| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melissa Herman, Robert Tarra. E-cigarettes, nicotine, the lung and the brain: multi-level cascading pathophysiology. The Journal of physiology. vol 598. issue 22. 2021-03-01. PMID:32515030. |
nicotine's reinforcing properties are primarily mediated by activation of the brain's mesolimbic reward circuitry and release of the neurotransmitter dopamine that contribute to the development of addiction. |
2021-03-01 |
2023-08-13 |
human |
| Tangfeng Su, Lei Pe. Acupuncture and oxytocinergic system: The promising treatment for autism. Translational neuroscience. vol 12. issue 1. 2021-02-27. PMID:33633868. |
furthermore, serotonin and dopamine are involved in the reward response mediated by ot. |
2021-02-27 |
2023-08-13 |
mouse |
| David L Bernstein, Sunyl U Nayak, Chicora F Oliver, Scott M Rawls, Slava Ro. Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates. Neuroscience research. vol 155. 2021-02-23. PMID:31302200. |
knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. |
2021-02-23 |
2023-08-13 |
rat |
| Mark W Mille. Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis. The Biological bulletin. vol 239. issue 3. 2021-02-19. PMID:33347799. |
functions attributed to dopamine in the mammalian brain include regulation of motor circuits, valuation of sensory stimuli, and mediation of reward or reinforcement signals. |
2021-02-19 |
2023-08-13 |
Not clear |
| Oliver D Howes, Emily J Hird, Rick A Adams, Philip R Corlett, Philip McGuir. Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis. Biological psychiatry. vol 88. issue 4. 2021-02-18. PMID:32430200. |
we review these and summarize the evidence for dopamine dysfunction, reward processing, and salience abnormalities in people at clinical high risk of psychosis (chr) relative to findings in patients with psychosis. |
2021-02-18 |
2023-08-13 |
human |
| Oliver D Howes, Emily J Hird, Rick A Adams, Philip R Corlett, Philip McGuir. Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis. Biological psychiatry. vol 88. issue 4. 2021-02-18. PMID:32430200. |
this review identifies consistent evidence for dysregulated subcortical dopamine function in people at chr, but also indicates a number of areas where neurobiological processes are different in chr subjects relative to patients with psychosis, particularly in reward processing. |
2021-02-18 |
2023-08-13 |
human |
| Andreas Heinz, Laura S Daedelow, Carolin Wackerhagen, Gaetano Di Chiar. Addiction theory matters-Why there is no dependence on caffeine or antidepressant medication. Addiction biology. vol 25. issue 2. 2021-02-16. PMID:30896084. |
for example, common reinforcers such as food and sex increase dopamine transmission in the nucleus accumbens, but unlike in addictive substances, their effect is regulated by reward predictability and habituation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Ewa Galaj, Xiao Han, Hui Shen, Chloe J Jordan, Yi He, Bree Humburg, Guo-Hua Bi, Zheng-Xiong X. Dissecting the Role of GABA Neurons in the VTA The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 46. 2021-02-16. PMID:33046548. |
dissecting the role of gaba neurons in the vta opioid reward has traditionally been thought to be mediated by gaba-induced disinhibition of dopamine (da) neurons in the vta. |
2021-02-16 |
2023-08-13 |
Not clear |
| J P H Verharen, Yichen Zhu, Stephan Lamme. Aversion hot spots in the dopamine system. Current opinion in neurobiology. vol 64. 2021-01-27. PMID:32146296. |
together, these discoveries have raised the possibility that individual groups of dopamine cells make a unique contribution to the processing of reward and aversion. |
2021-01-27 |
2023-08-13 |
Not clear |
| Ruidong Chen, Jesse H Goldber. Actor-critic reinforcement learning in the songbird. Current opinion in neurobiology. vol 65. 2021-01-27. PMID:32898752. |
first, when a singing bird unexpectedly hits the right note, its dopamine (da) neurons are activated as when a thirsty monkey receives an unexpected juice reward. |
2021-01-27 |
2023-08-13 |
monkey |
| Ben Wagner, Mareike Clos, Tobias Sommer, Jan Peter. Dopaminergic Modulation of Human Intertemporal Choice: A Diffusion Model Analysis Using the D2-Receptor Antagonist Haloperidol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 41. 2021-01-19. PMID:32948675. |
the neurotransmitter dopamine is implicated in diverse functions, including reward processing, reinforcement learning, and cognitive control. |
2021-01-19 |
2023-08-13 |
human |
