| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele L Mietus-Snyder, Robert H Lusti. Childhood obesity: adrift in the "limbic triangle". Annual review of medicine. vol 59. 2008-05-07. PMID:17845135. |
neuroendocrine mechanisms within the limbic core of the brain prevent starvation (ventromedial hypothalamus), heighten reward (ventral tegmental area and nucleus accumbens), and attenuate stress (amygdala), in order to promote food-seeking and ingestive behavior and to conserve energy output. |
2008-05-07 |
2023-08-12 |
human |
| Marianne Benoit-Marand, Patricio O'Donnel. D2 dopamine modulation of corticoaccumbens synaptic responses changes during adolescence. The European journal of neuroscience. vol 27. issue 6. 2008-05-05. PMID:18331340. |
dopaminergic afferents from the ventral tegmental area (vta) modulate information processing in the nucleus accumbens (na), a brain region critical for motivation and reward mechanisms. |
2008-05-05 |
2023-08-12 |
rat |
| Hsiun Ing Chen, Yu Min Kuo, Chung-Hsien Liao, Chauying J Jen, A Min Huang, Chianfang G Cherng, Shu-Wen Su, Lung Y. Long-term compulsive exercise reduces the rewarding efficacy of 3,4-methylenedioxymethamphetamine. Behavioural brain research. vol 187. issue 1. 2008-03-11. PMID:17949827. |
we conclude that the long-term, compulsive exercise is effective in curbing the reward efficacy of mdma possibly via its direct effect on reversing the mdma-stimulated dopamine release in nucleus accumbens. |
2008-03-11 |
2023-08-12 |
mouse |
| Yann S Mineur, Marina R Picciott. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochemical pharmacology. vol 75. issue 1. 2008-02-26. PMID:17632086. |
genetic engineering studies in mice have identified a number of subunits that are critical for the ability of nicotine to activate the reward system in the brain, consisting of the dopaminergic cell bodies in the ventral tegmental area and their terminals in the nucleus accumbens and other portions of the mesolimbic system. |
2008-02-26 |
2023-08-12 |
mouse |
| Christina M Gremel, Christopher L Cunningha. Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol-conditioned behavior in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 5. 2008-02-19. PMID:18234886. |
for the first time, these results demonstrate the role of the acb and amy in the acquisition and expression of ethanol-induced conditioned reward. |
2008-02-19 |
2023-08-12 |
mouse |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, dbs to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. |
2008-02-06 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. |
2008-02-06 |
2023-08-12 |
Not clear |
| Dino Levy, Maytal Shabat-Simon, Uri Shalev, Noam Barnea-Ygael, Ayelet Cooper, Abraham Zange. Repeated electrical stimulation of reward-related brain regions affects cocaine but not "natural" reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094257. |
the behavioral findings were accompanied by glutamate receptor subtype alterations in the nucleus accumbens and the ventral tegmental area, both key structures of the reward system. |
2008-01-14 |
2023-08-12 |
Not clear |
| William Renthal, Ian Maze, Vaishnav Krishnan, Herbert E Covington, Guanghua Xiao, Arvind Kumar, Scott J Russo, Ami Graham, Nadia Tsankova, Tod E Kippin, Kerry A Kerstetter, Rachael L Neve, Stephen J Haggarty, Timothy A McKinsey, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. vol 56. issue 3. 2008-01-08. PMID:17988634. |
chronic, but not acute, exposure to cocaine or stress decreases hdac5 function in the nucleus accumbens (nac), a major brain reward region, which allows for increased histone acetylation and transcription of hdac5 target genes. |
2008-01-08 |
2023-08-12 |
Not clear |
| Zheng-Xiong Xi, Zheng Yang, Shi-Jiang Li, Xia Li, Christopher Dillon, Xiao-Qing Peng, Krista Spiller, Eliot L Gardne. Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology. vol 53. issue 6. 2007-12-21. PMID:17888459. |
in vivo microdialysis demonstrated that l-thp slightly elevates extracellular nucleus accumbens da by itself, but dose-dependently potentiates cocaine-augmented da, suggesting that a postsynaptic, rather than presynaptic, da receptor antagonism underlies l-thp's actions on cocaine reward. |
2007-12-21 |
2023-08-12 |
rat |
| Mark R Hutchinson, Sondra T Bland, Kirk W Johnson, Kenner C Rice, Steven F Maier, Linda R Watkin. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. TheScientificWorldJournal. vol 7. 2007-12-06. PMID:17982582. |
