| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth Blum, Edward J Modestino, Jennifer Neary, Marjorie C Gondré-Lewis, David Siwicki, Mark Moran, Mary Hauser, Eric R Braverman, David Baron, Bruce Steinberg, Thomas Mc Laughlin, Rajendra D Badgaiya. Promoting Precision Addiction Management (PAM) to Combat the Global Opioid Crisis. Biomedical journal of scientific & technical research. vol 2. issue 2. 2020-10-01. PMID:30370423. |
it is universally agreed that dopamine is a major neurotransmitter in terms of reward dependence, however, there remains controversy regarding how to modulate its role clinically to treat and prevent relapse for both substance and non-substance-related addictive behaviors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kenneth Blum, Edward J Modestino, Jennifer Neary, Marjorie C Gondré-Lewis, David Siwicki, Mark Moran, Mary Hauser, Eric R Braverman, David Baron, Bruce Steinberg, Thomas Mc Laughlin, Rajendra D Badgaiya. Promoting Precision Addiction Management (PAM) to Combat the Global Opioid Crisis. Biomedical journal of scientific & technical research. vol 2. issue 2. 2020-10-01. PMID:30370423. |
it is also agreed by most that there is a need to provide early genetic identification possibly through a novel researched technology referred to genetic addiction risk score(gars).™ the existing fda-approved medications promote blocking dopamine, however, we argue that a more prudent paradigm shift should be biphasic-short-term blockade and long-term upregulation, enhancing functional connectivity of brain reward. |
2020-10-01 |
2023-08-13 |
Not clear |
| Koji Ohir. Dopamine as a growth differentiation factor in the mammalian brain. Neural regeneration research. vol 15. issue 3. 2020-10-01. PMID:31571646. |
the catecholamine, dopamine, plays an important role in the central nervous system of mammals, including executive functions, motor control, motivation, arousal, reinforcement, and reward. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lane Strathearn, Carol E Mertens, Linda Mayes, Helena Rutherford, Purva Rajhans, Guifeng Xu, Marc N Potenza, Sohye Ki. Pathways Relating the Neurobiology of Attachment to Drug Addiction. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31780957. |
we approach this from three different levels: molecular, neuroendocrine and behavioral; and examine the oxytocin affiliation system, dopamine reward system, and glucocorticoid stress response system in this regard. |
2020-10-01 |
2023-08-13 |
human |
| Mehmet Atilla Uysal, Ülgen Sever, Ayşe Feyda Nursal, Sacide Pehlİva. Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. Noro psikiyatri arsivi. vol 56. issue 4. 2020-10-01. PMID:31903031. |
dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stefan du Plessis, Minke Bekker, Chanelle Buckle, Matthijs Vink, Soraya Seedat, Soraya Bardien, Jonathan Carr, Shameemah Abraham. Association Between a Variable Number Tandem Repeat Polymorphism Within the DAT1 Gene and the Mesolimbic Pathway in Parkinson's Disease. Frontiers in neurology. vol 11. 2020-10-01. PMID:32982958. |
genes implicated in dopamine transmission, such as the dopamine transporter gene (dat1) may influence the clinical heterogeneity seen in pd, including reward processing. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mitra Heshmati, Scott J Russ. Anhedonia and the brain reward circuitry in depression. Current behavioral neuroscience reports. vol 2. issue 3. 2020-09-30. PMID:26525751. |
the mesolimbic dopamine circuit, also known as the brain's reward circuit, is integral to processing the rewarding salience of stimuli to guide actions. |
2020-09-30 |
2023-08-13 |
human |
| David M White, Nina V Kraguljac, Meredith A Reid, Adrienne C Laht. Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: a combined magnetic resonance spectroscopy/functional imaging study. NPJ schizophrenia. vol 1. 2020-09-30. PMID:26878032. |
because dopamine neurons signal a mismatch between expected and actual reward called prediction error (pe), aberrant pe signals in schizophrenia have been attributed to known dopaminergic abnormalities. |
2020-09-30 |
2023-08-13 |
Not clear |
| K Blum, M Febo, R D Badgaiya. Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial. Austin addiction sciences. vol 1. issue 2. 2020-09-30. PMID:27840857. |
dopamine along with other chemical messengers like serotonin, cannabinoids, endorphins and glutamine, play significant roles in brain reward processing. |
2020-09-30 |
2023-08-13 |
Not clear |
| K Blum, M Febo, R D Badgaiya. Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial. Austin addiction sciences. vol 1. issue 2. 2020-09-30. PMID:27840857. |
we review, herein, the history of the development of a glutaminergic-dopaminergic optimization complex called kb220 to provide for the possible eventual balancing of the brain reward system and the induction of "dopamine homeostasis." |
2020-09-30 |
2023-08-13 |
Not clear |
| Ali Siahposht-Khachaki, Zahra Fatahi, Abbas Haghparas. Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats. Basic and clinical neuroscience. vol 7. issue 4. 2020-09-30. PMID:27872695. |
