| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Wei Yao, Lu Liu, Patrick D Worhunsky, Sarah Lichenstein, Shan-Shan Ma, Lei Zhu, Xin-Hui Shi, Songshan Yang, Jin-Tao Zhang, Sarah W Yi. Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder. NeuroImage. Clinical. vol 26. 2021-03-26. PMID:32045732. |
however, given that drugs of abuse can directly impact reward-related dopamine circuitry, it is difficult to determine the extent to which reward processing alterations are a trait feature of individuals with addictions, or primarily a consequence of exogenous drug exposure. |
2021-03-26 |
2023-08-13 |
Not clear |
| Marie A Doyle, Ali R Stark, Geza Fejes-Tóth, Aniko Náray-Fejes-Tóth, Michelle S Mazei-Robiso. Behavioral effects of SGK1 knockout in VTA and dopamine neurons. Scientific reports. vol 10. issue 1. 2021-03-26. PMID:32901079. |
using transgenic mouse models, we investigated the effect of sgk1 knockout in the vta and in dopamine (da) neurons to evaluate the necessity of protein expression for natural and drug reward behaviors. |
2021-03-26 |
2023-08-13 |
mouse |
| Chaya Shor, Wanhong Zuo, Jean D Eloy, Jiang-Hong Y. The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders. International journal of molecular sciences. vol 21. issue 21. 2021-03-26. PMID:33143210. |
recently, interest in the lateral habenula, a small epithalamic brain structure, has increased because it becomes hyperactive in depression and alcohol use disorders, and can inhibit dopamine and serotonin neurons in the midbrain reward center, the hypofunction of which is believed to be a critical contributor to the etiology of depressive disorders and alcohol use disorders as well as their comorbidities. |
2021-03-26 |
2023-08-13 |
Not clear |
| Rita R Fagan, Patrick J Kearney, Haley E Melikia. In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home. Neurochemical research. vol 45. issue 6. 2021-03-22. PMID:32146647. |
dopamine (da) is critical for motivation, reward, movement initiation, and learning. |
2021-03-22 |
2023-08-13 |
human |
| Dajung J Kim, Hassan Jassar, Manyoel Lim, Thiago D Nascimento, Alexandre F DaSilv. Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine. Journal of pain research. vol 14. 2021-03-19. PMID:33727857. |
however, there is a lack of evidence whether the altered reward system connectivity is directly associated with clinical manifestations, including negative affect and ictal pain severity and, at the molecular level, the dopamine (da) d2/d3 receptors (d2/3rs) signaling implicated in encoding motivational and emotional cues. |
2021-03-19 |
2023-08-13 |
Not clear |
| Jaime J Castrellon, James Meade, Lucy Greenwald, Katlyn Hurst, Gregory R Samanez-Larki. Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis. Psychopharmacology. vol 238. issue 3. 2021-03-16. PMID:33215269. |
although numerous studies have suggested that pharmacological alteration of the dopamine (da) system modulates reward discounting, these studies have produced inconsistent findings. |
2021-03-16 |
2023-08-13 |
rat |
| Jessica G Mills, Susan J Thomas, Theresa A Larkin, Chao Den. Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine. Appetite. vol 148. 2021-03-15. PMID:31926176. |
in the central nervous system, dopamine is a neurotransmitter associated with reward salience and food intake, whereas peripheral dopamine is involved in sympathetic stress regulation, digestion and gastrointestinal motility. |
2021-03-15 |
2023-08-13 |
human |
| Luca Botticelli, Emanuela Micioni Di Bonaventura, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Adele Romano, Wilma Quaglia, Carlo Cifani, Maria Vittoria Micioni Di Bonaventur. Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors. Nutrients. vol 12. issue 8. 2021-03-15. PMID:32751662. |
the dopamine d4 receptor (drd4) has a predominant expression in the prefrontal cortex (pfc), brain area strictly involved in the modulation of reward processes related to both food and drug consumption. |
2021-03-15 |
2023-08-13 |
human |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. |
2021-03-13 |
2023-08-13 |
monkey |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
