| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B C Albensi, P G Sullivan, M B Thompson, S W Scheff, M P Mattso. Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739643. |
post-tbi administration of cyclosporin a, a compound that stabilizes mitochondrial function, resulted in a highly significant amelioration of the impairment of ltp and completely prevented the enhancement of ltd. our data suggest that alterations in hippocampal synaptic plasticity may be responsible for learning and memory deficits resulting from tbi and that agents such as cyclosporin a that stabilize mitochondrial function may be effective treatments for tbi. |
2000-05-23 |
2023-08-12 |
rat |
| C A Stewart, I C Rei. Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity. Psychopharmacology. vol 148. issue 3. 2000-04-27. PMID:10755734. |
repeated ecs and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity. |
2000-04-27 |
2023-08-12 |
rat |
| M Korte, L Minichiello, R Klein, T Bonhoeffe. Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation. Neuropharmacology. vol 39. issue 5. 2000-04-12. PMID:10699438. |
we found that homo- and heterozygous mutant mice show no difference in the induction-rate or magnitude of e-ltp and l-ltp induced by theta-burst or tetanus stimulation, suggesting that the shc-binding site in the trkb receptor and its downstream activated signaling cascade is not involved in hippocampal synaptic plasticity. |
2000-04-12 |
2023-08-12 |
mouse |
| Q S Chen, B L Kagan, Y Hirakura, C W Xi. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. Journal of neuroscience research. vol 60. issue 1. 2000-04-12. PMID:10723069. |
our findings demonstrated that subneurotoxic concentrations of abeta peptides could strongly suppress long-term synaptic plasticity in the hippocampus. |
2000-04-12 |
2023-08-12 |
rat |
| K Miyaguchi, Y Maeda, C Collin, R K Siha. Gene transfer into hippocampal slice cultures with an adenovirus vector driven by cytomegalovirus promoter: stable co-expression of green fluorescent protein and lacZ genes. Brain research bulletin. vol 51. issue 3. 2000-03-30. PMID:10718511. |
virus-mediated gene transfer into identified neurons of organotypic hippocampal slice cultures offers a great potential for studying the cellular and molecular mechanisms of synaptic plasticity. |
2000-03-30 |
2023-08-12 |
rat |
| Y Hayashi, S H Shi, J A Esteban, A Piccini, J C Poncer, R Malino. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science (New York, N.Y.). vol 287. issue 5461. 2000-03-30. PMID:10731148. |
to elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (ampa-rs) with an electrophysiological tag were expressed in rat hippocampal neurons. |
2000-03-30 |
2023-08-12 |
rat |
| R Gerlai, A McNamar. Anesthesia induced retrograde amnesia is ameliorated by ephrinA5-IgG in mice: EphA receptor tyrosine kinases are involved in mammalian memory. Behavioural brain research. vol 108. issue 2. 2000-03-21. PMID:10701657. |
recently, however, these proteins were shown to be expressed in the adult mouse brain, primarily in the hippocampus, and were implicated in hippocampal synaptic plasticity and learning. |
2000-03-21 |
2023-08-12 |
mouse |
| C Papatheodoropoulos, G Kostopoulo. Decreased ability of rat temporal hippocampal CA1 region to produce long-term potentiation. Neuroscience letters. vol 279. issue 3. 2000-03-17. PMID:10688058. |
these results suggest that a significant functional differentiation at the local synaptic plasticity level occurs between the two poles of hippocampus, which together with the substantial differences in their extrinsic connections, may help explain the reported differential participation of neurons in these parts of hippocampus during animal memory tests. |
2000-03-17 |
2023-08-12 |
rat |
| Y Nakagami, K Abe, N Nishiyama, N Matsuk. Laminin degradation by plasmin regulates long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684901. |
to explore the possibility that the pa-plasmin system regulates synaptic plasticity, we investigated the effect of plasmin on degradation of ecm and synaptic plasticity by using organotypic hippocampal cultures. |
2000-03-09 |
2023-08-12 |
Not clear |
| P R Blanque. Identification of two persistently activated neurotrophin-regulated pathways in rat hippocampus. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670437. |
