| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayder M Al-Kuraishy, Ghassan M Sulaiman, Hamdoon A Mohammed, Salim Albukhaty, Ali K Albuhadily, Ali I Al-Gareeb, Daniel J Klionsky, Mosleh M Abomughai. The Compelling Role of Brain-Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators. CNS neuroscience & therapeutics. vol 30. issue 12. 2024-12-10. PMID:39654365. |
through activation of ntrk2/trkb (neurotrophic receptor tyrosine kinase 2), bdnf promotes neuronal survival, synaptic plasticity, and neuronal growth, whereas it inhibits microglial activation and the release of pro-inflammatory cytokines. |
2024-12-10 |
2024-12-12 |
Not clear |
| Xiaoping Zhu, Shengnan Han, Yulu Geng, Wenzhi Ren, Fushi Qua. Brain-Derived Neurotrophic Factor-TrkB Pathway on Synaptic Plasticity in Ischemic Stroke Rats. International heart journal. vol 65. issue 6. 2024-12-01. PMID:39617500. |
in this study, a rat cerebral ischemiareperfusion (middle cerebral artery occlusion) model was established, and the reliability of this model was determined.the expression changes of key proteins of the bdnf trkb pathway and synaptic plasticity markers (syp, psd-95, and map-2) were detected at different time points.the results showed that bdnf expression increased rapidly in the acute phase, and the expression of synaptic plasticity markers decreased, and blocking the bdnf-trkb pathway with the specific blocker k252a also had a significant effect.this suggests that changes in the bdnf-trkb signaling pathway can affect the synaptic plasticity in nerve cells of stroke patients. |
2024-12-01 |
2024-12-06 |
human |
| Nicola Mottolese, Manuela Loi, Stefania Trazzi, Marianna Tassinari, Beatrice Uguagliati, Giulia Candini, Khalid Iqbal, Giorgio Medici, Elisabetta Cian. Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder. Journal of neurodevelopmental disorders. vol 16. issue 1. 2024-11-27. PMID:39592934. |
p021, a tetra-peptide derived from the biologically active region of the human ciliary neurotrophic factor (cntf), was found to enhance neurogenesis and synaptic plasticity by promoting an increase in bdnf expression in preclinical models of brain disorders, such as alzheimer's disease and down syndrome, resulting in a beneficial therapeutic effect. |
2024-11-27 |
2024-11-29 |
mouse |
| Soomin Jeong, Charles K Davis, Raghu Vemugant. Mechanisms of time-restricted feeding-induced neuroprotection and neuronal plasticity in ischemic stroke as a function of circadian rhythm. Experimental neurology. vol 383. 2024-11-10. PMID:39510297. |
animal studies show that trf enhances brain-derived neurotrophic factor (bdnf) signaling and regulates autophagy and neuroinflammation, supporting synaptic plasticity, neurogenesis and neuroprotection. |
2024-11-10 |
2024-11-16 |
Not clear |
| In-Ae Choi, Ji Hee Yun, Jongmin Lee, Dong-Hee Cho. Neuropeptide FF Promotes Neuronal Survival and Enhances Synaptic Protein Expression Following Ischemic Injury. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519132. |
post-injury rnpff treatment led to a significant upregulation of pro-brain-derived neurotrophic factor (bdnf) and mature bdnf, which play critical roles in neuronal survival, growth, and synaptic plasticity. |
2024-11-09 |
2024-11-17 |
Not clear |
| Annabell Jäger, Anima Pieper, Kathlen Priebe, Rainer Hellweg, Kristina Meyer, Sarah Herrmann, Bernd Wolfarth, Maximilian Grummt, Andreas Ströhle, Nikola Schoof. Effects of high intensity interval training on serum brain-derived neurotrophic factor in individuals with PTSD. Journal of psychiatric research. vol 180. 2024-11-09. PMID:39520767. |
brain-derived neurotrophic factor (bdnf) is a protein important for synaptic plasticity and formation of memory. |
2024-11-09 |
2024-11-17 |
Not clear |
| Emily Z Huie, Xin Yang, Mengia S Rioult-Pedotti, Kyle Tran, Emma R Monsen, Kim Hansen, Michelle A Erickson, Mandar Naik, Anna Y Yotova, William A Banks, Yu-Wen Alvin Huang, Jill L Silverman, John Marshal. Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-11-08. PMID:39511336. |
brain-derived neurotrophic factor (bdnf), and its receptor tropomyosin receptor kinase b (trkb), have a well-established role as regulators of synaptic plasticity, dendritic outgrowth and spine formation. |
2024-11-08 |
2024-11-16 |
mouse |
| Richard C Allsopp, Lisa M Hernández, Marcus K Taylo. The Val66Met variant of brain-derived neurotrophic factor is linked to reduced telomere length in a military population: a pilot study. Scientific reports. vol 14. issue 1. 2024-11-07. PMID:39506036. |
brain-derived neurotrophic factor (bdnf) is a central nervous system protein that is important for neuronal function and synaptic plasticity. |
2024-11-07 |
2024-11-09 |
human |
| Chinelo Uju, Katayoon Karimzadeh, Suraj Unniappa. Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 2024-10-30. PMID:39475794. |
brain-derived neurotrophic factor (bdnf) is a peptide widely known for its role in neurogenesis and synaptic plasticity. |
2024-10-30 |
2024-11-02 |
zebrafish |
| Yi-Cheng Tsai, Chih-Hui Chang, Yoon Bin Chong, Chieh-Hsin Wu, Hung-Pei Tsai, Tian-Lu Cheng, Chih-Lung Li. MicroRNA-195-5p Inhibits Intracerebral Hemorrhage-Induced Inflammatory Response and Neuron Cell Apoptosis. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408651. |