here, we demonstrate a tonic firing mode of dopamine neurons that effectively tracks changing reward values. |
2021-03-13 |
2023-08-13 |
monkey |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
we recorded dopamine neuron activity in monkeys during a pavlovian procedure in which the value of a cued reward gradually increased or decreased. |
2021-03-13 |
2023-08-13 |
monkey |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
dopamine neurons tonically increased and decreased their activity as the reward value changed. |
2021-03-13 |
2023-08-13 |
monkey |
| Yawei Wang, Osamu Toyoshima, Jun Kunimatsu, Hiroshi Yamada, Masayuki Matsumot. Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. eLife. vol 10. 2021-03-13. PMID:33689680. |
our findings suggest that dopamine neurons change their firing mode to effectively signal reward values in a given situation. |
2021-03-13 |
2023-08-13 |
monkey |
| Jessica A Mollick, Luke J Chang, Anjali Krishnan, Thomas E Hazy, Kai A Krueger, Guido K W Frank, Tor D Wager, Randall C O'Reill. The Neural Correlates of Cued Reward Omission. Frontiers in human neuroscience. vol 15. 2021-03-10. PMID:33679345. |
both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. |
2021-03-10 |
2023-08-13 |
human |
| Kenneth Blum, Ali Raza, Tiffany Schultz, Rehan Jalali, Richard Green, Raymond Brewer, Panyotis K Thanos, Thomas McLaughlin, David Baron, Abdalla Bowirrat, Igor Elman, B William Downs, Debasis Bagchi, Rajendra D Badgaiya. Should We Embrace the Incorporation of Genetically Guided "Dopamine Homeostasis" in the Treatment of Reward Deficiency Syndrome (RSD) as a Frontline Therapeutic Modality? Acta scientific neurology. vol 4. issue 2. 2021-03-10. PMID:33681869. |
should we embrace the incorporation of genetically guided "dopamine homeostasis" in the treatment of reward deficiency syndrome (rsd) as a frontline therapeutic modality? |
2021-03-10 |
2023-08-13 |
Not clear |
| C E Strong, D P Hagarty, A Brea Guerrero, K J Schoepfer, S M Cajuste, M Kabba. Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific reports. vol 10. issue 1. 2021-03-09. PMID:33154463. |
the nucleus accumbens (nac), considered the hub of reward circuitry, is comprised of two medium spiny neuron (msn) subtypes that are classified by their enrichment of dopamine 1 (d1) or 2 (d2) receptors. |
2021-03-09 |
2023-08-13 |
rat |
| Yanfei Sun, Jing Cao, Chunpeng Xu, Xiaofeng Liu, Zicheng Wang, Hua Zha. Rostromedial tegmental nucleus-substantia nigra pars compacta circuit mediates aversive and despair behavior in mice. Experimental neurology. vol 333. 2021-03-05. PMID:32791155. |
gabaergic neurons in the rostromedial tegmental nucleus (rmtg) receive major input from the lateral habenula (lhb), which conveys negative reward and motivation related information, and project intensively to midbrain dopamine neurons, including those in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-03-05 |
2023-08-13 |
mouse |
| Vaibhav R Konanur, Ted M Hsu, Scott E Kanoski, Matthew R Hayes, Mitchell F Roitma. Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4. Physiology & behavior. vol 215. 2021-03-04. PMID:31821815. |
phasic dopamine activity is evoked by reliable predictors of food reward and plays a role in cue-triggered, goal-directed behavior. |
2021-03-04 |
2023-08-13 |
rat |
| Qiu T Ruan, Neema Yazdani, Eric R Reed, Jacob A Beierle, Lucy P Peterson, Kimberly P Luttik, Karen K Szumlinski, William E Johnson, Peter E A Ash, Benjamin Wolozin, Camron D Bryan. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-04. PMID:32401417. |
we have since shown that hnrnph1 mutants also exhibit reduced methamphetamine-induced reward, reinforcement, and dopamine release. |
2021-03-04 |
2023-08-13 |
mouse |
| Sofia Carozza, Victoria Leon. The Role of Affectionate Caregiver Touch in Early Neurodevelopment and Parent-Infant Interactional Synchrony. Frontiers in neuroscience. vol 14. 2021-03-04. PMID:33584178. |
these touch-related bonding effects are known to be mediated primarily by the oxytocin system, but touch also activates mesocorticolimbic dopamine and endogenous opioid systems which aid the development of social cognitive processes such as social learning and reward processing. |
2021-03-04 |
2023-08-13 |
human |