| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisca Villavicencio-Tejo, Osvaldo Flores-Bastías, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahania. Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959021. |
neuroinflammation decreases glutamate transporter (glt-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic reward areas, driving long-term drinking behavior. |
2021-05-08 |
2023-08-13 |
rat |
| Luis A- Trujillo Villarreal, Marcela Cárdenas-Tueme, Roger Maldonado-Ruiz, Diana Reséndez-Pérez, Alberto Camacho-Morale. Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorder. Journal of neurochemistry. vol 156. issue 4. 2021-05-04. PMID:32902852. |
defects in the mesocorticolimbic reward pathway have been modulated in transgenic murine models using d2 dopamine receptor heterozygous (d2+/-) or dopamine transporter knockout mice, which exhibit sociability deficits and repetitive behaviors observed in asd phenotypes. |
2021-05-04 |
2023-08-13 |
mouse |
| Luis A- Trujillo Villarreal, Marcela Cárdenas-Tueme, Roger Maldonado-Ruiz, Diana Reséndez-Pérez, Alberto Camacho-Morale. Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorder. Journal of neurochemistry. vol 156. issue 4. 2021-05-04. PMID:32902852. |
here, we will describe how obesity/maternal overnutrition may prime microglia, causing abnormalities in dopamine neurotransmission of the mesocorticolimbic reward pathway, postulating a possible immune role in the development of asd. |
2021-05-04 |
2023-08-13 |
mouse |
| Samuel Floren, Nicholas King, Allonso Carrasco, Nachum Dafn. Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate. Behavioural brain research. vol 380. 2021-05-03. PMID:31783089. |
the ventral tegmental area (vta) is one of the primary sources of dopamine in the cns and is a part of the reward circuits affected by mpd. |
2021-05-03 |
2023-08-13 |
rat |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
dopamine (da) neurotransmitter act on dopamine receptors (d1-d5) to regulate motor functions, reward, addiction and cognitive behavior. |
2021-04-29 |
2023-08-13 |
rat |
| Meredith K Loth, Zoe R Donaldso. Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia. Endocrinology. vol 162. issue 2. 2021-04-28. PMID:33367612. |
therefore, in this review, we focus on how the social neuropeptide, oxytocin, interacts with classical reward system modulators, including dopamine and endogenous opioids, during bond formation and maintenance. |
2021-04-28 |
2023-08-13 |
mouse |
| Andrea Stojakovic, Syed Muzzammil Ahmad, Kabirullah Lutf. Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine. Brain sciences. vol 11. issue 4. 2021-04-28. PMID:33810331. |
alterations of amphetamine reward by prior nicotine and alcohol treatment: the role of age and dopamine. |
2021-04-28 |
2023-08-13 |
mouse |
| Jodi R Godfrey, Melanie Pincus, Zsofia Kovacs-Balint, Eric Feczko, Eric Earl, Oscar Miranda-Dominguez, Damien A Fair, Sara R Jones, Jason Locke, Mar M Sanchez, Mark E Wilson, Vasiliki Michopoulo. Obesogenic diet-associated C-reactive protein predicts reduced central dopamine and corticostriatal functional connectivity in female rhesus monkeys. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32240763. |
alterations in dopamine (da) signaling and reductions in functional connectivity (fc; a measure of temporal correlations of activity between different brain regions) within dopaminergic reward pathways are implicated in the etiology of psychopathology and have been associated with increased concentrations of inflammatory markers, including c-reactive protein. |
2021-04-27 |
2023-08-13 |
monkey |
| Akihiro Shiina, Tadashi Hasegawa, Masaomi Iy. Possible effect of blonanserin on gambling disorder: A clinical study protocol and a case report. World journal of clinical cases. vol 9. issue 11. 2021-04-24. PMID:33889612. |
growing evidence suggests that dopamine d3 receptor plays a specific role in the brain reward system. |
2021-04-24 |
2023-08-13 |
Not clear |
| Kathryn M Rothenhoefer, Tao Hong, Aydin Alikaya, William R Stauffe. Rare rewards amplify dopamine responses. Nature neuroscience. vol 24. issue 4. 2021-04-23. PMID:33686298. |
however, it is unknown whether individual dopamine neurons reflect the shape of reward distributions. |
2021-04-23 |
2023-08-13 |
Not clear |
| Farzaneh Saebi Rad, Abbas Haghparast, Afsaneh Eliass. Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats. Basic and clinical neuroscience. vol 11. issue 6. 2021-04-16. PMID:33850614. |
ventral tegmental area (vta) dopamine neurons play an important role in reward mechanisms of food intake, and vta dopamine receptors exist on the terminal of glutamatergic and gabaergic neurons and regulate gamma-aminobutyric acid (gaba) and glutamate release. |
