| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Sool Shim, Ken Berglund, Shan Ping Y. Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia. Neuro-degenerative diseases. 2023-09-04. PMID:37666228. |
the diverse lines of evidence have revealed that lithium reduces amyloid and tau pathology, attenuates neuronal loss, enhances synaptic plasticity and improves cognitive function. |
2023-09-04 |
2023-09-07 |
Not clear |
| Yaoyao Ren, Shengtao Q. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023-08-24. PMID:37619620. |
these isoflavones prevent a\xce\xb2 aggregation, inhibit tau hyperphosphorylation, increase cholinergic neurotransmitter levels, reduce neuroinflammation and oxidative stress, improve synaptic plasticity, promote nerve regeneration, and prevent apoptosis. |
2023-08-24 |
2023-09-07 |
Not clear |
| Faisal Holil AlAnazi, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Mohamed H Mazhar Ashour, Saud A Alnaaim, Omnya Elhussieny, Hebatallah M Saad, Gaber El-Saber Batih. Primary Hypothyroidism and Alzheimer's Disease: A Tale of Two. Cellular and molecular neurobiology. 2023-08-04. PMID:37540395. |
hpt promotes the progression of ad by inducing the production of amyloid beta (a\xce\xb2) and tau protein phosphorylation with the development of synaptic plasticity and memory dysfunction. |
2023-08-04 |
2023-08-14 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, R\\xc3\\xb3is\\xc3\\xadn Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and A\\xc3\\x9f in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
here, we explore how intracerebral injection of a\xc3\x9f and tau present in such aqueous extracts of patient brain contribute to disruption of synaptic plasticity in the ca1 area of the male rat hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, R\\xc3\\xb3is\\xc3\\xadn Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and A\\xc3\\x9f in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
these findings support a critical role for diffusible tau in causing rapid onset, persistent synaptic plasticity deficits and in promoting a\xc3\x9f-mediated synaptic dysfunction. |
2023-07-25 |
2023-08-14 |
rat |
| Junkai Xie, Shichen Wu, Hailey Szadowski, Sehong Min, Yang Yang, Aaron B Bowman, Jean-Christophe Rochet, Jennifer L Freeman, Chongli Yua. Developmental Pb exposure increases AD risk via altered intracellular Ca The Journal of biological chemistry. 2023-07-09. PMID:37423307. |
differentiated neurons exhibit altered calcium homeostasis, synaptic plasticity, epigenetic landscape along with elevated ad-like pathogenesis markers, including phosphorylated tau, tau aggregates and a\xce\xb242/40. |
2023-07-09 |
2023-08-14 |
human |
| Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-\\xce\\xb2 aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
however, the drug seems to alleviate the key alzheimer-like phenotypes induced by a\xce\xb2 aggregation as we found attenuated neuroinflammation, improved post-synaptic density expression, associated with synaptic plasticity, and decreased phosphorylated tau levels. |
2023-07-05 |
2023-08-14 |
mouse |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in alzheimer's disease (ad) and related tauopathies. |
2023-07-03 |
2023-08-14 |
mouse |
| Grant Kauwe, Kristeen A Pareja-Navarro, Lei Yao, Jackson H Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T Grinberg, William W Seeley, Joel H Kramer, Todd C Sacktor, Birgit Schilling, Li Gan, Kaitlin B Casaletto, Tara E Trac. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398236. |
instead, we find that ct-kibra binds to and stabilizes protein kinase m\xce\xb6 (pkm\xce\xb6) to maintain synaptic plasticity and memory despite tau mediated pathogenesis. |
2023-07-03 |
2023-08-14 |
mouse |
| Bakhtiarzadeh Fatemeh, Shahpasand Koorosh, Shojaei Amir, Fathollahi Yaghoub, Mirnajafi-Zadeh Java. Intra-hippocampal cis-P tau microinjection induces long-term changes in behavior and synaptic plasticity in mice. Behavioral and brain functions : BBF. vol 19. issue 1. 2023-05-25. PMID:37231523. |
intra-hippocampal cis-p tau microinjection induces long-term changes in behavior and synaptic plasticity in mice. |
2023-05-25 |
2023-08-14 |
mouse |
| Maya Jammoul, Dareen Jammoul, Kevin K Wang, Firas Kobeissy, Ralph G Depalm. Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century. Biological psychiatry. 2023-05-22. PMID:37217015. |
we examine the hypothesis that a tbi "first hit" induces a neuroinflammatory process involving microglial priming, which upon a "second hit"-related to opioid exposure-, exacerbates neuroinflammation, modifies synaptic plasticity, and spreads tau aggregates to promote neurodegeneration. |