| Seyed Mostafa Ahmadian, Parisa Ghahremani, Hojjatallah Alae. Microinjection of a Dopamine-D1 Receptor Agonist into the Ventral Tegmental Area Reverses the Blocked Expression of Morphine Conditioned Place Preference by N-Methyl-D-Aspartate Receptor Antagonist. Advanced biomedical research. vol 9. 2021-01-19. PMID:33457337. |
the release of dopamine (da) in the posterior ventral tegmental area (pvta) plays an important role in cue-related learning, reward, and relapse. |
2021-01-19 |
2023-08-13 |
Not clear |
| Yash Khemchandani, Stephen O'Hagan, Soumitra Samanta, Neil Swainston, Timothy J Roberts, Danushka Bollegala, Douglas B Kel. DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. Journal of cheminformatics. vol 12. issue 1. 2021-01-15. PMID:33431037. |
we extend our method successfully to use a multi-objective reward function, in this case for generating novel molecules that bind with dopamine transporters but not with those for norepinephrine. |
2021-01-15 |
2023-08-13 |
Not clear |
| Elseline Hoekzema, Christian K Tamnes, Puck Berns, Erika Barba-Müller, Cristina Pozzobon, Marisol Picado, Florencio Lucco, Magdalena Martínez-García, Manuel Desco, Agustín Ballesteros, Eveline A Crone, Oscar Vilarroya, Susanna Carmon. Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues. Psychoneuroendocrinology. vol 112. 2021-01-11. PMID:31757430. |
animal studies show that this is mediated by dopamine release into the nucleus accumbens, a core component of the brain's reward system located in the ventral striatum (vstr). |
2021-01-11 |
2023-08-13 |
human |
| Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-Peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J Manzoni, Rainer Spanage. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. iScience. vol 23. issue 3. 2021-01-10. PMID:32179475. |
synaptic plasticity in dopamine d1 and d2 receptor medium spiny neurons (msns) of the nac and the endogenous cannabinoid (ecb) system have been implicated in reward seeking. |
2021-01-10 |
2023-08-13 |
Not clear |
| George F Koo. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement. Biological psychiatry. vol 87. issue 1. 2021-01-06. PMID:31400808. |
such negative emotional states that drive negative reinforcement are hypothesized to derive from the within-system dysregulation of key neurochemical circuits that mediate incentive-salience and/or reward systems (dopamine, opioid peptides) in the ventral striatum and from the between-system recruitment of brain stress systems (corticotropin-releasing factor, dynorphin, norepinephrine, hypocretin, vasopressin, glucocorticoids, and neuroimmune factors) in the extended amygdala. |
2021-01-06 |
2023-08-13 |
Not clear |
| Cintia Folgueira, Daniel Beiroa, Begoña Porteiro, Manon Duquenne, Emma Puighermanal, Marcos F Fondevila, Silvia Barja-Fernández, Rosalia Gallego, René Hernández-Bautista, Cecilia Castelao, Ana Senra, Patricia Seoane, Noemi Gómez, Pablo Aguiar, Diana Guallar, Miguel Fidalgo, Amparo Romero-Pico, Roger Adan, Clemence Blouet, Jose Luís Labandeira-García, Françoise Jeanrenaud, Imre Kallo, Zsolt Liposits, Javier Salvador, Vincent Prevot, Carlos Dieguez, Miguel Lopez, Emmanuel Valjent, Gema Frühbeck, Luisa M Seoane, Ruben Nogueira. Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nature metabolism. vol 1. issue 8. 2021-01-06. PMID:31579887. |
dopamine signaling is a crucial part of the brain reward system and can affect feeding behavior. |
2021-01-06 |
2023-08-13 |
Not clear |
| Qian Li, Bing Zhang, Hang Cao, Wei Liu, Fei Guo, Fuyi Shen, Binglu Ye, Huan Liu, Yang Li, Zhiqiang Li. Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC. Neuropharmacology. vol 162. 2021-01-06. PMID:31682854. |
oxytocin (ot) and dopamine (da) are two important elements that are closely related to mental and reward processes in the brain. |
2021-01-06 |
2023-08-13 |
Not clear |
| Randal A Serafini, Kerri D Pryce, Venetia Zachario. The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities. Biological psychiatry. vol 87. issue 1. 2021-01-06. PMID:31806085. |
dysregulation of dopamine function in the brain reward center may further promote comorbid mood disorders and vulnerability to addiction. |
2021-01-06 |
2023-08-13 |
Not clear |
| Marine Salery, Pierre Trifilieff, Jocelyne Caboche, Peter Vanhoutt. From Signaling Molecules to Circuits and Behaviors: Cell-Type-Specific Adaptations to Psychostimulant Exposure in the Striatum. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31928716. |
drugs of abuse increase dopamine (da) concentration in these brain areas, including the striatum, which shapes an abnormal memory trace of drug consumption that virtually highjacks reward processing. |
2021-01-06 |
2023-08-13 |
Not clear |