2021-04-16 |
2023-08-13 |
rat |
| Sari Goldstein Ferber, Aron Weller, Gal Yadid, Alexander Friedma. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33668515. |
interestingly, in cortico-striatal-dopaminergic pathways within the reward and cost circuits, the expression of dopamine and its contribution to reward are modulated by endocannabinoid receptors. |
2021-04-15 |
2023-08-13 |
Not clear |
| Sari Goldstein Ferber, Aron Weller, Gal Yadid, Alexander Friedma. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico-Striatal Loop That Are Implicated in Major Depression. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33668515. |
this review aims to show the crosstalk between endocannabinoid and dopamine receptors and their vulnerability to stress in the reward circuits, especially in corticostriatal regions. |
2021-04-15 |
2023-08-13 |
Not clear |
| Kenneth Blum, Shan Kazmi, Edward J Modestino, Bill William Downs, Debasis Bagchi, David Baron, Thomas McLaughlin, Richard Green, Rehan Jalali, Panayotis K Thanos, Igor Elman, Rajendra D Badgaiyan, Abdalla Bowirrat, Mark S Gol. A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. Journal of personalized medicine. vol 11. issue 3. 2021-04-13. PMID:33809702. |
this article describes a unique therapeutic precision intervention, a formulation of enkephalinase inhibitors, enkephalin, and dopamine-releasing neuronutrients, to induce dopamine homeostasis for detoxification and treatment of individuals genetically predisposed to developing reward deficiency syndrome (rds). |
2021-04-13 |
2023-08-13 |
Not clear |
| Lee Anne Cannella, Allison M Andrews, Fionya Tran, Roshanak Razmpour, Hannah McGary, Ceryce Collie, Tarik Tsegaye, Marquis Maynard, Marc J Kaufman, Scott M Rawls, Servio H Ramire. Experimental Traumatic Brain Injury during Adolescence Enhances Cocaine Rewarding Efficacy and Dysregulates Dopamine and Neuroimmune Systems in Brain Reward Substrates. Journal of neurotrauma. vol 37. issue 1. 2021-04-12. PMID:31347447. |
experimental traumatic brain injury during adolescence enhances cocaine rewarding efficacy and dysregulates dopamine and neuroimmune systems in brain reward substrates. |
2021-04-12 |
2023-08-13 |
mouse |
| Emilie Werlen, Soon-Lim Shin, Francois Gastambide, Jennifer Francois, Mark D Tricklebank, Hugh M Marston, John R Huxter, Gary Gilmour, Mark E Walto. Amphetamine disrupts haemodynamic correlates of prediction errors in nucleus accumbens and orbitofrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31703234. |
this type of learning is typically thought to depend on prediction error, the difference between expected and experienced events and in the reward domain that has been closely linked to mesolimbic dopamine. |
2021-03-30 |
2023-08-13 |
human |
| Brenna Bray, Kaci A Clement, Dana Bachmeier, Matthew A Weber, Gina L Forste. Corticosterone in the ventral hippocampus differentially alters accumbal dopamine output in drug-naïve and amphetamine-withdrawn rats. Neuropharmacology. vol 165. 2021-03-30. PMID:31881169. |
dysregulation in glucocorticoid stress and accumbal dopamine reward systems can alter reward salience to increase motivational drive in control conditions while contributing to relapse during drug withdrawal. |
2021-03-30 |
2023-08-13 |
rat |
| Alexander Soutschek, Rouba Kozak, Nicholas de Martinis, William Howe, Christopher J Burke, Ernst Fehr, Alexander Jetter, Philippe N Toble. Activation of D1 receptors affects human reactivity and flexibility to valued cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31962344. |
while the capacity of reward cues to trigger motivation ('reactivity') as well as flexibility in cue-reward associations have been linked to the neurotransmitter dopamine in humans, the specific contribution of the dopamine d1 receptor family to these behaviors remained elusive. |
2021-03-30 |
2023-08-13 |
human |
| Jessica E McGovern, Michael D Masucci, Thanh P Le, Alex S Cohe. The (b)link between amotivation and psychosis: Insights through phasic eye blink rate. Psychiatry research. vol 294. 2021-03-30. PMID:33038790. |
motivation deficits within schizophrenia spectrum disorders (ssds) are associated with abnormal striatal dopamine responses during reward processing. |
2021-03-30 |
2023-08-13 |
Not clear |
| Dominik K E Beyer, Annika Mattukat, Nadja Freun. Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus. International journal of bipolar disorders. vol 9. issue 1. 2021-03-29. PMID:33683478. |
prefrontal dopamine d1 receptor (d1r) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. |
2021-03-29 |
2023-08-13 |
rat |