brain-derived neurotrophic factor contributes profoundly to modulate activity-dependent synaptic plasticity in adult brain areas such as the hippocampus, but the mechanisms underlying this important role still remain unclear. |
2000-03-01 |
2023-08-12 |
rat |
| P R Blanque. Casein kinase 2 as a potentially important enzyme in the nervous system. Progress in neurobiology. vol 60. issue 3. 2000-02-25. PMID:10658642. |
at present, with respect to recent findings, four essential features suggest potentially important roles for this enzyme in specific neural functions: (1) ck2 is much more abundant in brain than in any other tissue; (2) there appear to be a myriad of substrates for ck2 in both synaptic and nuclear compartments that have clear implications in development, neuritogenesis, synaptic transmission, synaptic plasticity, information storage and survival; (3) ck2 seems to be associated with mechanisms underlying long-term potentiation in hippocampus; and (4) neurotrophins stimulate activity of ck2 in hippocampus. |
2000-02-25 |
2023-08-12 |
Not clear |
| A R Costenla, A de Mendonça, J A Ribeir. Adenosine modulates synaptic plasticity in hippocampal slices from aged rats. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642848. |
adenosine modulates synaptic plasticity in hippocampal slices from aged rats. |
2000-02-24 |
2023-08-12 |
rat |
| A R Costenla, A de Mendonça, J A Ribeir. Adenosine modulates synaptic plasticity in hippocampal slices from aged rats. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642848. |
adenosine is known to modulate synaptic plasticity in the hippocampus of young animals through activation of adenosine a1 receptors. |
2000-02-24 |
2023-08-12 |
rat |
| A R Costenla, A de Mendonça, J A Ribeir. Adenosine modulates synaptic plasticity in hippocampal slices from aged rats. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642848. |
the objective of the present study is to investigate whether the modulatory role of adenosine on phenomena of synaptic plasticity is maintained or modified in the hippocampus of aged animals. |
2000-02-24 |
2023-08-12 |
rat |
| D L Brody, D T Yu. Relief of G-protein inhibition of calcium channels and short-term synaptic facilitation in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 3. 2000-02-18. PMID:10648693. |
here, we provide evidence that such relief of inhibition contributes to short-term synaptic plasticity in microisland-cultured hippocampal neurons. |
2000-02-18 |
2023-08-12 |
human |
| B C Albensi, M P Mattso. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse (New York, N.Y.). vol 35. issue 2. 2000-02-17. PMID:10611641. |
evidence for the involvement of tnf and nf-kappab in hippocampal synaptic plasticity. |
2000-02-17 |
2023-08-12 |
mouse |
| B C Albensi, M P Mattso. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse (New York, N.Y.). vol 35. issue 2. 2000-02-17. PMID:10611641. |
because data indicate that tnf is produced, and nf-kappab activated, under conditions associated with learning and memory, we performed experiments in the hippocampal slice preparation aimed at elucidating roles for tnf and nf-kappab in modulating synaptic plasticity. |
2000-02-17 |
2023-08-12 |
mouse |
| B C Albensi, M P Mattso. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse (New York, N.Y.). vol 35. issue 2. 2000-02-17. PMID:10611641. |
collectively, these data suggest important roles for tnf and signaling pathways that modulate nf-kappab activity in regulation of hippocampal synaptic plasticity. |
2000-02-17 |
2023-08-12 |
mouse |
| M Good, M Day, J L Mui. Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594677. |
these findings are discussed with reference to: (i) the modulatory effects of oestrogen on n-methyl-d-aspartate (nmda) receptor function and gamma-aminobutyric acid (gaba) neurotransmission in the hippocampus; and (ii) the functional implications that such cyclical changes in synaptic plasticity have for learning and memory processes supported by the hippocampus. |
2000-02-10 |
2023-08-12 |
rat |
| M Zhuo, D M Holtzman, Y Li, H Osaka, J DeMaro, M Jacquin, G B. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632583. |
it has been reported that induction of tpa expression may contribute to activity-dependent synaptic plasticity in the hippocampus and cerebellum. |
2000-02-09 |
2023-08-12 |
mouse |