| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anatoly V Skalny, Michael Aschner, Abel Santamaria, Tommaso Filippini, Viktor A Gritsenko, Yousef Tizabi, Feng Zhang, Xiong Guo, Joao B T Rocha, Alexey A Tinko. The Role of Gut Microbiota in the Neuroprotective Effects of Selenium in Alzheimer's Disease. Molecular neurobiology. 2024-07-16. PMID:39012446. |
correspondingly, supplementation with various forms of se in cellular and animal models of ad was shown to reduce aβ formation, tau phosphorylation, reverse the decline in brain antioxidant levels, inhibit neuronal oxidative stress and proinflammatory cytokine production, improve synaptic plasticity and neurogenesis, altogether resulting in improved cognitive functions. |
2024-07-16 |
2024-07-18 |
Not clear |
| Li Lu, Anna M Kotowska, Stefanie Kern, Min Fang, Timothy R Rudd, Morgan R Alexander, David J Scurr, Zheying Zh. Metabolomic and Proteomic Analysis of ApoE4-Carrying H4 Neuroglioma Cells in Alzheimer's Disease Using OrbiSIMS and LC-MS/MS. Analytical chemistry. 2024-07-11. PMID:38989551. |
apolipoprotein e4 (apoe4) is one of the most significant genetic risk factors for alzheimer's disease (ad), which is not only associated with the ad pathological features such as amyloid-β deposition, phosphorylation of tau proteins, and neuroinflammation but is also involved in metabolism, neuron growth, and synaptic plasticity. |
2024-07-11 |
2024-07-13 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Najah R Hadi, Abdullah A Assiri, Mohammed Alrouji, Nermeen N Welson, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon. Cellular and molecular neurobiology. vol 44. issue 1. 2024-07-08. PMID:38977507. |
glucagon/glp-1 has been shown to promote synaptogenesis, hippocampal synaptic plasticity, and learning and memory, while attenuating amyloid and tau pathologies. |
2024-07-08 |
2024-07-12 |
Not clear |
| Jana Hroudová, Zdeněk Fiša. Alzheimer's disease approaches - Focusing on pathology, biomarkers and clinical trial candidates. Progress in neuro-psychopharmacology & biological psychiatry. 2024-06-25. PMID:38917881. |
the main targets of new drugs for ad are processes related to amyloid beta and tau neurotoxicity, neurotransmission, inflammation, metabolism and bioenergetics, synaptic plasticity, and oxidative stress. |
2024-06-25 |
2024-06-29 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Yin Yang, Qiancheng Zhang, Brian J Rodriguez, Michael J Rowa. Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 379. issue 1906. 2024-06-10. PMID:38853565. |
remarkably, the persistent disruption of synaptic plasticity by patient-derived brain tau was rapidly reversed by a single intracerebral injection of different anti-tau monoclonal antibodies, including one directed to a specific human tau amino acid sequence. |
2024-06-10 |
2024-06-14 |
human |
| Magham Sai Varshini, Ramakkamma Aishwarya Reddy, Praveen Thaggikuppe Krishnamurth. Unlocking Hope: GSK-3 Inhibitors and Wnt Pathway Activation in Alzheimer's Therapy. Journal of drug targeting. 2024-06-05. PMID:38838023. |
the modulation of wnt signaling appears to have multifaceted benefits including the reduction of amyloid-β production, tau hyperphosphorylation, enhancement of synaptic plasticity, and inhibition of neuroinflammation. |
2024-06-05 |
2024-06-08 |
Not clear |
| Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioe. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease. Science (New York, N.Y.). vol 384. issue 6699. 2024-05-30. PMID:38815015. |
in amyloid-β and tau-driven mouse models of disease, res19-t agents restored synaptic plasticity, normalized brain network activity, and attenuated the development of both amyloid-β and tau pathology. |
2024-05-30 |
2024-06-14 |
mouse |
| Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na W. Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-04-29. PMID:38682858. |
then, immunohistochemistry, western blotting and elisa were used to detect aβ deposition, tau phosphorylation and neuroinflammation, and electrophysiological and wheel-running activity recording were recorded to observe hippocampal synaptic plasticity and circadian rhythm. |
