| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Smijin K Soman, Maryann Swain, Ruben K Dagd. BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases. Molecular neurobiology. 2024-07-19. PMID:39030441. |
brain-derived neurotrophic factor (bdnf) plays a pivotal role in neuronal development, synaptic plasticity, and overall neuronal health by binding to its receptor, tyrosine receptor kinase b (trkb). |
2024-07-19 |
2024-07-22 |
Not clear |
| Morgan K Foret, Chiara Orciani, Lindsay A Welikovitch, Chunwei Huang, A Claudio Cuello, Sonia Do Carm. Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. Communications biology. vol 7. issue 1. 2024-07-14. PMID:39004677. |
we also found increased expression of synaptic plasticity genes (grin2b (nr2b), camkiiα, bdnf, c-fos, and homer1a) and increased protein levels of top2β. |
2024-07-14 |
2024-07-18 |
rat |
| Anastasia Bougea, Efthalia Angelopoulou, Efthimios Vasilopoulos, Philippos Gourzis, Sokratis Papageorgio. Emerging Therapeutic Potential of Fluoxetine on Cognitive Decline in Alzheimer's Disease: Systematic Review. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928248. |
fluoxetine promoted neurogenesis and enhanced synaptic plasticity in preclinical models of ad, through a decrease in aβ pathology and increase in bdnf, by activating diverse pathways (such as the daf-16-mediated, tgf-beta1, ilk-akt-gsk3beta, and creb/p-creb/bdnf). |
2024-06-27 |
2024-06-29 |
human |
| Emily Z Huie, Xin Yang, Mengia S Rioult-Pedotti, Mandar Naik, Yu-Wen Alvin Huang, Jill L Silverman, John Marshal. Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895218. |
brain-derived neurotrophic factor (bdnf), and its receptor trkb, have a well-established role as regulators of synaptic plasticity, dendritic outgrowth, dendritic spine formation and maintenance. |
2024-06-19 |
2024-06-21 |
mouse |
| Sasa Wang, Xinlei Zhang, Yuru Zhao, Haoxuan Lv, Pengyu Li, Zhihao Zhang, Xiaomeng Qia. BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF. Journal of molecular neuroscience : MN. vol 74. issue 3. 2024-06-18. PMID:38890235. |
extracellular regulated protein kinases (erk) maintain neuronal survival, growth, and regulation of synaptic plasticity by phosphorylating specific transcription factors to regulate expression of brain-derived neurotrophic factor (bdnf). |
2024-06-18 |
2024-06-21 |
mouse |
| Sri-Arun Iamjan, Siriluk Veerasakul, Gavin P Reynolds, Samur Thanoi, Sutisa Nudmamud-Thano. Regional-specific changes in rat brain BDNF in a model of methamphetamine abuse. Neuroscience letters. 2024-06-17. PMID:38885757. |
brain-derived neurotrophic factor (bdnf), a member of the neurotrophin family, plays key roles in neuronal protection and synaptic plasticity. |
2024-06-17 |
2024-06-21 |
rat |
| Gayathri Rajamanickam, Andy Thiam Huat Lee, Ping Lia. Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain. Neurochemical research. 2024-06-10. PMID:38856889. |
brain-derived neurotrophic factor (bdnf) is vital for synaptic plasticity, cell persistence, and neuronal development in peripheral and central nervous systems (cns). |
2024-06-10 |
2024-06-14 |
Not clear |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Juhyun Son. BDNF Signaling in Vascular Dementia and Its Effects on Cerebrovascular Dysfunction, Synaptic Plasticity, and Cholinergic System Abnormality. Journal of lipid and atherosclerosis. vol 13. issue 2. 2024-06-03. PMID:38826183. |
bdnf signaling in vascular dementia and its effects on cerebrovascular dysfunction, synaptic plasticity, and cholinergic system abnormality. |
2024-06-03 |
2024-06-05 |
human |
| Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Son. Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity. Clinical nutrition research. vol 13. issue 2. 2024-05-24. PMID:38784850. |
recently, adiponectin, brain-derived neurotrophic factor (bdnf), and glucose-like peptide-1 (glp-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. |
2024-05-24 |
2024-05-27 |
Not clear |
| Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Son. Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity. Clinical nutrition research. vol 13. issue 2. 2024-05-24. PMID:38784850. |
our findings demonstrate the therapeutic potential of adiponectin, bdnf, and glp-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. |
