nr2b. |
2017-10-02 |
2023-08-13 |
rat |
| Ali Hummos, Satish S Nai. An integrative model of the intrinsic hippocampal theta rhythm. PloS one. vol 12. issue 8. 2017-09-29. PMID:28787026. |
the model was developed by matching biological data characterizing neuronal firing patterns, synaptic dynamics, short-term synaptic plasticity, neuromodulatory inputs, and the three-dimensional organization of the hippocampus. |
2017-09-29 |
2023-08-13 |
Not clear |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
we hypothesized that fgf21 prevented cognitive decline in obese-insulin resistant rats by improving hippocampal synaptic plasticity, dendritic spine density, brain mitochondrial function and brain fgf21 signaling as well as decreasing brain cell apoptosis. |
2017-09-26 |
2023-08-13 |
human |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
at the end of the treatment, cognitive function, metabolic parameters, pro-inflammatory markers, brain mitochondrial function, cell apoptosis, hippocampal synaptic plasticity, dendritic spine density and brain fgf21 signaling were determined. |
2017-09-26 |
2023-08-13 |
human |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
the results showed that vehicle-treated hfd-fed rats developed obese-insulin resistance and cognitive decline with impaired hippocampal synaptic plasticity, decreased dendritic spine density, brain mitochondrial dysfunction and increased brain cell apoptosis. |
2017-09-26 |
2023-08-13 |
human |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats. Hormones and behavior. vol 85. 2017-09-26. PMID:27566237. |
fgf21-treated obese-insulin resistant rats had improved peripheral insulin sensitivity, increased hippocampal synaptic plasticity, increased dendritic spine density, restored brain mitochondrial function, attenuated brain cells apoptosis and increased brain fgf21 signaling, leading to a prevention of cognitive decline. |
2017-09-26 |
2023-08-13 |
human |
| S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, A H Smith, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen, J R Nyengaard, T E Willnow, K Jensen, A Nykjae. SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Molecular psychiatry. vol 21. issue 12. 2017-09-21. PMID:27457814. |
here we report that hippocampal n-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in sorcs2-deficient mice. |
2017-09-21 |
2023-08-13 |
mouse |
| Adam Kassan, Junji Egawa, Zheng Zhang, Angels Almenar-Queralt, Quynh My Nguyen, Yasaman Lajevardi, Kaitlyn Kim, Edmund Posadas, Dilip V Jeste, David M Roth, Piyush M Patel, Hemal H Patel, Brian P Hea. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. Journal of neurophysiology. vol 117. issue 1. 2017-09-20. PMID:27832597. |
finally, syncav1 delivery to the hippocampus of cav-1 ko mice and cav-1 ko neurons in culture restored expression of disc1 and markers of synaptic plasticity. |
2017-09-20 |
2023-08-13 |
mouse |
| Piangkwan Sa-Nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicology and applied pharmacology. vol 333. 2017-09-20. PMID:28807765. |
however, only dapagliflozin improved hippocampal synaptic plasticity. |
2017-09-20 |
2023-08-13 |
rat |
| Xing-Hua Yue, Jia-Qing Tong, Zhao-Jun Wang, Jun Zhang, Xu Liu, Xiao-Jie Liu, Hong-Yan Cai, Jin-Shun Q. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Hormones and behavior. vol 83. 2017-09-07. PMID:27222435. |
we found that: (1) du-14 effectively attenuated the aβ1-42-induced cognitive deficits in spatial learning and memory of rats in morris water maze test; (2) du-14 prevented aβ1-42-induced decrease in the cholinergic theta rhythm of hippocampal local field potential (lfp) in the ca1 region; (3) du-14 protected hippocampal synaptic plasticity against aβ1-42-induced suppression of long term potentiation (ltp). |
2017-09-07 |
2023-08-13 |
rat |
| Beata Fuchsova, Anabel Alvarez Juliá, Hooriyah S Rizavi, Alberto Carlos Frasch, Ghanshyam N Pande. Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression. Neuroscience. vol 333. 2017-09-06. PMID:27474226. |
stress induces alterations at the level of structural and functional synaptic plasticity accompanied by reductions in size and activity of the hippocampus and the prefrontal cortex (pfc). |
2017-09-06 |
2023-08-13 |
human |
| Xin-Jia Han, Zhong-Shan Shi, Luo-Xing Xia, Li-Hui Zhu, Ling Zeng, Jun-Hua Nie, Zao-Cheng Xu, Yi-Wen Rua. Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia. Neuroscience. vol 327. 2017-08-31. PMID:27090818. |
changes in synaptic plasticity and expression of glutamate receptor subunits in the ca1 and ca3 areas of the hippocampus after transient global ischemia. |
2017-08-31 |
2023-08-13 |
rat |
| David J Clarke, Jordyn Stuart, Iain S McGregor, Jonathon C Arnol. Endocannabinoid dysregulation in cognitive and stress-related brain regions in the Nrg1 mouse model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 72. 2017-08-30. PMID:27521758. |
nrg1 application to hippocampal slices decreased 2-arachidonoylglycerol (2-ag) signalling and disrupted long-term depression, a form of synaptic plasticity critical to spatial learning. |
2017-08-30 |
2023-08-13 |
mouse |
| Weilin Liu, Jie Wu, Jia Huang, Peiyuan Zhuo, Yunjiao Lin, Lulu Wang, Ruhui Lin, Lidian Chen, Jing Ta. Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke. Neural plasticity. vol 2017. 2017-08-29. PMID:28116173. |
electroacupuncture regulates hippocampal synaptic plasticity via mir-134-mediated limk1 function in rats with ischemic stroke. |
2017-08-29 |
2023-08-13 |
rat |
| Weilin Liu, Jie Wu, Jia Huang, Peiyuan Zhuo, Yunjiao Lin, Lulu Wang, Ruhui Lin, Lidian Chen, Jing Ta. Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke. Neural plasticity. vol 2017. 2017-08-29. PMID:28116173. |
therefore, mir-134-mediated limk1 was involved in ea-induced hippocampal synaptic plasticity, which served as a contributor to improving learning and memory during the recovery stage of ischemic stroke. |
2017-08-29 |
2023-08-13 |
rat |
| Julien Gibon, Nicolas Unsain, Karine Gamache, Rhalena A Thomas, Andres De Leon, Aaron Johnstone, Karim Nader, Philippe Séguéla, Philip A Barke. The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27189977. |
hippocampal long-term depression (ltd) is an active form of synaptic plasticity that is necessary for consolidation of spatial memory, contextual fear memory, and novelty acquisition. |
2017-08-22 |
2023-08-13 |
mouse |
| Julien Gibon, Nicolas Unsain, Karine Gamache, Rhalena A Thomas, Andres De Leon, Aaron Johnstone, Karim Nader, Philippe Séguéla, Philip A Barke. The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27189977. |
in the present study, we examined the role of x-linked inhibitor of apoptosis (xiap), a putative endogenous casp inhibitor, in synaptic plasticity in the hippocampus. |
2017-08-22 |
2023-08-13 |
mouse |
| Xia Tian, Yanlin Liu, Guangwei Ren, Ling Yin, Xiaoyan Liang, Tao Geng, Heqin Dang, Rufeng A. Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. Brain research. vol 1650. 2017-08-21. PMID:27566063. |
resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity. |
2017-08-21 |
2023-08-13 |
rat |