2024-04-29 |
2024-05-02 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
besides its role in stabilizing microtubules, tau is localized at postsynaptic sites and can regulate synaptic plasticity. |
2024-03-29 |
2024-04-01 |
mouse |
| Margrethe A Olesen, Eugenia Pradenas, Francisca Villavicencio-Tejo, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging. Free radical biology & medicine. 2024-03-29. PMID:38552927. |
we previously showed that caspase-3 cleaved tau, a relevant tau form in alzheimer's disease (ad), affects mitochondrial bioenergetics, dynamics and synaptic plasticity by the opening of mitochondrial permeability transition pore (mptp). |
2024-03-29 |
2024-04-01 |
mouse |
| Chun Yuen Jerry Wong, Alberto Baldelli, Camilla M Hoyos, Ole Tietz, Hui Xin Ong, Daniela Train. Insulin Delivery to the Brain via the Nasal Route: Unraveling the Potential for Alzheimer's Disease Therapy. Drug delivery and translational research. 2024-03-05. PMID:38441832. |
notably, intranasal insulin has shown neuroprotective effects, impacting aβ clearance, tau phosphorylation, and synaptic plasticity. |
2024-03-05 |
2024-03-07 |
Not clear |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. |
2024-03-04 |
2024-03-06 |
Not clear |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
the aim of this study is to show the relationship between the change in the strengthening of synaptic plasticity and tau phosphorylation and tau-kinases and phosphatase. |
2024-03-04 |
2024-03-06 |
Not clear |
| Burak Tan, Esra Tufan, Özlem Barutçu, Ezgi Aslan-Gülpınar, Nurcan Dursun, Cem Süe. Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity. Physiology international. 2024-03-04. PMID:38436684. |
if the increase in phosphorylation of tau cannot be prevented, together with inhibition of the subsequent ltp, this may indicate that the physiological role of hyperphosphorylated tau in synaptic plasticity may extend to pathological processes. |
2024-03-04 |
2024-03-06 |
Not clear |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. vol 134. issue 3. 2024-02-01. PMID:38299587. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2024-02-01 |
2024-02-03 |
mouse |
| Daniel P Chapman, Sarah D Power, Stefano Vicini, Tomás J Ryan, Mark P Burn. Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-01-16. PMID:38228367. |
in sham mice the hippocampal engram neurons exhibited synaptic plasticity, evident in amplified ampa:nmda ratio, enhanced ampa-weighted tau, and increased dendritic spine volume compared to non-engram neurons. |
2024-01-16 |
2024-01-19 |
mouse |
| Hana Baek, Sanjay, Miey Park, Hae-Jeung Le. Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model. Journal of neuroinflammation. vol 20. issue 1. 2023-11-18. PMID:37978414. |
however, as the effects of c3g on the amyloidogenic pathway, autophagy, tau phosphorylation, neuronal cell death, and synaptic plasticity in alzheimer's disease models have not been reported, we attempted to investigate the same in the brains of appswe/ps1Δe9 mice were analyzed. |
2023-11-18 |
2023-11-20 |
mouse |
| Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Ca. High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy. Experimental neurology. 2023-10-28. PMID:37898395. |
hfd may reduce synaptic plasticity and cause tau hyperphosphorylation, but the mechanisms involved remain unclear. |
2023-10-28 |
2023-11-08 |
mouse |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |
| Pinky, Neha, Mubashshir Ali, Prachi Tiwari, Mohammad Mumtaz Alam, Haroonrashid M Hattiwale, Azfar Jamal, Suhel Parve. Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer's Disease: Critical role of the restoration of neuronal circuits. Ageing research reviews. 2023-09-11. PMID:37696304. |
increasing evidence suggests that ros may affect many pathological aspects of ad, including aβ accumulation, tau hyperphosphorylation, synaptic plasticity, and mitochondrial dysfunction, which may collectively result in neurodegeneration in the brain. |
2023-09-11 |
2023-10-07 |
Not clear |