in addition, nmda receptors play a major role in brain reward system and activation of these receptors can change firing pattern of dopamine neurons. |
2020-09-30 |
2023-08-13 |
rat |
| Ada Ledonne, Nicola B Mercur. Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28228718. |
dopamine (da) is a key neurotransmitter modulating essential functions of the central nervous system (cns), like voluntary movement, reward, several cognitive functions and goal-oriented behaviors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jason C D Nguyen, Saher F Ali, Sepideh Kosari, Owen L Woodman, Sarah J Spencer, A Simon Killcross, Trisha A Jenkin. Western Diet Chow Consumption in Rats Induces Striatal Neuronal Activation While Reducing Dopamine Levels without Affecting Spatial Memory in the Radial Arm Maze. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28232794. |
it is clear from previous studies, however, that motivation and reward factor into the memory deficits associated with obesity and high-fat diet consumption, and that the prefrontal cortex and striatum and neurotransmitter dopamine play important roles in cognitive performance. |
2020-09-30 |
2023-08-13 |
rat |
| Anna Brancato, Gianluca Lavanco, Angela Cavallaro, Fulvio Plescia, Carla Cannizzar. Acetaldehyde, Motivation and Stress: Behavioral Evidence of an Addictive Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28232795. |
recent studies shed light on the behavioral correlates of acd administration and the possible interactions with key neurotransmitters for motivation, reward and stress-related response, such as dopamine and endocannabinoids. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kristoffer C Aberg, Julia Müller, Sophie Schwart. Trial-by-Trial Modulation of Associative Memory Formation by Reward Prediction Error and Reward Anticipation as Revealed by a Biologically Plausible Computational Model. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28261071. |
we additionally measured trait estimates of reward and punishment sensitivity and found that individuals with increased reward (vs. punishment) sensitivity had better memory for associations encoded during positive (vs. negative) prediction errors when tested after 20 min, but a negative trend when tested after 24 h. in conclusion, modeling trial-by-trial fluctuations in the magnitude of reward, as we did here for prediction errors and expected value computations, provides a comprehensive and biologically plausible description of the dynamic interplay between reward, dopamine, and associative memory formation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Anni Richter, Adriana Barman, Torsten Wüstenberg, Joram Soch, Denny Schanze, Anna Deibele, Gusalija Behnisch, Anne Assmann, Marieke Klein, Martin Zenker, Constanze Seidenbecher, Björn H Schot. Behavioral and Neural Manifestations of Reward Memory in Carriers of Low-Expressing versus High-Expressing Genetic Variants of the Dopamine D2 Receptor. Frontiers in psychology. vol 8. 2020-09-30. PMID:28507526. |
behavioral and neural manifestations of reward memory in carriers of low-expressing versus high-expressing genetic variants of the dopamine d2 receptor. |
2020-09-30 |
2023-08-13 |
human |
| Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiya. Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission. Journal of systems and integrative neuroscience. vol 3. issue 3. 2020-09-30. PMID:28736624. |
lyme and dopaminergic function: hypothesizing reduced reward deficiency symptomatology by regulating dopamine transmission. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiya. Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission. Journal of systems and integrative neuroscience. vol 3. issue 3. 2020-09-30. PMID:28736624. |
this, in itself, can reduce dopamine function leading to many reward deficiency syndrome behaviors, including depression and possibly, anxiety. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kenneth Blum, Marcelo Febo, Lyle Fried, David Baron, Eric R Braverman, Kristina Dushaj, Mona Li, Zsolt Demetrovics, Rajendra D Badgaiya. Pro-Dopamine Regulator - (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome (RDS). Journal of reward deficiency syndrome and addiction science. vol 3. issue 1. 2020-09-30. PMID:28804788. |
kb220 may likely alter the function of these regions and provide for the possible eventual balancing the brain reward system and the induction of "dopamine homeostasis." |
2020-09-30 |
2023-08-13 |
Not clear |
| Yasumasa Ueda, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Naoyuki Matsumoto, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Kae Nakamura, Minoru Kimur. Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28824386. |
reinforcement learning models posit that action reward value is encoded by the firing activity of striatal medium spiny neurons (msns) and updated upon changing reinforcement contingencies by dopamine (da) signaling to these neurons. |
2020-09-30 |
2023-08-13 |
monkey |