2023-05-22 |
2023-08-14 |
Not clear |
| Carola Tapia-Monsalves, Margrethe A Olesen, Francisca Villavicencio-Tejo, Rodrigo A Quintanill. Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3. Molecular and cellular neurosciences. 2023-05-14. PMID:37182572. |
these tau forms affect synaptic plasticity contributing to the cognitive decline observed in the early stages of ad. |
2023-05-14 |
2023-08-14 |
mouse |
| Alba Clara Fern\\xc3\\xa1ndez-Rilo, Nicola Forte, Letizia Palomba, Lea Tunisi, Fabiana Piscitelli, Roberta Imperatore, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristin. Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity. Molecular metabolism. 2023-03-28. PMID:36977433. |
here, we investigated the hypothesis that, under acute (6h fasting in wt mice) or chronic (in ob/ob mice) hypothalamic leptin signaling reduction, ox-a-induced enhancement of 2-ag levels leads to the production of the 2-ag-derived 2-arachidonoyl-sn-glycerol-3-phosphate (2-agp), a bioactive lipid belonging to the class of lysophosphatidic acids (lpas), which then regulates hypothalamic synaptic plasticity by disassembling \xce\xb1-msh anorexigenic inputs via gsk-3\xce\xb2-mediated tau phosphorylation, ultimately affecting food intake. |
2023-03-28 |
2023-08-14 |
mouse |
| Irep Uras, Merve Karayel-Basar, Betul Sahin, Ahmet Tarik Bayka. Detection of early proteomic alterations in 5xFAD Alzheimer's disease neonatal mouse model via MALDI-MSI. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-19. PMID:36934297. |
ad is considered a multifactorial disorder where multiple processes like amyloid-beta and tau accumulation, axonal degeneration, synaptic plasticity, and autophagic processes plays an important role. |
2023-03-19 |
2023-08-14 |
mouse |
| Valentina Latina, Margherita De Introna, Chiara Caligiuri, Alessia Loviglio, Rita Florio, Federico La Regina, Annabella Pignataro, Martine Ammassari-Teule, Pietro Calissano, Giuseppina Amador. Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36839831. |
we found out that non-invasive administration of 12 a12mab markedly reduced the pathological accumulation of both truncated tau and a\xce\xb2 in the v1 area, correlated to significant improvement in visual recognition memory performance along with local increase in two direct readouts of cortical synaptic plasticity, including the dendritic spine density and the expression level of activity-regulated cytoskeleton protein arc/arg3.1. |
2023-02-25 |
2023-08-14 |
mouse |
| Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na W. Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid \\xce\\xb2 metabolism. Neurobiology of aging. vol 124. 2023-02-09. PMID:36758468. |
in the present study, the effects of oxa on cognitive functions, synaptic plasticity, a\xce\xb2 levels, tau hyperphosphorylation, bace1 and nep expression, and circadian locomotor rhythm were evaluated. |
2023-02-09 |
2023-08-14 |
mouse |
| Dilek Mercan, Michael Thomas Henek. The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease. Biology. vol 11. issue 12. 2022-12-23. PMID:36552331. |
since the lc is the main source of noradrenaline (na) in the brain, degeneration of the lc in ad leads to decreased na levels, causing increased neuroinflammation, enhanced amyloid and tau burden, decreased phagocytosis and impairment in cognition and long-term synaptic plasticity. |
2022-12-23 |
2023-08-14 |
Not clear |
| Itzhak Fische. Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533137. |
tau plays important roles in modulating microtubule dynamics, axonal transport, synaptic plasticity, and dna repair, and has also been associated with neurodegenerative diseases (tauopathies) including alzheimer's disease and frontotemporal dementia. |
2022-12-19 |
2023-08-14 |
human |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
brain cells becoming resistant to insulin leads to elevated blood glucose levels, impaired synaptic plasticity, microglial overactivation, mitochondrial dysfunction, neuronal apoptosis, nutrient deprivation, tau (tubulin-associated unit) phosphorylation, and cholinergic dysfunction. |
2022-12-11 |
2023-08-14 |
Not clear |
| Nastaran Karimi, Feyza Bayram \\xc3\\x87atak, Ebru Arslan, Amene Saghazadeh, Nima Rezae. Tau immunotherapy in Alzheimer's disease and progressive supranuclear palsy. International immunopharmacology. vol 113. issue Pt B. 2022-11-21. PMID:36410182. |
tau contributes to the synaptic plasticity of axons; hyperphosphorylated and aggregated tau have been shown to increase the likelihood of cognitive impairments. |
2022-11-21 |
2023-08-14 |
Not clear |