2024-05-24 |
2024-05-27 |
Not clear |
| Zhenhuan Wang, Qi Hu, Chao Tian, Ruipeng Wang, Qingyan Jiao, Feng Chen, Tongrui Wu, Jialiang Wang, Yuxuan Zhu, Aili Liu, Wei Zhang, Jie Li, Hui She. Prophylactic Effects of n-Acethylcysteine on Inflammation-induced Depression-like Behaviors in Mice. Neuroscience. 2024-05-16. PMID:38729599. |
this study sought to determine whether nac use could mitigate inflammatory depressive behavior through the enhancement of synaptic transmission, synaptic plasticity, and increasing levels of brain-derived neurotrophic factor (bdnf). |
2024-05-16 |
2024-05-27 |
mouse |
| Carmen Almodóvar-Payá, Maria Guardiola-Ripoll, Maria Giralt-López, Maitane Oscoz-Irurozqui, Erick Jorge Canales-Rodríguez, Mercè Madre, Joan Soler-Vidal, Núria Ramiro, Luis F Callado, Bárbara Arias, Carme Gallego, Edith Pomarol-Clotet, Mar Fatjó-Vila. NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia. Brain structure & function. 2024-05-08. PMID:38720004. |
the expression of neuritin-1 (nrn1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the brain derived neurotrophic factor (bdnf). |
2024-05-08 |
2024-05-27 |
human |
| Tareq I Jibril, Karem H Alzoubi, Nizar M Mhaidat, Omar F Khabour, Mohammad A Y Alqudah, Abeer M Rababa'h, Nasr Alrabadi, Doaa Al-Udat. Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor. Current research in pharmacology and drug discovery. vol 6. 2024-05-06. PMID:38706525. |
reduced brain-derived neurotrophic factor (bdnf) levels, increased oxidative stress, and alteration of synaptic plasticity biomarkers are also possible contributors to the negative impact of stress on learning and memory. |
2024-05-06 |
2024-05-08 |
rat |
| Jiena Hong, Jiemei Chen, Chao Li, Fei Zhao, Jiantao Zhang, Yilong Shan, Hongmei We. High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia. Behavioural brain research. vol 467. 2024-04-28. PMID:38678971. |
the underlying mechanism might be modulating the synaptic plasticity and up-regulating the expression psd95, syn, and bdnf in the hippocampus. |
2024-04-28 |
2024-05-01 |
rat |
| Theresa Harvey, Maribel Rio. The Role of BDNF and TrkB in the Central Control of Energy and Glucose Balance: An Update. Biomolecules. vol 14. issue 4. 2024-04-27. PMID:38672441. |
bdnf is a highly conserved neurotrophin that signals via the tropomyosin-related kinase b (trkb) receptor to facilitate neuronal survival, differentiation, and synaptic plasticity and function. |
2024-04-27 |
2024-04-29 |
Not clear |
| Guillermo Moya-Alvarado, Xavier Valero-Peña, Alejandro Aguirre-Soto, Fernando J Bustos, Oscar M Lazo, Francisca C Bronfma. PLC-γ-Ca Frontiers in molecular neuroscience. vol 17. 2024-04-26. PMID:38660384. |
the binding of bdnf to trkb triggers the activation of different signaling pathways, including the erk, plc-γ and pi3k-mtor pathways, to induce dendritic growth and synaptic plasticity. |
2024-04-26 |
2024-04-28 |
Not clear |
| Alexandros Tsimpolis, Konstantinos Kalafatakis, Ioannis Charalampopoulo. Recent advances in the crosstalk between the brain-derived neurotrophic factor and glucocorticoids. Frontiers in endocrinology. vol 15. 2024-04-22. PMID:38645426. |
brain-derived neurotrophic factor (bdnf), a key neurotrophin within the brain, by selectively activating the trkb receptor, exerts multimodal effects on neurodevelopment, synaptic plasticity, cellular integrity and neural network dynamics. |
2024-04-22 |
2024-04-24 |
Not clear |
| Rafael Penadés, Carmen Almodóvar-Payá, Clemente García-Rizo, Victoria Ruíz, Rosa Catalán, Sergi Valero, Til Wykes, Mar Fatjó-Vilas, Bárbara Aria. Changes in BDNF methylation patterns after cognitive remediation therapy in schizophrenia: A randomized and controlled trial. Journal of psychiatric research. vol 173. 2024-03-27. PMID:38537483. |
a gene central to synaptic plasticity, the bdnf, has been proposed as one potential route. |
2024-03-27 |
2024-03-30 |
human |
| Suxin You, Zhouyun Ma, Pei Zhang, Wenwen Xu, Changsen Zhan, Nina Sang, Jiazhen Xu, Feiyun Wang, Jiange Zhan. Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-03-23. PMID:38520864. |
shpl-49 enhanced synaptic plasticity and increased gap43 protein levels via activation of the bdnf pathway in the ogd primary neuron model. |
2024-03-23 |
2024-03-26 |
rat |