| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiyu Zhang, Xianling Zhang, Huan Wang, Xin Guo, Honggui Li, Ying Wang, Xin Xu, Lyhun Tan, Mara T Mashek, Chunxiang Zhang, Yingjie Chen, Douglas G Mashek, Marc Foretz, Chuhong Zhu, Huaijun Zhou, Xu Liu, Benoit Viollet, Chaodong Wu, Yuqing Hu. AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity. Diabetes. vol 61. issue 12. 2013-01-25. PMID:22829451. |
interestingly, upon hfd feeding, irradiated wt mice that received the bone marrow of ampkα1(-/-) mice showed increased insulin resistance but not obesity, whereas irradiated ampkα1(-/-) mice with wt bone marrow had a phenotype of metabolic dysregulation that was similar to that of global ampkα1(-/-) mice. |
2013-01-25 |
2023-08-12 |
mouse |
| Roberto A Gulli, Justine M Tishinsky, Tara MacDonald, Lindsay E Robinson, David C Wright, David J Dyc. Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 10. 2013-01-25. PMID:23054173. |
in the current study, insulin and ad resistance were induced in rodents with 4 wk of hf feeding (hf(4); low-fat fed animals used as control). |
2013-01-25 |
2023-08-12 |
rat |
| Roberto A Gulli, Justine M Tishinsky, Tara MacDonald, Lindsay E Robinson, David C Wright, David J Dyc. Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 10. 2013-01-25. PMID:23054173. |
we conclude that the exercise and pharmacologically (β-gpa)-induced recovery of skeletal muscle insulin response after hf feeding is not dependent on the restoration of ad response, as assessed ex vivo. |
2013-01-25 |
2023-08-12 |
rat |
| Katrina Weston-Green, Xu-Feng Huang, Jiamei Lian, Chao Den. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 5. 2013-01-22. PMID:21982116. |
m3r binding correlations to body weight, food intake, insulin, ghrelin and cholecystokinin (cck) were analyzed. |
2013-01-22 |
2023-08-12 |
rat |
| Katrina Weston-Green, Xu-Feng Huang, Jiamei Lian, Chao Den. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 5. 2013-01-22. PMID:21982116. |
olanzapine increased m3r binding density in the arc, vmh and dvc, body weight, food intake, circulating plasma ghrelin and cck levels, and decreased plasma insulin and glucose. |
2013-01-22 |
2023-08-12 |
rat |
| Katrina Weston-Green, Xu-Feng Huang, Jiamei Lian, Chao Den. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 5. 2013-01-22. PMID:21982116. |
m3r negatively correlated to insulin, and positively correlated to ghrelin, cck, food intake and body weight. |
2013-01-22 |
2023-08-12 |
rat |
| Katrina Weston-Green, Xu-Feng Huang, Jiamei Lian, Chao Den. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 5. 2013-01-22. PMID:21982116. |
olanzapine acts on m3r in regions of the brain that control food intake and insulin secretion. |
2013-01-22 |
2023-08-12 |
rat |
| Ramesh C Khanal, Luke R Howard, Samuel E Wilkes, Theodore J Rogers, Ronald L Prio. Effect of dietary blueberry pomace on selected metabolic factors associated with high fructose feeding in growing Sprague-Dawley rats. Journal of medicinal food. vol 15. issue 9. 2013-01-22. PMID:22856519. |
compared with the control, hf feeding increased fasting plasma insulin and fasting and postprandial plasma triglycerides as well as homeostatic scores of insulin resistance and β-cell function, but not weight gain, diet intake and efficiency, abdominal fat, oral glucose tolerance, and fasting and postprandial plasma glucose, cholesterol, and leptin levels. |
2013-01-22 |
2023-08-12 |
rat |
| Sergio Vaira, Chang Yang, Aaron McCoy, Kelly Keys, Shurong Xue, Edward J Weinstein, Deborah V Novack, Xiaoxia Cu. Creation and preliminary characterization of a leptin knockout rat. Endocrinology. vol 153. issue 11. 2013-01-17. PMID:22948215. |
leptin, a cytokine-like hormone secreted mainly by adipocytes, regulates various pathways centered on food intake and energy expenditure, including insulin sensitivity, fertility, immune system, and bone metabolism. |
2013-01-17 |
2023-08-12 |
rat |
| S A Patel, K L Hoehn, R T Lawrence, L Sawbridge, N A Talbot, J L Tomsig, N Turner, G J Cooney, J P Whitehead, E W Kraegen, M E Cleasb. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. Endocrinology. vol 153. issue 11. 2013-01-17. PMID:22989629. |
although neither hfd feeding nor adipor1 oe caused generalized changes in sphingolipids, adipor1 oe did reduce levels of sphingosine 1-phosphate, ceramide 18:1, ceramide 20:2, and dihydroceramide 20:0, plus mrna levels of the ceramide synthetic enzymes serine palmitoyl transferase and sphingolipid Δ-4 desaturase, changes that are associated with increased insulin sensitivity. |