the mir-195-5p treatment significantly improved neurological function; modulated macrophage polarization by promoting anti-inflammatory marker (cd206 and arg1) production and inhibiting pro-inflammatory marker (cd68 and inos) production; enhanced akt signalling, reduced oxidative stress by increasing sirt1 and nrf2 levels, and attenuated inflammation by decreasing nf-κb activation; inhibited apoptosis via increased bcl-2 and decreased cleaved caspase-3 levels; and regulated synaptic plasticity by modulating nmdar2a, nmdar2b, bdnf, and trkb expression and erk and creb phosphorylation. |
2024-10-16 |
2024-10-18 |
rat |
| Minji Kim, Haeun Lee, Sangoh Kwon, Seungmok Cho, Min Young U. Phlorotannin Supplement Improves Scopolamine-Induced Memory Dysfunction by Rescuing Synaptic Damage in Mice. Journal of microbiology and biotechnology. vol 34. issue 11. 2024-09-24. PMID:39317682. |
additionally , ps enhanced brain-derived neurotrophic factor (bdnf ) signaling and activated the extracellular signal-regulated kinase/camp response element binding protein ( erk-creb) pathway, essential for synaptic plasticity. |
2024-09-24 |
2024-09-27 |
mouse |
| Suman Samaddar, Moqbel Ali Moqbel Redhwan, Mohan Muttanahally Eraiah, Raju Koner. Neurotrophins in Peripheral Neuropathy: Exploring Pathophysiological Mechanisms and Emerging Therapeutic Opportunities. CNS & neurological disorders drug targets. 2024-09-06. PMID:39238380. |
neurotrophins, including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin- 3 (nt-3), and neurotrophin-4 (nt-4), are essential for neuronal survival, axonal growth, and synaptic plasticity. |
2024-09-06 |
2024-09-08 |
Not clear |
| Daniel Wolf, Maurilyn Ayon-Olivas, Michael Sendtne. BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200225. |
activation of tropomyosin receptor kinase b (trkb) by bdnf is necessary for the induction of long-term potentiation (ltp), a form of synaptic plasticity, in the hippocampus and striatum. |
2024-08-29 |
2024-09-01 |
Not clear |
| Daniel Wolf, Maurilyn Ayon-Olivas, Michael Sendtne. BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200225. |
given its essential role in promoting neuronal survival and meditating synaptic plasticity in the motor system, bdnf might have an important impact on the pathophysiology of neurodegenerative diseases, such as pd. |
2024-08-29 |
2024-09-01 |
Not clear |
| Jingxian Cao, Philip Gorwood, Nicolas Ramoz, Odile Viltar. The Role of Central and Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker of Anorexia Nervosa Reconceptualized as a Metabo-Psychiatric Disorder. Nutrients. vol 16. issue 16. 2024-08-29. PMID:39203753. |
beginning with an overview of bdnf's fundamental functions in neurodevelopment and synaptic plasticity, the review delves into recent clinical and preclinical evidence implicating bdnf in the pathophysiology of an. |
2024-08-29 |
2024-09-04 |
Not clear |
| Lorenzo Morè, Lucia Privitera, Marcia Lopes, J Simon C Arthur, Julie C Lauterborn, Sonia A L Corrêa, Bruno G Frenguell. MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning. Neuropharmacology. 2024-08-11. PMID:39128584. |
we have previously shown that msk1, by virtue of its ability to regulate gene transcription, converts the elevation of bdnf associated with environmental enrichment into molecular, synaptic, cognitive and genomic adaptations that underlie enrichment-induced enhanced synaptic plasticity and learning and memory, a property that msk1 retains across the lifespan. |
2024-08-11 |
2024-08-14 |
mouse |
| Farhad Sanaeifar, Sina Pourranjbar, Mohammad Pourranjbar, Sana Ramezani, Samira Rostami Mehr, Al-Hassan Soliman Wadan, Farnaz Khazeifar. Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration. Experimental gerontology. 2024-08-08. PMID:39116955. |
neurotrophins such as brain-derived neurotrophic factor (bdnf) are critical for neuron survival and synaptic plasticity, which is required for learning and memory. |
2024-08-08 |
2024-08-12 |
Not clear |
| Jiwon Park, Dong Yeol Kim, Eok-Soo Oh, Inn-Oc Ha. Light-Dependent Circadian Rhythm Governs O-GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish. Journal of pineal research. vol 76. issue 5. 2024-08-02. PMID:39092800. |
osmi-1 inhibited the expression of c-fos, bdnf, and calm1, key genes associated with brain function and synaptic plasticity, and decreased the binding of o-glcnacylated h2b and ogt to promoter regions of these genes. |
2024-08-02 |
2024-08-05 |
zebrafish |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
the aim of the present study was to evaluate the effect of rosiglitazone (rsg) or pioglitazone (pog) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (bdnf), and nitric oxide (no) metabolites in the hippocampus of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
| Smijin K Soman, Maryann Swain, Ruben K Dagd. BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases. Molecular neurobiology. 2024-07-19. PMID:39030441. |
brain-derived neurotrophic factor (bdnf) plays a pivotal role in neuronal development, synaptic plasticity, and overall neuronal health by binding to its receptor, tyrosine receptor kinase b (trkb). |
2024-07-19 |
2024-07-22 |
Not clear |