attenuating central nervous system glial activation was also found to reduce the development of opioid dependence, and opioid reward at a behavioral (conditioned place preference) and neurochemical (nucleus accumbens microdialysis of morphine-induced elevations in dopamine) level of analysis. |
2007-12-06 |
2023-08-12 |
Not clear |
| Alexandra Jean, Grégory Conductier, Christine Manrique, Constantin Bouras, Philippe Berta, René Hen, Yves Charnay, Joël Bockaert, Valérie Compa. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 41. 2007-11-28. PMID:17913892. |
we hypothesized that anorexia may involve altered signaling events within the nucleus accumbens (nac), a brain structure involved in reward. |
2007-11-28 |
2023-08-12 |
mouse |
| Shaun Fallon, Erin Shearman, Henry Sershen, Abel Lajth. Food reward-induced neurotransmitter changes in cognitive brain regions. Neurochemical research. vol 32. issue 10. 2007-11-20. PMID:17721820. |
using microdialysis for the assay, we found changes in the hippocampus, cortex, amygdala, and the thalamic nucleus, (considered cognitive areas), in addition to those in the nucleus accumbens and ventral tegmental area (considered reward areas). |
2007-11-20 |
2023-08-12 |
Not clear |
| Giovanni Hernandez, Eric Haines, Heshmat Rajabi, Jane Stewart, Andreas Arvanitogiannis, Peter Shizga. Predictable and unpredictable rewards produce similar changes in dopamine tone. Behavioral neuroscience. vol 121. issue 5. 2007-11-20. PMID:17907821. |
however, recent evidence suggests that reward predictability may fail to influence da signaling over longer scales: in rats passively receiving rewarding electrical brain stimulation, the concentration of da in dialysate obtained from nucleus accumbens probes was similar regardless of whether reward onset was predictable (g. hernandez et al., 2006). |
2007-11-20 |
2023-08-12 |
rat |
| Junchao Tong, Oleh Hornykiewicz, Yoshiaki Furukawa, Stephen J Kis. Marked dissociation between high noradrenaline versus low noradrenaline transporter levels in human nucleus accumbens. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17484728. |
we recently identified a noradrenaline-rich caudomedial subdivision of the human nucleus accumbens (nacs), implying a special function for noradrenaline in this basal forebrain area involved in motivation and reward. |
2007-11-06 |
2023-08-12 |
human |
| William J A Eiler, Harry L Jun. Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats. Neuropharmacology. vol 52. issue 8. 2007-10-25. PMID:17451754. |
these receptors may be under the regulation of reciprocal gabaergic inputs from forebrain components of the mesolimbic path such as the nucleus accumbens (nacc), a classic etoh reward substrate, and the bed nucleus of the stria terminalis, a substrate recently implicated in etoh reinforcement, forming a self-regulating feedback loop. |
2007-10-25 |
2023-08-12 |
rat |
| G C Harris, M Hummel, M Wimmer, S D Mague, G Aston-Jone. Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. Neuroscience. vol 147. issue 3. 2007-10-19. PMID:17560044. |
elevations of fosb in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. |
2007-10-19 |
2023-08-12 |
rat |
| Regina M Carell. The nucleus accumbens and reward: neurophysiological investigations in behaving animals. Behavioral and cognitive neuroscience reviews. vol 1. issue 4. 2007-09-25. PMID:17712985. |
the nucleus accumbens and reward: neurophysiological investigations in behaving animals. |
2007-09-25 |
2023-08-12 |
Not clear |
| Regina M Carell. The nucleus accumbens and reward: neurophysiological investigations in behaving animals. Behavioral and cognitive neuroscience reviews. vol 1. issue 4. 2007-09-25. PMID:17712985. |
the nucleus accumbens (acb) is a crucial component of the brain reward system. |
2007-09-25 |
2023-08-12 |
Not clear |
| Regina M Carell. The nucleus accumbens and reward: neurophysiological investigations in behaving animals. Behavioral and cognitive neuroscience reviews. vol 1. issue 4. 2007-09-25. PMID:17712985. |
finally, because the acb is one neural substrate of a larger brain reward circuit, the influence of afferent input (hippocampus and prefrontal cortex) on acb cell firing during behavior is also discussed. |
2007-09-25 |
2023-08-12 |
Not clear |