2013-01-17 |
2023-08-12 |
rat |
| Young Min Cho, Catherine E Merchant, Timothy J Kieffe. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology & therapeutics. vol 135. issue 3. 2013-01-14. PMID:22659620. |
gip is rapidly released from intestinal k-cells following food intake and stimulates glucose-dependent insulin secretion from β-cells and the storage of fat in adipocytes. |
2013-01-14 |
2023-08-12 |
Not clear |
| Young Min Cho, Catherine E Merchant, Timothy J Kieffe. Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology & therapeutics. vol 135. issue 3. 2013-01-14. PMID:22659620. |
similar to gip, glp-1 is released from intestinal l-cells following food intake and potentiates glucose-dependent insulin secretion from β-cells. |
2013-01-14 |
2023-08-12 |
Not clear |
| Jeb S Orr, Michael J Puglisi, Kate L J Ellacott, Carey N Lumeng, David H Wasserman, Alyssa H Hast. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes. vol 61. issue 11. 2013-01-14. PMID:22751700. |
despite the observed shift in atm phenotype, neither global nor hematopoietic cell tlr4 deficiency influenced systemic insulin sensitivity after high-fat feeding. |
2013-01-14 |
2023-08-12 |
mouse |
| Marcus Lin. Incretin therapy and its effect on body weight in patients with diabetes. Primary care diabetes. vol 6. issue 3. 2013-01-11. PMID:22613745. |
glucagon-like peptide 1 (glp-1) analogues and dipeptidyl peptidase-4 (dpp-4) inhibitors are two classes of treatments for type 2 diabetes, which enhance the well-known 'incretin effect' of increased insulin secretion in response to food intake. |
2013-01-11 |
2023-08-12 |
human |
| Xu Zhang, Yufeng Zhao, Menghui Zhang, Xiaoyan Pang, Jia Xu, Chaoying Kang, Meng Li, Chenhong Zhang, Zhiguo Zhang, Yifei Zhang, Xiaoying Li, Guang Ning, Liping Zha. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PloS one. vol 7. issue 8. 2013-01-10. PMID:22880019. |
in this study, we revealed that berberine effectively prevented the development of obesity and insulin resistance in high-fat diet (hfd)-fed rats, which showed decreased food intake. |
2013-01-10 |
2023-08-12 |
rat |
| Heesook Park, Minhee Kim, Gyoo Taik Kwon, Do Young Lim, Rina Yu, Mi-Kyung Sung, Ki Won Lee, James W Daily, Jung Han Yoon Par. A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. Molecular carcinogenesis. vol 51. issue 11. 2013-01-07. PMID:21919080. |
hfd feeding increased the serum levels of egf, insulin, igf-i, ifn-γ, leptin, rantes, mcp-1, il-1ra, and sdf-1α and media conditioned by epididymal fat tissue explants from hfd-fed mice caused an increase in microvessel outgrowth from the mouse aorta and tube formation of human umbilical vein endothelial cells. |
2013-01-07 |
2023-08-12 |
mouse |
| Mirian Bassi, Jussara M do Carmo, John E Hall, Alexandre A da Silv. Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats. Peptides. vol 37. issue 1. 2013-01-07. PMID:22749987. |
the higher dose slightly reduced food intake (14±1 to 11±1g/day), whereas vo(2), insulin and leptin levels were not affected by the treatment. |
2013-01-07 |
2023-08-12 |
rat |
| Wilfred Ip, Weijuan Shao, Yu-ting Alex Chiang, Tianru Ji. The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis. American journal of physiology. Endocrinology and metabolism. vol 303. issue 9. 2013-01-07. PMID:22967502. |
we examined hepatic wnt activity in the topgal transgenic mouse, assessed hepatic tcf7l2 expression in mice upon feeding, determined the effect of insulin on tcf7l2 expression and β-cat ser⁶⁷⁵ phosphorylation, and investigated the effect of wnt activation and tcf7l2 knockdown on gluconeogenic gene expression and glucose production in hepatocytes. |
2013-01-07 |
2023-08-12 |
mouse |
| Wilfred Ip, Weijuan Shao, Yu-ting Alex Chiang, Tianru Ji. The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis. American journal of physiology. Endocrinology and metabolism. vol 303. issue 9. 2013-01-07. PMID:22967502. |
insulin and feeding stimulated hepatic tcf7l2 expression in vitro and in vivo, respectively. |
2013-01-07 |
2023-08-12 |
mouse |
| Barbara Stoll, Patrycja Jolanta Puiman, Liwei Cui, Xiaoyan Chang, Nancy Marie Benight, Caroline Bauchart-Thevret, Bolette Hartmann, Jens Juul Holst, Douglas Guy Burri. Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs. JPEN. Journal of parenteral and enteral nutrition. vol 36. issue 5. 2013-01-03. PMID:22549765. |
we previously showed that parenteral nutrition (pn) compared with formula feeding results in hepatic insulin resistance and steatosis in neonatal pigs. |
2013-01-03 |
2023-08-12 |
Not clear |